scholarly journals Influence of the bursa of Fabricius on the pathogenesis of Marek's disease.

1981 ◽  
Vol 31 (1) ◽  
pp. 199-207 ◽  
Author(s):  
K A Schat ◽  
B W Calnek ◽  
J Fabricant
Keyword(s):  
Marek's Disease ◽  
Bursa Of Fabricius ◽  
Marek’S Disease

scholarly journals Host responses in the bursa of Fabricius of chickens infected with virulent Marek's disease virus

Virology ◽  
2008 ◽  
Vol 379 (2) ◽  
pp. 256-265 ◽  
Author(s):  
M.F. Abdul-Careem ◽  
B.D. Hunter ◽  
L.F. Lee ◽  
J.H. Fairbrother ◽  
H.R. Haghighi ◽  
...  
Keyword(s):  
Disease Virus ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Bursa Of Fabricius ◽  
Host Responses ◽  
Marek’S Disease Virus ◽  
Marek’S Disease

scholarly journals Histological evaluation of immune organs in chicken embryos inoculated with Marek’s disease virus and lymphokines

2001 ◽  
Vol 49 (2) ◽  
pp. 163-174 ◽  
Author(s):  
Mireya Ortiz ◽  
V. M. Petrone ◽  
G. Téllez ◽  
T. Fehérvári
Keyword(s):  
Bone Marrow ◽  
Embryonic Development ◽  
Early Stage ◽  
Yolk Sac ◽  
Marek's Disease ◽  
Bursa Of Fabricius ◽  
Histological Evaluation ◽  
Marek’S Disease ◽  
Chicken Embryos ◽  
Significant Difference

The aim of the present study was to evaluate the presence of lymphocytes and granulocytes in different stages of embryonic development and on the first posthatching day. The lymphocytes present in the bursa of Fabricius and thymus were evaluated by histological analysis of the yolk sac, bursa of Fabricius, thymus, liver and bone marrow of 100 chicken embryos divided into groups and treated with: (I) Marek’s disease vaccine as viral antigen, (II) Marek’s disease vaccine plus lymphokines, (III) lymphokines, and (IV) vaccine diluent. Group V was not treated. Samples were taken on days 14, 17 and 20 of incubation and on the first posthatching day. An increase in the number of epithelial matrix as precursors of lymphoid follicles was observed in the bursa of Fabricius of embryos inoculated with lymphokines compared to embryos in all the other groups (p < 0.05). In addition, a higher amount of granulocytes was found in the yolk sac and liver of embryos inoculated with lymphokines than in the embryos of all other groups (p < 0.05). In the bone marrow, no significant difference was observed among the treated groups concerning the amount of granulocytes. The results suggest that administration of antigens or protein molecules at an early stage of embryonic development increases the presence of granulocytes in the liver and granulopoiesis in the yolk sac, and also increases the number of epithelial matrixs in the bursa of Fabricius.

scholarly journals Hallazgos clínico patológicos de la enfermedad de Marek en aves de combate

2019 ◽  
Vol 5 ◽  
Author(s):  
Norma Leticia Calderón Apodaca ◽  
Mayra Itzel Araujo Mayorga ◽  
Andrea Paloma Zepeda Velázquez
Keyword(s):  
Clinical Signs ◽  
Marek's Disease ◽  
Bursa Of Fabricius ◽  
Histopathological Study ◽  
Marek’S Disease ◽  
Pathological Findings ◽  
Vaccination Programs ◽  
Cell Changes ◽  
Lymphoid Infiltrates ◽  
Lymphocyte Infiltrate

Descripción de los casos. Se analizaron siete casos clínicos de doce aves de combate de diferentes edades, estos casos fueron documentados entre 2015 y 2016. El diagnóstico presuntivo fue la enfermedad de Marek, porque expresaron signos de esta enfermedadHallazgos clínicos e interpretación. Los signos clínicos fueron principalmente respiratorios, circulatorios y nerviosos. La observación histopatológica reveló cambios celulares importantes con infiltrado linfoide en diferentes tejidos, mayoritariamente en pulmón, hígado, encéfalo, nervios, intestino, riñón y bazo, con lo que se diagnosticó enfermedad de Marek.Tratamiento y evolución. Se desconoce si se aplicó tratamiento.Pruebas de laboratorio. En el estudio histopatológico, los cortes se incluyeron en formol al 10 % con tinciones de rutina. Las muestras analizadas fueron tejido perineural, encéfalo, nervio ciático braquial, pulmón, corazón, hígado, duodeno, páncreas, riñón, bazo, ciegos, bolsa de Fabricio y piel de los senos infraorbitarios. Se determinó la severidad y virulencia del virus infectante según el criterio de infiltrado linfocitario definido en las pruebas de laboratorio.Relevancia clínica. Debido a que la crianza de aves de combate se realiza en pequeña y mediana escala, y bajo métodos tradicionales, el virus de la enfermedad de Marek persiste en estas aves. Por lo tanto, se requiere el diseño y la implementación de programas especiales de vacunación, incluyendo la producción de vacunas en una presentación adecuada para pequeños avicultores. Clinical and pathological findings of Marek’s disease in fighting cocksCases report. Seven clinical cases of twelve fighting cocks of different ages, were analyzed, this cases were documented between 2015 and 2016. The presuntive diagnosis was Marek’s disease, because they expressed signs of this diseaseClinical findings. The clinical signs were mainly respiratory, circulatory and nervous. Histopathological observation revealed major cell changes with lymphoid infiltrates in different tissues, mostly in the lung, liver, brain, nerves, bowel, kidney, and spleen, leading to the diagnosis of Marek’s disease.Treatment and evolution. Whether treatment was applied is unknown.Laboratory tests. In the histopathological study, the cuts were included in 10 % formaldehyde with routine stains. The samples analyzed were perineural tissue, brain, sciatic brachial nerve, lung, heart, liver, duodenum, pancreas, kidney, spleen, blind, bursa of Fabricius and skin of infraorbital sinuses. The severity and virulence of the infecting virus was determined according to the lymphocyte infiltrate criterion defined in the laboratory tests.Clinical relevance. Because the breeding of fighting cocks is realized in small to medium scale and under traditional methods, the Marek’s disease virus persists in these birds. Therefore the design and implementation of special vaccination programs are required, including the production of vaccines in a presentation suitable for small flocks.Keywords. fighting cocks, Marek´s disease, tumor, vaccination

scholarly journals Marek's disease herpesvirus serotype 1 in broiler breeder and layer chickens in Malaysia

2019 ◽  
Vol 12 (3) ◽  
pp. 472-476 ◽  
Author(s):  
Iryanti Othman ◽  
Erkihun Aklilu
Keyword(s):  
Pcr Amplification ◽  
Time Frame ◽  
Marek's Disease ◽  
Bursa Of Fabricius ◽  
Marek’S Disease ◽  
Gene Encoding ◽  
Tissue Samples ◽  
Broiler Breeder ◽  
Serotype 1 ◽  
Layer Chickens

Aim: This study aimed to investigate the occurrence of Marek's disease (MD) in five poultry farms in Malaysia using postmortem examination, histopathology, and polymerase chain reaction (PCR). Materials and Methods: Tissue samples were collected from 24 broiler breeder chickens from four commercial broiler breeder farms and six layer chickens from one layer farm. Gross and histopathological examinations and PCR amplification of the gene encoding for avian MD herpesvirus (MDV-1) were conducted. Results: Gross pathological changes including hepatomegaly, splenomegaly, lymphomatous lesion at the mesentery, oviduct atrophy, and follicular atresia with lymphomatous were observed, whereas diffuse multifocal whitish infiltration of the spleen, neoplastic infiltration in the liver, intrafollicular lymphoid infiltration of the bursa of Fabricius, and lymphomatous tumor at the mesentery were seen on histopathological examinations. Confirmation by PCR showed that a total of 16 (53.33%) samples were positive for avian MDV-1. Although the outbreak involved a much larger number of birds in the respective farms, our investigation was limited based on resource and time frame allocated for the study. Conclusion: The findings from this study help in emphasizing the potential threats of MDV to the poultry industry globally, in general, and in Malaysia, in particular. As the scope of the current study is limited, future studies focusing on MDV pathogenesis, typing, and causes of vaccine failures are recommended.

Early Changes in Bursa of Fabricius from Marek's Disease

1969 ◽  
Vol 13 (1) ◽  
pp. 215 ◽  
Author(s):  
R. M. Jakowski ◽  
T. N. Fredrickson ◽  
R. E. Luginbuhl ◽  
C. F. Helmboldt
Keyword(s):  
Marek's Disease ◽  
Bursa Of Fabricius ◽  
Marek’S Disease

scholarly journals Effect of fowl adenovirus on replication of vaccine strain of Marek’s disease virus in chickens

2013 ◽  
Vol 57 (4) ◽  
pp. 467-472 ◽  
Author(s):  
Jowita Samanta Niczyporuk ◽  
Grzegorz Woźniakowski ◽  
Elżbieta Samorek-Salamonowicz ◽  
Hanna Czekaj
Keyword(s):  
Disease Virus ◽  
Marek's Disease Virus ◽  
Marek's Disease ◽  
Field Strain ◽  
Bursa Of Fabricius ◽  
Marek’S Disease Virus ◽  
Marek’S Disease ◽  
Group Iii ◽  
Fowl Adenovirus ◽  
Group I

Abstract The aim of the study was to determine the effect of field strain, serotype 7 (FAdV-7 JN-5/10), of fowl adenovirus infection on the replication of Rispens/CVI988 strain of Marek’s disease virus. Ninety one-day-old SPF chickens were divided into six groups. The chickens from group I were vaccinated against Marek’s disease (MD) and 24 h later infected with the adenovirus; chickens from group II were vaccinated and infected simultaneously; chickens from group III were infected with the adenovirus and 24 h after the infection vaccinated against MD. The chickens from groups IV-VI were: control of infection (IV), control of vaccination (V), and neither vaccinated nor infected (VI). After 3, 7, 14, 21, and 28 d post infection, the number of copies of pp38 gene of Rispens strain and hexon gene of FAdV strain was determined in the bursa of Fabricius and liver using real-time PCR. The results indicated that in all cases the replication of Rispens strain was reduced to about 1.0 log10 - 3.5 log10 in chickens infected with the adenovirus and vaccinated against MD compared with the chickens only vaccinated. Sixty-three one-day-old SPF chickens infected with adenovirus and vaccinated against MD were challenged with vv MD virus field strain. The protection index in this experiment was 55.6%-77.8%.

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