In Vivo Competence of Murine Cytomegalovirus under the Control of the Human Cytomegalovirus Major Immediate-Early Enhancer in the Establishment of Latency and Reactivation
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ABSTRACT The human cytomegalovirus (HCMV) major immediate-early enhancer has been postulated to play a pivotal role in the control of latency and reactivation. However, the absence of an animal model has obstructed a direct test of this hypothesis. Here we report on the establishment of an in vivo, experimentally tractable system for quantitatively investigating physiological functions of the HCMV enhancer. Using a neonate BALB/c mouse model, we show that a chimeric murine CMV under the control of the HCMV enhancer is competent in vivo, replicating in key organs of mice with acute CMV infection and exhibiting latency/reactivation features comparable for the most part to those of the parental and revertant viruses.
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2021 ◽
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A Novel Peptide Aldehyde with Activity against Human Cytomegalovirus in Two Different in Vivo Models
2000 ◽
Vol 11
(1)
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pp. 51-59
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1993 ◽
Vol 13
(2)
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pp. 1238-1250
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2000 ◽
Vol 74
(1)
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pp. 513-517
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