scholarly journals AB1263 THE EFFICACY OF PULMONARY REHABILITATION IN PATIENTS WITH ANKYLOSING SPONDYLITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1923.1-1923
Author(s):  
N. Sahin ◽  
N. Sarioğlu ◽  
B. Görcan
Keyword(s):  
Ankylosing Spondylitis ◽  
Pulmonary Rehabilitation ◽  
Research Council ◽  
Medical Research Council ◽  
Activity Index ◽  
Short Form ◽  
Disease Activity Index ◽  
Bode Index ◽  
Sf 36 ◽  
Significant Difference

Background:Ankylosing spondylitis (AS) is a rheumatic disease that can cause a restrictive lung condition. Pulmonary rehabilitation increases lung capacity in patients with lung disease. In this study, we aimed to show increase in exercise capacity, decrease in dyspnea and change in quality of life with pulmonary rehabilitation in patients with AS.Objectives:In this study, we included 20 AS patients of whom admitted to our outpatient clinic. At the beginning and end of the study, patients some findings such as SFT, FEV1 values, saturations, arterial blood pressures and heart rates were recorded separately. Also, BODE index results, 6-minute walk test (MWT) values, BORG dyspnea scores, Modified Medical Research Council (MMRC) dyspnea scales, Anxiety Stress Scales (ASS) were examined. Short Form-36 (SF-36) questionnaires were filled out.Methods:Patients underwent rehabilitation for 8 weeks, two days in a week at hospital and one day at home. According to their exercise tolerances in rehabilitation, patients were given upper and lower limb endurance training, strength training, flexibility and stretching exercises, balance exercises, inspiratory muscles training.Results:In our study, patients with AS showed significant improvement in MMRC, borg dyspnea scales and 6 MWT at the end of rehabilitation compared to beginning of rehabilitation (p<0.05). It is shown that there was significant improvement in the values of PEF % and FVC%, when the difference averages before and after rehabilitation were compared (p < 0.05) but there was no difference in FEV1 %, FEV1/FVC values (p > 0.05). There was also significant improvement in BASDAI-BASFI values (P=0.006, P=0.016, respectively). The bode index showed no significant difference (p > 0.05). There was significant improvement in anxiety on ASS. Only the mental parameter showed significant improvement when parameters evaluated by the SF-36 survey (p < 0.05). There was no significant difference in the rest of all parameters (p>0.05).P* Wilcoxon signed rank test. n, number of participants; SD, standard deviation; FVC,forced vital capacity;FEV1,forced expiratory volume;PEF,pik expiratory volüme; MMRC, Modified Medical Research Council;O2,oxygen; BASDAI,Bath Ankylosing Spondylitis Disease Activity Index; BASFI,Bath Ankylosing Spondylitis Disease Activity Index;SF-36, Short Form-36.Conclusion:After pulmonary rehabilitation in patients with AS dyspnea symptoms decreased. As a result of this study, it is thought that pulmonary rehabilitation applied to patients with AS can minimize the adverse effects of the disease over the respiratory system.Key words; pulmonary rehabilitation, ankylosing spondylitis, respiratory function testReferences:[1]Zão A, Cantista P.The role of land and aquatic exercise in ankylosing spondylitis: a systematic review. Rheumatol Int. 2017; 37: 1979-1990.[2]Fuschillo S, De Felice A, Martucci M et al. Pulmonary Rehabilitation Improves Exercise Capacity in Subjects with Kyphoscoliosis and Severe Respiratory Impairment. Respir Care. 2015; 60(1): 96-101.[3]Spruit MA, Pitta F, McAuley E et al. Pulmonary Rehabilitation and Physical Activity in Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2015; 15;192(8): 924-33.[4]Drăgoi RG, Amaricai E, Drăgoi M et al. Inspiratory muscle training improves aerobic capacity and pulmonary function in patients with ankylosing spondylitis: A randomized controlled study. Clin Rehabil. 2016; 30(4):340-346.Disclosure of Interests:None declared

scholarly journals AB0664 DIAGNOSIS DELAY IN ANKYLOSING SPONDYLITIS PATIENTS IN EGYPT: FACTORS, SOCIOECONOMIC AND CLINICAL OUTCOME

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1627.2-1627
Author(s):  
F. I. Abdelrahman ◽  
M. Mortada
Keyword(s):  
Ankylosing Spondylitis ◽  
Social Life ◽  
Activity Index ◽  
Diagnostic Delay ◽  
Disease Activity Index ◽  
Diagnosis Delay ◽  
Functional Index ◽  
Delay In Diagnosis ◽  
Significant Difference ◽  
The Mean

Background:Ankylosing spondylitis (AS) is a destructive inflammatory disease which was reported to have the longest diagnostic delay among the inflammatory rheumatic disease. This lag period have a great impact on the clinical outcome and socioeconomic state of the patients. With the advent of tumor necrosis factor-α (TNF-α) inhibitors, early diagnosis in AS has become important(1).Objectives:to evaluate the period from symptom onset to diagnosis of AS in Egyptian patients and to examine possible reasons for delayed diagnosis and its impact on the economic and social life of the patients.Methods:The study included 87 AS patients diagnosed according to the Assessment of Spondyloarthritis international Society (ASAS) criteria (2). A face-to-face interview was applied to take medical history, and a questionnaire that contains some clinical aspects of disease was used. Diagnosis delay was described as the gap between first AS symptom and correct diagnosis of AS. Clinical and functional assessment of axial SpA measured by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI). The direct medical cost during years of delay (including costs of medical consultations, medications, investigations, physiotherapy and surgical treatment) had been estimated by Egyptian pound.Results:The study included 87 AS patients with mean age (30.03±8.3), 70 male (80.5%) and 17 female (19.5%).Mean delay in diagnosis was(5.7 ±4.9) years. Mean of diagnostic delay for patient diagnosed before 2010 is (14±4.4) and that of patients diagnosed after 2010 is (3.5±1.8) with significant difference between both (p value<0.0001). The main cause of delay was incorrect diagnosis as follow degenerative disc disease (43/87, 49.4%), non-specific back pain (31/87, 35.6%), rheumatoid arthritis (10/87,11.5%), rheumatic fever (2/87, 2.3%) and tuberculosis of spine (1/87, 1.1%). The mean of the medical visits was (6±5.4). Most incorrect initial diagnoses were made by orthopedicians (57.9%), followed by neurologists (22.2%) followed by rheumatologist (10%) and general phyisicians (9.9%). Absence of extra-articular manifestations, negative family history and juvenile age are significantly associated with diagnostic delay. Delay in diagnosis is significantly associated with higher disease activity index(BASDAI), functional index (BASFI), and damage index(BASMI). The mean of the costs during years of delay is (15671.3±546.1) with the mean of cost per each year delay (660.9±6.6) with high significant association between the cost and longer delay in diagnosis (<0.0001). Regarding work ability, we found that(32.2%) are fit for work, unfit (29.9%), partially fit (37.9%) with high significant difference between ability of work and shorter delay. Regarding social effect, 40.2 % of patients developed negative effect on social life with significant association to diagnostic delay (0.004).Conclusion:Our study confirmed the importance of early diagnosis of AS due to its impact on patient’s health outcome and socioeconomic state.We recommend to increase the awareness about the disease among healthcare professionals in our region.References:[1]Sykes M. et al: Diagnostic delay in patients with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis; Ann Rheum Dis.2015;74:e44.[2]Rudwaleit M. et al: The development of Assessment of Spondyloarthritis international Society classification criteria for axial spondyloarthritis; Ann Rheum Dis, 68 (2009), pp.777-783.Disclosure of Interests:None declared

scholarly journals AB0669 PARTICULARITIES OF TUNISIAN FEMALE AXIAL SPONDYLOARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1629.2-1629
Author(s):  
K. Ben Abdelghani ◽  
Y. Gzam ◽  
A. Fazaa ◽  
S. Miladi ◽  
K. Ouenniche ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Axial Spondyloarthritis ◽  
Activity Index ◽  
Age At Onset ◽  
Disease Onset ◽  
Disease Activity Index ◽  
Reactive Protein ◽  
Significant Difference ◽  
The Mean

Background:Axial spondyloarthritis (ax-SpA) is a chronic rheumatic disease that mainly affects men. However, the female form of ax-SpA remains insufficiently studied.Objectives:The aim of this study was to determine the clinical characteristics, the disease activity and the functional impact of female ax-SpA in comparison with male ax-SpA.Methods:This is a retrospective study including patients diagnosed with ax-SpA fulfilling the criteria of the Assessment of SpondyloArthritis international Society (ASAS) 2009.Clinical parameters, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Bath ankylosing spondylitis disease activity index (BASDAI) and Bath ankylosing spondylitis functional index (BASFI) were compared between groups of female and male ax-SpA.Results:Two hundred ax-SpA patients were included with 31% of female (n=62) and a mean age of 43,3 ± 11,2 years.The mean age at onset of symptoms was 31,8 ± 8,9 years for women and 25,3 ± 9,1 years for men (p <0,0001). The mean age at diagnosis was 36,4 ± 9,6 years for women and 31,7 ± 10,4 years for men (p = 0,003). Ax-SpA with juvenile onset was noted in 1,7% of women and 12,1% of men (p = 0,02). Male ax-SpA were significantly more smokers (46.8% vs 5.4%; p <0.001). The mean duration of morning stiffness was 11,3 ± 9,2 minutes for women versus 21,6 ± 19,3 minutes for men (p = 0,005).The mean ESR was 42,4 ± 29,8 mm for women and 28,3 ± 23,4 mm for men (p = 0,001). Radiographic sacroiliitis was present in 69,3% of women versus 84,7% of men (p = 0,01). The use of anti-TNF alpha was less frequent in women (29% vs 48,5%; p = 0,01).Our study didn’t found a statistically significant difference in peripheral manifestations, extraarticular manifestations, CRP, BASDAI and BASFI between the two groups.Conclusion:Female ax-SpA seems to have a better prognosis than male with older age in disease onset, less inflammation, less radiographic sacroiliitis and less use of biological treatments.References:[1]Rusman T, et al. Curr Rheumatol Rep. 2018; 20(6).[2]Siar N, et al. Curr Rheumatol Rev. 2019;Disclosure of Interests:None declared

Fibromyalgia in Spondyloarthritis: Effect on Disease Activity Assessment in Clinical Practice

2016 ◽  
Vol 43 (11) ◽  
pp. 2056-2063 ◽  
Author(s):  
Jean Wach ◽  
Marie-Claude Letroublon ◽  
Fabienne Coury ◽  
Jacques Guy Tebib
Keyword(s):  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Activity Index ◽  
Short Form ◽  
Disease Activity Index ◽  
Patient Characteristics ◽  
Cross Sectional Study ◽  
Moderate Activity ◽  
Cross Sectional ◽  
American College Of Rheumatology

Objective.Spondyloarthritis (SpA) is the second most frequent inflammatory rheumatic disease, characterized by spinal involvement, peripheral arthritis, or enthesitis with marked pain, stiffness, and fatigue. Fibromyalgia (FM) may be associated with SpA, and shares some common symptoms. We aimed to determine how FM influences assessment of SpA disease activity, which is mainly dependent on patient-based outcome measures such as the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) or the Ankylosing Spondylitis Disease Activity Score (ASDAS).Methods.This single-center cross-sectional study included consecutive patients with SpA according to the Assessment of SpondyloArthritis International Society criteria. FM was diagnosed according to the 1990 American College of Rheumatology criteria. Patient characteristics, BASDAI, ASDAS/C-reactive protein (CRP), Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Metrology Index, and the Medical Outcomes Study Short Form-36 questionnaire were recorded and compared.Results.The study included 103 patients with SpA; 81 with axial and 22 with peripheral forms. Eighteen patients presented with concomitant FM, of whom 12 had axial SpA and 6 peripheral SpA. Demographic characteristics did not differ except for sex, with a female predominance in the FM group that was more marked in peripheral forms. BASDAI was higher in patients with FM [median (IQR): 4.2 (4.2) vs 2.2 (3.1); p = 0.0068], whereas ASDAS-CRP was not significantly different [median (IQR): 2.7 (2) vs 2 (1.3); p = 0.1264]. Nevertheless, median ASDAS-CRP corresponded to high disease activity in patients with SpA or FM compared with moderate activity in non-FM patients.Conclusion.FM is a frequent comorbidity in patients with SpA, especially in peripheral forms. In patients with SpA-FM, disease activity may be overestimated when measured by BASDAI and to a lesser extent by ASDAS-CRP, and this overestimation could lead to inappropriate treatment escalation.

scholarly journals Fatores preditores da qualidade de vida relacionada à saúde física e mental em pacientes com doença pulmonar intersticial: uma análise multifatorial

2010 ◽  
Vol 36 (5) ◽  
pp. 562-570 ◽  
Author(s):  
Ana Cláudia Coelho ◽  
Marli Maria Knorst ◽  
Marcelo Basso Gazzana ◽  
Sérgio Saldanha Menna Barreto
Keyword(s):  
Medical Research ◽  
Research Council ◽  
Medical Research Council ◽  
Short Form ◽  
Medical Outcomes ◽  
Sf 36 ◽  
Outcomes Study

OBJETIVO: Avaliar fatores preditores da qualidade de vida relacionada à saúde (QVRS) em pacientes com doença pulmonar intersticial (DPI). MÉTODOS: Estudo transversal com 63 pacientes, submetidos a provas de função pulmonar e teste de caminhada de seis minutos. Foram aplicados os seguintes instrumentos: Medical Outcomes Study 36-item Short-form Survey (SF-36), Saint George's Respiratory Questionnaire (SGRQ), os inventários de ansiedade e depressão de Beck e Modified Medical Research Council Dyspnea Scale. A análise de componentes principais foi utilizada para reduzir as variáveis em fatores preditivos, e a análise de regressão linear múltipla foi utilizada como um modelo explicativo. RESULTADOS: Dos 63 pacientes, 34 eram mulheres. A média de idade foi de 60,1 ± 13,3 anos, média de CVF = 64,17 ± 15,54% do previsto e média de DLCO = 44,21 ± 14,47% do previsto. Todos os pacientes avaliados tinham sua QVRS prejudicada, e os piores escores foram observados nos domínios capacidade funcional do SF-36 e atividade do SGRQ. Dos pacientes avaliados 60,3% e 57,1% apresentaram sintomas de ansiedade e depressão, respectivamente. A análise de componentes principais identificou um fator preditor para QVRS física e um fator preditor para QVRS mental. A depressão apresentou uma forte influência sobre o fator preditor de QVRS mental, e o grau de dispneia apresentou uma influência significativa sobre os dois fatores preditores de QVRS nos pacientes avaliados. Variáveis relacionadas à função pulmonar, capacidade de exercício e ansiedade não apresentaram impactos sobre esses fatores preditores. CONCLUSÕES: Em nossa amostra de pacientes com DPI, o grau de dispneia teve um impacto importante sobre a QVRS física e mental, e a depressão teve um impacto sobre a QVRS mental nos pacientes com DPI.

A home-based pulmonary rehabilitation mHealth system to enhance the exercise capacity of patients with COPD: Development and evaluation (Preprint)

2021 ◽  
Author(s):  
Ning Deng ◽  
Leiyi Sheng ◽  
Yongfa Hao ◽  
Wangshu Jiang ◽  
Qingdong Huang ◽  
...  
Keyword(s):  
Technology Acceptance ◽  
Exercise Capacity ◽  
Pulmonary Rehabilitation ◽  
Research Council ◽  
Medical Research Council ◽  
Exercise Prescription ◽  
Home Based ◽  
Copd Patients ◽  
Significant Difference ◽  
Over Time

BACKGROUND Patients with Chronic Obstructive Pulmonary Disease (COPD) experience deficits in exercise capacity and physical activity as their disease progresses. Pulmonary rehabilitation (PR) can enhance exercise capacity of patients and it is crucial for patients to maintain a long-term physically active lifestyle. OBJECTIVE This study aimed to develop a home-based rehabilitation mHealth system incorporating Behavior Change Techniques (BCTs) for COPD patients, and evaluate its technology acceptance and feasibility. METHODS Guided by the Medical Research Council (MRC) framework the process of this study is divided into four steps. In the first step the prescription was constructed. The second step is to formulate specific intervention functions based on the Behavior Change Wheel (BCW) theory. Subsequently, in the third step iterative system development was conducted. And in the last step two polit studies were performed, the first is for the improvement of system functions and the second is to validate the acceptance and usability. Primary outcomes were the exercise capacity measured by Six-Minute Walk Test (6MWT). Secondary clinical outcomes included changes in disease specific health status measured by COPD Assessment Test (CAT), measure of breathlessness indicated by mMRC (modified British medical Research Council) and indicators of mental health such as Hospital Anxiety and Depression Scale (HAD). Compliance, technology acceptance, and feasibility of the system were also used as outcome indicators. RESULTS Two-stage study was conducted to evaluate the proposed system. A total of 17 patients was enrolled. 12 patients completed the 12-week study. At the end of the first study, the 6MWT showed significant increase over time (P=0.028). Participants reported that this app had a positive effect on promoting exercise at home. The results of the second stage study is the final result of this study. For the clinical outcomes, 6MWT scores showed significant difference (P=.023) over time with an improvement exceeded the Minimal Clinically Important Difference (MCID). Change in respiratory symptom (CAT score) was statistically different (P=.023) with a greater decrease of -3.17 points that exceeded the MCID. The mMRC levels reduced overall and showed significant difference. HAD did not show statistically significant difference in this study but non-inferiority. The overall compliance of this study reached 82.20% (±1.68%). CONCLUSIONS This study developed a home-based PR mHealth system for COPD patients. The use of BCW in the intervention developing process offers a systematic method for designing a theory-driven intervention. The pilot study in Yinchuan verified the technical acceptance and availability of the system, and demonstrated the benefits of applying mHealth technology and BCT to Home-based PR for COPD patients. The proposed system plays an important auxiliary role in the process of prescribing exercise prescription according to the characteristics of patients. And it provides means and tools for further individuation of exercise prescription in the future.

From gene expression to serum proteins: biomarker discovery in ankylosing spondylitis

2008 ◽  
Vol 69 (01) ◽  
pp. 297-300 ◽  
Author(s):  
N Haroon ◽  
F W L Tsui ◽  
F D O’Shea ◽  
B Chiu ◽  
H W Tsui ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ankylosing Spondylitis ◽  
Biomarker Discovery ◽  
Serum Proteins ◽  
Activity Index ◽  
Disease Activity Index ◽  
Fold Change ◽  
Reactive Protein ◽  
Qrt Pcr ◽  
Significant Difference

Objectives:Studying post-infliximab gene expression changes could provide insights into the pathogenesis of ankylosing spondylitis (AS).Methods:Gene expression changes were screened by microarray on peripheral blood RNA of 16 AS patients at baseline and 2 weeks post-infliximab, and selected results were confirmed by quantitative real-time (qRT)–PCR. Corresponding serum-soluble LIGHT (sLIGHT) was estimated by ELISA and the fold change in sLIGHT was correlated to the fold change in erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and the Bath AS disease activity index.Results:Post-infliximab, 69% of the patients (11/16) achieved an ASAS20 response. Six candidate genes were differentially expressed by microarray; four of which were validated by qRT–PCR. sLIGHT showed the most significant difference. There was good correlation of baseline sLIGHT with CRP (R  =  0.60; p = 0.01) and ESR (R  =  0.51; p = 0.04). The fold change in sLIGHT correlated with change in both CRP (R  =  0.71, p = 0.002) and ESR (R  =  0.77, p<0.001).Conclusion:LIGHT is significantly downregulated by infliximab. sLIGHT correlated well with changes in inflammatory markers.

Is There an Advantage Over SF-36 with a Quality of Life Measure That Is Specific to Systemic Lupus Erythematosus?

2011 ◽  
Vol 38 (9) ◽  
pp. 1898-1905 ◽  
Author(s):  
ZAHI TOUMA ◽  
DAFNA D. GLADMAN ◽  
DOMINIQUE IBAÑEZ ◽  
MURRAY B. UROWITZ
Keyword(s):  
Quality Of Life ◽  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Activity Index ◽  
Short Form ◽  
Disease Activity Index ◽  
Systemic Lupus ◽  
Sf 36

Objective.To assess whether the Lupus Quality of Life (LupusQoL) questionnaire contributed additional information not obtained using the Medical Outcomes Study Short-Form 36 questionnaire (SF-36) in a cohort of patients with systemic lupus erythematosus (SLE).Methods.Forty-one patients seen at a single center were followed at monthly intervals for 12 months. The LupusQoL and the SF-36 questionnaires were coadministered monthly. Disease activity was determined by the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) every 30 days. We determined the correlation of the 4 comparable domains of both questionnaires. For the 4 noncomparable domains of the LupusQoL we determined the correlation between each domain with the Physical Component Summary scores (PCS) and the Mental Component Summary scores (MCS) of the SF-36. The effect size (ES) and the standardized response mean (SRM) were used to compare the responsiveness of both questionnaires when a clinically significant change in disease activity occurred as determined by SLEDAI-2K.Results.Three hundred seventy-six patient visits were recorded. There was a strong correlation between comparable domains in both questionnaires. For the 4 noncomparable domains of the LupusQoL, there was a correlation with the MCS and PCS of SF-36. The mean scores for comparable domains in both questionnaires were similar. Both questionnaires displayed responsiveness, as determined by ES and SRM among patients who flared and improved, but not among patients in remission, when compared to the previous visit.Conclusion.LupusQoL and SF-36 were equivalent in assessing quality of life over time in this group of patients. Both questionnaires are responsive measures of quality of life in patients with SLE flares and improvement.

scholarly journals Serum Oxytocin Levels in Patients with Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis and their Association with Disease Activity

2021 ◽  
Author(s):  
Ozkan Yukselmis ◽  
Pelin Oktayoğlu ◽  
Mehmet Caglayan ◽  
Nuriye Mete
Keyword(s):  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Axial Spondyloarthritis ◽  
Complete Blood Count ◽  
Inflammatory Diseases ◽  
Activity Index ◽  
Disease Activity Index ◽  
Serum Levels ◽  
Spinal Mobility ◽  
Significant Difference

Abstract Objectives Spondyloarthritis refers to a group of chronic inflammatory diseases that particularly involve the sacroiliac joints and spine but may also have an influence on extra-articular involvement in some patients. Oxytocin is a peptide hormone released from the hypothalamus and stored in the pituitary gland. It is known to have anti-inflammatory effects. The aim of this study was to investigate the serum levels of oxytocin and their potential association with disease activity and spinal mobility in patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nrAxSpA). Material and Methods Seventy-one patients with nrAxSpA, 38 patients with AS and 67 healthy control subjects were included in this study. Disease activity was assessed by the Bath Ankylosing Spondylitis Disease Activity Index, and spinal mobility by the Bath Ankylosing Spondylitis Metrologic Index. Laboratory examinations included complete blood count, ESR, CRP and oxytocin tests. Results There was no significant difference in serum levels of oxytocin among the 3 groups (p=0.973). However, serum levels of oxytocin correlated negatively with both ESR (r=− 0.359, p=0.027), CRP (r=− 0.316, p=0.056) and BASDAI scores (r=− 0,448, p=0.005) in patients with AS. On the other hand, serum levels of oxytocin had a negative correlation only with ESR in patients with nrAxSpA (r=− 0.321 p=0.009).Conclusion This study lays the foundation for further studies that may aim to investigate how addition of oxytocin to the treatment regimen impacts on disease activity in patients with AS who exhibit particularly low levels of oxytocin during the active disease period.

scholarly journals Percepção da qualidade de vida e funcionalidade em obesos candidatos a cirurgia bariátrica: um estudo transversal

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Larissa Battisti ◽  
Aurélio De Melo Barbosa ◽  
Katryne Holanda Silva ◽  
Geovana Cristina Pacheco Batista ◽  
Luila Aluanda Vieira de Farias ◽  
...  
Keyword(s):  
Medical Research ◽  
Research Council ◽  
Medical Research Council ◽  
Short Form ◽  
Medical Outcomes ◽  
Form Health ◽  
Sf 36 ◽  
Outcomes Study ◽  
Short Form Health

OBJETIVO: Traçar perfil funcional e de qualidade de vida (QV) de pacientes obesos mórbidos, submetidos ao Programa de Controle e Cirurgia da Obesidade (PCCO) atendidos no ambulatório de fisioterapia do Hospital Alberto Rassi (HGG).MÉTODOS: Estudo transversal e descritivo, composto por 155 obesos. Como instrumentos foram aplicados o questionário de QV Medical Outcomes Study 36-Item Short-Form Health (SF36), o Questionário Internacional de Atividade Física (QIAF), a Medida de Independência Funcional (MIF), a Escala Visual Analógica (EVA) de dor e o Medical Research Council (MRC). A análise foi realizada a partir de estatística descritiva e correlações.RESULTADOS: A prevalência foi do sexo feminino, em meia idade, sendo não tabagista, não etilista, sedentários e hipertensos. 118 referem dor durante avaliação, e a região corporal dolorosa mais referida foram ambos os joelhos (n=35). Para o SF-36, os pacientes possuem déficit em capacidade funcional e aspectos físicos com escores abaixo da média. Na MIF, grande parte possui leve limitação de independência funcional. Houve correlações negativas entre idade e QV por capacidade e independência funcional nas atividades básicas de vida diária (ABVD), índice de massa corporal (IMC) e QV por capacidade funcional na amostra estudada. A correlação foi positiva quanto ao MRC em grande parte dos domínios do SF-36.CONCLUSÕES: O estudo indica que a piora da QV está correlacionada com maior IMC, maior idade, redução da força muscular global, dor e leve incapacidade funcional nas ABVD em obesos mórbidos.

scholarly journals Accelerometer Quantification of Physical Activity and Activity Patterns in Patients with Ankylosing Spondylitis and Population Controls

2015 ◽  
Vol 42 (12) ◽  
pp. 2369-2375 ◽  
Author(s):  
Simon van Genderen ◽  
Annelies Boonen ◽  
Désirée van der Heijde ◽  
Liesbeth Heuft ◽  
Jolanda Luime ◽  
...  
Keyword(s):  
Physical Activity ◽  
Ankylosing Spondylitis ◽  
Functional Ability ◽  
Activity Index ◽  
Short Form ◽  
Activity Patterns ◽  
Disease Activity Index ◽  
Medical Outcomes ◽  
Outcomes Study ◽  
Population Controls

Objective.To compare the total amount of physical activity (TPA) and time spent in various activity intensities of patients with ankylosing spondylitis (AS) and population controls, and to explore factors related to physical activity (PA).Methods.Subjects were asked to wear a triaxial accelerometer for 7 days and to complete a series of questionnaires. Multivariable regressions were used to assess generic determinants of TPA in patients and controls, and in patients to explore demographic and disease-specific determinants of various PA intensities.Results.One hundred and thirty-five patients [51 ± 13 yrs, 60% men, body mass index (BMI) 26.0 ± 4.3 kg/m2] and 99 controls (45 ± 12 yrs, 67% men, BMI 25.1 ± 4.3 kg/m2) were included. Patients did not differ from controls regarding TPA (589 vs 608 vector count/min, p = 0.98), minutes/day spent in sedentary (524 vs 541, p = 0.17), and light PA (290 vs 290 p = 0.95), but spent fewer minutes/day in moderate to vigorous PA (MVPA; 23 vs 30 min/day, p = 0.006). Perceived functional ability (physical component summary of the Medical Outcomes Study Short Form-36) and BMI were associated with TPA independent of having AS (p interaction = 0.21 and 0.94, respectively). Additional analyses in patients showed that time spent in MVPA was negatively influenced by BMI, physical function (Bath AS Functional Index), and disease duration. In patients ≥ 52 years old, a higher Bath AS Disease Activity Index was associated with less time spent in sedentary and more time spent in light activities.Conclusion.Compared with controls, patients with AS had similar TPA, but may avoid engagement in higher intensities of PA. Lower levels of functional ability and higher BMI were associated with lower TPA in both patients and controls.

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