The Impact of Silver Nanoparticles Stabilized with Surfactant on Endothelial Cell Cycle Progression

Pollen grains represent the highly reduced haploid male gametophyte generation in angiosperms. They play an essential role in plant fertility by generating and delivering twin sperm cells to the embryo sac to undergo double fertilization. The functional specialization of the male gametophyte and double fertilization are considered to be key innovations in the evolutionary success of angiosperms. The haploid nature of the male gametophyte and its highly tractable ontogeny makes it an attractive system to study many fundamental biological processes, such as cell fate determination, cell-cycle progression and gene regulation. The present mini-review encompasses key advances in our understanding of the molecular mechanisms controlling male gametophyte patterning in angiosperms. A brief overview of male gametophyte development is presented, followed by a discussion of the genes required at landmark events of male gametogenesis. The value of the male gametophyte as an experimental system to study the interplay between cell fate determination and cell-cycle progression is also discussed and exemplified with an emerging model outlining the regulatory networks that distinguish the fate of the male germline from its sister vegetative cell. We conclude with a perspective of the impact emerging data will have on future research strategies and how they will develop further our understanding of male gametogenesis and plant development.

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Curcumin inhibits the proliferation and cell cycle progression of human umbilical vein endothelial cell

Cancer Letters ◽

10.1016/0304-3835(96)04357-1 ◽

1996 ◽

Vol 107 (1) ◽

pp. 109-115 ◽

Cited By ~ 62

Author(s):

Anoop K. Singh ◽

Gurmel S. Sidhu ◽

T. Deepa ◽

Radha K. Maheshwari

Keyword(s):

Cell Cycle ◽

Endothelial Cell ◽

Cell Cycle Progression ◽

Umbilical Vein ◽

Cycle Progression ◽

Human Umbilical Vein

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P2Y2 purinergic receptor activation is essential for efficient hepatocyte proliferation in response to partial hepatectomy

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.00092.2014 ◽

2014 ◽

Vol 307 (11) ◽

pp. G1073-G1087 ◽

Cited By ~ 26

Author(s):

Bryan C. Tackett ◽

Hongdan Sun ◽

Yu Mei ◽

Janielle P. Maynard ◽

Sayuri Cheruvu ◽

...

Keyword(s):

Cell Cycle ◽

Partial Hepatectomy ◽

Cell Cycle Progression ◽

Purinergic Receptors ◽

Purinergic Receptor ◽

Receptor Activation ◽

Hepatocyte Proliferation ◽

Receptor Subtypes ◽

Cycle Progression ◽

The Impact

Extracellular nucleotides via activation of P2 purinergic receptors influence hepatocyte proliferation and liver regeneration in response to 70% partial hepatectomy (PH). Adult hepatocytes express multiple P2Y (G protein-coupled) and P2X (ligand-gated ion channels) purinergic receptor subtypes. However, the identity of key receptor subtype(s) important for efficient hepatocyte proliferation in regenerating livers remains unknown. To evaluate the impact of P2Y2 purinergic receptor-mediated signaling on hepatocyte proliferation in regenerating livers, wild-type (WT) and P2Y2 purinergic receptor knockout (P2Y2−/−) mice were subjected to 70% PH. Liver tissues were analyzed for activation of early events critical for hepatocyte priming and subsequent cell cycle progression. Our findings suggest that early activation of p42/44 ERK MAPK (5 min), early growth response-1 (Egr-1) and activator protein-1 (AP-1) DNA-binding activity (30 min), and subsequent hepatocyte proliferation (24–72 h) in response to 70% PH were impaired in P2Y2−/− mice. Interestingly, early induction of cytokines (TNF-α, IL-6) and cytokine-mediated signaling (NF-κB, STAT-3) were intact in P2Y2−/− remnant livers, uncovering the importance of cytokine-independent and nucleotide-dependent early priming events critical for subsequent hepatocyte proliferation in regenerating livers. Hepatocytes isolated from the WT and P2Y2−/− mice were treated with ATP or ATPγS for 5–120 min and 12–24 h. Extracellular ATP alone, via activation of P2Y2 purinergic receptors, was sufficient to induce ERK phosphorylation, Egr-1 protein expression, and key cyclins and cell cycle progression of hepatocytes in vitro. Collectively, these findings highlight the functional significance of P2Y2 purinergic receptor activation for efficient hepatocyte priming and proliferation in response to PH.

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Delphinidin inhibits endothelial cell proliferation and cell cycle progression through a transient activation of ERK-1/-2

Biochemical Pharmacology ◽

10.1016/s0006-2952(02)01568-x ◽

2003 ◽

Vol 65 (4) ◽

pp. 669-675 ◽

Cited By ~ 62

Author(s):

Sophie Martin ◽

Laure Favot ◽

Rachel Matz ◽

Claire Lugnier ◽

Ramaroson Andriantsitohaina

Keyword(s):

Cell Cycle ◽

Cell Proliferation ◽

Endothelial Cell ◽

Cell Cycle Progression ◽

Endothelial Cell Proliferation ◽

Cycle Progression ◽

Transient Activation

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Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flow

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1205476109 ◽

2012 ◽

Vol 109 (20) ◽

pp. 7770-7775 ◽

Cited By ~ 53

Author(s):

J. Zhou ◽

P.-L. Lee ◽

C.-S. Tsai ◽

C.-I. Lee ◽

T.-L. Yang ◽

...

Keyword(s):

Cell Cycle ◽

Endothelial Cell ◽

Cell Cycle Progression ◽

Vascular Endothelial Cell ◽

Vascular Endothelial ◽

Cycle Progression ◽

Disturbed Flow

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Genotypic and Phenotypic Variables Affect Meiotic Cell Cycle Progression, Tumor Ploidy, and Cancer-Associated Mortality in a brca2-Mutant Zebrafish Model

Journal of Oncology ◽

10.1155/2019/9218251 ◽

2019 ◽

Vol 2019 ◽

pp. 1-15 ◽

Cited By ~ 1

Author(s):

L. Mensah ◽

J. L. Ferguson ◽

H. R. Shive

Keyword(s):

Cell Cycle ◽

Cancer Cells ◽

Germ Cells ◽

Cell Cycle Progression ◽

Chromosomal Abnormalities ◽

Somatic Cells ◽

Zebrafish Model ◽

Cycle Progression ◽

Human Cancers ◽

The Impact

Successful cell replication requires both cell cycle completion and accurate chromosomal segregation. The tumor suppressor BRCA2 is positioned to influence both of these outcomes, and thereby influence genomic integrity, during meiotic and mitotic cell cycles. Accordingly, mutations in BRCA2 induce chromosomal abnormalities and disrupt cell cycle progression in both germ cells and somatic cells. Despite these findings, aneuploidy is not more prevalent in BRCA2-associated versus non-BRCA2-associated human cancers. More puzzlingly, diploidy in BRCA2-associated cancers is a negative prognostic factor, unlike non-BRCA2-associated cancers and many other human cancers. We used a brca2-mutant/tp53-mutant cancer-prone zebrafish model to explore the impact of BRCA2 mutation on cell cycle progression, ploidy, and cancer-associated mortality by performing DNA content/cell cycle analysis on zebrafish germ cells, somatic cells, and cancer cells. First, we determined that combined brca2/tp53 mutations uniquely disrupt meiotic progression. Second, we determined that sex significantly influences ploidy outcome in zebrafish cancers. Third, we determined that brca2 mutation and female sex each significantly reduce survival time in cancer-bearing zebrafish. Finally, we provide evidence to support a link between BRCA2 mutation, tumor diploidy, and poor survival outcome. These outcomes underscore the utility of this model for studying BRCA2-associated genomic aberrations in normal and cancer cells.

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