A laminar optical tomography system for the early cervical cancer diagnosis

BACKGROUND: MicroRNAs (miRNA) are promising biomarkers for cancer diagnosis and prognosis; miR-100 expression is decreased in cervical cancer tissues. OBJECTIVE: To determine whether miR-100 is a useful biomarker for early cervical cancer diagnosis. METHODS: Total RNA was extracted from the sera of 34 healthy controls (HC), 64 cervical intraepithelial neoplasia patients (CIN), and 46 cervical cancer patients (CC). miR-100 expression levels were measured with quantitative real-time PCR. Correlations between clinicopathological factors and miR-100 expression levels were also assessed. The cut-off value for miR-100 was calculated from the Receiver Operating Characteristic (ROC) curve. RESULTS: Relative expression levels of miR-100 in serum were 1.84 ± 1.72, 3.93 ± 2.52, and 5.32 ± 3.39 in CC, CIN, and HC, respectively; it was significantly lower in CC (p< 0.001). The area under the ROC curve was 0.879 and the cut-off value was 2.451. miR-100 expression levels were significantly higher in metastasis cases that were lymph node negative than positive (p< 0.05). CC patients with miR-100 expression levels below the cut-off value tended to have a poor prognosis. CONCLUSIONS: Serum miR-100 may be a useful diagnostic biomarker for CC, and for predicting lymph node metastasis and disease free survival in CC patients.

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Healthcare system: A digital green filter for smart health early cervical cancer diagnosis

2016 IEEE 2nd International Forum on Research and Technologies for Society and Industry Leveraging a better tomorrow (RTSI) ◽

10.1109/rtsi.2016.7740564 ◽

2016 ◽

Cited By ~ 1

Author(s):

S. Letizia Digiovanni ◽

Cataldo Guaragnella ◽

Maria Rizzi ◽

Maddalena Falagario

Keyword(s):

Cervical Cancer ◽

Healthcare System ◽

Cancer Diagnosis ◽

Green Filter ◽

System A ◽

Smart Health ◽

Early Cervical Cancer

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Enhancement of Early Cervical Cancer Diagnosis with Epithelial Layer Analysis of Fluorescence Lifetime Images

PLoS ONE ◽

10.1371/journal.pone.0125706 ◽

2015 ◽

Vol 10 (5) ◽

pp. e0125706 ◽

Cited By ~ 8

Author(s):

Jun Gu ◽

Chit Yaw Fu ◽

Beng Koon Ng ◽

Lin Bo Liu ◽

Soo Kim Lim-Tan ◽

...

Keyword(s):

Cervical Cancer ◽

Cancer Diagnosis ◽

Fluorescence Lifetime ◽

Epithelial Layer ◽

Layer Analysis ◽

Early Cervical Cancer

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Transrectal ultrasound (TRUS) and MRI in staging of early cervical cancer

Ultraschall in der Medizin - European Journal of Ultrasound ◽

10.1055/s-2007-988913 ◽

2007 ◽

Vol 28 (S 1) ◽

Author(s):

D Fischerova ◽

D Cibula ◽

M Zikan ◽

P Calda ◽

H Vondrichova ◽

...

Keyword(s):

Cervical Cancer ◽

Transrectal Ultrasound ◽

Early Cervical Cancer

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Efficiency of diagnosis and treatment non-invasive and microinvasive sgamous cell cervical cancer

HEALTH OF WOMAN ◽

10.15574/hw.2020.149.71 ◽

2020 ◽

pp. 71-74

Author(s):

M.M. Melnyk ◽

◽

S.V. Nespradko ◽

I.V. Goncharuk ◽

M.V. Marchenko ◽

...

Keyword(s):

Cervical Cancer ◽

Key Words ◽

National Cancer Institute ◽

Reproductive Function ◽

Diagnosis And Treatment ◽

Non Invasive ◽

Corpus Uteri ◽

Complex Program ◽

Early Cervical Cancer

The objective: analyse the effectiveness of diagnosis and treatment for early cervical cancer. Materials and methods. Analysed 107 cases of women’s disease on CIN ІІІ, cancer in situ, they were on treatment in National cancer institute and Kyiv dictrict cancer dispensary from 2010 till 2015 years. Results. Diagnosed percent relapse CIN ІІІ, cancer in situ contain 4.57% uninvasive and invasive form – 0.94%. Conclusion. According diagnostic CIN ІІ and CIN ІІІ is recommended to do treatment conization and dynamic dispensary observation. Are making complex program of infection HPV16, 18. In appering of margins resection some elements of tumor after wider conization by forms of cancer in situ. Many of expansive burns in cervical glands, in making of reproductive function, going disease (nodel leiomyoma of corpus uteri etc). In perspective is accept the notion of looking after and screening research of considering infection HPV16, 18 on CIN І, CIN ІІ. Key words: cervical cancer, сancer in situ, CIN І–ІІІ, diagnostic, treatment, conization.

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