In Vitro Activities of Echinocandins against Candida krusei Determined by Three Methods: MIC and Minimal Fungicidal Concentration Measurements and Time-Kill Studies
2009 ◽
Vol 53
(7)
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pp. 3108-3111
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Keyword(s):
The Mean
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ABSTRACT We evaluated the in vitro activities of anidulafungin, micafungin, and caspofungin against Candida krusei by determining MIC and minimum fungicidal concentration (MFC) measurements and by the time-kill method. The geometric mean (GM)-MIC/GM-MFC values were 0.1/0.34, 0.25/0.44, and 1/2.29, respectively. The mean times to reach 99.9% growth reduction were 19.1 ± 18.2 h (mean ± standard deviation) for 2 mg/liter anidulafungin, 37.4 ± 8.8 h for 2 mg/liter caspofungin, and 30.7 ± 12.2 h for 1 mg/liter micafungin. Anidulafungin exhibited the highest time-kill rate, followed by micafungin. The three echinocandins showed fungicidal activity at concentrations reached in serum.
2002 ◽
Vol 46
(12)
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pp. 3846-3853
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2019 ◽
Vol 74
(8)
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pp. 2295-2302
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Keyword(s):
Keyword(s):
1999 ◽
Vol 37
(7)
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pp. 2197-2200
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Keyword(s):
1998 ◽
Vol 42
(11)
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pp. 3012-3013
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Keyword(s):
2019 ◽
Vol 74
(12)
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pp. 3511-3514
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