Effect of Pseudoephedrine on 800-m-Run Times of Female Collegiate Track Athletes

2012 ◽  
Vol 7 (3) ◽  
pp. 237-241 ◽  
Author(s):  
Caroline Berry ◽  
Dale R. Wagner
Keyword(s):  
Heart Rate ◽  
Time Trial ◽  
Crossover Design ◽  
Anxiety State ◽  
Double Blind ◽  
Over The Counter ◽  
Significant Difference ◽  
Ergogenic Effects ◽  
World Anti Doping Agency ◽  
Track Athletes

Context:Pseudoephedrine (PSE) is an over-the-counter decongestant that might have ergogenic effects. The World Anti-Doping Agency has prohibited large doses (>150 μg/mL) of PSE, while the National College Athletic Association (NCAA) does not include it on their banned-substance list.Purpose:This study examined the effect of body-weight dosing of PSE on 800-m-run times of NCAA female runners.Methods:Fifteen NCAA female track athletes volunteered to participate in the randomized, double-blind, crossover design. Participants were given 2.5 mg/kg PSE or placebo in trials separated by a week. Ninety minutes postingestion, participants completed an 800-m individual time trial on an indoor track. Finishing time was recorded with an automated video timing device. Heart rate and anxiety state scores were recorded immediately after each trial.Results:Fourteen runners completed both trials, and 1 was an outlier: N = 13. Despite the dose being well above normal therapeutic levels (144 ± 17 mg), there was no significant difference (P = .92) in 800-m times between PSE (2:39.447 ± 9.584) and placebo (2:39.372 ± 9.636) trials, in postexercise heart rate (P = .635; PSE = 177.9 ± 14.5 beats/min, placebo = 178.4 ± 18.5 beats/min), or in anxiety-state levels (P = .650; PSE = 38.4 ± 11.6, placebo = 38.1 ± 8.8).Conclusion:A 2.5-mg/kg dose of PSE had no effect on 800-m performance for female NCAA runners. More research is needed to determine if PSE should be a specified banned substance.

scholarly journals The Effect of Dietary Nitrate Supplementation on Physiology and Performance in Trained Cyclists

2017 ◽  
Vol 12 (5) ◽  
pp. 684-689 ◽  
Author(s):  
Joseph A. McQuillan ◽  
Deborah K. Dulson ◽  
Paul B. Laursen ◽  
Andrew E. Kilding
Keyword(s):  
Time Trial ◽  
Crossover Design ◽  
Moderate Intensity ◽  
Beetroot Juice ◽  
Double Blind ◽  
Dietary Nitrate ◽  
Performance Time ◽  
Exercise Economy ◽  
Nitrate Supplementation ◽  
And Performance

Purpose:To determine the effect of dietary nitrate (NO3 –) supplementation on physiology and performance in well-trained cyclists after 6–8 d of NO3 – supplementation.Methods:Eight competitive male cyclists (mean ± SD age 26 ± 8 y, body mass 76.7 ± 6.9 kg, VO2peak 63 ± 4 mL · kg–1 · min–1) participated in a double-blind, placebo-controlled, crossover-design study in which participants ingested 70 mL of beetroot juice containing ~4 mmol NO3 – (NIT) or a NO3 –-depleted placebo (PLA), each for 8 d. Replicating pretreatment measures, participants undertook an incremental ramp assessment to determine VO2peak and first (VT1) and second (VT2) ventilatory thresholds on d 6 (NIT6 and PLA6), moderate-intensity cycling economy on d 7 (NIT7 and PLA7), and a 4-km time trial (TT) on d 8 (NIT8 and PLA8).Results:Relative to PLA, 6 d of NIT supplementation produced unclear effects for VO2peak (mean ± 95% confidence limit: 1.8% ± 5.5%) and VT1 (3.7% ± 12.3%) and trivial effects for both VT2 (–1.0% ± 3.0%) and exercise economy on d 7 (–1.0% ± 1.6%). However, effects for TT performance time (–0.7% ± 0.9%) and power (2.4% ± 2.5%) on d 8 were likely beneficial.Conclusions:Despite mostly unclear outcomes for standard physiological determinants of performance, 8 d of NO3 – supplementation resulted in likely beneficial improvements to 4-km TT performance in well-trained male endurance cyclists.

scholarly journals Caffeine Supplementation for 4 Days Does Not Induce Tolerance to the Ergogenic Effects Promoted by Acute Intake on Physiological, Metabolic, and Performance Parameters of Cyclists: A Randomized, Double-Blind, Crossover, Placebo-Controlled Study

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2101
Author(s):  
Anderson Pontes Morales ◽  
Felipe Sampaio-Jorge ◽  
Thiago Barth ◽  
Anna Paola Trindade Rocha Pierucci ◽  
Beatriz Gonçalves Ribeiro
Keyword(s):  
Time Trial ◽  
Minute Volume ◽  
Controlled Study ◽  
Performance Parameters ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Ergogenic Effects ◽  
And Performance ◽  
Experimental Trials ◽  
Acute Intake

The present study investigated whether the caffeine supplementation for four days would induce tolerance to the ergogenic effects promoted by acute intake on physiological, metabolic, and performance parameters of cyclists. A double-blind placebo-controlled cross-over design was employed, involving four experimental trials; placebo (4-day)-placebo (acute)/PP, placebo (4-day)-caffeine (acute)/PC, caffeine (4-day)-caffeine (acute)/CC and caffeine (4-day)-placebo (acute)/CP. Fourteen male recreationally-trained cyclists ingested capsules containing either placebo or caffeine (6 mg∙kg−1) for 4 days. On day 5 (acute), capsules containing placebo or caffeine (6 mg∙kg−1) were ingested 60 min before completing a 16 km time-trial (TT). CC and PC showed improvements in time (3.54%, ES = 0.72; 2.53%, ES = 0.51) and in output power (2.85%, ES = 0.25; 2.53%, ES = 0.20) (p < 0.05) compared to CP and PP conditions, respectively. These effects were accompanied by increased heart rate (2.63%, ES = 0.47; 1.99%, ES = 0.34), minute volume (13.11%, ES = 0.61; 16.32%, ES = 0.75), expired O2 fraction (3.29%, ES = 0.96; 2.87, ES = 0.72), lactate blood concentration (immediately after, 29.51% ES = 0.78; 28.21% ES = 0.73 recovery (10 min), 36.01% ES = 0.84; 31.22% ES = 0.81), and reduction in expired CO2 fraction (7.64%, ES = 0.64; 7.75%, ES = 0.56). In conclusion, these results indicate that caffeine, when ingested by cyclists in a dose of 6 mg∙kg−1 for 4 days, does not induce tolerance to the ergogenic effects promoted by acute intake on physiological, metabolic, and performance parameters.

Effect of Evening Bromazepam Administration on Blood Pressure and Heart Rate in Mild Hypertensive Patients

Pharmacology ◽  
2019 ◽  
Vol 104 (1-2) ◽  
pp. 1-6
Author(s):  
Alfredo Costa ◽  
Daniele Bosone ◽  
Matteo Cotta Ramusino ◽  
Giulia Perini ◽  
Natascia Ghiotto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Ambulatory Monitoring ◽  
Night Time ◽  
Double Blind ◽  
Hypertensive Patients ◽  
Treatment Groups ◽  
Significant Difference ◽  
Nocturnal Increase ◽  
Mild Hypertensive

Aim: To assess the effects of chronic evening oral administration of bromazepam alone or in combination with propranolol on ambulatory blood pressure (BP) and heart rate (HR) in mild hypertensive subjects. Methods: Thirty-seven mild hypertensive patients after a 2-week placebo period were randomized to bromazepam 3 mg, propranolol 40 mg, bromazepam 3 mg plus propranolol 40 mg or placebo for 2 weeks according to a double-blind, double dummy, cross-over design. After each treatment period, 24-h BP and HR ambulatory monitoring was performed by using a non-invasive device. Results: Ambulatory monitoring showed that during night-time SBP and DBP values were unaffected by bromazepam as compared to placebo, whereas SBP was significantly reduced by propranolol both when taken alone and in combination with bromazepam. HR nocturnal values were significantly reduced by propranolol, whereas they were significantly increased by bromazepan both when taken alone (+11.5%, p < 0.05 vs. placebo) and in combination with propranolol (+12.8%, p < 0.05 vs. propranolol). No significant difference in day-time values of SBP, DBP and HR was observed among the 4 treatment groups. Conclusions: In mild hypertensive patients, evening consumption of bromazepam for a 2-week period did not affect BP, while it increased nocturnal HR. Such an increase was observed both when bromazepam was taken alone and in combination with propranolol, which suggests that it depends on a bromazepam mediated decrease in vagal tone. Whatever the mechanism, the HR nocturnal increase might be of clinical relevance, due to the role of high HR as cardiovascular risk factor, particularly in already at risk hypertensive subjects.

scholarly journals Acute Caffeine Supplementation Does Not Improve Performance in Trained CrossFit® Athletes

Sports ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 54 ◽  
Author(s):  
Jesse A. Stein ◽  
Melitza Ramirez ◽  
Katie M. Heinrich
Keyword(s):  
Washout Period ◽  
Learning Effect ◽  
Crossover Design ◽  
Future Research ◽  
Improve Performance ◽  
Double Blind ◽  
Paired Samples ◽  
Ergogenic Effects ◽  
Effect Of Treatment ◽  
Treatment Order

Caffeine’s ergogenic effects persist during various exercise modalities; however, information establishing its efficacy during CrossFit® protocols is limited. This study aimed to determine the effects of caffeine supplementation on CrossFit® performance. Twenty CrossFit®-trained men (age = 26.7 ± 6.2 years, experience = 3.7 ± 2.9 years) were randomized in a double-blind, crossover design. Participants completed two sessions separated by a seven-day washout period, 60 min after consuming 5 mg/kg body mass of caffeine or a placebo. In each session, participants completed as many rounds as possible in 20 min of five pull-ups, 10 push-ups, and 15 air squats. CrossFit® performance was the total number of repetitions completed in 20 min. Paired-samples t-tests were used to compare CrossFit® performance between caffeine and placebo conditions and to test for a potential learning effect between the first and second sessions. CrossFit® performance was not significantly different during the caffeine condition compared to the placebo (468.6 ± 114.7 vs. 466.7 ± 94.3 repetitions, p = 0.861). A significant learning effect was identified between the first and second sessions (452.4 ± 101 vs. 483.8 ± 106.5 repetitions, p = 0.001), with no significant effect of treatment order (p = 0.438). Caffeine’s ergogenic effect were not present during the CrossFit® workout “Cindy”; however, future research should include familiarization sessions and examine other CrossFit® workouts in novice and women participants.

scholarly journals The Effect of a Second Runner on Pacing Strategy and RPE During a Running Time Trial

2012 ◽  
Vol 7 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Deryn Bath ◽  
Louise A. Turner ◽  
Andrew N. Bosch ◽  
Ross Tucker ◽  
Estelle V. Lambert ◽  
...  
Keyword(s):  
Heart Rate ◽  
Time Trial ◽  
Subjective Assessment ◽  
Running Speed ◽  
Male Athletes ◽  
Pacing Strategy ◽  
Significant Difference ◽  
The Subject ◽  
Performance Times ◽  
Subject Performance

Purpose:The aim of this study was to examine performance, pacing strategy and perception of effort during a 5 km time trial while running with or without the presence of another athlete.Methods:Eleven nonelite male athletes participated in five 5 km time trials: two self-paced, maximal effort trials performed at the start and end of the study, and three trials performed in the presence of a second runner. In the three trials, the second runner ran either in front of the subject, behind the subject, or next to the subject. Performance times, heart rate, RPE, and a subjective assessment of the effect of the second runner on the athlete’s performance were recorded during each of the trials.Results:There was no significant difference in performance times, heart rate or RPE between any of the five trials. Running speed declined from the 1st to the 4th kilometer and then increased for the last kilometer in all five trials. Following the completion of all trials, 9 of the 11 subjects perceived it to be easier to complete the 5 km time trial with another runner in comparison with running alone.Conclusions:While the athletes perceived their performance to be improved by the presence of another runner, their pacing strategy, running speed, heart rate and RPE were not significantly altered. These findings indicate that an athlete’s subconscious pacing strategy is robust and is not altered by the presence of another runner.

Nitrate Supplementation’s Improvement of 10-km Time-Trial Performance in Trained Cyclists

2012 ◽  
Vol 22 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Naomi M. Cermak ◽  
Martin J. Gibala ◽  
Luc J.C. van Loon
Keyword(s):  
Repeated Measures ◽  
Time Trial ◽  
Submaximal Exercise ◽  
Beetroot Juice ◽  
Limited Data ◽  
Double Blind ◽  
Time Trial Performance ◽  
Ergogenic Effects ◽  
Nitrate Supplementation ◽  
Trial Performance

Six days of dietary nitrate supplementation in the form of beetroot juice (~0.5 L/d) has been reported to reduce pulmonary oxygen uptake (VO2) during submaximal exercise and increase tolerance of high-intensity work rates, suggesting that nitrate can be a potent ergogenic aid. Limited data are available regarding the effect of nitrate ingestion on athletic performance, and no study has investigated the potential ergogenic effects of a small-volume, concentrated dose of beetroot juice. The authors tested the hypothesis that 6 d of nitrate ingestion would improve time-trial performance in trained cyclists. Using a double-blind, repeated-measures crossover design, 12 male cyclists (31 ± 3 yr, VO2peak = 58 ± 2 ml · kg−1 · min−1, maximal power [Wmax] = 342 ± 10 W) ingested 140 ml/d of concentrated beetroot (~8 mmol/d nitrate) juice (BEET) or a placebo (nitrate-depleted beetroot juice; PLAC) for 6 d, separated by a 14-d washout. After supplementation on Day 6, subjects performed 60 min of submaximal cycling (2 × 30 min at 45% and 65% Wmax, respectively), followed by a 10-km time trial. Time-trial performance (953 ± 18 vs. 965 ± 18 s, p < .005) and power output (294 ± 12 vs. 288 ± 12 W, p < .05) improved after BEET compared with PLAC supplementation. Submaximal VO2 was lower after BEET (45% Wmax = 1.92 ± 0.06 vs. 2.02 ± 0.09 L/min, 65% Wmax 2.94 ± 0.12 vs. 3.11 ± 0.12 L/min) than with PLAC (main effect, p < .05). Wholebody fuel selection and plasma lactate, glucose, and insulin concentrations did not differ between treatments. Six days of nitrate supplementation reduced VO2 during submaximal exercise and improved time-trial performance in trained cyclists.

scholarly journals Comparison the Sedation Effect and Satisfaction of Two Combinations, Dexmedetomidine and Fentanyl with Midazolam and Fentanyl, in Patients Undergoing Bronchoscopy

2021 ◽  
Vol 6 (6) ◽  
Author(s):  
Alireza Kamali ◽  
Sepideh Sarkhosh ◽  
Hosein Kazemizadeh
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Oxygen Saturation ◽  
Statistical Tests ◽  
Arterial Oxygen Saturation ◽  
Mean Blood Pressure ◽  
Arterial Oxygen ◽  
P Value ◽  
Double Blind ◽  
Significant Difference

Objectives: The aim of this study was to compare sedative effects of dexmedetomidine and fentanyl with midazolam and fentanyl in patients undergoing bronchoscopy. Methods: This study was a double-blind randomized clinical trial that was performed on 92 patients who referred to Amir al Momenin Hospital in Arak for bronchoscopy and underwent ASA 1 or 2 underlying grading procedure. Patients were randomly divided into two groups of dexmedetomidine and fentanyl (D) midazolam and fentanyl (M). Primary vital signs including hypertension and arterial oxygen saturation were monitored and recorded. Then all patients were injected with 2 μg / kg fentanyl as a painkiller and after 3 minutes 30 μg dexmedetomidine in syringe with code A and midazolam 3 mg in syringe with code B were injected to patients by an anesthesiologist. Then the two groups were compared in terms of pain at injection, conscious relaxation, satisfaction of operation, recovery time, hypotension and arterial oxygen saturation and drug side effects and data were analyzed by using statistical tests. Results: There was no significant difference between the two groups in terms of mean age and sex distribution. According to the results of this study, there was no significant difference between the two groups in mean blood pressure (P-value = 0.6) and mean heart rate (P-value = 0.4) at the time of bronchoscopy, but at 5 and 10 minutes after bronchoscopy there was a significant difference, mean blood pressure and heart rate were significantly lower in dexmedetomidine group. Conclusion: Both dexmedetomidine and midazolam drug groups contributed to the development of stable and sedative hemodynamics and satisfaction in patients undergoing bronchoscopy, however, the dexmedetomidine and fentanyl group showed a significant decrease in blood pressure and heart rate compared to midazolam and fentanyl and a weaker decrease in arterial oxygen saturation, and patients with bronchoscopy were more satisfied in the dexmedetomidine group.

scholarly journals Dose Response of a Novel Exogenous Ketone Supplement on Physiological, Perceptual, and Performance Parameters

2020 ◽  
Author(s):  
Philip Prins ◽  
Dominic P. D’Agostino ◽  
Christopher Q. Rogers ◽  
Dana L. Ault ◽  
Gary L. Welton ◽  
...  
Keyword(s):  
Heart Rate ◽  
Cognitive Performance ◽  
Blood Lactate ◽  
Exercise Performance ◽  
Ketone Bodies ◽  
Time Trial ◽  
Gaseous Exchange ◽  
Double Blind ◽  
Post Exercise ◽  
And Performance

Abstract Background: Interest into the health, disease, and performance impact of exogenous ketone bodies has rapidly expanded due to their multifaceted physiological and signaling properties but limiting our understanding is the isolated analyses of individual types and dose/dosing protocols. Methods: Thirteen recreational male distance runners (24.8±9.6y, 72.5±8.3kg, VO2max 60.1±5.4ml/kg/min) participated in this randomized, double-blind, crossover design study. The first two sessions consisted of a 5-km running time trial (TT) familiarization and a VO2max test. During subsequent trials, subjects were randomly assigned to one (KS1:22.1g) or two (KS2:44.2g) doses of beta-hydroxybutyrate (βHB) and medium chain triglycerides (MCTs) or flavor matched placebo (PLA). Blood R-βHB, glucose, and lactate concentrations were measured at baseline (0-min), post-supplement (30 & 60mins), post-exercise (+0min, +15mins). Time, HR, RPE, affect, RER, VO2, VCO2, and VE were measured during exercise. Cognitive performance was evaluated prior to and post-exercise. Results: KS significantly increased R-βHB, with more potent and prolonged elevations in KS2, illustrating an administrative and dosing effect. R-βHB was significantly decreased in KS1 compared to KS2 illustrating a dosing and exercise interaction effect. Blood glucose elevated post-exercise but was unchanged across groups. Blood lactate significantly increased post-exercise but was augmented by KS administration. Gaseous exchange, respiration, heart rate, affect, RPE, and exercise performance was unaltered with KS administration. However, clear responders and none-responders were indicated. KS2 significantly augmented cognitive function in pre-exercise conditions, while exercise increased cognitive performance for KS1 and PLA to pre-exercise KS2 levels. Conclusion: Novel βHB+MCT formulation had a dosing effect on R-βHB and cognitive performance, an administrative response on blood lactate, while not influencing gaseous exchange, respiration, heart rate, affect, RPE, and exercise performance.

Capsaicin Supplementation during High-intensity Continuous Exercise: A Double-blind Study

2020 ◽  
Vol 41 (14) ◽  
pp. 1061-1066 ◽  
Author(s):  
Camila S. Padilha ◽  
Francois Billaut ◽  
Caique Figueiredo ◽  
Valéria Leme Gonçalves Panissa ◽  
Fabrício Eduardo Rossi ◽  
...  
Keyword(s):  
Heart Rate ◽  
High Intensity ◽  
Physiological Responses ◽  
Energy Systems ◽  
Exercise Session ◽  
Exercise Heart Rate ◽  
Time To Exhaustion ◽  
Double Blind ◽  
Continuous Exercise ◽  
Significant Difference

AbstractTo investigate the effect of acute capsaicin (CAP) supplementation on time to exhaustion, physiological responses and energy systems contribution during continuous high-intensity exercise session in runners. Fifteen recreationally-trained runners completed two randomized, double-blind continuous high-intensity exercises at the speed eliciting 90% V̇O2peak (90% s V̇O2peak), 45 minutes after consuming capsaicin or an isocaloric placebo. Time to exhaustion, blood lactate concentration, oxygen consumption during and 20-min post-exercise, energy systems contribution, time to reach V̇O2peak, heart rate and the rate of perceived exertion (RPE) were evaluated. There was no significant difference between conditions for time to reach V̇O2peak (CAP:391.71±221.8 vs. PLA:298.20±174.5 sec, ES:0.58, p=0.872), peak lactate (CAP:7.98±2.11 vs. PLA:8.58±2.15 µmol, ES:−0.28, p=0.257), time to exhaustion (CAP:654.28±195.44 vs. PLA:709.20±208.44 sec, ES:−0.28, p=0.462, end-of-exercise heart rate (CAP:177.6±14.9 vs. PLA:177.5±17.9 bpm, ES:−0.10, p=0.979) and end-of-exercise RPE (CAP: 19±0.8 vs. PLA: 18±2.4, ES: 0.89, p=0.623). In conclusion, acute CAP supplementation did not increase time to exhaustion during high-intensity continuous exercise nor alter physiological responses in runners.

Effects of a New Evaporative Cooling Solution During Rowing in a Warm Environment

2010 ◽  
Vol 5 (3) ◽  
pp. 412-416 ◽  
Author(s):  
Iñigo Mujika ◽  
Rafa González De Txabarri ◽  
David Pyne
Keyword(s):  
Evaporative Cooling ◽  
Time Trial ◽  
Crossover Design ◽  
Physiological Measures ◽  
Mean Power ◽  
Double Blind ◽  
Warm Environment ◽  
Rowing Performance ◽  
Post Test ◽  
The Difference

Energicer is a new solution which purportedly increases evaporative cooling during exercise in the heat.Purpose:To evaluate the effect of Energicer on performance during indoor rowing in a warm environment.Methods:Eighteen highly trained rowers (age 23.3 ± 6.7 y, height 181.3 ± 6.0 cm, mass 76.7 ± 5.0 kg, peak aerobic power (PAP) 322.1 ± 24.3 W; mean ± SD) performed two indoor rowing trials at 25.0°C and 65.0% relative humidity. Each trial consisted of 10 min at 55% PAP, 5 min of rest, 10 min at 70% PAP, 10 min of rest, and 2000 m time trial. Subjects were randomly assigned to an experimental (COOL) or a placebo (PLA) condition, using a double-blind, crossover design. During COOL, subjects wore sweatbands soaked in Energicer on both forearms; during PLA, they wore identical sweatbands soaked in cool water. Physiological measures and rowing performance were analyzed in a post-test-only crossover design. Magnitude of the difference between treatments was interpreted using the Cohen’s effect statistic.Results:No substantial differences were observed in heart rate, blood lactate and RPE between treatments during the submaximal row (COOL 163 ± 10 bpm, 4.3 ± 1.0 mM, 14.5 ± 1.8; PLA 165 ± 11 bpm, 4.8 ± 1.4 mM, 14.6 ± 1.6) and the time trial (COOL 179 ± 9 bpm, 10.7 ± 2.3 mM, 20 ± 0; PLA 179 ± 10 bpm, 11.1 ± 2.2 mM, 20 ± 0). Time (419 ± 11 vs 420 ± 12 s), mean power (305 ± 24 vs 304 ± 26 W), sweat loss (1013 ± 186 vs 981 ± 161 mL) and pacing strategy during the time trial were similar in COOL and PLA. The magnitude of differences between treatments was trivial for all measured variables.Conclusion:Energicer failed to provide a substantial benefit during indoor rowing in a warm environment. Whether Energicer is beneficial during more prolonged exercise and/or under more stressful environmental conditions remains to be elucidated.

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