Effect of Vitamin C Supplementation on Oxidative Stress Markers Following Thirty Minutes Moderate Intensity Exercise in Healthy Young Women

2008 ◽  
Vol 8 (8) ◽  
pp. 1333-1337 ◽  
Author(s):  
M. Karandish ◽  
S.T. Rahideh ◽  
A.Z. Moghaddam
2020 ◽  
Vol 11 (SPL4) ◽  
pp. 2807-2813
Author(s):  
Resmi C R ◽  
Kedari G S R ◽  
Deepa P K

CAD is recognized as a multifactorial disease that is influenced by environmental and genetic factors. This study aimed to evaluate the levels of lipid parameters, oxidative stress and antioxidant markers in subjects with CAD compared to their age & sex matched controls and to analyze the relationship between atherogenic Index and oxidative stress among them 62 clinically proved CAD patients and 62 healthy age and sex matched subjects without CAD were selected for this study. 5 ml of fasting venous blood was collected from all the subjects and investigations such as FPG, lipid profile, oxidative markers Malondialdehyde (MDA), F2 isoprostanes (F2iso) and antioxidants glutathione S-transferase (GST), superoxide dismutase (SOD), vitamin-C, vitamin-E were performed. This study showed that levels of lipid parameters total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-c) and AI were significantly higher whereas high density lipoprotein cholesterol (HDL-c) were significantly low in CAD patients compared to normal controls. Oxidative stress markers MDA and F2 Isoprostanes level were significantly high, whereas enzymatic antioxidants GST and SOD and non-enzymatic antioxidants Vitamin-C and Vitamin-E levels were significantly low in CAD patients. Oxidative stress markers were found to significantly influence the AI. Results of this study showed that oxidative stress markers F2iso and MDA and antioxidants GST, VIT-C and VIT-E are found to influence the atherogenic index significantly.


2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Rade Grbic ◽  
Dijana J Miric ◽  
Bojana Kisic ◽  
Ljiljana Popovic ◽  
Vojkan Nestorovic ◽  
...  

In bacterial bone infections, excessively formed oxidants may result in local and systemic oxidative stress. Vitamin C is the major extracellular nonenzymatic antioxidant, also implicated in bone cells metabolism and viability. The physiological functions of vitamin C largely depend on its redox status. We sequentially assessed oxidative stress markers, hydroperoxides and malondialdehyde (MDA), total antioxidant activity (AOA), total vitamin C, ascorbic acid (Asc), and oxidized/reduced vitamin C ratio in 137 patients with acute osteomyelitis (OM). Compared to 52 healthy controls, in OM group baseline serum hydroperoxides, MDA and oxidized/reduced vitamin C ratio were higher whilst Asc and AOA were lower (P < 0.05, resp.). On the other side, total vitamin C levels in patients and controls were similar(P > 0.05), thereby suggesting a relative rather than absolute vitamin C deficiency in OM. During the follow-up, oxidative stress markers, AOA, and oxidizedreduced vitamin C ratio were gradually returned to normal, while there was no apparent change of total vitamin C concentrations. Persistently high values of oxidized/reduced vitamin C ratio and serum MDA were found in subacute OM. In conclusion, acute OM was associated with enhanced systemic oxidative stress and the shift of vitamin C redox status towards oxidized forms.


2011 ◽  
Vol 107 (8) ◽  
pp. 1119-1127 ◽  
Author(s):  
Helen Hermana M. Hermsdorff ◽  
Kiriaque B. F. Barbosa ◽  
Ana Carolina P. Volp ◽  
Blanca Puchau ◽  
Josefina Bressan ◽  
...  

The aim of the present cross-sectional study was to assess the potential relationships between fruit and vegetable (FV) consumption and some oxidative stress markers in young adults, with particular emphasis on fibre and vitamin C intake. The study enrolled 246 healthy subjects (eighty-eight men and 158 women), with a mean age of 22 (sd3) years and a mean BMI of 21·9 (sd2·8) kg/m2. Dietary intake, anthropometry, blood pressure, lifestyle features and blood biochemical data were assessed with validated procedures. Those subjects in the highest tertile (T) of FV consumption ( ≥ 705 g/d) had statistically lower oxidised LDL (ox-LDL) concentrations as well as higher plasma total antioxidant capacity (TAC) and glutathione peroxidase (GPx) activity (Pfor trend < 0·05), after adjusting for sex, age, energy intake, physical activity, smoking, BMI, vitamin supplement use and other confounding factors. Moreover, plasma ox-LDL concentrations showed a decreasing trend and TAC an increasing trend across tertiles of fibre (T3: ≥ 14 g/d) and vitamin C (T3: ≥ 150 mg/d) from FV intake, while GPx activity was positively associated with vitamin C intake (Pfor trend < 0·05). In conclusion, greater FV consumption was independently associated with reduced ox-LDL as well as increased TAC and GPx activity in healthy young adults, with dietary fibre and vitamin C from FV clearly being implicated in this beneficial relationship.


2012 ◽  
Vol 113 (7) ◽  
pp. 2223-2233 ◽  
Author(s):  
Marina Guimarães Gobbo ◽  
Daniele Lisboa Ribeiro ◽  
Sebastião Roberto Taboga ◽  
Eduardo Alves de Almeida ◽  
Rejane Maira Góes

2014 ◽  
Vol 46 ◽  
pp. 497
Author(s):  
Jean C. Zambrano ◽  
Ramón A. Marquina ◽  
Yarelis K. Araque ◽  
J-Bonamí Candales ◽  
Thairy G. Reyes-Valero ◽  
...  

2016 ◽  
Vol 74 (4) ◽  
pp. 149-158 ◽  
Author(s):  
Zeinab Sharifinasab ◽  
Mahdi Banaee ◽  
Mohammad Mohiseni ◽  
Ahmad Noori

Abstract The purpose of this study was to examine the effects of antioxidants, including vitamin C, chitosan or a combination of both, on oxidative stress markers in muscles, as edible tissues of fish, exposed to paraquat. Fish exposed to 0.02 mg/L paraquat for 21 days were fed different diets: a normal diet, a diet containing chitosan (1000 mg/kg diet), a diet with vitamin C (1000 mg/kg diet) or both vitamin C and chitosan. Oxidative stress markers, including the activity of catalase, total antioxidant and malondialdehyde (MDA), as well as biochemical parameters including the activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine phosphokinase (CPK), lactate dehydrogenase (LDH) and acetylcholinesterase (AChE), were measured in muscles. Fish exposure to paraquat increased LDH, CPK, catalase and MDA activity significantly, while it significantly decreased AST, ALT and AChE activity and total antioxidant capacity in muscles. Administration of vitamin C, combined with chitosan, to fish exposed to paraquat was effective in regulating AChE, AST, ALT, LDH, CPK and catalase activity. A significant increase in the total antioxidant status and a significant decrease in MDA levels were observed in fish fed chitosan-vitamin C complex. In conclusion, it is suggested that combined supplementation with vitamin C and chitosan may improve the detoxification system in the muscles of fish and protect common carp from paraquat toxicity.


Stroke ◽  
2004 ◽  
Vol 35 (1) ◽  
pp. 163-168 ◽  
Author(s):  
Concepción Sánchez-Moreno ◽  
John F. Dashe ◽  
Tammy Scott ◽  
David Thaler ◽  
Marshal F. Folstein ◽  
...  

2013 ◽  
Vol 4 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Tabita Benjamin ◽  
Abdul S Aziz ◽  
Madhav G Kalekar ◽  
Adinath N Suryakar ◽  
Milsee M Prakashan ◽  
...  

ABSTRACT Introduction Chronic periodontitis is the inflammatory disease of the periodontium; the tissue that surround and support the teeth. The aim of the study was to estimate and compare some biochemical oxidative stress markers in patients with chronic periodontitis and healthy controls and to assess the effect of nonsurgical periodontal therapy on these parameters. Materials and methods Eighty-two chronic periodontitis patients and 120 healthy controls were recruited for the study. The periodontal status was evaluated using gingival index (GI), plaque index (PI), papillary bleeding index (PBI) and clinical attachment loss (CAL). The biochemical parameters estimated were total antioxidant capacity (TAOC), antioxidant enzymes RBC-superoxide dismutase (RBC-SOD) and glutathione peroxidase (GPx), vitamin C, malondialdehyde (MDA) and Creactive protein (CRP) were also evaluated. Nonsurgical periodontal therapy (scaling and root planing; SRP) was performed on chronic periodontitis patients and a follow-up was done after 3 months. Results The study suggests that oxidative stress is induced in chronic periodontitis, as the levels of CRP, MDA and RBC-SOD were significantly higher (p < 0.001) and those of TAOC, GPx and vitamin C were significantly lower (p < 0.001) compared to healthy controls at baseline. SRP therapy significantly improved the clinical and biochemical oxidative stress markers in periodontitis patients. Conclusion Chronic periodontitis patients show higher inflammatory manifestations and oxidative stress. SRP therapy helps in lowering inflammatory burden and improving systemic oxidant: Antioxidant imbalance. The SRP therapy may be a useful support in the control and prevention of various inflammatory diseases associated with periodontitis. How to cite this article Aziz AS, Kalekar MG, Benjamin T, Suryakar AN, Prakashan MM, Bijle MNA. Effect of Nonsurgical Periodontal Therapy on Some Oxidative Stress Markers in Patients with Chronic Periodontitis: A Biochemical Study. World J Dent 2013;4(1):17-23.


2018 ◽  
Vol 46 (11) ◽  
pp. 4624-4633 ◽  
Author(s):  
Xiang Lu ◽  
Zhengmu Wu ◽  
Min Wang ◽  
Weiwei Cheng

Objective This study was performed to investigate the effect of vitamin C (VitC) supplementation on the outcomes of in vitro fertilization–embryo transfer (IVF-ET) in patients with endometriosis (EMs). Methods A total of 280 patients with EMs underwent IVF-ET (VitC treatment group, n=160; VitC non-treatment group, n=120). An additional 150 patients who did not have EMs but underwent IVF-ET (control group) were also enrolled in this study. Superoxide dismutase (SOD), total antioxidant capacity (TAC), malondialdehyde (MDA) and reactive oxygen species (ROS) were measured to determine the role of VitC on oxidative stress markers in serum and follicular fluid (FF). Results In total, 245 patients with EMs and 132 patients without EMs underwent successful IVF-ET and follow-up. The serum or FF levels of VitC, SOD, and TAC were lower in the EMs than control group; however, the MDA and ROS levels in serum or FF were higher in the EMs than control group. After 2 months of VitC treatment, the serum VitC levels in serum and FF were significantly increased, while oxidative stress markers were unaffected. Conclusion Treatment with VitC oral formulation improved the serum and FF levels of VitC but did not affect oxidative stress markers in patients with EMs.


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