Porous Ceramics Based on Substituted Tricalcium Phosphates for Bone Tissue Recovery

2019 ◽  
Vol 10 (4) ◽  
pp. 796-801 ◽  
Author(s):  
I. V. Fadeeva ◽  
A. S. Fomin ◽  
G. A. Davydova ◽  
Ya. Yu. Filippov ◽  
M. E. Shaposhnikov ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Porous Ceramics ◽  
Tissue Recovery ◽  
Tricalcium Phosphates

scholarly journals Comparative Characteristics of Bone-Plastic Materials for Mastoidoplasty

2021 ◽  
Vol 6 (2) ◽  
Author(s):  
Roman Reznikov
Keyword(s):  
Composite Materials ◽  
Bone Tissue ◽  
Middle Ear ◽  
Open Type ◽  
Plastic Materials ◽  
Temporal Bones ◽  
Tricalcium Phosphates

The paper presents the results of the comparative characteristics of the use of various bone-plastic materials for mastoidoplasty. The study included 30 patients who underwent an open-type sanitizing operation with mastoidoplasty with osteoplastic materials. When comparing drugs, the following criteria were used: 1) convenience of modeling the material; 2) the course of the wound process; 3) osseointegration - the process of formation of "new bone tissue (CT of the temporal bones 6 and 12 months). As a result, it was confirmed that the samples of the main groups of bone replacements studied by us. preparations (biositalls, composite materials and β- tricalcium phosphates) can be successfully used in mastoidoplasty after open types of sanitizing operations on the middle ear.

Comparison of Osteoinduction by Autologous Bone and Biphasic Calcium Phosphate Ceramic in Goats

2007 ◽  
Vol 330-332 ◽  
pp. 1063-1066 ◽  
Author(s):  
Borhane H. Fellah ◽  
Olivier Gauthier ◽  
Pierre Weiss ◽  
Daniel Chappard ◽  
Pierre Layrolle
Keyword(s):  
Calcium Phosphate ◽  
Low Temperature ◽  
Bone Tissue ◽  
Orthopedic Surgery ◽  
Biphasic Calcium Phosphate ◽  
Porous Ceramics ◽  
Calcium Phosphate Ceramic ◽  
Autologous Bone ◽  
Osteoinductive Property

Autologous bone chips are widely used in orthopedic surgery to fill large defects due to osteoinductive property but are limited in quantity. Several groups have reported the formation of mineralized bone after implantation of bioceramics in ectopic sites of different animals. However, osteoinduction by bioceramics has not yet proved to be equivalent to those of autologous bone. In this study, we compare the bone inducing capability of autologous bone chips and synthetic biphasic calcium phosphate (BCP) ceramics granules sintered at various temperatures. Both materials were implanted in muscles and femurs of goats inside hollow containers for 6, 12 and 24 weeks and analyzed by histology. This study showed that bone tissue formed in contact with micro porous ceramics sintered at low temperature as well as autologous bone chips both in ectopic and intrafemoral sites of goats.

scholarly journals Modeling of Bone Tissue Structure and Porous Ceramics

2018 ◽  
Vol 1045 ◽  
pp. 012022 ◽  
Author(s):  
T V Kolmakova ◽  
S P Buyakova ◽  
S N Kulkov
Keyword(s):  
Bone Tissue ◽  
Porous Ceramics ◽  
Tissue Structure

scholarly journals Physicochemical and Biological Characterisation of Diclofenac Oligomeric Poly(3-hydroxyoctanoate) Hybrids as β-TCP Ceramics Modifiers for Bone Tissue Regeneration

2020 ◽  
Vol 21 (24) ◽  
pp. 9452
Author(s):  
Katarzyna Haraźna ◽  
Ewelina Cichoń ◽  
Szymon Skibiński ◽  
Tomasz Witko ◽  
Daria Solarz ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Functional Materials ◽  
Bone Tissue Regeneration ◽  
Cell Penetration ◽  
In Vitro Biocompatibility ◽  
Osteoblast Cell Line ◽  
The Matrix ◽  
Biocompatibility Study ◽  
Tricalcium Phosphates

Nowadays, regenerative medicine faces a major challenge in providing new, functional materials that will meet the characteristics desired to replenish and grow new tissue. Therefore, this study presents new ceramic-polymer composites in which the matrix consists of tricalcium phosphates covered with blends containing a chemically bounded diclofenac with the biocompatible polymer—poly(3-hydroxyoctanoate), P(3HO). Modification of P(3HO) oligomers was confirmed by NMR, IR and XPS. Moreover, obtained oligomers and their blends were subjected to an in-depth characterisation using GPC, TGA, DSC and AFM. Furthermore, we demonstrate that the hydrophobicity and surface free energy values of blends decreased with the amount of diclofenac modified oligomers. Subsequently, the designed composites were used as a substrate for growth of the pre-osteoblast cell line (MC3T3-E1). An in vitro biocompatibility study showed that the composite with the lowest concentration of the proposed drug is within the range assumed to be non-toxic (viability above 70%). Cell proliferation was visualised using the SEM method, whereas the observation of cell penetration into the scaffold was carried out by confocal microscopy. Thus, it can be an ideal new functional bone tissue substitute, allowing not only the regeneration and restoration of the defect but also inhibiting the development of chronic inflammation.

scholarly journals Magnetomechanical stimulation of bone tissue regeneration

2021 ◽  
pp. 90-93
Author(s):  
G.S. Zamay ◽  
◽  
O.S. Kolovskaya ◽  
D.S. Grek ◽  
V.A. Babkin ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Low Frequency ◽  
Rgd Peptide ◽  
Superparamagnetic Nanoparticles ◽  
Bone Tissue Regeneration ◽  
Complete Restoration ◽  
Transverse Osteotomy ◽  
Tissue Recovery ◽  
Magnetic Fi Eld

The aim of the research. To assess the ability of superparamagnetic nanoparticles functionalized with the RGD peptide to accelerate bone tissue recovery aft er transverse osteotomy under the infl uence of a low-frequency alternating magnetic fi eld. Material and methods. We used superparamagnetic nanoparticles ferroarabinogalactans (FeAG) functionalized with the RGD peptide for targeted binding to integrins. Th e model for assessing the ability of FeAG-RGD to accelerate bone regeneration was the transverse osteotomy of the radius of the ICR mice. To induce the process of bone tissue regeneration aft er the injection of FeAG-RGD particles, mice were placed in an alternating magnetic fi eld (50 Hz 100 Oe) for 60 min. Th e therapy was performed daily for 5 days. Results. Th e paper tested the hypothesis about the acceleration of bone tissue regeneration by the method of magnetomechanical therapy using superparamagnetic FeAG-RGD nanoparticles. It has been established that FeAG-RGD under conditions of an alternating magnetic fi eld (50 Hz 100 Oe) are able to change their orientation in space and, thus, cause mechanical stress in the proteins of the cell membrane – integrins, which trigger the process of osteogenic diff erentiation. Th e research results showed that 5 procedures of magnetomechanical therapy lead to complete restoration of bone tissue at the site of the transverse osteotomy, while in the group of control animals no fusion of bones is observed. Conclusion. Th e use of the method of magnetomechanical therapy using ferroarabinogalactans functionalized with the targeting ligand RGD for binding to integrins of osteogenic cells is a promising technology for bone tissue regeneration

scholarly journals APPLICATION OF BIOCERAMICS IN THE TREATMENT OF POST-TRAUMATIC PERIODONTITIES OF PERMANENT TEETH IN CHILDREN

2018 ◽  
Vol 14 (3-4) ◽  
pp. 90-94
Author(s):  
O.M. Plyska ◽  
О.І. Ostapko
Keyword(s):  
Bone Tissue ◽  
Root Canal ◽  
Bone Structure ◽  
Endodontic Treatment ◽  
Permanent Teeth ◽  
Root Canal Filling ◽  
Regeneration Of Bone Tissue ◽  
Post Traumatic ◽  
Tissue Recovery ◽  
Regeneration Of Bone

Relevance. In children, post-traumatic complications in the teeth with incomplete formation of the root often lead to stopping the development of the root and premature loss of teeth. The instability of the results of endodontic treatment with calcium hydroxide preparations leads to the search for new treatments. Materials based on tricalcium phosphate ceramics attract attention because they contribute to the regeneration of bone tissue. Objective: to evaluate the effectiveness of endodontic treatment of post-traumatic periodontitis of permanent teeth with incomplete root formation using bioceramics based on biological hydroxyapatite "Osteopatite ceramic" brand "OK 015". Materials and methods. In children aged 9-15 years, 17 permanent teeth with post-traumatic complications were treated. In 12 cases, this was chronic granulating periodontitis. For a prolonged temporary obturation of root canals, a paste was used, which was prepared by mixing metronidazole and "OK 015" granules. The treatment was monitored every other day, 2 weeks, 1, 3, 6, 9, 12 months. Permanent root canal filling was performed after apexification. Results. In the early stages of the observation of complications of treatment was not observed. 3 months after treatment, bone structure regeneration was activated, in 1 tooth – apexification. After 6 months, the positive dynamics of bone regeneration was observed in 100 % of children. X-ray reconstruction of bone tissue was confirmed in 35,3 % of cases, apexification occurred in 41,2 %. After 9 months, bone resection was observed in 59 % of cases, apexification – in 64 % of the teeth. After 12 months, bone tissue recovery occurred in 76,5 % of cases, in 94 % – apexification. Thus, the rate of apexification is ahead of the processes of reparative osteogenesis. The formation of a mineralized barrier is not always accompanied by a complete restoration of the structure of the periapical bone. Conclusion. Material based on biological hydroxyapatite "Osteoapatite ceramic" brand "OK 015" for temporary obturation of the root canal promotes apexification and regeneration of bone tissue in the periapical region in the process of endodontic treatment of permanent teeth with unformed root in children.

scholarly journals Exosome: A Novel Nanocarrier Delivering Noncoding RNA for Bone Tissue Engineering

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Keda Liu ◽  
Nanjue Cao ◽  
Yuhe Zhu ◽  
Wei Wang
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Noncoding Rna ◽  
Bone Growth ◽  
Research Progress ◽  
Current Status ◽  
Extracellular Stimuli ◽  
Basic Characteristics ◽  
Tissue Recovery

Bone growth and metabolism are mainly regulated by a series of intracellular molecules and extracellular stimuli. Exosome, as a nanoscale substance secreted to the outside of the cells, plays an extensive role in intercellular communication. This review provides theoretical references and evidences for further exploration of exosomes as noncoding RNA carriers to regulate bone tissue recovery through the following aspects: (1) basic characteristics of exosomes, (2) research progress of exosomal noncoding RNA in bone tissue engineering, (3) current status and advantages of engineering exosomes as nanocarriers for noncoding RNA delivery, and (4) problems and application prospects of exosome therapy in the field of orthopedics.

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