scholarly journals Anterior cingulate inputs to nucleus accumbens control the social transfer of pain and analgesia

Science ◽  
2021 ◽  
Vol 371 (6525) ◽  
pp. 153-159 ◽  
Author(s):  
Monique L. Smith ◽  
Naoyuki Asada ◽  
Robert C. Malenka
Keyword(s):  
Nucleus Accumbens ◽  
Social Communication ◽  
Basolateral Amygdala ◽  
Brain Area ◽  
Anterior Cingulate ◽  
Social Partner ◽  
Emotional States ◽  
Morphine Analgesia ◽  
The Social ◽  
Social Transfer

Empathy is an essential component of social communication that involves experiencing others’ sensory and emotional states. We observed that a brief social interaction with a mouse experiencing pain or morphine analgesia resulted in the transfer of these experiences to its social partner. Optogenetic manipulations demonstrated that the anterior cingulate cortex (ACC) and its projections to the nucleus accumbens (NAc) were selectively involved in the social transfer of both pain and analgesia. By contrast, the ACC→NAc circuit was not necessary for the social transfer of fear, which instead depended on ACC projections to the basolateral amygdala. These findings reveal that the ACC, a brain area strongly implicated in human empathic responses, mediates distinct forms of empathy in mice by influencing different downstream targets.

scholarly journals Social transfer of pain in mice

2016 ◽  
Vol 2 (10) ◽  
pp. e1600855 ◽  
Author(s):  
Monique L. Smith ◽  
Caroline M. Hostetler ◽  
Mary M. Heinricher ◽  
Andrey E. Ryabinin
Keyword(s):  
Social Environment ◽  
Social Communication ◽  
Inflammatory Pain ◽  
Model System ◽  
Olfactory Cues ◽  
Complex Relationship ◽  
Experimental Animals ◽  
The Social ◽  
Social Transfer ◽  
Proper Consideration

A complex relationship exists between the psychosocial environment and the perception and experience of pain, and the mechanisms of the social communication of pain have yet to be elucidated. The present study examined the social communication of pain and demonstrates that “bystander” mice housed and tested in the same room as mice subjected to inflammatory pain or withdrawal from morphine or alcohol develop corresponding hyperalgesia. Olfactory cues mediate the transfer of hyperalgesia to the bystander mice, which can be measured using mechanical, thermal, and chemical tests. Hyperalgesia in bystanders does not co-occur with anxiety or changes in corticosterone and cannot be explained by visually dependent emotional contagion or stress-induced hyperalgesia. These experiments reveal the multifaceted relationship between the social environment and pain behavior and support the use of mice as a model system for investigating these factors. In addition, these experiments highlight the need for proper consideration of how experimental animals are housed and tested.

scholarly journals Indirect exposure to socially defeated conspecifics using recorded video activates the HPA axis and reduces reward sensitivity in mice

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yuko Nakatake ◽  
Hiroki Furuie ◽  
Masatoshi Ukezono ◽  
Misa Yamada ◽  
Kazumi Yoshizawa ◽  
...  
Keyword(s):  
Stress Responses ◽  
Visual Information ◽  
Forced Swim Test ◽  
Preference Test ◽  
Plasma Corticosterone ◽  
Reward Sensitivity ◽  
Anterior Cingulate ◽  
Emotional States ◽  
The Social ◽  
Sucrose Preference Test

Abstract Rodents perceive the emotional states of conspecifics using vision. In the present study, we demonstrated that exposure to the video-recorded distress of conspecifics induces stress responses in male C57BL/6J mice. A single exposure to a video-recorded scene of the social defeat stress (SDS) increased plasma corticosterone levels in these mice. This physiological change was suppressed by blocking the visual information, suggesting that vision plays a crucial role in inducing stress responses. Furthermore, after exposure to the video, there were increased numbers of c-Fos-positive neurons in the anterior cingulate cortex and other brain areas that are associated with the negative valence and empathy systems, but not in the regions related to the pain signaling. In addition, repeated exposure to SDS videos induced an apparent reduction in reward sensitivity in the sucrose preference test, but did not affect avoidance behaviour in the social interaction test or immobility behaviour in the forced swim test. Reduced reward sensitivity in mice reflects anhedonia, which is a core symptom of depression in humans. Our video SDS model therefore provides a unique opportunity to not only understand the mechanisms underlying stress-induced anhedonia, but also to screen effective candidate molecules for stress-related disorders with greater reproducibility.

scholarly journals Specialized medial prefrontal-amygdala coordination in other-regarding decision preference

2019 ◽  
Author(s):  
Olga Dal Monte ◽  
Cheng-Chi J. Chu ◽  
Nicholas A. Fagan ◽  
Steve W. C. Chang
Keyword(s):  
Cognitive Processes ◽  
Basolateral Amygdala ◽  
Brain Regions ◽  
Brain Network ◽  
Anterior Cingulate ◽  
Social Brain ◽  
Social Decisions ◽  
The Social ◽  
Oscillatory Coupling ◽  
Other Regarding

AbstractSocial behaviors recruit multiple cognitive processes requiring coordinated interactions among brain regions. Oscillatory coupling provides one mechanism for cortical and subcortical neurons to synchronize their activity. However, it remains unknown how neurons from different nodes in the social brain network interact when making social decisions. We investigated neuronal coupling between the rostral anterior cingulate gyrus of the medial prefrontal cortex and the basolateral amygdala while monkeys expressed context-dependent positive other-regarding preference (ORP) or negative ORP impacting the reward of another monkey. We found an enhanced synchronization between the two nodes for positive ORP, but a suppressed synchronization for negative ORP. These interactions occurred in dedicated frequency channels depending on the area contributing spikes, exhibited a specific directionality of information flow associated with expressing positive ORP, and could be used to decode social decisions. These findings support that specialized coordination in the medial prefrontal-amygdala network underlies social decision preference.

Applying Item Response Theory Modeling to Identify Social (Pragmatic) Communication Disorder

2020 ◽  
Vol 63 (6) ◽  
pp. 1916-1932 ◽  
Author(s):  
Haiying Yuan ◽  
Christine Dollaghan
Keyword(s):  
Item Response Theory ◽  
Item Response ◽  
Sensitivity And Specificity ◽  
Social Communication ◽  
National Database ◽  
Communication Disorder ◽  
Social Communication Questionnaire ◽  
Autism Research ◽  
The Social ◽  
Pragmatic Communication

Purpose No diagnostic tools exist for identifying social (pragmatic) communication disorder (SPCD), a new Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition category for individuals with social communication deficits but not the repetitive, restricted behaviors and interests (RRBIs) that would qualify them for a diagnosis of autism spectrum disorder (ASD). We explored the value of items from a widely used screening measure of ASD for distinguishing SPCD from typical controls (TC; Aim 1) and from ASD (Aim 2). Method We applied item response theory (IRT) modeling to Social Communication Questionnaire–Lifetime ( Rutter, Bailey, & Lord, 2003 ) records available in the National Database for Autism Research. We defined records from putative SPCD ( n = 54), ASD ( n = 278), and TC ( n = 274) groups retrospectively, based on National Database for Autism Research classifications and Autism Diagnostic Interview–Revised responses. After assessing model assumptions, estimating model parameters, and measuring model fit, we identified items in the social communication and RRBI domains that were maximally informative in differentiating the groups. Results IRT modeling identified a set of seven social communication items that distinguished SPCD from TC with sensitivity and specificity > 80%. A set of five RRBI items was less successful in distinguishing SPCD from ASD (sensitivity and specificity < 70%). Conclusion The IRT modeling approach and the Social Communication Questionnaire–Lifetime item sets it identified may be useful in efforts to construct screening and diagnostic measures for SPCD.

ПРИНЦИПИ ПІЗНАННЯ ПОБУТУВАННЯ ПЕРФОРМАНСУ

2020 ◽  
pp. 54-60
Author(s):  
Admink Admink ◽  
Жанна Шкляренко
Keyword(s):  
Social Media ◽  
Performance Art ◽  
Research Performance ◽  
Emotional States ◽  
Performance Study ◽  
Modern Culture ◽  
Cultural Phenomenon ◽  
The Social ◽  
The Creation ◽  
Dividing Line

Стаття присвячена дослідженню шляхів вивчення перформансу як культурного явища. Зростаюча увага до цього феномену зумовлена відсутністю лінії розмежування його з життям, створенню особливої реальності, спроможністю викликати потужні емоційні стани та взаємоемпатії. Проблематичність у вивченні його полягає у складності архівування, хиткий своєрідний наратив, що вислизає зі сприйняття непідготовленого глядача, міграція з виставкових зал у соціальну сферу, супроводжувана жанровими новоутвореннями. Даним дослідженням зроблено спробу аналізу шляхів пізнання культурного явища перформансу, визначені особливості побутування, виявлено закономірності проявів та варіативність в сучасній культурі. The article is devoted to the study of ways to research performance study as a cultural phenomenon. The growing interest in the phenomenon of performance art is due to the lack of a dividing line with our life, the creation of a special reality, the ability to cause strong emotional states and mutual empathy. The difficulty of study is also in trouble archiving it, shaky kind of narrative which escapes the perception of the unprepared viewer, the migration of the exhibition halls and in the social media sphere, followed by the creation of new genres. This analyzes the ways of understanding the cultural phenomenon of performance art. The features of being are determined, patterns and a variety of its manifestations in modern culture are revealed.

New Democracy in Digital Era through Social Media and News Online

Humaniora ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 13
Author(s):  
Abitassha Az Zahra ◽  
Eko Priyo Purnomo ◽  
Aulia Nur Kasiwi
Keyword(s):  
Social Media ◽  
Social Network ◽  
Communication Networks ◽  
Social Communication ◽  
Development Policy ◽  
Online News ◽  
Digital Era ◽  
The Social ◽  
New Democracy

The research aimed to explain the pattern of social communication on the issue of rejection of the PLTU Batang development policy. It used data on Twitter accounts involved in the rejection of the PLTU Batang development policy. In analyzing existing data, qualitative methods and social analysis networks were used. To see social networks in the rejection of the PLTU Batang development policy, the research used the NodeXL application to find out the patterns of social communication networks in #TolakPLTUBatang. From the results, it can be seen that in the dissemination of social networking information, the @praditya_wibby account is the most central account in the social network and has a strong influence on the social network. The @praditya_wibby account has a role in moving the community through Twitter to make a critical social movement. This means that in the current digital era, democracy enters a new form through the movement of public opinion delivery through social media. Besides, by encouraging the role of online news, the distribution of information becomes faster to form new perceptions of an issue. This is evident from the correlation network where the @praditya_wibby account has correlations with several compass online media accounts, tirto.id, okezonenews, vice, antaranews, BBCIndonesia, and CNN Indonesia.

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