scholarly journals Tumor-homing peptides as tools for targeted delivery of payloads to the placenta

2016 ◽  
Vol 2 (5) ◽  
pp. e1600349 ◽  
Author(s):  
Anna King ◽  
Cornelia Ndifon ◽  
Sylvia Lui ◽  
Kate Widdows ◽  
Venkata R. Kotamraju ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Targeted Delivery ◽  
Normal Development ◽  
Coated Nanoparticles ◽  
Mouse Placenta ◽  
Pregnant Mice ◽  
Tumor Homing ◽  
Homing Peptide ◽  
And Function ◽  
Proof Of Principle

The availability of therapeutics to treat pregnancy complications is severely lacking mainly because of the risk of causing harm to the fetus. As enhancement of placental growth and function can alleviate maternal symptoms and improve fetal growth in animal models, we have developed a method for targeted delivery of payloads to the placenta. We show that the tumor-homing peptide sequences CGKRK and iRGD bind selectively to the placental surface of humans and mice and do not interfere with normal development. Peptide-coated nanoparticles intravenously injected into pregnant mice accumulated within the mouse placenta, whereas control nanoparticles exhibited reduced binding and/or fetal transfer. We used targeted liposomes to efficiently deliver cargoes of carboxyfluorescein and insulin-like growth factor 2 to the mouse placenta; the latter significantly increased mean placental weight when administered to healthy animals and significantly improved fetal weight distribution in a well-characterized model of fetal growth restriction. These data provide proof of principle for targeted delivery of drugs to the placenta and provide a novel platform for the development of placenta-specific therapeutics.

scholarly journals Treatment of Peritoneal Carcinomatosis by Targeted Delivery of the Radio-Labeled Tumor Homing Peptide 213Bi-DTPA-[F3]2 into the Nucleus of Tumor Cells

PLoS ONE ◽  
2009 ◽  
Vol 4 (5) ◽  
pp. e5715 ◽  
Author(s):  
Enken Drecoll ◽  
Florian C. Gaertner ◽  
Matthias Miederer ◽  
Birgit Blechert ◽  
Mario Vallon ◽  
...  
Keyword(s):  
Peritoneal Carcinomatosis ◽  
Tumor Cells ◽  
Targeted Delivery ◽  
Tumor Homing ◽  
Homing Peptide

Abstract 382: In-vivo imaging of lung cancer using tumor homing peptide coated nanoparticles

2012 ◽  
Author(s):  
Apurva R. Patel ◽  
Ed Lim ◽  
Ning Zhang ◽  
Kevin Francis ◽  
Stephen Safe ◽  
...  
Keyword(s):  
Lung Cancer ◽  
In Vivo Imaging ◽  
Coated Nanoparticles ◽  
Tumor Homing ◽  
Homing Peptide

scholarly journals Maternal growth factor regulation of human placental development and fetal growth

2010 ◽  
Vol 207 (1) ◽  
pp. 1-16 ◽  
Author(s):  
Karen Forbes ◽  
Melissa Westwood
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Fetal Growth ◽  
Mechanism Of Action ◽  
Normal Development ◽  
Receptor Interaction ◽  
Placental Development ◽  
Maternal Circulation ◽  
Successful Pregnancy ◽  
And Function

Normal development and function of the placenta is critical to achieving a successful pregnancy, as normal fetal growth depends directly on the transfer of nutrients from mother to fetus via this organ. Recently, it has become apparent from both animal and human studies that growth factors within the maternal circulation, for example the IGFs, are important regulators of placental development and function. Although these factors act via distinct receptors to exert their effects, the downstream molecules activated upon ligand/receptor interaction are common to many growth factors. The expression of numerous signaling molecules is altered in the placentas from pregnancies affected by the fetal growth complications, fetal growth restriction, and macrosomia. Thus, targeting these molecules may lead to more effective treatments for complications of pregnancy associated with altered placental development. Here, we review the maternal growth factors required for placental development and discuss their mechanism of action.

scholarly journals A smart viral vector for targeted delivery of hydrophobic drugs

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sukanya Ghosh ◽  
Manidipa Banerjee
Keyword(s):  
Targeted Delivery ◽  
Viral Vector ◽  
Fundamental Problem ◽  
Target Cells ◽  
Immune Reactivity ◽  
Hydrophobic Drugs ◽  
Drug Release Profile ◽  
Capsid Shell ◽  
Tumor Homing ◽  
Homing Peptide

AbstractTargeted delivery of hydrophobic chemotherapeutic drugs to tumor cells remains a fundamental problem in cancer therapy. Effective encapsulation of hydrophobic drugs in nano-vehicles can improve their pharmacokinetics, bioavailability and prevent off-target localization. We have devised a method for easy chemical conjugation and multivalent display of a tumor-homing peptide to virus-like particles of a non-mammalian virus, Flock House Virus (FHV), to engineer it into a smart vehicle for targeted delivery of hydrophobic drugs. This conjugation method provides dual functionalization to the VLPs, first, a 2 kDa PEG spacer arm shields VLPs from immune reactivity, and second, attachment of the tumor homing peptide tLyP-1 chauffeurs the encapsulated hydrophobic drugs to target cells. The fortuitous affinity of the FHV capsid towards hydrophobic molecules, and dependence on Ca2+ for maintaining a stable capsid shell, were utilized for incorporation of hydrophobic drugs—doxorubicin and ellipticine—in tLyP-1 conjugated VLPs. The drug release profile from the VLP was observed to be gradual, and strictly endosomal pH dependent. We propose that this accessible platform empowers surface functionalization of VLP with numerous ligands containing terminal cysteines, for generating competent delivery vehicles, antigenic display and other biomedical applications.

scholarly journals Biology and pathology of the uterine microenvironment and its natural killer cells

2021 ◽  
Author(s):  
Fuyan Wang ◽  
Anita Ellen Qualls ◽  
Laia Marques-Fernandez ◽  
Francesco Colucci
Keyword(s):  
Natural Killer ◽  
Fetal Growth ◽  
Immune Cells ◽  
Smooth Muscle Actin ◽  
Lymphoid Cells ◽  
Unk Cells ◽  
New Frontier ◽  
Uterine Mucosa ◽  
Blastocyst Implantation ◽  
And Function

AbstractTissues are the new frontier of discoveries in immunology. Cells of the immune system are an integral part of tissue physiology and immunity. Determining how immune cells inhabit, housekeep, and defend gut, lung, brain, liver, uterus, and other organs helps revealing the intimate details of tissue physiology and may offer new therapeutic targets to treat pathologies. The uterine microenvironment modulates the development and function of innate lymphoid cells [ILC, largely represented by natural killer (NK) cells], macrophages, T cells, and dendritic cells. These immune cells, in turn, contribute to tissue homeostasis. Regulated by ovarian hormones, the human uterine mucosa (endometrium) undergoes ~400 monthly cycles of breakdown and regeneration from menarche to menopause, with its fibroblasts, glands, blood vessels, and immune cells remodeling the tissue into the transient decidua. Even more transformative changes occur upon blastocyst implantation. Before the placenta is formed, the endometrial glands feed the embryo by histiotrophic nutrition while the uterine spiral arteries are stripped of their endothelial layer and smooth muscle actin. This arterial remodeling is carried out by invading fetal trophoblast and maternal immune cells, chiefly uterine NK (uNK) cells, which also assist fetal growth. The transformed arteries no longer respond to maternal stimuli and meet the increasing demands of the growing fetus. This review focuses on how the everchanging uterine microenvironment affects uNK cells and how uNK cells regulate homeostasis of the decidua, placenta development, and fetal growth. Determining these pathways will help understand the causes of major pregnancy complications.

Macrophage membrane coated nanoparticles: a biomimetic approach for enhanced and targeted delivery

2022 ◽  
Author(s):  
Nafeesa Khatoon ◽  
Zefei Zhang ◽  
Chunhui Zhou ◽  
Maoquan Chu
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Systemic Toxicity ◽  
Coated Nanoparticles ◽  
Biomimetic Approach ◽  
Targeted Drug ◽  
Macrophage Membrane

The enhanced and targeted drug delivery with low systemic toxicity and subsequent release of drugs is the major concern among researchers and pharmaceutics. Inspite of greater advancement and discoveries in...

Sign in / Sign up

Export Citation Format

Share Document