Automated segmentation of nine retinal layers with layer thickness information on SD-OCT images

Purpose: To provide a spectral-domain optical coherence tomography (SD-OCT)-based analysis of retinal layers thickness and nasal displacement of closed macular hole after internal limiting membrane peeling in macular hole surgery. Methods: In this nonrandomized prospective interventional study, 36 eyes of 32 patients were subjected to pars plana vitrectomy and 3.5 mm diameter internal limiting membrane (ILM) peeling for idiopathic macular hole (IMH). Nasal and temporal internal retinal layer thickness were assessed with SD-OCT. Each scan included optic disc border so that distance between optic disc border and fovea were measured. Results: Thirty-six eyes had a successful surgery with macular hole closure. Total nasal retinal thickening (p<0.001) and total temporal retinal thinning (p<0.0001) were observed. Outer retinal layers increased thickness after surgery (nasal p<0.05 and temporal p<0.01). Middle part of inner retinal layers (mIRL) had nasal thickening (p<0.001) and temporal thinning (p<0.05). The mIRL was obtained by deducting ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) thickness from overall thickness of the inner retinal layer. Papillofoveal distance was shorter after ILM peeling in macular hole surgery (3,651 ± 323 μm preoperatively and 3,361 ± 279 μm at 6 months; p<0.0001). Conclusions: Internal limiting membrane peel is associated with important alteration in inner retinal layer architecture, with thickening of mIRL and shortening of papillofoveal distance. These factors may contribute to recovery of disrupted foveal photoreceptor and vision improvement after IMH closure.

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Faculty Opinions recommendation of Automated segmentation errors when using optical coherence tomography to measure retinal nerve fiber layer thickness in glaucoma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726937566.793525178 ◽

2016 ◽

Author(s):

Julian Garcia-Feijoo ◽

Federico Saenz-Frances

Keyword(s):

Optical Coherence Tomography ◽

Nerve Fiber ◽

Layer Thickness ◽

Retinal Nerve Fiber Layer ◽

Automated Segmentation ◽

Optical Coherence ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Nerve Fiber Layer Thickness ◽

Retinal Nerve Fiber

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Graph search: active appearance model based automated segmentation of retinal layers for optic nerve head centered OCT images

10.1117/12.2250168 ◽

2017 ◽

Author(s):

Enting Gao ◽

Fei Shi ◽

Weifang Zhu ◽

Chao Jin ◽

Min Sun ◽

...

Keyword(s):

Optic Nerve ◽

Optic Nerve Head ◽

Graph Search ◽

Appearance Model ◽

Active Appearance Model ◽

Automated Segmentation ◽

Retinal Layers ◽

Model Based ◽

Active Appearance

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Assessment of Global and Local Alterations in Retinal Layer Thickness in Ins2 (Akita) Diabetic Mice by Spectral Domain Optical Coherence Tomography

Journal of Ophthalmology ◽

10.1155/2018/7253498 ◽

2018 ◽

Vol 2018 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Andrew W. Francis ◽

Justin Wanek ◽

Mahnaz Shahidi

Keyword(s):

Optical Coherence Tomography ◽

Mouse Model ◽

Layer Thickness ◽

Retinal Thickness ◽

Normative Values ◽

Retinal Layer ◽

Wild Type ◽

Global And Local ◽

Akita Mice ◽

Sd Oct

Purpose/Aim. The Ins2 (Akita) mouse is a spontaneous diabetic mouse model with a heterozygous mutation in the insulin 2 gene that results in sustained hyperglycemia. The purpose of the study was to assess global and local retinal layer thickness alterations in Akita mice by analysis of spectral domain optical coherence tomography (SD-OCT) images.Materials and Methods. SD-OCT imaging was performed in Akita and wild-type mice at 12 and 24 weeks of age. Inner retinal thickness (IRT), outer retinal thickness (ORT), total retinal thickness (TRT), and photoreceptor outer segment length (OSL) were measured. Mean global thickness values were compared between Akita and wild-type mice. Local thickness variations in Akita mice were assessed based on normative values in wild-type mice.Results. Akita mice had higher blood glucose levels and lower body weights (p<0.001). On average, IRT, ORT, and TRT were approximately 2% lower in Akita mice than in wild-type mice (p≤0.02). In Akita mice, the percent difference between retinal areas with thickness below and above normative values for IRT, ORT, and TRT was 22%, 32%, and 38%, respectively.Conclusions. These findings support the use of the Akita mouse model to study the retinal neurodegenerative effects of hyperglycemia.

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Beyond Retinal Layers: An Automatic Active Contour Model with Pre-Fitting Energy for Subretinal Fluid Segmentation in SD-OCT Images

2018 IEEE 3rd International Conference on Image, Vision and Computing (ICIVC) ◽

10.1109/icivc.2018.8492862 ◽

2018 ◽

Cited By ~ 1

Author(s):

Nursultan Taubaldy ◽

Zexuan Ji

Keyword(s):

Active Contour ◽

Active Contour Model ◽

Subretinal Fluid ◽

Retinal Layers ◽

Contour Model ◽

Sd Oct

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Ocular abnormalities in Polish Hunting Dogs

PLoS ONE ◽

10.1371/journal.pone.0258636 ◽

2021 ◽

Vol 16 (11) ◽

pp. e0258636

Author(s):

Ireneusz Balicki ◽

Małgorzata Goleman ◽

Agnieszka Balicka

Keyword(s):

Clinical Signs ◽

Eye Diseases ◽

Ophthalmological Examination ◽

Progressive Retinal Atrophy ◽

Ocular Abnormalities ◽

Retinal Lesions ◽

Retinal Layers ◽

Hunting Dogs ◽

Interdigitation Zone ◽

Sd Oct

This study aimed to describe and determine the prevalence of ocular abnormalities in Polish Hunting Dogs. The study was conducted with 193 Polish Hunting Dogs: 101 female and 92 male animals, aged between 3 months and 12 years. Ophthalmic examinations were performed using slit lamp biomicroscopy, ophthalmoscopy, and tonometry based on the ophthalmological protocol for the examination of hereditary eye diseases. Spectral-domain optical coherence tomography (SD-OCT) was performed for dogs with sudden acquired retinal degeneration syndrome (SARDS) and progressive retinal atrophy (PRA), while electroretinography was also performed in dogs with SARDS. Five dogs (2.6%) were diagnosed with cataract, iris coloboma in 3 dogs (1.6%), ocular dermoid in 1 dog (0.5%), and retinal dysplasia, distichiasis and entropion in 1 dog (1%). Three dogs (1.6%) were diagnosed with PRA and SARDS occurred in 1 dog. Retinal lesions was observed in 16 dogs (8.3%). The clinical signs of retinopathy observed in Polish Hunting Dogs included discoloration of the tapetal fundus, patchy increased reflectivity in the region of discoloration, focus of hyperpigmentation and an area of tapetal hyper-reflectivity with a pigmented center. SD-OCT performed in the 3 dogs with PRA revealed alteration in the retinal layers, which was most advanced in the non-tapetal fundus. Although SD-OCT revealed retinal layers with normal architecture only in some parts of the dorsal, nasal and temporal regions in dogs with SARDS, areas of disorganized external limiting membrane, myeloid zone, ellipsoid zone, outer photoreceptor segment and interdigitation zone were also observed. Polish Hunting Dogs should undergo periodic ophthalmological examination for the evaluation of other hereditary eye diseases. The prevalence of retinal lesions in Polish Hunting Dogs requires further research.

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Automated retinal layers segmentation in SD-OCT images using dual-gradient and spatial correlation smoothness constraint

Computers in Biology and Medicine ◽

10.1016/j.compbiomed.2014.08.028 ◽

2014 ◽

Vol 54 ◽

pp. 116-128 ◽

Cited By ~ 25

Author(s):

Sijie Niu ◽

Qiang Chen ◽

Luis de Sisternes ◽

Daniel L. Rubin ◽

Weiwei Zhang ◽

...

Keyword(s):

Spatial Correlation ◽

Retinal Layers ◽

Smoothness Constraint ◽

Dual Gradient ◽

Sd Oct

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Outer Retinal Layers’ Thickness Changes in relation to Age and Choroidal Thickness in Normal Eyes

Journal of Ophthalmology ◽

10.1155/2019/1698967 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Mona Kamal Abdellatif ◽

Yasser Abdelmaguid Mohamed Elzankalony ◽

Ahmed Abdelmonsef Abdelhamid Ebeid ◽

Weam Mohamed Ebeid

Keyword(s):

Choroidal Thickness ◽

Pigment Epithelium ◽

Retinal Pigment ◽

Enhanced Depth Imaging ◽

Old Patients ◽

Retinal Layers ◽

Age Related ◽

Significant Difference ◽

Group 3 ◽

Sd Oct

Purpose. To identify and correlate age-related changes in outer retinal layers’ thickness and choroidal thickness (CT) in the normal eyes using spectral-domain optical coherence tomography (SD-OCT) and to investigate factors affecting these changes. Study Design. Observational cross-sectional study. Subjects and Methods. We studied 125 healthy Egyptians between 20 and 79 years old. Patients were divided into 3 groups: group 1 (20–40 years), group 2 (40–60 years), and group 3 (>60 years). All patients had full ophthalmic examination. SD-OCT was done to measure the 9 ETDRS macular grid sectors of retinal pigment epithelium and photoreceptor outer segment (RPE-OS), outer nuclear layer and photoreceptor inner segment (ONL-IS), and choroidal thickness (CT) (by enhanced depth imaging). Results. RPE-OS was significantly thinner in group 3 than in the other 2 groups (central: P<0.001). Moreover, the 3 groups were significantly different from each other regarding the CT (central: P<0.001); significant thinning was noticed in the choroid with age. The 3 groups did not show significant difference concerning the ONL-IS thickness. RPE-OS and CT showed statistically significant negative correlation with age (central RPE-OS: r = −0 C.345, P<0.001, and central CT: r = −0.725, P<0.001) while ONL-IS showed statistically nonsignificant correlation with age (central ONL-IS: r = −0.08, P=0.376). Multiple regression analysis revealed that the most important determinant of central 1 mm RPE-OS thickness in this study was age (β = −0.087, P=0.010) rather than choroidal thinning (β = 0.001, P=0.879). Conclusion. RPE-OS layer thickness shows significant thinning with increasing age, and with decrease in CT, however, age is the most determinant factor of this thinning.

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