scholarly journals Sustained and targeted delivery of checkpoint inhibitors by metal-organic frameworks for cancer immunotherapy

2021 ◽  
Vol 7 (4) ◽  
pp. eabe7174
Author(s):  
Shahad K. Alsaiari ◽  
Somayah S. Qutub ◽  
Shichao Sun ◽  
Walaa Baslyman ◽  
Mansour Aldehaiman ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Hematological Malignancies ◽  
Checkpoint Inhibitor ◽  
Checkpoint Inhibitors ◽  
Metal Organic Frameworks ◽  
Controlled Delivery ◽  
Zeolitic Imidazolate Frameworks ◽  
Life Threatening ◽  
Metal Organic ◽  
Cancer Immunotherapies

The major impediments to the implementation of cancer immunotherapies are the sustained immune effect and the targeted delivery of these therapeutics, as they have life-threatening adverse effects. In this work, biomimetic metal-organic frameworks [zeolitic imidazolate frameworks (ZIFs)] are used for the controlled delivery of nivolumab (NV), a monoclonal antibody checkpoint inhibitor that was U.S. Food and Drug Administration–approved back in 2014. The sustained release behavior of NV-ZIF has shown a higher efficacy than the naked NV to activate T cells in hematological malignancies. The system was further modified by coating NV-ZIF with cancer cell membrane to enable tumor-specific targeted delivery while treating solid tumors. We envisage that such a biocompatible and biodegradable immunotherapeutic delivery system may promote the development and the translation of hybrid superstructures into smart and personalized delivery platforms.

Tuning and understanding the electronic effect of Co-Mo-O sties in bifunctional electrocatalysts for ultralong-lasting rechargable zinc-air battery

2021 ◽  
Author(s):  
Yi Guan ◽  
Nan Li ◽  
Jiao He ◽  
Yongliang Li ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Electronic Effect ◽  
Metal Organic Frameworks ◽  
Core Shell ◽  
Zeolitic Imidazolate Frameworks ◽  
Assembly Strategy ◽  
The Core ◽  
Bifunctional Electrocatalysts ◽  
Metal Organic ◽  
Air Battery

Herein, we report a post-assembly strategy by growing the bimetallic Co/Zn zeolitic imidazolate frameworks (BIMZIF) on the surface of the customized Mo metal-organic frameworks (MOFs) (Mo-MOF) to prepare the core-shell...

scholarly journals Rheumatic immune-related adverse events from checkpoint inhibitor therapy: a case series

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Antonella Laria ◽  
Alfredomaria Lurati ◽  
Laura Castelnovo ◽  
Antonio Tamburello ◽  
Paola Maria Faggioli ◽  
...  
Keyword(s):  
Adverse Events ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Checkpoint Inhibitor ◽  
Checkpoint Inhibitors ◽  
Case Series ◽  
Hematologic Malignancies ◽  
Checkpoint Inhibitor Therapy ◽  
Cancer Immunotherapies ◽  
Cell Death Protein

Immune checkpoint inhibitors (ICIs) targeting cytotoxic T-lymphocyte associated protein-4 (CTLA-4), programmed cell death protein-1 (PD-1), and its ligand PD-L1 are established cancer immunotherapies for solid tumor and hematologic malignancies. These therapies are involved in immune-related adverse events (irAE), both general and rheumatic ones. In general, immune-related adverse events (irAE) management includes drug-holding, tapering doses of corticosteroids, and specific immunosuppression for clinically severe cases, such as infliximab or mycophenolate.

Reticular Chemistry and Metal-Organic Frameworks for Clean Energy

MRS Bulletin ◽  
2009 ◽  
Vol 34 (9) ◽  
pp. 682-690 ◽  
Author(s):  
Omar M. Yaghi ◽  
Qiaowei Li
Keyword(s):  
Carbon Dioxide ◽  
Metal Organic Frameworks ◽  
Clean Energy ◽  
Building Blocks ◽  
Zeolitic Imidazolate Frameworks ◽  
Design Concepts ◽  
Surface Areas ◽  
Molecular Building Blocks ◽  
Metal Organic ◽  
Molecular Aspects

AbstractReticular chemistry concerns the linking of molecular building blocks into predetermined structures using strong bonds. We have been working on creating and developing the conceptual and practical basis of this new area of research. As a result, new classes of crystalline porous materials have been designed and synthesized: metal-organic frameworks, zeolitic imidazolate frameworks, and covalent organic frameworks. Crystals of this type have exceptional surface areas (2,000−6,000 m2/g) and take up voluminous amounts of hydrogen (7.5 wt% at 77 K and 3−4 × 106 Pa), methane (50 wt% at 298 K and 2.5 × 106 Pa), and carbon dioxide (140 wt% at 298 K and 3 × 106 Pa). We have driven the basic science all the way to applications without losing sight of our quest for understanding the underlying molecular aspects of this chemistry. The presentation was focused on the design concepts, synthesis, and structure of these materials, with emphasis on their applications to onboard energy storage.

scholarly journals Detect it so you can treat it: a case series and proposed checklist to detect neurotoxicity in checkpoint therapy

2020 ◽  
Author(s):  
Saskia Bolz ◽  
Thivyah Ramakrishnan ◽  
Michael Fleischer ◽  
Elisabeth Livingstone ◽  
Benjamin Stolte ◽  
...  
Keyword(s):  
Adverse Events ◽  
Checkpoint Inhibitor ◽  
Checkpoint Inhibitors ◽  
Case Series ◽  
Transverse Myelitis ◽  
University Hospital ◽  
Life Threatening ◽  
Checkpoint Inhibitor Therapy ◽  
Cancer Types ◽  
Brachial Plexus Neuritis

Abstract Background: Checkpoint inhibitors show impressive and durable responses in various cancer types and provide new avenues for cancer immunotherapy. However, these drugs have a variety of adverse events. Common autoimmune-related adverse effects include fatigue, hepatitis, skin rash, endocrine deficiencies, and colitis. Neurotoxicity has been reported, but its incidence and course remain unclear.Methods: To illustrate the broad spectrum of neurotoxicity, we exemplarily report the neurological adverse events of five patients with melanoma and one patient with differentiated thyroid cancer who received checkpoint inhibitors at Essen University Hospital (Essen, Germany).Results: After treatment with ipilimumab, nivolumab or pembrolizumab, neurotoxic effects included hypophysitis-associated neck pain and headache, Guillain-Barré syndrome, transverse myelitis, acute brachial plexus neuritis, and ocular myasthenia gravis.Conclusions: Checkpoint inhibitor therapy remains a success story; however, neurological immune-related adverse events may cause severe life-threatening conditions. We propose a checklist for the early detection of neurological adverse events during routine clinical treatment to prevent more severe courses of checkpoint inhibitor-induced neurotoxicity.

Carbon Dioxide Captured by Metal Organic Frameworks and Its Subsequent Resource Utilization Strategy: A Review and Prospect

2019 ◽  
Vol 19 (6) ◽  
pp. 3059-3078 ◽  
Author(s):  
Xinbo Lian ◽  
Leilei Xu ◽  
Mindong Chen ◽  
Cai-e Wu ◽  
Wenjing Li ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Resource Utilization ◽  
Power Plants ◽  
Energy Requirement ◽  
Metal Organic Frameworks ◽  
Research Progress ◽  
Zeolitic Imidazolate Frameworks ◽  
Wide Range ◽  
Metal Organic ◽  
And Storage

The carbon dioxide (CO2) is notorious as the greenhouse gas, which could cause the global warming and climate change. Therefore, the reduction of the atmospheric CO2 emissions from power plants and other industrial facilities has become as an increasingly urgent concern. In the recent years, CO2 capture and storage technologies have received a worldwide attention. Adsorption is considered as one of the efficient options for CO2 capture because of its cost advantage, low energy requirement and extensive applicability over a relatively wide range of temperature and pressure. The metal organic frameworks (MOFs) show widely potential application prospects in CO2 capture and storage owing to their outstanding textural properties, such as the extraordinarily high specific surface area, tunable pore size, ultrahigh porosity (up to 90%), high crystallinity, adjustable internal surface properties, and controllable structure. Herein, the most important research progress of MOFs materials on the CO2 capture and storage in recent years has been comprehensively reviewed. The extraordinary characteristics and CO2 capture performance of Zeolitic Imidazolate Frameworks (ZIFs), Bio-metal organic frameworks (bio-MOFs), IL@MOFs and MOF-composite materials were highlighted. The promising strategies for improving the CO2 adsorption properties of MOFs materials, especially the low-pressure adsorption performance under actual flue gas conditions, are also carefully summarized. Besides, CO2 is considered as an abundant, nontoxic, nonflammable, and renewable C1 resource for the synthesis of useful chemicals and fuels. The potential routes for resource utilization of the captured CO2 are briefly proposed.

scholarly journals Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

Pharmaceutics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 232 ◽  
Author(s):  
Mengru Cai ◽  
Gongsen Chen ◽  
Liuying Qin ◽  
Changhai Qu ◽  
Xiaoxv Dong ◽  
...  
Keyword(s):  
Drug Targeting ◽  
Drug Loading ◽  
Metal Organic Frameworks ◽  
Zeolitic Imidazolate Frameworks ◽  
Passive Targeting ◽  
Normal Tissues ◽  
Excellent Research ◽  
Targeting Delivery ◽  
Metal Organic ◽  
University Of Oslo

In recent years, metal organic frameworks (MOFs) have been widely developed as vehicles for the effective delivery of drugs to tumor tissues. Due to the high loading capacity and excellent biocompatibility of MOFs, they provide an unprecedented opportunity for the treatment of cancer. However, drugs which are commonly used to treat cancer often cause side effects in normal tissue accumulation. Therefore, the strategy of drug targeting delivery based on MOFs has excellent research significance. Here, we introduce several intelligent targeted drug delivery systems based on MOFs and their characteristics as drug-loading systems, and the challenges of MOFs are discussed. This article covers the following types of MOFs: Isoreticular Metal Organic Frameworks (IRMOFs), Materials of Institute Lavoisier (MILs), Zeolitic Imidazolate Frameworks (ZIFs), University of Oslo (UiOs), and MOFs-based core-shell structures. Generally, MOFs can be reasonably controlled at the nanometer size to effectively achieve passive targeting. In addition, different ligands can be modified on MOFs for active or physicochemical targeting. On the one hand, the targeting strategy can improve the concentration of the drugs at the tumor site to improve the efficacy, on the other hand, it can avoid the release of the drugs in normal tissues to improve safety. Despite the challenges of clinical application of MOFs, MOFs have a number of advantages as a kind of smart delivery vehicle, which offer possibilities for clinical applications.

Spiers Memorial Lecture: : Progress and prospects of reticular chemistry

2017 ◽  
Vol 201 ◽  
pp. 9-45 ◽  
Author(s):  
Bunyarat Rungtaweevoranit ◽  
Christian S. Diercks ◽  
Markus J. Kalmutzki ◽  
Omar M. Yaghi
Keyword(s):  
Metal Organic Frameworks ◽  
Memorial Lecture ◽  
Chemical Information ◽  
Covalent Organic Frameworks ◽  
Zeolitic Imidazolate Frameworks ◽  
New Materials ◽  
New Directions ◽  
Metal Organic ◽  
The Way

Reticular chemistry, the linking of molecular building units by strong bonds to make crystalline, extended structures such as metal–organic frameworks (MOFs), zeolitic imidazolate frameworks (ZIFs), and covalent organic frameworks (COFs), is currently one of the most rapidly expanding fields of science. In this contribution, we outline the origins of the field; the key intellectual and practical contributions, which have led to this expansion; and the new directions reticular chemistry is taking that are changing the way we think about making new materials and the manner with which we incorporate chemical information within structures to reach additional levels of functionality. This progress is described in the larger context of chemistry and unexplored, yet important, aspects of this field are presented.

Enzyme encapsulation in zeolitic imidazolate frameworks: a comparison between controlled co-precipitation and biomimetic mineralisation

2016 ◽  
Vol 52 (3) ◽  
pp. 473-476 ◽  
Author(s):  
Kang Liang ◽  
Campbell J. Coghlan ◽  
Stephen G. Bell ◽  
Christian Doonan ◽  
Paolo Falcaro
Keyword(s):  
Protective Coatings ◽  
Metal Organic Frameworks ◽  
Zeolitic Imidazolate Frameworks ◽  
Enzyme Encapsulation ◽  
Metal Organic ◽  
Co Precipitation

Recent studies have demonstrated that metal–organic frameworks can be employed as protective coatings for enzymes.

scholarly journals Síntese e Caracterização de Redes Metalorgânicas, ZIF-8 e ZIF-67.

2016 ◽  
Vol 12 (5) ◽  
Author(s):  
Simonise Figueiredo Amarante ◽  
André Luis Dantas Ramos ◽  
Maikon Alves Freire ◽  
Douglas Thainan Silva Lima Mendes
Keyword(s):  
Metal Organic Frameworks ◽  
Zeolitic Imidazolate Frameworks ◽  
Metal Organic

Redes metalorgânicas (metal-organic frameworks, MOFs), também chamadas polímeros de coordenação, representam uma nova classe de materiais híbridos inorgânico-orgânicos que se caracterizam pela sua grande estabilidade, alta porosidade e estruturas cristalinas bem definidas. Esses materiais têm se apresentado promissores para inúmeras aplicações, inclusive na área de catálise onde ganham destaque por poderem atuar como catalisadores bifuncionais ativos. As vantagens da utilização destes catalisadores em relação a outros já reportados na literatura passa pelas suas características como área superficial elevada e controle do caráter ácido-básico dos sítios (Brönsted ou Lewis). Zeolitic imidazolate frameworks (ZIFs) é uma subfamília das MOFs que tem adquirido interesse principalmente por combinar as vantagens das redes metalorgânicas com a elevada estabilidade térmica e química das zeólitas. As MOFs, e consequentemente as ZIFs, podem ser sintetizadas de modo a possuir sítios ácidos e básicos, simultaneamente. Essa especificidade possui grande atratividade, em especial, para reações que podem ocorrer por mecanismos que exigem ambos os sítios, tal como a produção do biodiesel. O presente trabalho apresenta a síntese de catalisadores heterogêneos bifuncionais, à base de redes metalorgânicas com o preparo da ZIF-8 e da ZIF-67 acompanhada da caracterização das mesmas através das técnicas de difração de raios X (DRX), Fisissorção de nitrogênio e Espectroscopia de infravermelho (FTIR). As análises dos resultados obtidos evidenciam elevada cristalinidade, presença de grupos funcionais característicos das estruturas dos catalisadores e valores de propriedades texturais baixos. Os dados encontrados mostram-se de acordo com o padrão teórico observado na literatura sugerindo o sucesso das sínteses realizadas.

Sign in / Sign up

Export Citation Format

Share Document