Ebolavirus VP35 Interacts with the Cytoplasmic Dynein Light Chain 8
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Type I
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ABSTRACT The viral protein VP35 of ebolavirus (EBOV) is implicated to have diverse roles in the viral life cycle. We employed a yeast two-hybrid screen to search for VP35 binding partners and identified the cytoplasmic dynein light chain (DLC8) as a protein that interacts with VP35. Mapping analysis unraveled a consensus motif, SQTQT, within VP35 through which VP35 binds to DLC8. The disruption of DLC8 binding does not affect the ability of VP35 to inhibit type I IFN production. Given that VP35 from various EBOV species interacts with DLC8, this interaction may have a role in regulating the EBOV life cycle.
2011 ◽
Vol 22
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pp. 2690-2701
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2005 ◽
Vol 16
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pp. 3107-3116
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1996 ◽
Vol 16
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pp. 1966-1977
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pp. 145-154
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2004 ◽
Vol 15
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pp. 3005-3014
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2000 ◽
Vol 74
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pp. 10212-10216
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p150Glued, Dynein, and Microtubules Are Specifically Required for Activation of MKK3/6 and p38 MAPKs
2004 ◽
Vol 279
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pp. 45308-45311
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