Remote, non-genetic modulation of cellular activity using hybrid-nanomaterials

Author(s):  
Tzahi Cohen-Karni
Author(s):  
Oktay Arda ◽  
Ulkü Noyan ◽  
Selgçk Yilmaz ◽  
Mustafa Taşyürekli ◽  
İsmail Seçkin ◽  
...  

Turkish dermatologist, H. Beheet described the disease as recurrent triad of iritis, oral aphthous lesions and genital ulceration. Auto immune disease is the recent focus on the unknown etiology which is still being discussed. Among the other immunosupressive drugs, CyA included in it's treatment newly. One of the important side effects of this drug is gingival hyperplasia which has a direct relation with the presence of teeth and periodontal tissue. We are interested in the ultrastructure of immunocompetent target cells that were affected by CyA in BD.Three groups arranged in each having 5 patients with BD. Control group was the first and didn’t have CyA treatment. Patients who had CyA, but didn’t show gingival hyperplasia assembled the second group. The ones displaying gingival hyperplasia following CyA therapy formed the third group. GMC of control group and their granules are shown in FIG. 1,2,3. GMC of the second group presented initiation of supplementary cellular activity and possible maturing functional changes with the signs of increased number of mitochondria and accumulation of numerous dense cored granules next to few normal ones, FIG. 4,5,6.


Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
MS Hassoun ◽  
MJ Clément ◽  
M Cailleret ◽  
N Jarroux ◽  
I Hamdi ◽  
...  
Keyword(s):  

2020 ◽  
Vol 20 (11) ◽  
pp. 1017-1030
Author(s):  
Haonan Zhang ◽  
Zhengquan Gao ◽  
Chunxiao Meng ◽  
Xiangqian Li ◽  
Dayong Shi

Protein tyrosine phosphatase 2 (SHP-2) has long been proposed as a cancer drug target. Several small-molecule compounds with different mechanisms of SHP-2 inhibition have been reported, but none are commercially available. Pool selectivity over protein tyrosine phosphatase 1 (SHP-1) and a lack of cellular activity have hindered the development of selective SHP-2 inhibitors. In this review, we describe the binding modes of existing inhibitors and SHP-2 binding sites, summarize the characteristics of the sites involved in selectivity, and identify the suitable groups for interaction with the binding sites.


2004 ◽  
Vol 14 (9) ◽  
pp. 2127-2130 ◽  
Author(s):  
Andrew J Peat ◽  
Dulce Garrido ◽  
Joyce A Boucheron ◽  
Stephanie L Schweiker ◽  
Scott H Dickerson ◽  
...  
Keyword(s):  

2021 ◽  
Vol 294 ◽  
pp. 129737
Author(s):  
Xinmei Liu ◽  
Farsad Imtiaz Chowdhury ◽  
Lingju Meng ◽  
Qiwei Xu ◽  
Xihua Wang

2020 ◽  
Vol 6 (3) ◽  
pp. 410-413
Author(s):  
Petra J. Kluger ◽  
Svenja Nellinger ◽  
Simon Heine ◽  
Ann-Cathrin Volz

AbstractThe extracellular matrix (ECM) naturally surrounds cells in humans, and therefore represents the ideal biomaterial for tissue engineering. ECM from different tissues exhibit different composition and physical characteristics. Thus, ECM provides not only physical support but also contains crucial biochemical signals that influence cell adhesion, morphology, proliferation and differentiation. Next to native ECM from mature tissue, ECM can also be obtained from the in vitro culture of cells. In this study, we aimed to highlight the supporting effect of cell-derived- ECM (cdECM) on adipogenic differentiation. ASCs were seeded on top of cdECM from ASCs (scdECM) or pre-adipocytes (acdECM). The impact of ECM on cellular activity was determined by LDH assay, WST I assay and BrdU assay. A supporting effect of cdECM substrates on adipogenic differentiation was determined by oil red O staining and subsequent quantification. Results revealed no effect of cdECM substrates on cellular activity. Regarding adipogenic differentiation a supporting effect of cdECM substrates was obtained compared to control. With these results, we confirm cdECM as a promising biomaterial for adipose tissue engineering.


2021 ◽  
pp. 1-10
Author(s):  
Niels Neumann ◽  
Sofia Doello ◽  
Karl Forchhammer

Nitrogen starvation induces developmental transitions in cyanobacteria. Whereas complex multicellular cyanobacteria of the order Nostocales can differentiate specialized cells that perform nitrogen fixation in the presence of oxygenic photosynthesis, non-diazotrophic unicellular strains, such as <i>Synechococcus elongatus</i> or <i>Synechocystis</i> PCC 6803, undergo a transition into a dormant non-growing state. Due to loss of pigments during this acclimation, the process is termed chlorosis. Cells maintain viability in this state for prolonged periods of time, until they encounter a useable nitrogen source, which triggers a highly coordinated awakening process, termed resuscitation. The minimal set of cellular activity that maintains the viability of cells during chlorosis and ensures efficient resuscitation represents the organism’s equivalent of the BIOS, the basic input/output system of a computer, that helps “booting” the operation system after switching on. This review summarizes the recent research in the resuscitation of cyanobacteria, representing a powerful model for the awakening of dormant bacteria.


2021 ◽  
pp. 205301962110015
Author(s):  
Maurizio Meloni ◽  
Rachael Wakefield-Rann ◽  
Becky Mansfield

The Anthropocene literature has brought attention to the plasticity and porosity of Earth systems under the dramatic impact of human activities. Moving across scales of analysis, this paper focuses attention on anthropogenic effects at the micro-scale of genomic regulation, neuronal functioning and cellular activity. Building on expanding dialogues at the interface of Anthropocene science, biogeography, microbiology and ecotoxicology, we mobilize epigenetic findings to show increasing evidence of anthropogenic changes in plants, animals and human bodies. Treating human-induced changes at the macro-global and micro-biological scales as part of an intertwined process has implications for how these problems are conceptualised and addressed. While we are sceptics about major geo-bio-social syntheses, we believe that agile social-scientific tools can facilitate interaction across disciplines without denying unevenness, and differences. If rightly contextualized in broad anthropological and social science frameworks, biosocial work on epigenetics offers a compelling avenue to make detectable the ‘slow violence’ of everyday pollution, racism, inequalities and the disproportionate impact of the Anthropocene on the poor and vulnerable. Consolidating work at the Anthropocene/biology interface has potential to offer a richer and more complete picture of the present crisis at the macro and micro-scale alike.


Author(s):  
Tong Zhang ◽  
Hongwei Chu ◽  
Dong Li ◽  
Ying Li ◽  
Shengzhi Zhao ◽  
...  

In the present work, we synthesize a Fe3O4@Ti3C2 MXene hybrid nanomaterial. Comprehensive investigation on the morphology and structure of the prepared Fe3O4@Ti3C2 MXene demonstrates the strong interaction between Ti3C2 MXene...


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