scholarly journals Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination

2019 ◽  
Vol 11 (523) ◽  
pp. eaay7162 ◽  
Author(s):  
Kevin J. McHugh ◽  
Lihong Jing ◽  
Sean Y. Severt ◽  
Mache Cruz ◽  
Morteza Sarmadi ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Human Skin ◽  
Data Storage ◽  
Near Infrared ◽  
Learning Algorithm ◽  
Ex Vivo ◽  
Neutralizing Antibody ◽  
Nir Light ◽  
Antibody Titers

Accurate medical recordkeeping is a major challenge in many low-resource settings where well-maintained centralized databases do not exist, contributing to 1.5 million vaccine-preventable deaths annually. Here, we present an approach to encode medical history on a patient using the spatial distribution of biocompatible, near-infrared quantum dots (NIR QDs) in the dermis. QDs are invisible to the naked eye yet detectable when exposed to NIR light. QDs with a copper indium selenide core and aluminum-doped zinc sulfide shell were tuned to emit in the NIR spectrum by controlling stoichiometry and shelling time. The formulation showing the greatest resistance to photobleaching after simulated sunlight exposure (5-year equivalence) through pigmented human skin was encapsulated in microparticles for use in vivo. In parallel, microneedle geometry was optimized in silico and validated ex vivo using porcine and synthetic human skin. QD-containing microparticles were then embedded in dissolvable microneedles and administered to rats with or without a vaccine. Longitudinal in vivo imaging using a smartphone adapted to detect NIR light demonstrated that microneedle-delivered QD patterns remained bright and could be accurately identified using a machine learning algorithm 9 months after application. In addition, codelivery with inactivated poliovirus vaccine produced neutralizing antibody titers above the threshold considered protective. These findings suggest that intradermal QDs can be used to reliably encode information and can be delivered with a vaccine, which may be particularly valuable in the developing world and open up new avenues for decentralized data storage and biosensing.

Near-infrared emitting graphene quantum dots synthesized from reduced graphene oxide for in vitro/in vivo/ex vivo bioimaging applications

2D Materials ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 035013
Author(s):  
Md Tanvir Hasan ◽  
Bong Han Lee ◽  
Ching-Wei Lin ◽  
Ainsley McDonald-Boyer ◽  
Roberto Gonzalez-Rodriguez ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Near Infrared ◽  
Ex Vivo ◽  
Graphene Quantum Dots ◽  
Reduced Graphene

scholarly journals Applications of Vibrational Spectroscopy for Analysis of Connective Tissues

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 922
Author(s):  
William Querido ◽  
Shital Kandel ◽  
Nancy Pleshko
Keyword(s):  
Raman Spectroscopy ◽  
Vibrational Spectroscopy ◽  
Near Infrared ◽  
Ex Vivo ◽  
Biological Tissues ◽  
Label Free ◽  
Connective Tissues ◽  
Bone Properties ◽  
Composition And Structure

Advances in vibrational spectroscopy have propelled new insights into the molecular composition and structure of biological tissues. In this review, we discuss common modalities and techniques of vibrational spectroscopy, and present key examples to illustrate how they have been applied to enrich the assessment of connective tissues. In particular, we focus on applications of Fourier transform infrared (FTIR), near infrared (NIR) and Raman spectroscopy to assess cartilage and bone properties. We present strengths and limitations of each approach and discuss how the combination of spectrometers with microscopes (hyperspectral imaging) and fiber optic probes have greatly advanced their biomedical applications. We show how these modalities may be used to evaluate virtually any type of sample (ex vivo, in situ or in vivo) and how “spectral fingerprints” can be interpreted to quantify outcomes related to tissue composition and quality. We highlight the unparalleled advantage of vibrational spectroscopy as a label-free and often nondestructive approach to assess properties of the extracellular matrix (ECM) associated with normal, developing, aging, pathological and treated tissues. We believe this review will assist readers not only in better understanding applications of FTIR, NIR and Raman spectroscopy, but also in implementing these approaches for their own research projects.

scholarly journals Extending the Near-Infrared Emission Range of Indium Phosphide Quantum Dots for Multiplexed In Vivo Imaging

Nano Letters ◽  
2021 ◽  
Author(s):  
Alexander M. Saeboe ◽  
Alexey Yu. Nikiforov ◽  
Reyhaneh Toufanian ◽  
Joshua C. Kays ◽  
Margaret Chern ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Indium Phosphide ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Infrared Emission ◽  
Near Infrared Emission

In Vivo Fluorescence Imaging with Ag2S Quantum Dots in the Second Near-Infrared Region

2012 ◽  
Vol 51 (39) ◽  
pp. 9818-9821 ◽  
Author(s):  
Guosong Hong ◽  
Joshua T. Robinson ◽  
Yejun Zhang ◽  
Shuo Diao ◽  
Alexander L. Antaris ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Infrared Region ◽  
In Vivo Fluorescence ◽  
In Vivo Fluorescence Imaging ◽  
Near Infrared Region ◽  
Ag2s Quantum Dots

scholarly journals Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Black Phosphorus ◽  
Deep Penetration ◽  
Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

Near-infrared emissive lanthanide hybridized carbon quantum dots for bioimaging applications

2016 ◽  
Vol 4 (38) ◽  
pp. 6366-6372 ◽  
Author(s):  
Fengshou Wu ◽  
Huifang Su ◽  
Xunjin Zhu ◽  
Kai Wang ◽  
Zhenfeng Zhang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Near Infrared ◽  
Carbon Quantum Dots ◽  
Facile Preparation

Facile preparation of lanthanide hybridized carbon quantum dots (Ln-CQDs) and their potential for visible/NIR bioimagingin vivo.

scholarly journals PEGylated Phospholipid Micelle-Encapsulated Near-Infrared PbS Quantum Dots for in vitro and in vivo Bioimaging

Theranostics ◽  
2012 ◽  
Vol 2 (7) ◽  
pp. 723-733 ◽  
Author(s):  
Rui Hu ◽  
Wing-Cheung Law ◽  
Guimiao Lin ◽  
Ling Ye ◽  
Jianwei Liu ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Near Infrared ◽  
Pbs Quantum Dots

scholarly journals Synthesis, Properties and Bioimaging Applications of Silver-Based Quantum Dots

2021 ◽  
Vol 22 (22) ◽  
pp. 12202
Author(s):  
Mariya Borovaya ◽  
Inna Horiunova ◽  
Svitlana Plokhovska ◽  
Nadia Pushkarova ◽  
Yaroslav Blume ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Near Infrared ◽  
Semiconductor Nanocrystals ◽  
Current Status ◽  
Synthesis Properties ◽  
Semiconductor Nanomaterials ◽  
Electrooptical Properties ◽  
Basic Features

Ag-based quantum dots (QDs) are semiconductor nanomaterials with exclusive electrooptical properties ideally adaptable for various biotechnological, chemical, and medical applications. Silver-based semiconductor nanocrystals have developed rapidly over the past decades. They have become a promising luminescent functional material for in vivo and in vitro fluorescent studies due to their ability to emit at the near-infrared (NIR) wavelength. In this review, we discuss the basic features of Ag-based QDs, the current status of classic (chemical) and novel methods (“green” synthesis) used to produce these QDs. Additionally, the advantages of using such organisms as bacteria, actinomycetes, fungi, algae, and plants for silver-based QDs biosynthesis have been discussed. The application of silver-based QDs as fluorophores for bioimaging application due to their fluorescence intensity, high quantum yield, fluorescent stability, and resistance to photobleaching has also been reviewed.

scholarly journals Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles

2021 ◽  
Vol 9 ◽  
Author(s):  
Chuangjia Huang ◽  
Xiaoling Guan ◽  
Hui Lin ◽  
Lu Liang ◽  
Yingling Miao ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Near Infrared ◽  
Ex Vivo ◽  
Photoacoustic Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
Good Biocompatibility ◽  
Targeting Ability ◽  
Body Clearance

Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye approved by the Food and Drug Administration (FDA), has been extensively used as a photoacoustic (PA) probe for PA imaging. However, its practical application is limited by poor photostability in water, rapid body clearance, and non-specificity. Herein, we fabricated a novel biomimetic nanoprobe by coating ICG-loaded mesoporous silica nanoparticles with the cancer cell membrane (namely, CMI) for PA imaging. This probe exhibited good dispersion, large loading efficiency, good biocompatibility, and homologous targeting ability to Hela cells in vitro. Furthermore, the in vivo and ex vivo PA imaging on Hela tumor-bearing nude mice demonstrated that CMI could accumulate in tumor tissue and display a superior PA imaging efficacy compared with free ICG. All these results demonstrated that CMI might be a promising contrast agent for PA imaging of cervical carcinoma.

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