Mutants of Listeria monocytogenes Defective in In Vitro Invasion and Cell-to-Cell Spreading Still Invade and Proliferate in Hepatocytes of Neutropenic Mice
2000 ◽
Vol 68
(2)
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pp. 912-914
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Keyword(s):
ABSTRACT Listeria monocytogenes mutants defective in theactA gene, the plcB gene, and theinlA and inlB genes were less virulent when injected intravenously into BALB/c mice. The growth of these strains as well as of the virulent wild-type strains was increased by treating mice with a neutrophil-specific depleting monoclonal antibody, RB6-8C5. Histologic examination of the livers of the treated animals showed intrahepatocytic proliferation of the listeriae in all cases. Our data show that more than one pathway exists that allows L. monocytogenes to invade parenchymal cells. One pathway most likely involves the actA and plcB gene products, and a second one probably involves the internalins.
2012 ◽
Vol 56
(8)
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pp. 4146-4153
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2006 ◽
Vol 51
(3)
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pp. 1089-1091
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Keyword(s):
2003 ◽
Vol 48
(6)
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pp. 1537-1551
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2013 ◽
Vol 79
(18)
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pp. 5682-5688
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Keyword(s):
2004 ◽
Vol 72
(7)
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pp. 3849-3854
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2010 ◽
Vol 54
(9)
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pp. 3776-3782
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Keyword(s):
Keyword(s):