Aortic Valve Sinus Vorticity Dynamics and the Potential Role of Coronary Flow

2013 ◽  
Author(s):  
Brandon L. Moore ◽  
Lakshmi P. Dasi
Keyword(s):  
Aortic Valve ◽  
Coronary Flow ◽  
Potential Role ◽  
The United States ◽  
Calcific Aortic Valve Disease ◽  
Wide Range ◽  
Vorticity Dynamics ◽  
Spatio Temporal ◽  
Fluid Wall Shear Stress

Calcific aortic valve disease affects a wide range of the population in the United States. Each year there are approximately 50,000 valve replacements due to this disease [(Freeman & Otto, 2005)]. While it is unclear what the exact causes of CAVD are, it does appear to be correlated to local hemodynamic conditions particularly related to the complex spatio-temporal nature of fluid wall shear stress dynamics that the aortic side of the leaflets experience.

Abstract 27: Role of Sirtuin 6 in the Initiation and Progression of Calcific Aortic Valve Disease

2014 ◽  
Vol 34 (suppl_1) ◽  
Author(s):  
Carolyn M Roos ◽  
Bin Zhang ◽  
Grace Verzosa ◽  
Elise A Oehler ◽  
Michael A Hagler ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Disease ◽  
Valve Disease ◽  
Left Ventricular Ejection ◽  
Calcific Aortic Valve Disease ◽  
Valve Calcification ◽  
Age Related ◽  
Valve Function ◽  
Osteogenic Signaling

Increasing age is a major risk factor for calcific aortic valve disease (CAVD). Interestingly, SIRT6 knockout mice have a marked progeroid phenotype, and we recently reported that sirtuin enzyme expression is dramatically reduced with aging and that SIRT6 expression is reduced further in valves from patients with end-stage CAVD. It is unknown, however, whether experimentally reducing SIRT6 promotes osteogenic signaling in the valve and ultimately accelerates progression of CAVD. Thus, we used cultured mouse aortic valve interstitial cells and ldlr-deficient, apolipoprotein B100-only mice (LA) that were SIRT6 wild-type (LA-SIRT6 +/+ ) or heterozygous (LA-SIRT6 +/- ) and fed a Western diet for 3 or 12 months to determine the role of SIRT6 in valve calcification. In vitro , reduction of SIRT6 increased histone acetylation and significantly increased mRNA and protein levels of the osteogenic genes Runx2 and Sp7 in response to bone morphogenetic protein 2 (100ng/ml BMP2 for 18 hours), and siRNA knockdown of SIRT6 increased mRNA levels of Sp7 even in the absence of exogenous bone morphogens. Using high-resolution ultrasound to evaluate aortic valve function in vivo, we found that 3 month old LA-SIRT6 +/- mice did not have significant impairments in valve function compared to LA-SIRT6 +/+ mice. In contrast, 12 month old LA-SIRT6 +/- had dramatically worsened aortic valve dysfunction and stenosis compared to LA-SIRT6 +/+ mice, which was also associated with reductions in left ventricular ejection fraction. Collectively, our data strongly suggest SIRT6 plays a critical role in the tonic repression of osteogenic signaling in the aortic valve, and that age-related reductions in SIRT6 are likely to increase susceptibility to valve calcification in response to risk factors for CAVD such as hypercholesterolemia. Collectively, increasing activity of SIRT6 or reducing acetylation of its targets may serve as viable therapeutic strategies to slow progression of age-related valvular calcification and stenosis.

scholarly journals Adaptation of Newcastle Disease Virus (NDV) in Feral Birds and their Potential Role in Interspecies Transmission

2018 ◽  
Vol 12 (1) ◽  
pp. 52-68 ◽  
Author(s):  
Aziz-ul- Rahman ◽  
Momena Habib ◽  
Muhammad Zubair Shabbir
Keyword(s):  
Newcastle Disease ◽  
Potential Role ◽  
Vital Role ◽  
Wild Birds ◽  
Avian Species ◽  
Phylogenomic Analysis ◽  
Susceptible Host ◽  
Domestic Poultry ◽  
Wide Range

Introduction:Newcastle Disease (ND), caused by Avian avulavirus 1 (AAvV 1, avulaviruses), is a notifiable disease throughout the world due to the economic impact on trading restrictions and its embargoes placed in endemic regions. The feral birds including aquatic/migratory birds and other wild birds may act as natural reservoir hosts of ND Viruses (NDVs) and may play a remarkable role in the spread of the virus in environment. In addition, other 19 avulaviruses namely: AAvV 2 to 20, have been potentially recognized from feral avian species.Expalantion:Many previous studies have investigated the field prevailing NDVs to adapt a wide range of susceptible host. Still the available data is not enough to declare the potential role of feral birds in transmission of the virus to poultry and/or other avian birds. In view of the latest evidence related to incidences of AAvVs in susceptible avian species, it is increasingly important to understand the potential of viruses to transmit within the domestic poultry and other avian hosts. Genomic and phylogenomic analysis of several investigations has shown the same (RK/RQRR↓F) motif cleavage site among NDV isolates with same genotypes from domestic poultry and other wild hosts. So, the insight of this, various semi-captive/free-ranging wild avian species could play a vital role in the dissemination of the virus, which is an important consideration to control the disease outbreaks. Insufficient data on AAvV 1 transmission from wild birds to poultry and vice versa is the main constraint to understand about its molecular biology and genomic potential to cause infection in all susceptible hosts.Conclusion:The current review details the pertinent features of several historical and contemporary aspects of NDVs and the vital role of feral birds in its molecular epidemiology and ecology.

scholarly journals Autophagy is activated in the ovarian tissue of polycystic ovary syndrome

Reproduction ◽  
2018 ◽  
Vol 155 (1) ◽  
pp. 85-92 ◽  
Author(s):  
Da Li ◽  
Yue You ◽  
Fang-Fang Bi ◽  
Tie-Ning Zhang ◽  
Jiao Jiao ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Potential Role ◽  
Polycystic Ovary ◽  
Ovarian Tissue ◽  
Ovary Syndrome ◽  
Cellular Processes ◽  
Transmission Electron ◽  
Wide Range ◽  
Response To Stress

The importance of autophagy in polycystic ovary syndrome (PCOS)-related metabolic disorders is increasingly being recognized, but few studies have investigated the role of autophagy in PCOS. Here, transmission electron microscopy demonstrated that autophagy was enhanced in the ovarian tissue from both humans and rats with PCOS. Consistent with this, ovarian granulosa cells from PCOS rats showed increases in the autophagy marker protein light chain 3B (LC3B), whereas levels of the autophagy substrate SQSTM1/p62 were decreased. In addition, the ratio of LC3-II/LC3-I was markedly elevated in human PCOS ovarian tissue compared with normal ovarian tissue. Real-time PCR arrays indicated that 7 and 34 autophagy-related genes were down- and up-regulated in human PCOS , Signal-Net, and regression analysis suggested that there are a wide range of interactions among these 41 genes, and a potential network based on EGFR, ERBB2, FOXO1, MAPK1, NFKB1, IGF1, TP53 and MAPK9 may be responsible for autophagy activation in PCOS. Systematic functional analysis of 41 differential autophagy-related genes indicated that these genes are highly involved in specific cellular processes such as response to stress and stimulus, and are linked to four significant pathways, including the insulin, ERBB, mTOR signaling pathways and protein processing in the endoplasmic reticulum. This study provides evidence for a potential role of autophagy disorders in PCOS in which autophagy may be an important molecular event in the pathogenesis of PCOS.

Role of Ectonucleotidases and Purinergic Receptors in Calcific Aortic Valve Disease

2014 ◽  
pp. 117-126
Author(s):  
Patrick Mathieu ◽  
Ablajan Mahmut ◽  
Philippe Pibarot ◽  
Yohan Bossé ◽  
Marie-Chloé Boulanger
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Disease ◽  
Purinergic Receptors ◽  
Valve Disease ◽  
Calcific Aortic Valve Disease

Users’ Attitudes towards Institutional Repository in Jadavpur University: A Critical Study

2012 ◽  
Vol 1 (2) ◽  
pp. 45-52
Author(s):  
Sambhu Nath Halder ◽  
Suvra Chandra
Keyword(s):  
Potential Role ◽  
Point Of View ◽  
Academic Institution ◽  
Critical Study ◽  
Institutional Repository ◽  
Digital Environment ◽  
Institutional Repositories ◽  
Wide Range ◽  
User Friendly

This paper examines the user-aware of institutional repositories in Jadavpur University. The main objective of this study is to investigate the awareness of Institutional Repository (IR) in an academic institution and different aspects associated with it, such as, software, sources for user’s awareness, motivators for developing a repository, demand of the users in changing paradigms from traditional to digital environment, etc. In the present days, libraries are also adopting the latest technologies to provide best possible services in user friendly form. This paper also describes the potential role of institutional repositories and its easiness and simplicity of use are attracting more patrons in the use of institutional repositories. Only a wide range of user awareness is needed for proper usage of its beauty. Entirely this paper is based on a critical study, which measures the utility of institutional repositories in users’ point of view.

Drivers' Perceptions of Unsafe Driving Behaviors and Their Countermeasures: A Study in Saudi Arabia

2014 ◽  
Vol 70 (4) ◽  
Author(s):  
Tanweer Hasan ◽  
Ishtiaque Ahmed ◽  
Hamid O. Al-Bar
Keyword(s):  
Saudi Arabia ◽  
Police Officers ◽  
Time Pressure ◽  
Red Light ◽  
The United States ◽  
Aggressive Driving ◽  
Road Rage ◽  
Driving Behaviors ◽  
Wide Range

There is an increased public concern about the role of aggressive driving and "road rage" in crashes and traffic fatalities. There is no general agreement as to what constitutes aggressive driving. Consequently, the objective of the study was to survey of the perceptions on the specific unsafe driving acts. Perceptions and beliefs of drivers about unsafe and aggressive driving actions and their countermeasures are presented in this paper. The study primarily looked at the wide range of driver attitudes about speeding and other forms of unsafe driving behavior. The study was conducted in Jeddah, the second largest city of Saudi Arabia by interviewing a sample of 300 drivers. The results indicated that the drivers, in general, prefer to drive at higher speeds and could be considered as more aggressive compared to the drivers in the United States. The most dangerous reported driving act was "drive thru red light", followed by "racing another driver". Only 23% of the drivers thought that it was dangerous to drive over 30 km of the legal speed limits. The most often seen unsafe driving action was "speeding (70%), followed by "driving too closely (57%), "failing to use turn signals (53%), "drive inattentively (50%)", and "running red lights (43%)". The main causes of unsafe driving behaviors were "being in a hurry/time pressure (66%)", "aggressive behavior of others (52%)", and "refusing traffic rules (51%)". The countermeasure that was viewed to be the most effective in reducing unsafe driving behaviors was assigning more traffic police officers (66%). The study revealed that, more than half the drivers believed that more frequent ticketing (60%), doubling or tripling fines (54%), and doubling the length of imprisonment (53%) would be effective in reducing unsafe driving behaviors.

scholarly journals Potential role of full-length and nonfull-length progranulin in affecting aortic valve calcification

2020 ◽  
Vol 141 ◽  
pp. 93-104
Author(s):  
Gaigai Huang ◽  
Liqin An ◽  
Mengtian Fan ◽  
Menghao Zhang ◽  
Bin Chen ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Potential Role ◽  
Full Length ◽  
Aortic Valve Calcification ◽  
Valve Calcification
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