Secretory IgA, albumin, and bone-density level changes as markers of biostimulatory effects from laser radiation on the healing process after extraction of human molars on the lower jaw

This study aims to determine the efficacy of jatropha curcas L. cream in the maturation phase of healing of mice leather injuries. This study used nine rats with 3 treatments, ie treatment group I smeared cream base (P1), treatment group II smeared 0.1% sulfadiazine cream (P2) and treatment group III smeared jatropha curcas 10% (P3). The result of ANAVA test of treatment I, treatment II and treatment III had significant effect (P 0,05) on fibroblast cells but each treatment group on collagen density level showed significant effect (P 0.01). Duncan test results on fibroblasts, P3 was significantly different (P 0.05) with P2 and P3, whereas the results on P3 collagen density were significantly different (P 0.01) with P2 and P1. The conclusion that 10% jatropha gum cream for 10 days can decrease the number of fibroblast cells and increase the amount of collagen thus accelerate the process of maturation phase of healing of mice leather injuries.

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Changes in jaw dimensions and bone density in patients with osteoporosis

Stomatoloski glasnik Srbije ◽

10.2298/sgs0901015p ◽

2009 ◽

Vol 56 (1) ◽

pp. 15-22 ◽

Cited By ~ 1

Author(s):

Srdjan Postic

Keyword(s):

Bone Density ◽

Treatment Method ◽

Radiographic Analysis ◽

Panoramic Radiographs ◽

Jaw Bones ◽

Restorative Treatment ◽

Lower Jaw

Introduction Osteopenia and osteoporosis reduce the density and mass of jaw bones. Aim The aim of this study was to present the methods of radiographic analysis in patients with osteoporosis prior to restorative treatment. Method 127 panoramic radiographs (Kodak, USA) and 39 retroalveolar radiographs (KD 58-R 30?40 mm, USA) were used for the analysis of density (DT II 05 densitometer, England) and dimensions of jaw bones with respect to segments corresponding to bone layers. Results The results of this study indicated statistically significant differences in bone density (p<0.05 and p<0.01) in patients with osteopenia. Bone density was significantly reduced (p<0.01 and p<0.001) in osteoporotic patients, when compared to controls. Significant reductions of edentulous ridges in osteoporotic patients women X=23.05 mm (kV=30.72%) and X=22.85 mm (kV=28.81%), and men X=28.83 (kV=8.55%) as well as X=25.36 (kV=11.43%), were observed. Conclusion Bone density of the upper and lower jaw is reduced in osteoporotic patients. At the very beginning of restorative prosthodontic therapy of osteoporotic patients, retroalveolar radiographs and panoramic radiographs should be obtained. Reference lines should be assigned, contours of the alveolar and edentulous ridges on radiographs should be analysed and bone density assessed.

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ASSESSMENT OF BONE QUALITY IN THE FRONTAL PART OF MANDIBLES IN FEMALE PATIENTS OF VARIOUS AGES USING CONE-BEAM COMPUTED TOMOGRAPHY

The actual problems in dentistry ◽

10.18481/2077-7566-2020-16-3-83-89 ◽

2020 ◽

Vol 16 (3) ◽

pp. 83-89

Author(s):

Natal'ya Nurieva ◽

Irina Shelegova ◽

Dar'ya Vazhenina

Keyword(s):

Bone Density ◽

Optical Density ◽

Cone Beam ◽

Microsoft Excel ◽

Female Patients ◽

Lower Jaw ◽

Frontal Part ◽

Age Related ◽

The Right ◽

Symmetrical Points

Thing. The optical density of the lower jaw in the frontal part of female patients was studied, age-related differences in the optical density of the lower jaw were revealed. The aim is to reveal the variability of the values of optical density of the lower jaw in the anterior region in female patients. Methodology. Computed tomograms of the lower jaws of 26 patients were analyzed. The optical density of the bone was assessed using the method of computer densitometry in Hounsfield arbitrary units, measurements were carried out in the area of the root apexes of the lower canines. Statistical analysis was carried out using Microsoft Excel, Windows 9. Results. In 84.6 % of cases, the optical density of bone tissue in the area of 3.3 and 4.3 teeth is within the same class according to the Misch classification. In this group, 72.7 % of patients had class D2, 18.18 ― D1, 9 ― D3; in 15.4 %, the bone density on the right and left sides of the mandible belongs to D2 and D3. The optical density between two relatively symmetrical points is in the range from 2 to 238 units, between the right and left sides it is 129.66 HU. In the group of 30―39 (n = 6) years, in 50 % of cases, bone density belongs to class D2, in 33.33 ― D1, in 16.66 ― D3; 40―49 (n = 8) years in 87.5 % of cases ― D2, in 12.5 ― D1; 50―59 (n = 6) years at 50 % ― D2 and at 50 ― D3; 60―68 (n = 6) years at 50 % ― D2 and at 50 ― D3. Conclusions. With increasing age of patients, there is a decrease in bone density in the lower jaw in the canine area.

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The Relationship of Mandibular Bone Density Level to Femur Bone Density Level in Ovariectomized Female Rats given Isoflavones and 17-estradiol

Proceedings of the International Dental Conference of Sumatera Utara 2017 (IDCSU 2017) ◽

10.2991/idcsu-17.2018.81 ◽

2018 ◽

Author(s):

Wita Anngraini ◽

Tri Budi W. Rahardjo ◽

Ichramsjah A. Rachman ◽

Deddy Muchtadi

Keyword(s):

Bone Density ◽

Female Rats ◽

Density Level ◽

Mandibular Bone ◽

Femur Bone ◽

Relationship Of ◽

The Relationship

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Antiresorptive drug-related changes of the mandibular bone densitiy in medication-related osteonecrosis of the jaw patients

Dentomaxillofacial Radiology ◽

10.1259/dmfr.20190132 ◽

2019 ◽

Vol 48 (8) ◽

pp. 20190132 ◽

Cited By ~ 2

Author(s):

Nils Heim ◽

Werner Götz ◽

Franz-Josef Kramer ◽

Anton Faron

Keyword(s):

Bone Density ◽

Alveolar Bone ◽

Reference Group ◽

Mental Foramen ◽

Contralateral Side ◽

Osteonecrosis Of The Jaw ◽

Duration Of Treatment ◽

Lower Jaw ◽

Antiresorptive Drug ◽

Density Values

Objectives: Medication-related osteonecrosis of the jaw (MRONJ) is a well known side-effect of anti-resorptive drugs. Changes in bone density might potentially constitute the development of ONJ. This study aimed to investigate, to which degree bisphosphonates (bp) and denosumab (db) induce changes in bone density that can be determined from routine diagnostic CT. Methods: CT scans of 101 patients were investigated. MRONJ was present in 61 patients (n = 26: db-treated; n = 35 bp-treated). 40 patients were included as a reference group. Bone density was measured at two distinct locations in the mandible (M1: anterior of the mental foramen; M2: retromolar), each on the contralateral side to the necrosis. Results: The bone density values measured at both locations were found to be significantly higher in the bp-group compared to the db-group (p = 0.027) and to the reference-group (p = 0.016). Almost no difference (p = 0.84) in bone density value was found between the db- and reference-groups.Investigating the effect of duration of treatment, none of the measured values showed significant differences in both locations of db- and bp-group. Conclusion: The findings from this study suggest that that bisphosphonates change the microarchitecture of the alveolar bone by being embedded in the mandible, which may subsequently lead to a bp-specific corticalization, and a decrease in vascularization of the lower jaw. This process may be distinctive for bp-treatment and seems to induce the congestion of cancellous bone rather rapidly after the first administrations. This effect could not be determined in denosumab-treated patients.

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Is insulin topical gel better than simvastatin topical gel in full thickness wound?

Dermatology Reports ◽

10.4081/dr.2019.8051 ◽

2019 ◽

Author(s):

Timotius Hansen Arista ◽

Agus Santoso Budi ◽

Mirnasari Amirsyah ◽

Nanda Febry Setyawati

Keyword(s):

Healing Process ◽

Wound Healing Process ◽

Density Level ◽

Fibroblast Proliferation ◽

Full Thickness ◽

Topical Gel ◽

Acting Insulin ◽

Collagen Density ◽

Long Acting ◽

Full Thickness Wound

Due to issues of limited substances and expensive cost of wound treatment, topical insulin and simvastatin are being developed due to benefits including easy to find and applicable in every health center. Topical insulin can be used in treating diabetic patient’s wound. Simvastatin contributed in wound healing process by increasing angiogenesis and lymphangiogenesis. This experimental study is using randomized post test only control design in male Wistar mice, divided in 5 treatment groups with 9 mice each : carboxymethylcellulose sodium gel, short acting insulin topical gel, long acting insulin topical gel, simvastatin topical 2% gel, and simvastatin 3% topical gel. A full thickness wound was made randomly and observed in 5 days, followed with wound biopsy and analyzing using histopathological specimen measuring the epithelial thickness, fibroblast proliferation and collagen density from each group. Long acting insulin topical gel has the highest average rate of epithelial proliferation and fibroblast proliferation. In simvastatin 3% topical gel has the highest level of collagen density level among other groups. This study showed long acting insulin topical gel significantly has better outcome than other groups.

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Photobiomodulation by a 635nm Diode Laser on Peri-Implant Bone: Primary and Secondary Stability and Bone Density Analysis—A Randomized Clinical Trial

BioMed Research International ◽

10.1155/2019/2785302 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 16

Author(s):

Jacek Matys ◽

Katarzyna Świder ◽

Kinga Grzech-Leśniak ◽

Marzena Dominiak ◽

Umberto Romeo

Keyword(s):

Bone Density ◽

Total Energy ◽

Laser Irradiation ◽

Diode Laser ◽

Healing Process ◽

Average Power ◽

Titanium Implants ◽

Implant Stability ◽

The Impact ◽

Secondary Stability

Introduction. Various procedures in dental implantology are performed to enhance the bone healing process and implant stability. One of these methods can be a low-level laser therapy (LLLT).Objectives. The aim of our study was to evaluate the stabilization (primary and secondary) and bone density in peri-implant zone after LLLT protocol using a 635 nm diode laser.Material and Methods. The research included 40 implants placed in the posterior region of a mandible in 24 patients (8 women and 16 man; age: 46.7 ± 8.7 years). The patients were randomly divided into 2 groups G1 (n=12, 18 implants) and G2 (n=12, 22 implants) according to the treatment procedure; G1 (test): 635 nm laser, with handpiece diameter: 8mm, output power: 100mW, spot area: 0.5024cm2, average power density: 199.04mW/cm2, continuous mode, dose: 4J per point (8J/cm2), time: 40 sec per point, 2 points (irradiation on a buccal and a lingual side of the alveolus/implant), and total energy per session 8J; G2 (control): no laser irradiation. The G1 (test) group’s implants were irradiated according to the following protocol: 1 day before surgery, immediately after the surgery and 2, 4, 7, and 14 days after. The total energy after all therapeutic sessions was 48J. The implants stability was measured employing a Periotest device (Periotest Test Value: PTV) (measured immediately after the surgery, 7 days, 2 weeks, 4 weeks, and 2 and 3 months after the surgery) and the bone density using cone-beam computed tomography (grayscale value) (measured immediately after the surgery, 4 weeks and 12 weeks after the treatment).Results. The average implant stability at different time points showed lower PTV value (higher stability) at2ndand4thweek after 635 nm laser irradiation (G1) compared with a control (G2) group (p<0.01). The secondary stability of the implants after 12 weeks observation was not significantly higher for the laser group in contrast to none-irradiated implants (p>0.05). The mean grayscale value at the apical, middle, and cervical level of the titanium implants showed the reduction of pixel grayscale value after 2 weeks and was lower for the G1 group in contrast to the G2 group (p<0.01). The value of grayscale after 12 weeks was significantly higher at the middle and apical level of the implants in the G1group in contrast to the G2 group (p<0.01).Conclusion. The application of the 635 nm diode laser enhanced secondary implant stability and bone density. However, to assess the impact of the LLLT on peri-implant bone with different bone densities, further well-controlled long-term trials on larger study groups are needed.

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