Functional Characterization of Brucella melitensis NorMI, an Efflux Pump Belonging to the Multidrug and Toxic Compound Extrusion Family
2002 ◽
Vol 46
(9)
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pp. 3050-3053
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Keyword(s):
M Genome
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ABSTRACT Two putative proteins (NorMI and NorMII) similar to the multidrug efflux protein NorM of Vibrio parahaemolyticus are encoded by the Brucella melitensis 16 M genome. We show that a drug-hypersusceptible Escherichia coli strain overexpressing NorMI displays increased resistance to norfloxacin, ciprofloxacin, gentamicin, tetraphenylphosphonium ion, acriflavine, and berberine. This elevated resistance was proven to be mediated by an energy-dependent efflux mechanism. NorMI belongs to the multidrug and toxic compound extrusion family and is the first multidrug efflux protein identified in Brucella spp.
2009 ◽
Vol 191
(12)
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pp. 903-911
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2000 ◽
Vol 182
(23)
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pp. 6694-6697
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2003 ◽
Vol 47
(6)
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pp. 419-427
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Keyword(s):
2002 ◽
Vol 46
(11)
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pp. 3386-3393
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2008 ◽
Vol 54
(5)
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pp. 411-416
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2003 ◽
Vol 47
(12)
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pp. 937-943
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2003 ◽
Vol 47
(9)
◽
pp. 2990-2992
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Keyword(s):
2009 ◽
Vol 53
(5)
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pp. 1921-1925
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