Preexposure to Isavuconazole Increases the Virulence of Mucorales but Not Aspergillus fumigatus in a Drosophila melanogaster Infection Model
2018 ◽
Vol 63
(2)
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pp. e01896-18
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ABSTRACT Breakthrough mucormycosis in patients receiving isavuconazole prophylaxis or therapy has been reported. We compared the impact of isavuconazole and voriconazole exposure on the virulence of clinical isolates of Aspergillus fumigatus and different Mucorales species in a Drosophila melanogaster infection model. In contrast to A. fumigatus, a hypervirulent phenotype was found in all tested Mucorales upon preexposure to either voriconazole or isavuconazole. These findings may contribute to the explanation of breakthrough mucormycosis in isavuconazole-treated patients.
2015 ◽
Vol 59
(4)
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pp. 2113-2121
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2015 ◽
Vol 59
(7)
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pp. 4321-4325
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2011 ◽
Vol 56
(1)
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pp. 243-247
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2012 ◽
Vol 78
(9)
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pp. 3166-3176
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2011 ◽
Vol 55
(11)
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pp. 5004-5009
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