The Comparison of Aerodynamic Performance Data Acquired From Thermal Measurements and a Torquemeter on a Compressor Impeller

Author(s):  
Natalie R. Smith ◽  
Christopher Clarke ◽  
Timothy C. Allison ◽  
Michael Cave ◽  
Jason C. Wilkes

Full-thermal heat-soak of machinery is vital to acquiring accurate aerodynamic performance data, but this process often requires significant testing time to allow for all facility components to reach a steady state temperature. Even still, there is the potential for heat loss in a well-insulated facility, and this can lead to inaccurate results. The implementation of a torquemeter to calculate performance metrics, such as isentropic efficiency, has two potential advantages: 1) the method is not susceptible to effects due to thermal heat loss in the facility, and 2) a torquemeter directly measures actual torque, and thus work, input, which eliminates the need to fully heat-soak to measure the actual enthalpy rise of the gas. This paper presents a comparison of aerodynamic performance metrics calculated both from data acquired with thermal measurements as well as from a torquemeter. These tests were conducted over five speedlines for a shrouded impeller in the Southwest Research Institute Single Stage Test Rig facility. Isentropic efficiency calculated from the torquemeter was approximately 1–2 efficiency points lower than the isentropic efficiency based on thermal measurements. This corresponds to approximately 0.5–1°C in heat loss in the discharge collector and piping. Furthermore, observations from three full-thermal heat-soak points indicate the significant difference in time required to reach steady state performance within measurement uncertainty tolerances between the torque-based and thermal-based methods. This comparison, while largely suspected, has not yet been studied in previous publications.

2018 ◽  
Vol 141 (4) ◽  
Author(s):  
Natalie R. Smith ◽  
Timothy C. Allison ◽  
Jason C. Wilkes ◽  
Christopher Clarke ◽  
Michael Cave

Full-thermal heat-soak of machinery is vital for acquiring accurate aerodynamic performance data, but this process often requires significant testing time to allow all facility components to reach a steady-state temperature. Even still, there is the potential for heat loss in a well-insulated facility, and this can lead to inaccurate results. The implementation of a torquemeter to calculate performance metrics, such as isentropic efficiency, has two potential advantages: (1) the method is not susceptible to effects due to thermal heat loss in the facility, and (2) a torquemeter directly measures actual torque, and thus work, input, which eliminates the need to fully heat-soak to measure the actual enthalpy rise of the gas. This paper presents a comparison of aerodynamic performance metrics calculated both from data acquired with thermal measurements as well as from a torquemeter. These tests were conducted over five speedlines for a shrouded impeller in the Southwest Research Institute Single Stage Test Rig facility. Isentropic efficiency calculated from the torquemeter was approximately 1–2 efficiency points lower than the isentropic efficiency based on thermal measurements. This corresponds to approximately 0.5–1 °C in heat loss in the discharge collector and piping. Furthermore, observations from three full-thermal heat-soak points indicate the significant difference in time required to reach steady-state performance within measurement uncertainty tolerances between the torque-based and thermal-based methods. This comparison, while largely suspected, has not yet been studied in previous publications.


2019 ◽  
Vol 19 (8) ◽  
pp. 1198-1206 ◽  
Author(s):  
Yenny ◽  
Sonar S. Panigoro ◽  
Denni J. Purwanto ◽  
Adi Hidayat ◽  
Melva Louisa ◽  
...  

Background: Tamoxifen (TAM) is a frequently used hormonal prodrug for patients with breast cancer that needs to be activated by cytochrome P450 2D6 (CYP2D6) into Zusammen-endoxifen (Z-END). Objective: The purpose of the study was to determine the association between CYP2D6*10 (c.100C>T) genotype and attainment of the plasma steady-state Z-END minimal threshold concentration (MTC) in Indonesian women with breast cancer. Methods: A cross-sectional study was performed in 125 ambulatory patients with breast cancer consuming TAM at 20 mg/day for at least 4 months. The frequency distribution of CYP2D6*10 (c.100C>T) genotypes (C/C: wild type; C/T: heterozygous mutant; T/T: homozygous mutant) was detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), the results of which were subsequently confirmed by sequencing. The genotypes were categorized into plasma Z- END concentrations of <5.9 ng/mL and ≥5.9 ng/mL, which were measured using ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Results: Percentages of C/C, CT, and T/T genotypes were 22.4%, 29.6%, and 48.8%, respectively. Median (25-75%) Z-END concentrations in C/C, C/T, and T/T genotypes were 9.58 (0.7-6.0), 9.86 (0.7-26.6), and 3.76 (0.9-26.6) ng/mL, respectively. Statistical analysis showed a significant difference in median Z-END concentration between patients with T/T genotype and those with C/C or C/T genotypes (p<0.001). There was a significant association between CYP2D6*10 (c.100C>T) genotypes and attainment of plasma steady-state Z-END MTC (p<0.001). Conclusion: There was a significant association between CYP2D6*10 (c.100C>T) and attainment of plasma steady-state Z-END MTC in Indonesian breast cancer patients receiving TAM at a dose of 20 mg/day.


2021 ◽  
Vol 26 (2) ◽  
pp. 36
Author(s):  
Alejandro Estrada-Padilla ◽  
Daniela Lopez-Garcia ◽  
Claudia Gómez-Santillán ◽  
Héctor Joaquín Fraire-Huacuja ◽  
Laura Cruz-Reyes ◽  
...  

A common issue in the Multi-Objective Portfolio Optimization Problem (MOPOP) is the presence of uncertainty that affects individual decisions, e.g., variations on resources or benefits of projects. Fuzzy numbers are successful in dealing with imprecise numerical quantities, and they found numerous applications in optimization. However, so far, they have not been used to tackle uncertainty in MOPOP. Hence, this work proposes to tackle MOPOP’s uncertainty with a new optimization model based on fuzzy trapezoidal parameters. Additionally, it proposes three novel steady-state algorithms as the model’s solution process. One approach integrates the Fuzzy Adaptive Multi-objective Evolutionary (FAME) methodology; the other two apply the Non-Dominated Genetic Algorithm (NSGA-II) methodology. One steady-state algorithm uses the Spatial Spread Deviation as a density estimator to improve the Pareto fronts’ distribution. This research work’s final contribution is developing a new defuzzification mapping that allows measuring algorithms’ performance using widely known metrics. The results show a significant difference in performance favoring the proposed steady-state algorithm based on the FAME methodology.


1988 ◽  
Vol 8 (5) ◽  
pp. 1957-1969 ◽  
Author(s):  
R A Shapiro ◽  
D Herrick ◽  
R E Manrow ◽  
D Blinder ◽  
A Jacobson

As an approach to understanding the structures and mechanisms which determine mRNA decay rates, we have cloned and begun to characterize cDNAs which encode mRNAs representative of the stability extremes in the poly(A)+ RNA population of Dictyostelium discoideum amoebae. The cDNA clones were identified in a screening procedure which was based on the occurrence of poly(A) shortening during mRNA aging. mRNA half-lives were determined by hybridization of poly(A)+ RNA, isolated from cells labeled in a 32PO4 pulse-chase, to dots of excess cloned DNA. Individual mRNAs decayed with unique first-order decay rates ranging from 0.9 to 9.6 h, indicating that the complex decay kinetics of total poly(A)+ RNA in D. discoideum amoebae reflect the sum of the decay rates of individual mRNAs. Using specific probes derived from these cDNA clones, we have compared the sizes, extents of ribosome loading, and poly(A) tail lengths of stable, moderately stable, and unstable mRNAs. We found (i) no correlation between mRNA size and decay rate; (ii) no significant difference in the number of ribosomes per unit length of stable versus unstable mRNAs, and (iii) a general inverse relationship between mRNA decay rates and poly(A) tail lengths. Collectively, these observations indicate that mRNA decay in D. discoideum amoebae cannot be explained in terms of random nucleolytic events. The possibility that specific 3'-structural determinants can confer mRNA instability is suggested by a comparison of the labeling and turnover kinetics of different actin mRNAs. A correlation was observed between the steady-state percentage of a given mRNA found in polysomes and its degree of instability; i.e., unstable mRNAs were more efficiently recruited into polysomes than stable mRNAs. Since stable mRNAs are, on average, "older" than unstable mRNAs, this correlation may reflect a translational role for mRNA modifications that change in a time-dependent manner. Our previous studies have demonstrated both a time-dependent shortening and a possible translational role for the 3' poly(A) tracts of mRNA. We suggest, therefore, that the observed differences in the translational efficiency of stable and unstable mRNAs may, in part, be attributable to differences in steady-state poly(A) tail lengths.


Author(s):  
L. J. Yang

Wear rates obtained from different investigators could vary significantly due to lack of a standard test method. A test methodology is therefore proposed in this paper to enable the steady-state wear rate to be determined more accurately, consistently, and efficiently. The wear test will be divided into four stages: (i) to conduct the transient wear test; (ii) to predict the steady-state wear coefficient with the required sliding distance based on the transient wear data by using Yang’s second wear coefficient equation; (iii) to conduct confirmation runs to obtain the measured steady-state wear coefficient value; and (iv) to convert the steady-state wear coefficient value into a steady-state wear rate. The proposed methodology is supported by wear data obtained previously on aluminium based matrix composite materials. It is capable of giving more accurate steady-state wear coefficient and wear rate values, as well as saving a lot of testing time and labour, by reducing the number of trial runs required to achieve the steady-state wear condition.


2018 ◽  
Vol 8 (9) ◽  
pp. 1670 ◽  
Author(s):  
Wei Zhong ◽  
Xiang Ji ◽  
Chong Li ◽  
Jiwen Fang ◽  
Fanghua Liu

Sintered metal porous media are widely used in a broad range of industrial equipment. Generally, the flow properties in porous media are represented by an incompressible Darcy‒Forchheimer regime. This study uses a modified Forchheimer equation to represent the flow rate characteristics, which are then experimentally and theoretically investigated using a few samples of sintered metal porous media. The traditional steady-state method has a long testing time and considerable air consumption. With this in mind, a discharge method based on an isothermal chamber filled with copper wires is proposed to simultaneously determine the permeability and inertial coefficient. The flow rate discharged from the isothermal chamber is calculated by differentiating the measured pressure, and a paired dataset of pressure difference and flow rate is available. The theoretical representations of pressure difference versus flow rate show good agreement with the steady-state results. Finally, the volume limit of the isothermal chamber is addressed to ensure sufficient accuracy.


Sports ◽  
2018 ◽  
Vol 6 (4) ◽  
pp. 154 ◽  
Author(s):  
Paul Hafen ◽  
Pat Vehrs

The maximal lactate steady state (MLSS) is one of the factors that differentiates performance in aerobic events. The purpose of this study was to investigate the sex differences in oxygen consumption (VO2), heart rate (HR), and the respiratory exchange ratio (RER) at the MLSS in well-trained distance runners. Twenty-two (12 female, 10 male) well-trained distance runners (23 ± 5.0 years) performed multiple 30-min steady-state runs to determine their MLSS, during which blood lactate and respiratory gas exchange measures were taken. To interpret the MLSS intensity as a training tool, runners completed a time-to-exhaustion (TTE) run at their MLSS. The relative intensity at which the MLSS occurred was identical between males and females according to both oxygen consumption (83 ± 5 %O2max) and heart rate (89 ± 7 %HRmax). However, female runners displayed a significantly lower RER at MLSS compared to male runners (p < 0.0001; 0.84 ± 0.02 vs. 0.88 ± 0.04, respectively). There was not a significant difference in TTE at MLSS between males (79 ± 17 min) and females (80 ± 25 min). Due to the observed difference in the RER at the MLSS, it is suggested that RER derived estimates of MLSS be sex-specific. While the RER data suggest that the MLSS represents different metabolic intensities for males and females, the relative training load of MLSS appears to be similar in males and female runners.


2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Mingyu Shi ◽  
Liwei Ma ◽  
Jinsong Zhang ◽  
Qichang Yan

Background. The purpose of this observational case series study was to investigate the role of 25 MHz ultrasound biomicroscopy (UBM) in detecting subluxated lenses and compare it with 50 MHz UBM. Methods. 45 patients (49 eyes) with suspected subluxation of the lens and 20 normal volunteers (40 eyes) were included. Different cross-sectional images of the lens position were captured in axial and longitudinal scanning modes using 25 and 50 MHz UBM. The main outcome measurements included the linear distance between the lens equator and ciliary process, the difference value (D-value) between the same cross section of the above bilateral linear distance in the normal and the subluxated subjects, the diagnostic accuracy, and the testing times obtained with 25 and 50 MHz UBM. Results. The position of the lens on axial sections could be clearly shown by using 25 MHz UBM. The D-value of the subluxated eyes was 1-2 mm longer than that of the normal ones. There was a statistically significant difference between 25 and 50 MHz UBM in showing subluxation of the lens, the testing time was significantly faster (2.0 min versus 7.5 min), and the diagnostic accuracy was much higher (98.0% versus 71.4%) with 25 versus 50 MHz UBM. Fifteen eyes with slightly subluxated lens were detected by 25 MHz UBM, and only one eye with slight lens subluxation was detected by 50 MHz UBM. Conclusions. The results indicated that 25 MHz UBM has a greater diagnostic value than 50 MHz UBM in verifying the status of the lens subluxation and can provide reliable and quantitative imaging evidence for clinical use. This trial is registered with ChiCTR–DOD –15007603.


2018 ◽  
Vol 6 (7_suppl4) ◽  
pp. 2325967118S0016
Author(s):  
Brandon J. Erickson ◽  
Peter Nissen Chalmers ◽  
John D’Angelo ◽  
Kevin Ma ◽  
Anthony A. Romeo

Background: Isolated ulnar nerve decompression/transposition is an uncommon surgery amongst professional baseball players. Purpose: To determine the rate of return to sport (RTS) and performance upon RTS in professional baseball players following isolated ulnar nerve decompression/transposition, including those who required an ulnar nerve transposition/decompression following ulnar collateral ligament reconstruction (UCLR), and to determine if outcomes differ between players with isolated ulnar nerve decompression/transposition and matched controls. Hypothesis: There is a high rate of RTS in professional baseball players undergoing isolated ulnar nerve decompression/transposition with no significant difference in RTS rate or performance (specifically related to the primary outcome performance variables of earned run average (ERA), WHIP ((walks +hits)/innings pitched), wins above replacement (WAR), and on base + slugging percentage (OPS)) between cases and controls. Methods: All professional baseball players who underwent isolated ulnar nerve decompression/transposition between 2010-2016 were included. Demographic and performance data (pre and post surgery) for each player was recorded. Performance metrics were then compared between cases and a group of matched controls. Results: Overall 52 players, 83% pitchers (14 who underwent prior UCLR) were included. Most surgeries (92%) were anterior subcutaneous transpositions. Overall, 62% of players were able to successfully RTS and 56% returned to the same or a higher level. There was no significant difference between cases and controls in the majority of performance metrics pre-operative or post-operatively, specifically ERA, WHIP, WAR, and OPS. When players who had a UCLR prior to their ulnar nerve transposition/decompression were compared to controls with a history of a UCLR but who did not go on to have an ulnar nerve transposition/decompression, the only performance difference of all the recorded metrics was cases allowed more walks per 9 innings (4.4 vs. 2.8; p=0.011). Conclusion: Anterior subcutaneous transposition is the most common surgery in professional baseball players to address ulnar nerve compression. Players have a 62% rate of RTS. Upon RTS, players performance compared to matched controls remains the same in the majority of performance metrics including ERA, WHIP, WAR, and OPS. Post-operatively, pitchers with a UCLR prior to ulnar nerve transposition/decompression performed the same as matched controls with prior UCLR.


1978 ◽  
Vol 44 (6) ◽  
pp. 918-925 ◽  
Author(s):  
E. Kamon ◽  
B. Avellini ◽  
J. Krajewski

Heat-acclimated, lightly clothed men and women (four of each) walked on a treadmill at 25% and 43% VO2 max, respectively, (M =194 W.m-2), under seven air temperatures (Ta) ranging from 36 to 52 degrees C. Each experiment involved 1 h of fixed and a 2nd h of progressively increasing ambient vapor pressure (Pa). The relative steady state of rectal temperature (Tre), mean skin temperature (Tsk), and heart rate (HR) reached in the 1st h were forced upward during the 2nd h by the rising Pa. The critical air vapor pressure (Pcrit) was identified by the Tre point of inflection for each Ta. One man did not fully reach steady state, but inflection could be determined for his physiological responses. The mean values of all points of inflection were calculated for Tre, Tsk, and HR. Significant sex difference in HR was found only by excluding the results of the one man. Tre and Tsk showed no significant difference between men and women. The coefficient for evaporative heat transfer (he), which could be derived using the Pcrit for the low Ta range, was 14.5 +/- 2.2 W.m-1 Torr-1.


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