Di- and tripeptide N-alkyl- and N-aralkyl amides as chymotrypsin inhibitors
1988 ◽
Vol 53
(11)
◽
pp. 2877-2883
◽
Two competitive inhibitors of chymotrypsin, Glt-Ala-Ala-Leu-EtPh and Glt-Ala-Ala-Pro-NH-EtPh, were synthesized and their inhibition constants Ki were determined. The Ki-determination was carried also with a set of peptides of type X-(Ala)nNH-Y, where X is 3-carboxypropionyl- or 4-carboxybutyryl-, n is 2 or 3 and Y is methyl, ethyl, diethyl, isopropyl, propyl, butyl, isobutyl and 2-phenylethyl. Chymotrypsin inhibition was observed only with peptides containing an aralkyl residue whereas peptides with an alkyl are without any effect. Glt-Ala-Ala-Leu-NH-EtPh shows the highest Ki-value (80 μmol l-1).
1955 ◽
Vol 77
(9)
◽
pp. 2378-2383
◽
1984 ◽
Vol 62
(7)
◽
pp. 860-862
◽
1955 ◽
Vol 77
(12)
◽
pp. 3370-3372
◽
1971 ◽
Vol 29
◽
pp. 488-489
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