In a recent study, an effective means of mixing a low Reynolds number pressure-driven flow in a micro-channel was reported by Stroock et al. [10] using trenches on the lower wall that form a staggered herringbone pattern. In the present work numerical results are reported that indicate enhanced mixing using a similar herringbone pattern in the context of an electro-osmotically driven flow in microchannels. Instead of trenches, all walls are flush, making microfabrication easier. The lower wall would have lithographically deposited polymer coatings that exhibit a zeta potential of a sign opposite to that at the other walls. These coatings are chosen to form a herringbone pattern. If mixing can be achieved using purely electro-osmotic flows, then it becomes easier to scale the channel dimensions to smaller values without the penalty of a dramatic increase in pressure drop. Moreover, the possibility of mixing with purely electro-osmotic flows that do not require time varying electric fields leads to a simpler system with fewer moving parts. With current micro-fabrication techniques, it is difficult to produce periodic patterned coatings on all four walls of a rectangular microchannel. For this reason, this study limits its scope to coatings applied only on the lower surface of the microchannel, with a rectangular cross-section. Numerical simulations are used in order to elucidate the dominant mechanism responsible for mixing, which is identified as the blinking-vortex [3]. The flow regime chosen to illustrate these effects is the same as that used by Stroock et al. [10], characterized by Reynolds numbers that are O(10−2) and Pe´clet numbers that are of O(105). The presence of patterned zeta potentials in a microchannel violates conditions of ideal electro-osmosis [4] and hence the flows are necessarily three-dimensional. The efficiency of mixing is quantified by examining particle tracks at several downstream sections of the microchannel and averaging their concentration over boxes of finite size to model diffusion. It is found that the standard deviation of the concentration decays exponentially, and that the rate of decay is independent of the Pe´clet number when the latter is sufficiently large, indicating that chaotically-enhanced mixing is occurring.
Towards a multi-physics modelling framework for thrombolysis under the influence of blood flow
