scholarly journals Observation of cavitation governing fracture in glasses

2021 ◽  
Vol 7 (14) ◽  
pp. eabf7293
Author(s):  
Lai-Quan Shen ◽  
Ji-Hao Yu ◽  
Xiao-Chang Tang ◽  
Bao-An Sun ◽  
Yan-Hui Liu ◽  
...  
Keyword(s):  
Crack Propagation ◽  
Disordered Systems ◽  
Underlying Mechanism ◽  
Material Failure ◽  
Self Organized ◽  
Fundamental Understanding ◽  
Glassy Materials ◽  
Cavitation Behavior ◽  
Fracture Morphologies

Crack propagation is the major vehicle for material failure, but the mechanisms by which cracks propagate remain longstanding riddles, especially for glassy materials with a long-range disordered atomic structure. Recently, cavitation was proposed as an underlying mechanism governing the fracture of glasses, but experimental determination of the cavitation behavior of fracture is still lacking. Here, we present unambiguous experimental evidence to firmly establish the cavitation mechanism in the fracture of glasses. We show that crack propagation in various glasses is dominated by the self-organized nucleation, growth, and coalescence of nanocavities, eventually resulting in the nanopatterns on the fracture surfaces. The revealed cavitation-induced nanostructured fracture morphologies thus confirm the presence of nanoscale ductility in the fracture of nominally brittle glasses, which has been debated for decades. Our observations would aid a fundamental understanding of the failure of disordered systems and have implications for designing tougher glasses with excellent ductility.

Identification of N-Substituted Triazolo-azetidines as Novel Antibacterials using pDualrep2 HTS Platform

2019 ◽  
Vol 22 (5) ◽  
pp. 346-354
Author(s):  
Yan A. Ivanenkov ◽  
Renat S. Yamidanov ◽  
Ilya A. Osterman ◽  
Petr V. Sergiev ◽  
Vladimir A. Aladinskiy ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Large Scale ◽  
Underlying Mechanism ◽  
Luciferase Assay ◽  
Reporter System ◽  
E Coli ◽  
Starting Point ◽  
High Concentrations ◽  
Mic Value

Aim and Objective: Antibiotic resistance is a serious constraint to the development of new effective antibacterials. Therefore, the discovery of the new antibacterials remains one of the main challenges in modern medicinal chemistry. This study was undertaken to identify novel molecules with antibacterial activity. Materials and Methods: Using our unique double-reporter system, in-house large-scale HTS campaign was conducted for the identification of antibacterial potency of small-molecule compounds. The construction allows us to visually assess the underlying mechanism of action. After the initial HTS and rescreen procedure, luciferase assay, C14-test, determination of MIC value and PrestoBlue test were carried out. Results: HTS rounds and rescreen campaign have revealed the antibacterial activity of a series of Nsubstituted triazolo-azetidines and their isosteric derivatives that has not been reported previously. Primary hit-molecule demonstrated a MIC value of 12.5 µg/mL against E. coli Δ tolC with signs of translation blockage and no SOS-response. Translation inhibition (26%, luciferase assay) was achieved at high concentrations up to 160 µg/mL, while no activity was found using C14-test. The compound did not demonstrate cytotoxicity in the PrestoBlue assay against a panel of eukaryotic cells. Within a series of direct structural analogues bearing the same or bioisosteric scaffold, compound 2 was found to have an improved antibacterial potency (MIC=6.25 µg/mL) close to Erythromycin (MIC=2.5-5 µg/mL) against the same strain. In contrast to the parent hit, this compound was more active and selective, and provided a robust IP position. Conclusion: N-substituted triazolo-azetidine scaffold may be used as a versatile starting point for the development of novel active and selective antibacterial compounds.

Automatic 3-D Crack Propagation Calculations in Industrial Components: A Pure Hexahedral versus a Combined Hexahedral-Tetrahedral Approach

2007 ◽  
Vol 348-349 ◽  
pp. 45-48
Author(s):  
Guido Dhondt
Keyword(s):  
Crack Propagation ◽  
Computing Time ◽  
Propagation Direction ◽  
Hexahedral Elements ◽  
Crack Propagation Direction ◽  
Low Weight ◽  
Out Of Plane ◽  
Hexahedral Meshes ◽  
Crack Faces

In recent years, increased loading and low weight requirements have led to the need for automatic crack tracing software. At MTU a purely hexahedral code has been developed in the nineties for Mode-I applications. It has been used extensively for all kinds of components and has proven to be very flexible and reliable. Nevertheless, in transition regions between complex components curved cracks have been observed, necessitating the development of mixed-mode software. Due to the curvature of the crack faces, purely hexahedral meshes are not feasible, and therefore a mixture of hexahedral elements at the crack tip, combined with tetrahedral in the remaining structure has been selected. The intention of the present paper is to compare both methods and to point out the strength and weaknesses of each regarding accuracy, complexity, flexibility and computing time. Furthermore, difficulties arising from the out-of-plane growth of the crack such as the determination of the crack propagation direction are discussed.

Observation of the Pinning-Induced Crystal-Hexatic-Glass Transition in Two-Dimensional Colloidal Suspensions

2021 ◽  
Vol 38 (10) ◽  
pp. 106101
Author(s):  
Xiaoyan Sun ◽  
Huaguang Wang ◽  
Hao Feng ◽  
Zexin Zhang ◽  
Yuqiang Ma
Keyword(s):  
Glass Transition ◽  
Colloidal Suspensions ◽  
Two Dimensional ◽  
Colloidal Systems ◽  
Fundamental Understanding ◽  
New Strategy ◽  
Glassy Materials ◽  
Colloidal Glass ◽  
Orientational Correlation

Identification of the glass formation process in various conditions is of importance for fundamental understanding of the mechanism of glass transitions as well as for developments and applications of glassy materials. We investigate the role of pinning in driving the transformation of crystal into glass in two-dimensional colloidal suspensions of monodisperse microspheres. The pinning is produced by immobilizing a fraction of microspheres on the substrate of sample cells where the mobile microspheres sediment. Structurally, the crystal-hexatic-glass transition occurs with increasing the number fraction of pinning ρ pinning, and the orientational correlation exhibits a change from quasi-long-range to short-range order at ρ pinning = 0.02. Interestingly, the dynamics shows a non-monotonic change with increasing the fraction of pinning. This is due to the competition between the disorder that enhances the dynamics and the pinning that hinders the particle motions. Our work highlights the important role of the pinning on the colloidal glass transition, which not only provides a new strategy to prevent crystallization forming glass, but also is helpful for understanding of the vitrification in colloidal systems.

Management Of Enterprise Development Strategies Formation: Analysis And Synthesis Methods

2021 ◽  
Vol 38 (4) ◽  
Author(s):  
Olga Kalaman ◽  
Tetiana Stupnytska ◽  
Yurii Melnyk ◽  
Karine Doicheva
Keyword(s):  
Swot Analysis ◽  
Synthesis Methods ◽  
Enterprise Strategy ◽  
Strategy Formation ◽  
Local Synthesis ◽  
Self Organized ◽  
Analysis And Synthesis ◽  
Enterprise Activity ◽  
Brand Product

The purpose of the presented research is to analyze, systematize and formulate an enterprise strategy based on the analysis and synthesis of opportunities and threats of the external environment in combination with its strengths and weaknesses. Unconventional structuring of SWOT-factors, as well as their local synthesis for determination of the driving and inhibiting forces of the enterprise, has been offered. Ways to identify trends and patterns of external and internal environment based on a generalized model of SWOT-factors have been identified. Decisive in formulating a strategy (self-organized in nature) is a harmonization model of the goals system. General theoretical methods (analogy, abstraction, analysis and synthesis, idealization, imaginary modeling) and practical methods of research (observation, comparison, matching, analysis of statistical and other indicators) were used to solve the problems of the research. Methods such as empirical, statistical, graphical, etc. were used to process and summarize information.Thus, the approach study to the enterprise strategy formation based on the analysis and synthesis of the environment opportunities and threats in combination with its strengths and weaknesses allows to state that the development of a common structured list of major areas of enterprise activity is carried out taking into account the synthesis of all SWOT-analysis of the brand product, competitors and market segments, which allows the company to achieve a certain specific purpose of its activities.

Disordered materials studied using neutron polarization analysis on the multi-detector spectrometer, D7

2008 ◽  
Vol 42 (1) ◽  
pp. 69-84 ◽  
Author(s):  
J. R. Stewart ◽  
P. P. Deen ◽  
K. H. Andersen ◽  
H. Schober ◽  
J.-F. Barthélémy ◽  
...  
Keyword(s):  
Cross Sections ◽  
Disordered Systems ◽  
Disordered Materials ◽  
Polarization Analysis ◽  
Neutron Spectrometer ◽  
Neutron Polarization ◽  
Unambiguous Determination ◽  
Diffraction Patterns ◽  
Scattering Cross Sections

The technique of longitudinal neutron polarization analysis on a multi-detector neutron spectrometer (so-called `xyz'-polarization analysis) is presented. This technique allows the simultaneous and unambiguous determination of the nuclear, magnetic and nuclear spin-incoherent scattering cross sections as a function of both momentum transfer and energy transfer. The implementation ofxyz-polarization analysis on the recently upgraded D7 spectrometer at the Institut Laue–Langevin in Grenoble is described. Several examples of neutron polarization analysis studies of disordered systems on D7 are given, illustrating the valuable information which can be retrieved from the analysis of neutron diffraction patterns between the Bragg peaks.

scholarly journals Crack Propagation Velocity Determination by High-speed Camera Image Sequence Processing

2020 ◽  
Author(s):  
Frank Liebold ◽  
Ali A. Heravi ◽  
Oliver Mosig ◽  
Manfred Curbach ◽  
Viktor Mechtcherine ◽  
...  
Keyword(s):  
Crack Propagation ◽  
High Speed ◽  
Vector Fields ◽  
Displacement Vector ◽  
Image Sequence ◽  
High Speed Camera ◽  
Sequence Processing ◽  
Image Sequence Processing ◽  
Propagation Velocities

The determination of crack propagation velocities can provide valuable information for a better understanding of damage processes of concrete. The spatio-temporal analysis of crack patterns developing at a speed of several hundred meters per second is a rather challenging task. In the paper, a photogrammetric procedure for the determination of crack propagation velocities in concrete specimens using high-speed camera image sequences is presented. A cascaded image sequence processing which starts with the computation of displacement vector fields for a dense pattern of points on the specimen’s surface between consecutive time steps of the image sequence chain has been developed. These surface points are triangulated into a mesh, and as representations of cracks, discontinuities in the displacement vector fields are found by a deformation analysis applied to all triangles of the mesh. Connected components of the deformed triangles are computed using region-growing techniques. Then, the crack tips are determined using principal component analysis. The tips are tracked in the image sequence and the velocities between the time stamps of the images are derived. A major advantage of this method as compared to established techniques is in the fact of its allowing for spatio-temporally resolved, full-field measurements rather than point-wise measurements and that information on crack width can be obtained simultaneously. To validate the experimentation, the authors processed image sequences of tests on four compact-tension specimens performed on a split-Hopkinson tension bar. The images were taken by a high-speed camera at a frame rate of 160,000 images per second. By applying to these datasets the image sequence processing procedure as developed, crack propagation velocities of about 800 m/s were determined with a precision in the order of 50 m/s.

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