Effects of Quercetin Supplementation on Markers of Muscle Damage and Inflammation after Eccentric Exercise

2012 ◽  
Vol 22 (6) ◽  
pp. 430-437 ◽  
Author(s):  
Kevin S. O’Fallon ◽  
Diksha Kaushik ◽  
Bozena Michniak-Kohn ◽  
C. Patrick Dunne ◽  
Edward J. Zambraski ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
Recovery Period ◽  
Strength Loss ◽  
Exercise Session ◽  
Elbow Flexors ◽  
Reactive Protein ◽  
Arm Swelling ◽  
Postexercise Recovery ◽  
Exercise Induced

The flavonoid quercetin is purported to have potent antioxidant and anti-inflammatory properties. This study examined if quercetin supplementation attenuates indicators of exercise-induced muscle damage in a doubleblind laboratory study. Thirty healthy subjects were randomized to quercetin (QU) or placebo (PL) supplementation and performed 2 separate sessions of 24 eccentric contractions of the elbow flexors. Muscle strength, soreness, resting arm angle, upper arm swelling, serum creatine kinase (CK) activity, plasma quercetin (PQ), interleukin-6 (IL-6), and C-reactive protein (CRP) were assessed before and for 5 d after exercise. Subjects then ingested nutrition bars containing 1,000 mg/d QU or PL for 7 d before and 5 d after the second exercise session, using the opposite arm. PQ reached 202 ± 52 ng/ml after 7 d of supplementation and remained elevated during the 5-d postexercise recovery period (p < .05). Subjects experienced strength loss (peak = 47%), muscle soreness (peak = 39 ± 6 mm), reduced arm angle (–7° ± 1°), CK elevations (peak = 3,307 ± 1,481 U/L), and arm swelling (peak = 11 ± 2 mm; p < .0001), indicating muscle damage and inflammation; however, differences between treatments were not detected. Eccentric exercise did not alter plasma IL-6 (peak = 1.9 pg/ml) or CRP (peak = 1.6 mg/L) relative to baseline or by treatment. QU supplementation had no effect on markers of muscle damage or inflammation after eccentric exercise of the elbow flexors.

Effect of two maximal isometric contractions on eccentric exercise-induced muscle damage of the elbow flexors

2013 ◽  
Vol 113 (6) ◽  
pp. 1545-1554 ◽  
Author(s):  
Trevor C. Chen ◽  
Hsin-Lian Chen ◽  
Ming-Ju Lin ◽  
Che-Hsiu Chen ◽  
Alan J. Pearce ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
Isometric Contractions ◽  
Elbow Flexors ◽  
Exercise Induced

scholarly journals Diurnal variation, response to eccentric exercise, and association of inflammatory mediators with muscle damage variables

2008 ◽  
Vol 104 (2) ◽  
pp. 451-458 ◽  
Author(s):  
Mary P. Miles ◽  
Jan M. Andring ◽  
Sherri D. Pearson ◽  
Lindsay K. Gordon ◽  
Christine Kasper ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
Inflammatory Mediators ◽  
Isometric Force ◽  
Tumor Necrosis Factor Receptor ◽  
Random Order ◽  
Strength Loss ◽  
Reactive Protein ◽  
Arm Circumference ◽  
And Control

This investigation determined whether inflammatory mediators 1) have diurnal variations, 2) respond to high-force eccentric exercise, and 3) associate with markers of muscle damage after high-force eccentric exercise. College-aged men and women ( n = 51) completed exercise (3 × 15 maximal eccentric elbow flexor actions using 1 arm) and control conditions in random order. Blood was collected preexercise and 4, 8, 12, 24, 48, and 96 h postexercise. Additional measures included maximal isometric force and midbiceps arm circumference (to detect swelling). Serum and plasma were analyzed for soluble tumor necrosis factor receptor-1 (sTNFR1), IL-6, C-reactive protein, cortisol, and creatine kinase (CK) activity. Relative to the 7:00 AM point in the control condition, diurnal decreases were measured at 12:00 PM and 4:00 PM for IL-6 and at 12:00 PM, 4:00 PM, and 8:00 PM for sTNFR1 and cortisol. sTNFR1, IL-6, CK, swelling, and soreness were higher in the exercise compared with the control condition. The largest of the inflammatory mediator responses was measured for IL-6 8 h postexercise in the exercise (3.00 ± 3.59 pg/ml) relative to the control condition (1.15 ± 0.99 pg/ml). The IL-6 response (time-matched exercise − control concentration) at 8 h associated ( r > 0.282) with muscle soreness at 24 and 96 h, and the cortisol response at 8 h associated ( r > 0.285) with swelling at 8, 24, and 96 h. Thus soreness and swelling, but not CK and strength loss, had a low association with the inflammatory response following eccentric exercise.

scholarly journals Quercetin Supplementation Improves Neuromuscular Function Recovery from Muscle Damage

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2850
Author(s):  
Ilenia Bazzucchi ◽  
Federica Patrizio ◽  
Roberta Ceci ◽  
Guglielmo Duranti ◽  
Stefania Sabatini ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
Biochemical Parameters ◽  
Strength Loss ◽  
Neuromuscular Function ◽  
Double Blind ◽  
Maximal Voluntary Isometric Contraction ◽  
Velocity Relationship ◽  
Force Velocity ◽  
Exercise Induced

This study was aimed at investigating whether quercetin (Q) may improve the recovery of neuromuscular function and biochemical parameters in the 7 days following an eccentric exercise-induced muscle damage (EEIMD). Sixteen men (25.9 ± 3.3 y) ingested Q (1000 mg/day) or placebo (PLA) for 14 days following a double-blind crossover study design. A neuromuscular (NM) test was performed pre–post, 24 h, 48 h, 72 h, 96 h and 7 days after an intense eccentric exercise. The force–velocity relationship of the elbow flexor muscles and their maximal voluntary isometric contraction (MVIC) were recorded simultaneously to the electromyographic signals (EMG). Pain, joint angle, arm circumference, plasma creatine kinase (CK) and lactate-dehydrogenase (LDH) were also assessed. The results showed that Q supplementation significantly attenuated the strength loss compared to PLA. During the recovery, force–velocity relationship and mean fibers conduction velocity (MFCV) persisted significantly less when participants consumed PLA rather than Q, especially at the highest angular velocities (p < 0.02). A greater increase in biomarkers of damage was also evident in PLA with respect to Q. Q supplementation for 14 days seems able to ameliorate the recovery of eccentric exercise-induced weakness, neuromuscular function impairment and biochemical parameters increase probably due to its strong anti-inflammatory and antioxidant action.

scholarly journals The Effects of Quercetin Supplementation on Eccentric Exercise-Induced Muscle Damage

Nutrients ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 205 ◽  
Author(s):  
Ilenia Bazzucchi ◽  
Federica Patrizio ◽  
Roberta Ceci ◽  
Guglielmo Duranti ◽  
Paolo Sgrò ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
Strength Loss ◽  
Simultaneous Recording ◽  
Isometric Strength ◽  
Double Blind ◽  
Maximal Voluntary Isometric Contraction ◽  
Velocity Relationship ◽  
Force Velocity ◽  
Exercise Induced

The aim of the present investigation was to test the hypothesis that quercetin (Q) may prevent the strength loss and neuromuscular impairment associated with eccentric exercise-induced muscle damage (EEIMD). Twelve young men (26.1 ± 3.1 years) ingested either Q (1000 mg/day) or placebo (PLA) for 14 days using a randomized, double-blind, crossover study design. Participants completed a comprehensive neuromuscular (NM) evaluation before, during and after an eccentric protocol able to induce a severe muscle damage (10 sets of 10 maximal lengthening contractions). The NM evaluation comprised maximal voluntary isometric contraction (MVIC) and force–velocity relationship assessments with simultaneous recording of electromyographic signals (EMG) from the elbow flexor muscles. Soreness, resting arm angle, arm circumference, plasma creatine kinase (CK) and lactate dehydrogenase (LDH) were also assessed. Q supplementation significantly increased the isometric strength recorded during MVIC compared to baseline (+4.7%, p < 0.05). Moreover, the torque and muscle fiber conduction velocity (MFCV) decay recorded during the eccentric exercise was significant lower in Q compared to PLA. Immediately after the EEIMD, isometric strength, the force–velocity relationship and MFCV were significantly lower when participants were given PLA rather than Q. Fourteen days of Q supplementation seems able to attenuate the severity of muscle weakness caused by eccentric-induced myofibrillar disruption and sarcolemmal action potential propagation impairment.

Effects of wrist position on eccentric exercise‐induced muscle damage of the elbow flexors

2021 ◽  
Author(s):  
Wing Yin Lau ◽  
Anthony J. Blazevich ◽  
Michael J. Newton ◽  
Sam Shi Xuan Wu ◽  
Kazunori Nosaka
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
Elbow Flexors ◽  
Wrist Position ◽  
Exercise Induced

Effect of Whole-Body Periodic Acceleration on Exercise-Induced Muscle Damage after Eccentric Exercise

2014 ◽  
Vol 9 (6) ◽  
pp. 985-992 ◽  
Author(s):  
Daniel H. Serravite ◽  
Arlette Perry ◽  
Kevin A. Jacobs ◽  
Jose A. Adams ◽  
Kysha Harriell ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
Recovery Period ◽  
Voluntary Contraction ◽  
The Body ◽  
Whole Body ◽  
Protein Carbonyls ◽  
Control Group ◽  
Periodic Acceleration ◽  
Exercise Induced

Purpose:To examine the effects of whole-body periodic acceleration (pGz) on exercise-induced-muscle-damage (EIMD) -related symptoms induced by unaccustomed eccentric arm exercise.Methods:Seventeen active young men (23.4 ± 4.6 y) made 6 visits to the research facility over a 2-wk period. On day 1, subjects performed a 1-repetition-maximum (1RM) elbowflexion test and were randomly assigned to the pGz (n = 8) or control group (n = 9). Criterion measurements were taken on day 2, before and immediately after performance of the eccentric-exercise protocol (10 sets, 10 repetitions using 120% 1RM) and after the recovery period. During subsequent sessions (24, 48, 72, and 96 h) these data were collected before pGz or passive recovery. Measurements included isometric strength (maximal voluntary contraction [MVC]), blood markers (creatine kinase, myoglobin, IL-6, TNF-α, TBARS, PGF2α, protein carbonyls, uric acid, and nitrites), soreness, pain, circumference, and range of motion (ROM).Results:Significantly higher MVC values were seen for pGz throughout the recovery period. Within-group differences were seen in myoglobin, IL-6, IL-10, protein carbonyls, soreness, pain, circumference, and ROM showing small negative responses and rapid recovery for the pGz condition.Conclusion:Our results demonstrate that pGz can be an effective tool for the reduction of EIMD and may contribute to the training-adaptation cycle by speeding up the recovery of the body due to its performance-loss-lessening effect.

Increase in blood bradykinin concentration after eccentric weight-training exercise in men

1999 ◽  
Vol 87 (3) ◽  
pp. 1197-1201 ◽  
Author(s):  
Charles Blais ◽  
Albert Adam ◽  
Denis Massicotte ◽  
François Péronnet
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
Inflammatory Process ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Serum Creatine Kinase ◽  
Exercise Session ◽  
Rabbit Igg ◽  
Exercise Induced ◽  
Male Subjects

The purpose of this study was to verify the possible appearance in the blood of bradykinin (BK) and des-Arg9-bradykinin (des-Arg9-BK) after eccentric exercise in 13 male subjects. Eccentric exercise (5 × 10 leg presses at 120% maximal voluntary concentric contraction) resulted in muscle damage and inflammation, as suggested by the significant increase in serum creatine kinase activity (from 204 ± 41 to 322 ± 63 U/l 12 h postexercise) and by severe lasting pain, which also peaked at 12 h postexercise. Blood BK and des-Arg9-BK concentrations were measured by competitive enzyme immunoassays using highly specific polyclonal rabbit IgG. Des-Arg9-BK concentration was not modified (preexercise: 44 ± 14 pmol/l; pooled postexercise: 47 ± 4 pmol/l). In contrast, BK concentration significantly increased immediately after the exercise session (68 ± 9 vs. 42 ± 3 pmol/l preexercise) and returned to basal values at 12, 24, and 48 h (pooled value: 40 ± 4 pmol/l). This observation suggests that the inflammatory process due to eccentric exercise-induced muscle damage could be mediated in part by BK.

scholarly journals Two maximal isometric contractions attenuate the magnitude of eccentric exercise-induced muscle damage

2012 ◽  
Vol 37 (4) ◽  
pp. 680-689 ◽  
Author(s):  
Hsin-Lian Chen ◽  
Kazunori Nosaka ◽  
Alan J. Pearce ◽  
Trevor C. Chen
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
Muscle Soreness ◽  
Muscle Length ◽  
Peak Torque ◽  
Eccentric Contractions ◽  
Control Group ◽  
Isometric Contractions ◽  
Elbow Flexors ◽  
Exercise Induced

This study investigated whether maximal voluntary isometric contractions (MVC-ISO) would attenuate the magnitude of eccentric exercise-induced muscle damage. Young untrained men were placed into one of the two experimental groups or one control group (n = 13 per group). Subjects in the experimental groups performed either two or 10 MVC-ISO of the elbow flexors at a long muscle length (20° flexion) 2 days prior to 30 maximal isokinetic eccentric contractions of the elbow flexors. Subjects in the control group performed the eccentric contractions without MVC-ISO. No significant changes in maximal voluntary concentric contraction peak torque, peak torque angle, range of motion, upper arm circumference, plasma creatine kinase (CK) activity and myoglobin concentration, muscle soreness, and ultrasound echo intensity were evident after MVC-ISO. Changes in the variables following eccentric contractions were smaller (P < 0.05) for the 2 MVC-ISO group (e.g., peak torque loss at 5 days after exercise, 23% ± 3%; peak CK activity, 1964 ± 452 IU·L–1; peak muscle soreness, 46 ± 4 mm) or the 10 MVC-ISO group (13% ± 3%, 877 ± 198 IU·L–1, 30 ± 4 mm) compared with the control (34% ± 4%, 6192 ± 1747 IU·L–1, 66 ± 5 mm). The 10 MVC-ISO group showed smaller (P < 0.05) changes in all variables following eccentric contractions compared with the 2 MVC-ISO group. Therefore, two MVC-ISO conferred potent protective effects against muscle damage, whereas greater protective effect was induced by 10 MVC-ISO, which can be used as a strategy to minimize muscle damage.

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