Exercise-Induced Oxidative Stress before and after Vitamin C Supplementation

1997 ◽  
Vol 7 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Helaine M. Alessio ◽  
Allan H. Goldfarb ◽  
Guohua Cao
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Before And After ◽  
Vitamin C Supplementation ◽  
Exercise Induced

Effect of High Dose Vitamin C Supplementation on Muscle Soreness, Damage, Function, and Oxidative Stress to Eccentric Exercise

2006 ◽  
Vol 16 (3) ◽  
pp. 270-280 ◽  
Author(s):  
S.C. Bryer ◽  
A.H. Goldfarb
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Eccentric Exercise ◽  
Muscle Function ◽  
Muscle Soreness ◽  
Damage Function ◽  
High Dose ◽  
Before And After ◽  
Vitamin C Supplementation ◽  
Glutathione Oxidation

This study investigated if vitamin C supplementation before and after eccentric exercise could reduce muscle soreness (MS), oxidative stress, and muscle function. Eighteen healthy men randomly assigned to either a placebo (P) or vitamin C (VC) (3 g/d) treatment group took pills for 2 wk prior and 4 d after performing 70 eccentric elbow extensions with their non-dominant arm. MS increased in both groups with significantly reduced MS for the first 24 h with VC. Range of motion was reduced equally in both groups after the exercise (P ≥ 0.05). Muscle force declined equally and was unaffected by treatment. VC attenuated the creatine kinase (CK) increase at 48 h after exercise with similar CK after this time. Gluta-thione ratio (oxidized glutathione/total glutathione) was significantly increased at 4 and 24 h with P but VC prevented this change. These data suggest that vitamin C pretreatment can reduce MS, delay CK increase, and prevent blood glutathione oxidation with little influence on muscle function loss.

scholarly journals Type 2 Diabetes Mellitus And Vitamin C

2019 ◽  
Vol 09 (03) ◽  
pp. 232-236
Author(s):  
Shabzain Ishrat ◽  
Talea Hoor ◽  
Mohammed Sajid Abbas Jaffri
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin C ◽  
Good Control ◽  
Type 2 Dm ◽  
Vitamin C Supplementation ◽  
Antioxidant Supplements

Type 2 diabetes mellitus (DM) is a chronic disease which deteriorates the quality of life with time. Type 2 DM accounts for more than 90% cases of diabetes mellitus as compared to other types of this disease. There is significant oxidative stress in type 2 DM which plays an important role in the pathogenesis of disease. In order to combat this oxidative stress antioxidant supplements have to be added as add on therapy along with treatment of type 2 DM. Vitamin C is the safest antioxidant which plays significant role in diminishing the oxidative stress. The vitamin C supplementation have good control of FBS and HbA1c and therefore helps in achieving better glycemic control along with prevention of lipid abnormalities.

scholarly journals The effect of vitamin C on the gene expression profile of sperm protamines in the male partners of couples with recurrent pregnancy loss: A randomized clinical trial

2020 ◽  
Vol 47 (1) ◽  
pp. 68-76
Author(s):  
Saeideh Hamidian ◽  
Ali Reza Talebi ◽  
Farzaneh Fesahat ◽  
Mohammad Bayat ◽  
Ali Mohammad Mirjalili ◽  
...  
Keyword(s):  
Gene Expression ◽  
Vitamin C ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Sperm Chromatin ◽  
Dna Integrity ◽  
Male Partners ◽  
Expression Levels ◽  
Before And After ◽  
Vitamin C Supplementation

Objective: Since sperm abnormalities are known to be a major reason for recurrent pregnancy loss (RPL), any defects in DNA structure and chromatin condensation can place embryos at risk in the early stage of development and implantation. As antioxidants such as vitamin C may play a protective role against the destruction of protamine genes in sperm chromatin, this study was conducted to evaluate the effects of vitamin C on chromatin and the expression of protamine genes in the male partners of couples with RPL.Methods: Twenty male partners of couples with RPL were selected as the intervention group and received vitamin C supplementation (250 mg daily for 3 months). Healthy fertile men (n=20) were included as controls. Sperm chromatin, DNA integrity, and the expression levels of protamine genes were evaluated before and after treatment.Results: Significant differences were found in sperm morphology, protamine deficiency, and apoptosis between the two groups and before and after vitamin C administration. A significant change was found in mRNA levels of <i>PRM1, PRM2</i>, and the <i>PRM1/PRM2</i> ratio after treatment.Conclusion: Daily oral administration of vitamin C may improve human sperm parameters and DNA integrity by increasing protamine gene expression levels in the male partners of couples with RPL. The beneficial effects of vitamin C supplementation as an antioxidant for the male partners of couples with RPL could lead to improved pregnancy outcomes in these cases.

scholarly journals Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review

2018 ◽  
Vol 6 (10) ◽  
pp. 232596711880454 ◽  
Author(s):  
Nicholas N. DePhillipo ◽  
Zachary S. Aman ◽  
Mitchell I. Kennedy ◽  
J.P. Begley ◽  
Gilbert Moatshe ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Vitamin C ◽  
Collagen Synthesis ◽  
Musculoskeletal Injuries ◽  
Vitamin C Supplementation ◽  
And Oxidative Stress
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