SU-FF-T-357: Clinical Implementation of the OneDosePlusTM MOSFET Detector for in Vivo Dose Measurement

2009 ◽  
Vol 36 (6Part14) ◽  
pp. 2604-2604
Author(s):  
C Ainsley ◽  
S Both
Keyword(s):  
Dose Measurement ◽  
Clinical Implementation ◽  
Mosfet Detector

scholarly journals Rectal and Bladder Dose Measurements in the Intracavitary Applications of Cervical Cancer Treatment with HDR Afterloading System: Comparison of TPS Data with MOSFET Detector

2019 ◽  
Author(s):  
N Singh ◽  
Sh Ahamed ◽  
A Sinha ◽  
Sh Srivastava ◽  
N K Painuly ◽  
...  
Keyword(s):  
High Dose Rate ◽  
In Vivo Dosimetry ◽  
Intracavitary Brachytherapy ◽  
High Dose ◽  
Gradient Fields ◽  
Calculated Dose ◽  
Mosfet Detector ◽  
Dose Measurements

Background: Intracavitary brachytherapy plays a major role in management of cervical carcinoma. Assessment of dose received by OAR’s therefore becomes crucial for the estimation of radiation toxicities in high dose rate brachytherapy.Objective: The purpose of this study is to evaluate the role of in vivo dosimetry in HDR brachytherapy and to compare the actual doses delivered to OAR’s with those calculated during treatment planning.Materials and Methods: A total of 50 patients were treated with Microselectron HDR. Out of 50 patients, 26 were treated with a dose of 7 Gy and 24 with a dose of 9 Gy, prescribed to point A. Brachytherapy planning and evaluation of dose to the bladder and rectum was done on TPS & in vivo dosimetry was performed using portable MOSFET.Results: The calibration factors calculated for both the dosimeters are almost equal and are 0.984 cGy/mV and 1.0895 cGy/mV. For bladder, dose deviation was found to be within +/- 5% in 28 patients, +/- 5-10% in 14 patients, +/- 10-15% in 4 patients. The deviation between the TPS-calculated dose and the dose measured by MOSFET for rectum was within +/- 5% in 31 patients, +/- 5–10% in 8 patients, and +/- 10–15% in 7 patients.Conclusion: TPS calculated doses were slightly higher than that measured by MOSFET. The use of a small size of MOSFET dosimeter is an efficient method for accurately measuring doses in high-dose gradient fields typically seen in brachytherapy. Therefore, to reduce risk of large errors in the dose delivery, in vivo dosimetry can be done in addition to TPS computations.

CHARACTERISATION AND EVALUATION OF AL2O3:C-BASED OPTICALLY STIMULATED LUMINESCENT DOSEMETER SYSTEM FOR DIAGNOSTIC X-RAYS: PERSONAL AND IN VIVO DOSIMETRY

2019 ◽  
Vol 187 (4) ◽  
pp. 451-460
Author(s):  
J H D Wong ◽  
M Bakhsh ◽  
Y Y Cheah ◽  
W L Jong ◽  
J S Khor ◽  
...  
Keyword(s):  
Energy Dependence ◽  
In Vivo Dosimetry ◽  
X Rays ◽  
Dose Measurement ◽  
Total Uncertainty ◽  
Signal Stability ◽  
Depth Dose ◽  
Dose Curve ◽  
Depth Dose Curve

Abstract This study characterises and evaluates an Al2O3:C-based optically stimulated luminescent dosemeter (OSLD) system, commercially known as the nanoDot™ dosemeter and the InLight® microStar reader, for personal and in vivo dose measurements in diagnostic radiology. The system characteristics, such as dose linearity, reader accuracy, reproducibility, batch homogeneity, energy dependence and signal stability, were explored. The suitability of the nanoDot™ dosemeters was evaluated by measuring the depth dose curve, in vivo dose measurement and image perturbation. The nanoDot™ dosemeters were observed to produce a linear dose with ±2.8% coefficient variation. Significant batch inhomogeneity (8.3%) was observed. A slight energy dependence (±6.1%) was observed between 60 and 140 kVp. The InLight® microStar reader demonstrated good accuracy and a reproducibility of ±2%. The depth dose curve measured using nanoDot™ dosemeters showed slightly lower responses than Monte Carlo simulation results. The total uncertainty for a single dose measurement using this system was 11%, but it could be reduced to 9.2% when energy dependence correction was applied.

scholarly journals Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis

2020 ◽  
Vol 12 (547) ◽  
pp. eaaz2878 ◽  
Author(s):  
Peng Zhang ◽  
Xiaoqing Wu ◽  
Gulhumay Gardashova ◽  
Yang Yang ◽  
Yaohua Zhang ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Ductal Carcinoma ◽  
Metastatic Breast ◽  
Cancer Diagnostics ◽  
Matrix Metalloproteases ◽  
Tumor Evolution ◽  
Matrix Remodeling ◽  
Clinical Implementation

Longitudinal cancer monitoring is crucial to clinical implementation of precision medicine. There is growing evidence indicating important functions of extracellular vesicles (EVs) in tumor progression and metastasis, including matrix remodeling via transporting matrix metalloproteases (MMPs). However, the clinical relevance of EVs remains largely undetermined, partially owing to challenges in EV analysis. Distinct from existing technologies mostly focused on characterizing molecular constituents of EVs, here we report a nanoengineered lab-on-a-chip system that enables integrative functional and molecular phenotyping of tumor-associated EVs. A generalized, high-resolution colloidal inkjet printing method was developed to allow robust and scalable manufacturing of three-dimensional (3D) nanopatterned devices. With this nanochip platform, we demonstrated integrative analysis of the expression and proteolytic activity of MMP14 on EVs to detect in vitro cell invasiveness and monitor in vivo tumor metastasis, using cancer cell lines and mouse models. Analysis of clinical plasma specimen showed that our technology could be used for cancer detection including accurate classification of age-matched controls and patients with ductal carcinoma in situ, invasive ductal carcinoma, or locally metastatic breast cancer in a training cohort (n = 30, 96.7% accuracy) and an independent validation cohort (n = 70, 92.9% accuracy). With clinical validation, our technology could provide a useful liquid biopsy tool to improve cancer diagnostics and real-time surveillance of tumor evolution in patients to inform personalized therapy.

scholarly journals Colorectal Cancer Growth Retardation through Induction of Apoptosis, Using an Optimized Synergistic Cocktail of Axitinib, Erlotinib, and Dasatinib

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1878 ◽  
Author(s):  
Robert H. Berndsen ◽  
Nathalie Swier ◽  
Judy R. van Beijnum ◽  
Patrycja Nowak-Sliwinska
Keyword(s):  
Colorectal Cancer ◽  
Cell Lines ◽  
Kinase Inhibitors ◽  
Expression Profiles ◽  
Chorioallantoic Membrane ◽  
Treatment Strategies ◽  
Tumor Growth Inhibition ◽  
Clinical Implementation

Patients with advanced colorectal cancer (CRC) still depend on chemotherapy regimens that are associated with significant limitations, including resistance and toxicity. The contribution of tyrosine kinase inhibitors (TKIs) to the prolongation of survival in these patients is limited, hampering clinical implementation. It is suggested that an optimal combination of appropriate TKIs can outperform treatment strategies that contain chemotherapy. We have previously identified a strongly synergistic drug combination (SDC), consisting of axitinib, erlotinib, and dasatinib that is active in renal cell carcinoma cells. In this study, we investigated the activity of this SDC in different CRC cell lines (SW620, HT29, and DLD-1) in more detail. SDC treatment significantly and synergistically decreased cell metabolic activity and induced apoptosis. The translation of the in-vitro-based results to in vivo conditions revealed significant CRC tumor growth inhibition, as evaluated in the chicken chorioallantoic membrane (CAM) model. Phosphoproteomics analysis of the tested cell lines revealed expression profiles that explained the observed activity. In conclusion, we demonstrate promising activity of an optimized mixture of axitinib, erlotinib, and dasatinib in CRC cells, and suggest further translational development of this drug mixture.

scholarly journals Image-based multi-scale modelling and validation of radio-frequency ablation in liver tumours

2011 ◽  
Vol 369 (1954) ◽  
pp. 4233-4254 ◽  
Author(s):  
Stephen Payne ◽  
Ronan Flanagan ◽  
Mika Pollari ◽  
Tuomas Alhonnoro ◽  
Claire Bost ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Radio Frequency ◽  
Radio Frequency Ablation ◽  
High Intensity Focused Ultrasound ◽  
Imaging Data ◽  
Clinical Implementation ◽  
Liver Tumours ◽  
Advantages And Disadvantages ◽  
Wide Range

The treatment of cancerous tumours in the liver remains clinically challenging, despite the wide range of treatment possibilities, including radio-frequency ablation (RFA), high-intensity focused ultrasound and resection, which are currently available. Each has its own advantages and disadvantages. For non- or minimally invasive modalities, such as RFA, considered here, it is difficult to monitor the treatment in vivo . This is particularly problematic in the liver, where large blood vessels act as heat sinks, dissipating delivered heat and shrinking the size of the lesion (the volume damaged by the heat treatment) locally; considerable experience is needed on the part of the clinician to optimize the heat treatment to prevent recurrence. In this paper, we outline our work towards developing a simulation tool kit that could be used both to optimize treatment protocols in advance and to train the less-experienced clinicians for RFA treatment of liver tumours. This tool is based on a comprehensive mathematical model of bio-heat transfer and cell death. We show how simulations of ablations in two pigs, based on individualized imaging data, compare directly with experimentally measured lesion sizes and discuss the likely sources of error and routes towards clinical implementation. This is the first time that such a ‘loop’ of mathematical modelling and experimental validation in vivo has been performed in this context, and such validation enables us to make quantitative estimates of error.

scholarly journals EP-1409: Clinical implementation of an EPID based in vivo dosimetry system

2015 ◽  
Vol 115 ◽  
pp. S760-S761
Author(s):  
N. De Kerpel ◽  
N. De Maeseneire ◽  
T. Vercauteren ◽  
F. Decoster ◽  
Y. Lievens ◽  
...  
Keyword(s):  
In Vivo Dosimetry ◽  
Clinical Implementation ◽  
Dosimetry System

Mathematical estimation and in vivo dose measurement for cone-beam computed tomography on prostate cancer patients

2009 ◽  
Vol 92 (1) ◽  
pp. 57-61 ◽  
Author(s):  
Shiu-Chen Jeng ◽  
Chiao-Ling Tsai ◽  
Wen-Tung Chan ◽  
Chuan-Jong Tung ◽  
Jian-Kuen Wu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Computed Tomography ◽  
Cancer Patients ◽  
Cone Beam Computed Tomography ◽  
Cone Beam ◽  
Dose Measurement

Protein synthesis in crustaceans: a review focused on feeding and nutrition

2014 ◽  
Vol 9 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Chris Carter ◽  
Elena Mente
Keyword(s):  
Protein Synthesis ◽  
Diet Composition ◽  
Biotic Factors ◽  
Dose Measurement ◽  
Retention Efficiency ◽  
Future Directions ◽  
Dietary Amino Acid ◽  
Feeding Regimes ◽  
Abiotic And Biotic Factors

AbstractThis review aimed to place crustacean research on in vivo protein synthesis into a broader context, assess its potential for providing further insights into crustacean nutrition and physiology, and recommend future directions relevant to crustacean aquaculture. In crustaceans the flooding dose measurement of protein synthesis is the only method that has been used, it is relatively complex, time consuming and uses radioactive labels. Protein synthesis provides a subtle approach to assessing imbalances and deficiencies in dietary amino acid and energy. In addition, the calculation of protein synthesis retention efficiency (SRE) is recommended in order to understand and optimize parameters such as feeding regime and diet composition. For prawns, SRE was highest at optimum dietary protein content and quality. Similarly the most efficient feeding regimes in juvenile lobsters were demonstrated by the highest efficiency of retaining synthesized protein. Understanding how various abiotic and biotic factors influence protein synthesis has great potential for improving different aspects of crustacean aquaculture but very few studies have done this; better knowledge of how abiotic and biotic factors affect crustacean protein synthesis will contribute to optimising growth of crustaceans in culture.

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