Physical Activity and Sex Hormone–Binding Globulin in Older Adults

2019 ◽  
Vol 27 (5) ◽  
pp. 621-624
Author(s):  
Dietrich Rothenbacher ◽  
Dhayana Dallmeier ◽  
Michael D. Denkinger ◽  
Bernhard O. Boehm ◽  
Wolfgang Koenig ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Body Mass Index ◽  
Body Mass ◽  
Serum Levels ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Glutamyl Transferase ◽  
Relationship Of

Besides its known function as a transport protein for testosterone and other steroid hormones, sex hormone–binding globulin (SHBG) is a biomarker associated with many adverse health effects. The aim of this study was to investigate the association of physical activity with SHBG serum levels in older adults. The physical activity and SHBG values for 1,259 older adults (43.4% female; 56.6% male) with a mean age of 75.6 ± 6.5 years were included in the analysis. The average daily walking duration was 104.2 ± 40.4 (mean ± SD) min. A positive dose–response relationship of daily walking duration with quartiles of SHBG was seen after adjustment for age, sex, history of cardiovascular diseases, diabetes, smoking, γ-glutamyl transferase, and C-reactive protein (p for trend = .010). However, this relationship disappeared after adjustment for body mass index (p for trend = .977). Body mass index seems to be an important determinant of SHBG and a possible confounding factor in the relationship of physical activity and SHBG.

Concentrations of sex-hormone binding globulin and corticosteroid binding globulin in serum in relation to cardiovascular risk factors and to 12-year incidence of cardiovascular disease and overall mortality in postmenopausal women.

1986 ◽  
Vol 32 (1) ◽  
pp. 146-152 ◽  
Author(s):  
L Lapidus ◽  
G Lindstedt ◽  
P A Lundberg ◽  
C Bengtsson ◽  
T Gredmark
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Body Mass ◽  
Significant Risk ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Corticosteroid Binding Globulin ◽  
Overall Mortality

Abstract We determined sex-hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) by radioimmunoassay of serum samples from a group of 253 women, who were 54 or 60 years old when first studied in 1968-69. The SHBG concentration was highly significantly and inversely related to body mass, body mass index, waist-to-hip circumference ratio, and serum triglyceride concentration; CBG concentration was inversely related to body mass and body mass index. The concentration of neither protein was related to whether or not the subject smoked. Decrease in the concentration of SHBG, but not of CBG, was a significant risk factor for 12-year overall mortality. The plot of the 12-year incidence of myocardial infarction vs SHBG concentration was U-shaped. We recommend that SHBG be included when serum androgens or estrogens are being evaluated as risk factors for cardiovascular disease and death.

Serum Steroid Hormone Levels, Sex Hormone-Binding Globulin, and Body Mass Index in the Etiology of Postmenopausal Breast Cancer

Epidemiology ◽  
1996 ◽  
Vol 7 (1) ◽  
pp. 96-100 ◽  
Author(s):  
Loren Lipworth ◽  
Hans-Olov Adami ◽  
Dimitrios Trichopoulos ◽  
Kjell Cartström ◽  
Christos Mantzoros
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Body Mass ◽  
Steroid Hormone ◽  
Postmenopausal Breast Cancer ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Hormone Levels

Relationship of high density lipoprotein cholesterol with total and free testosterone and sex hormone binding globulin

1983 ◽  
Vol 104 (2) ◽  
pp. 253-256 ◽  
Author(s):  
R. F. Heller ◽  
M. J. Wheeler ◽  
J. Micallef ◽  
N. E. Miller ◽  
B. Lewis
Keyword(s):  
Body Mass Index ◽  
High Density Lipoprotein ◽  
Body Mass ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding

Abstract. A cross-sectional study was performed to see if the previously described association between high density lipoprotein (HDL) cholesterol and plasma total testosterone concentration reflected a relationship with free testosterone or with sex hormone binding globulin (SHBG). In 295 employed middle-aged men, measurements were made of total testosterone and SHBG in serum and of testosterone in saliva, and also of plasma total and HDL cholesterol, plasma triglycerides and other factors which might influence HDL cholesterol levels such as body mass index, alcohol and smoking habits and thyroid hormone levels. In a multiple regression analysis using the GLIM package programme total testosterone concentrations had a persistent positive association with HDL cholesterol (t = 3.5, P < 0.001) – this association was independent of SHBG (which had a negative association with HDL: t = −1.8, P <0.07. The association of HDL cholesterol with testosterone was independent of and stronger than the association of HDL cholesterol with body mass index, alcohol intake and cigarette smoking. Salivary testosterone (a measure of the circulating free hormone) also had a positive independent association with HDL cholesterol. The relationship between HDL cholesterol and testosterone thus appears to reflect an association with circulating hormone levels rather than with the hormone binding globulin.

Total testosterone and sex hormone-binding globulin are associated with metabolic syndrome independent of age and body mass index in Korean men

Maturitas ◽  
2013 ◽  
Vol 74 (2) ◽  
pp. 148-153 ◽  
Author(s):  
Doohee Hong ◽  
Young-Sang Kim ◽  
Eun Soo Son ◽  
Kyu-Nam Kim ◽  
Bom-Taeck Kim ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding

scholarly journals Age, Body Mass, Usage of Exogenous Estrogen, and Lifestyle Factors in Relation to Circulating Sex Hormone–Binding Globulin Concentrations in Postmenopausal Women

2014 ◽  
Vol 60 (1) ◽  
pp. 174-185 ◽  
Author(s):  
Atsushi Goto ◽  
Brian H Chen ◽  
Yiqing Song ◽  
Jane Cauley ◽  
Steven R Cummings ◽  
...  
Keyword(s):  
Physical Activity ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Lifestyle Factors ◽  
Dietary Factors ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Coffee Intake ◽  
Exogenous Estrogen

Abstract BACKGROUND Circulating concentrations of sex hormone–binding globulin (SHBG) have been associated with cardiovascular diseases, type 2 diabetes, metabolic syndrome, and hormone-dependent cancers; however, correlates of SHBG concentrations are not well understood. METHODS We comprehensively investigated correlates of SHBG concentrations among 13 547 women who participated in the Women's Health Initiative and who had SHBG measurements. We estimated study- and ethnicity-specific associations of age, reproductive history, usage of exogenous estrogen, body mass index (BMI), and lifestyle factors such as physical activity, smoking, alcohol consumption, coffee intake, and dietary factors with SHBG concentrations. These estimates were pooled using random-effects models. We also examined potential nonlinear associations using spline analyses. RESULTS There was no significant ethnic difference in the age-adjusted mean concentrations of SHBG. Age, exogenous estrogen use, physical activity, and regular coffee intake were positively associated with SHBG concentrations, whereas BMI was inversely associated with SHBG concentrations after adjustment for potential confounding factors. Similar patterns were observed among both ever users and never users of exogenous estrogen. The spline analysis indicated nonlinear relations of regular intake of coffee, age, and BMI with SHBG concentrations. Two or more cups/day of regular coffee consumption and age of 60 years or older were associated with higher SHBG concentrations; the inverse BMI–SHBG relation was especially strong among women whose BMI was below 30. CONCLUSIONS In this large sample of postmenopausal women, age, exogenous estrogen use, physical activity, regular coffee intake, and BMI were significant correlates of SHBG concentrations, presenting potential targets for interventions.

scholarly journals Sex hormone binding globulin levels across the adult lifespan in women — The role of body mass index and fasting insulin

2008 ◽  
Vol 31 (7) ◽  
pp. 597-601 ◽  
Author(s):  
M. Maggio ◽  
F. Lauretani ◽  
S. Basaria ◽  
G. P. Ceda ◽  
S. Bandinelli ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Fasting Insulin ◽  
Hormone Binding ◽  
Adult Lifespan

TV or Not TV: Fat Is the Question

PEDIATRICS ◽  
1993 ◽  
Vol 91 (2) ◽  
pp. 499-501
Author(s):  
WILLIAM H. DIETZ ◽  
STEVEN L. GORTMAKER
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Body Mass ◽  
Adolescent Girls ◽  
Television Viewing ◽  
Physical Activities ◽  
Reciprocal Relationship ◽  
Seventh Grade ◽  
Relationship Of

The manuscript entitled "Does television viewing increase obesity and reduce physical activity?" published by Robinson and coauthors in this issue of Pediatrics1 is a careful and well-written study of the effect of television viewing on adiposity and physical activity among sixth- and seventh-grade adolescent girls. In contrast to two other large studies of children,2,3 the authors failed to find a significant association between hours of television viewed and adiposity, measured by body mass index. Physical activity was weakly and inversely correlated to time spent viewing television. The latter observation is consistent with prior data which demonstrate a reciprocal relationship of fitness and television viewing,4 perhaps because television viewing displaces more vigorous physical activities.5

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