Induction of bovine papillomavirus E2 gene expression and early region transcription by cell growth arrest: correlation with viral DNA amplification and evidence for differential promoter induction.

1990 ◽  
Vol 64 (11) ◽  
pp. 5529-5541 ◽  
Author(s):  
S Burnett ◽  
A C Ström ◽  
N Jareborg ◽  
A Alderborn ◽  
J Dillner ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Growth ◽  
Growth Arrest ◽  
Dna Amplification ◽  
Bovine Papillomavirus ◽  
Viral Dna ◽  
Cell Growth Arrest ◽  
E2 Gene ◽  
Early Region

scholarly journals HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci

2016 ◽  
Vol 215 (3) ◽  
pp. 325-334 ◽  
Author(s):  
Katherine M. Aird ◽  
Osamu Iwasaki ◽  
Andrew V. Kossenkov ◽  
Hideki Tanizawa ◽  
Nail Fatkhutdinov ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Growth ◽  
Cellular Senescence ◽  
Growth Arrest ◽  
High Mobility ◽  
Cell Growth Arrest ◽  
Cytokines And Chemokines ◽  
Secreted Factors ◽  
Genes Encoding ◽  
Secretory Phenotype

Cellular senescence is a stable cell growth arrest that is characterized by the silencing of proliferation-promoting genes through compaction of chromosomes into senescence-associated heterochromatin foci (SAHF). Paradoxically, senescence is also accompanied by increased transcription of certain genes encoding for secreted factors such as cytokines and chemokines, known as the senescence-associated secretory phenotype (SASP). How SASP genes are excluded from SAHF-mediated global gene silencing remains unclear. In this study, we report that high mobility group box 2 (HMGB2) orchestrates the chromatin landscape of SASP gene loci. HMGB2 preferentially localizes to SASP gene loci during senescence. Loss of HMGB2 during senescence blunts SASP gene expression by allowing for spreading of repressive heterochromatin into SASP gene loci. This correlates with incorporation of SASP gene loci into SAHF. Our results establish HMGB2 as a novel master regulator that orchestrates SASP through prevention of heterochromatin spreading to allow for exclusion of SASP gene loci from a global heterochromatin environment during senescence.

Inducing cell growth arrest and apoptosis by silencing long non-coding RNA PCAT-1 in human bladder cancer

Tumor Biology ◽  
2015 ◽  
Vol 36 (10) ◽  
pp. 7685-7689 ◽  
Author(s):  
Li Liu ◽  
Yuchen Liu ◽  
Chengle Zhuang ◽  
Wen Xu ◽  
Xing Fu ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cell Growth ◽  
Growth Arrest ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Cell Growth Arrest ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Lipid biomarkers of glioma cell growth arrest and cell death detected by 1 H magic angle spinning MRS

2012 ◽  
Vol 25 (11) ◽  
pp. 1253-1262 ◽  
Author(s):  
Ladan Mirbahai ◽  
Martin Wilson ◽  
Christopher S. Shaw ◽  
Carmel McConville ◽  
Roger D. G. Malcomson ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Growth ◽  
Glioma Cell ◽  
Growth Arrest ◽  
Magic Angle Spinning ◽  
Lipid Biomarkers ◽  
Magic Angle ◽  
Cell Growth Arrest ◽  
Angle Spinning

Cr (VI) induces cell growth arrest through hydrogen peroxide-mediated reactions

2001 ◽  
pp. 77-83
Author(s):  
Zhuo Zhang ◽  
Stephen S. Leonard ◽  
Suwei Wang ◽  
Val Vallyathan ◽  
Vince Castranova ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Growth ◽  
Growth Arrest ◽  
Cell Growth Arrest
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