Occidiofungin's Chemical Stability andIn VitroPotency against Candida Species
2011 ◽
Vol 56
(2)
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pp. 765-769
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Keyword(s):
ABSTRACTOccidiofungin is a cyclic glyco-lipopeptide produced byBurkholderia contaminans. MICs againstCandidaspecies were between 0.5 and 2.0 μg/ml. Occidiofungin retains itsin vitropotency in the presence of 5% and 50% human serum with a minimal lethal concentration (MLC) of 2 and 4 μg/ml, respectively. Time-kill and postantifungal effect (PAFE) experiments of occidiofungin againstCandida albicanswere performed. The results demonstrate that occidiofungin is fungicidal. Occidiofungin was also found to be a very stable molecule. It is resistant to extreme temperatures and pH and maintains its activity following exposure to gastric proteases.
2012 ◽
Vol 56
(5)
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pp. 2553-2558
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Keyword(s):
2012 ◽
Vol 56
(6)
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pp. 3250-3260
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Keyword(s):
2000 ◽
Vol 44
(10)
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pp. 2887-2890
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Keyword(s):
2016 ◽
Vol 60
(10)
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pp. 6179-6188
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Keyword(s):
2011 ◽
Vol 56
(1)
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pp. 148-153
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Keyword(s):
Keyword(s):
2014 ◽
Vol 59
(2)
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pp. 1341-1343
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Keyword(s):
2012 ◽
Vol 57
(1)
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pp. 445-451
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Keyword(s):
2012 ◽
Vol 57
(1)
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pp. 333-342
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