FRI0561 PRO-INFLAMMATORY DIETS ARE ASSOCIATED WITH INCREASED C-REACTIVE PROTEIN AND RHEUMATOID ARTHRITIS IN THE UK BIOBANK COHORT

Background:Several individual dietary components have been associated with the risk of rheumatoid arthritis (RA) and recent studies have suggested that dietary indices, which account for the consumption of multiple foods, can be used as more complete measures of risk.Objectives:In this study we aimed to use the Dietary Inflammatory Index (DII), an independent index of dietary variable associated with inflammatory biomarkers, to evaluate potential associations between pro-inflammatory exposures in the diet, an inflammation biomarker (C-reactive protein) and RA onset using the UK Biobank cohort.Methods:The DII was calculated from data obtained in 24-hour dietary recall questionnaires collected on healthy participants on four separate occasions over an approximate annual period between Feb 2011 and April 2012. Cases of RA in the UK Biobank cohort were identified from the participants with appropriate ICD10 codes and compared against a randomly selected subsample of controls matched (20:1) for age, sex, smoking status and BMI.Results:Among the 502,519 subjects enrolled in Biobank, 141,769 had completed 24-hour dietary recall questionnaires and had full data for the 18 dietary variables that were required to create the DII (mean=0.03, range: -3.88, 4.22). Higher (positive) DII values indicate more pro-inflammatory diets. This index was positively correlated (p<0.001) with C-reactive protein (CRP), attesting to the validity of this index for assessing dietary inflammatory potential. A total of 1,423 participants were classified as having RA (1% prevalence in ‘dietary’ cohort of 141,769) according to their ICD10 codes that were last updated in 2018. Their mean age at enrolment (2006-10) was 59 years. There was a significant association between DII and RA: OR 1.05 [1.01-1.09]; p=0.028) that suggested RA cases were more likely to be consuming a pro-inflammatory diet.Conclusion:These data show a significant association between diet, inflammation (CRP) and RA in the UK Biobank population. The findings are consistent with a recent analysis of the US Nurse’s Health Study which was based on data only from females, indicating that these findings are likely to be robust and generalisable. Diet is one of the few modifiable factors that has the potential to reduce the risk of future RA onset. These results open the way to providing evidence-based health advice and for designing clinical interventions.References:[1] Shivappa N, Steck SE, Hurley TG, Hussey JR, Hebert JR. Designing and developing a literature-derived, population-based dietary inflammatory index. Public health nutrition 2014;17:1689-96.Acknowledgments:This research has been conducted using the UK Biobank Resource under Application Number ‘33557’Disclosure of Interests:None declared

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A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS)

Public Health Nutrition ◽

10.1017/s1368980013002565 ◽

2013 ◽

Vol 17 (8) ◽

pp. 1825-1833 ◽

Cited By ~ 279

Author(s):

Nitin Shivappa ◽

Susan E Steck ◽

Thomas G Hurley ◽

James R Hussey ◽

Yunsheng Ma ◽

...

Keyword(s):

Seasonal Variation ◽

High Sensitivity ◽

Population Based ◽

Blood Cholesterol ◽

Dietary Inflammatory Index ◽

C Reactive Protein ◽

Dietary Recall ◽

Inflammatory Index ◽

Reactive Protein ◽

Hs Crp

AbstractObjectiveTo perform construct validation of the population-based Dietary Inflammatory Index (DII) using dietary data from two different dietary assessments and serum high-sensitivity C-reactive protein (hs-CRP) as the construct validator.DesignUsing data derived from (i) three 24 h dietary recalls (24HR) at baseline and at the end of each subsequent quarter (i.e. up to fifteen over a year) and (ii) a 7 d dietary recall (7DDR) measured at baseline and then quarterly, regression analyses were conducted to test the effect of the DII score on serum hs-CRP as dichotomous (≤3 mg/l, >3 mg/l), while controlling for important potential confounders.SettingExisting data from the Seasonal Variation of Blood Cholesterol Study (SEASONS), a longitudinal observational study of healthy participants recruited in Worcester, MA, USA and participants were followed for 1 year.SubjectsParticipants who had at least one hs-CRP measurement over her/his 1-year participation (n495 for 24HR,n559 for 7DDR).ResultsHigher DII scores were associated with values of hs-CRP >3 mg/l (OR = 1·08; 95 % CI 1·01, 1·16,P= 0·035 for the 24HR; and OR = 1·10; 95 % CI 1·02, 1·19,P= 0·015 for the 7DDR).ConclusionsThe population-based DII was associated with interval changes in hs-CRP using both the 24HR and 7DDR. The success of this first-of-a-kind attempt at relating individuals’ intakes of inflammation-modulating foods using this refined DII, and the finding that there is virtually no drop-off in predictive capability using a structured questionnaire in comparison to the 24HR standard, sets the stage for use of the DII in a wide variety of other epidemiological and clinical studies.

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Long-term associations between inflammatory dietary scores in relation to long-term C-reactive protein status measured 12 years later: findings from the Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) cohort

British Journal Of Nutrition ◽

10.1017/s0007114517000034 ◽

2017 ◽

Vol 117 (2) ◽

pp. 306-314 ◽

Cited By ~ 21

Author(s):

Chantal Julia ◽

Karen E. Assmann ◽

Nitin Shivappa ◽

James R. Hebert ◽

Michael D. Wirth ◽

...

Keyword(s):

Underlying Mechanism ◽

Low Grade ◽

Dietary Inflammatory Index ◽

C Reactive Protein ◽

Cross Sectional ◽

Inflammatory Index ◽

Reactive Protein ◽

Modifiable Factors ◽

Dietary Records

AbstractChronic low-grade inflammation has been recognised as a key underlying mechanism for several chronic diseases, including cancer and CVD. Nutrition represents a host of key modifiable factors that influence chronic inflammation. Dietary inflammatory scores were developed to assess the inflammatory potential of the diet and have been associated with inflammatory biomarkers in cross-sectional and short-term longitudinal studies. The objective of this study was to investigate the relationship between the dietary inflammatory index (DII), the alternate dietary inflammatory index (ADII) and long-term C-reactive protein (CRP). We also tested age as an effect modifier of this relationship. Participants were selected in the Supplémentation en Vitamines et Minéraux Antioxydants study, which included subjects aged 45–60 years old for men and 35–60 years old for women in 1994. Participants with ≥3 24-h dietary records at baseline and a CRP measurement at the 12-year follow-up evaluation were included in the present study (n 1980). The relationships between the DII and ADII and elevated CRP (>3 mg/l) were investigated using logistic multivariable regression. All analyses were stratified by age (cut-off at median age=50 years old). The overall associations between DII and ADII and long-term CRP were not statistically significant (Ptrend across tertiles=0·16 for DII and 0·10 for ADII). A quantitative interaction was found between ADII score and age (P=0·16 for ADII, 0·36 for DII). In stratified analyses the ADII was significantly prospectively associated with CRP only in younger participants: OR tertile 3 v. tertile 1: 1·79 (95 % CI 1·04, 3·07). Pro-inflammatory diets may have long-term effect on CRP only in younger subjects.

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A Dietary Inflammatory Index and associations with C-reactive protein in a general adult population

European Journal of Nutrition ◽

10.1007/s00394-021-02573-5 ◽

2021 ◽

Author(s):

Michael J. Hart ◽

Susan J. Torres ◽

Sarah A. McNaughton ◽

Catherine M. Milte

Keyword(s):

Adult Population ◽

Dietary Inflammatory Index ◽

C Reactive Protein ◽

Inflammatory Index ◽

Reactive Protein ◽

General Adult Population

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Abstract 021: C-reactive Protein Partially Mediates The Inverse Association Between Coffee Consumption And Risk Of Type 2 Diabetes: Findings From The UK Biobank And The Rotterdam Studies

Circulation ◽

10.1161/circ.143.suppl_1.021 ◽

2021 ◽

Vol 143 (Suppl_1) ◽

Author(s):

Carolina Ochoa-Rosales ◽

Niels van der Schaft ◽

Kim V Braun ◽

Frederick Ho ◽

Fanny Petermann ◽

...

Keyword(s):

Type 2 Diabetes ◽

Coffee Consumption ◽

Inverse Association ◽

Statistical Regression ◽

Uk Biobank ◽

C Reactive Protein ◽

Coffee Intake ◽

Reactive Protein ◽

The Uk

Background: Coffee intake has been linked to lower type 2 diabetes (T2D) risk. We hypothesized this may be mediated by coffee’s effects on inflammation. Methods: Using participants from the UK Biobank (UKB n=145370) and Rotterdam Study (RS n=7172) cohorts, we studied associations of coffee intake with incident T2D; longitudinally measured insulin resistance (HOMA IR); serum levels of inflammation markers; and the mediating role of inflammation. Statistical regression models were adjusted for sociodemographic, lifestyle and health factors. Results: The median follow up was 7 (UKB) and 9 (RS) years. An increase of one coffee cup/day was associated with 4-6% lower T2D risk (RS HR=0.94 [95% CI 0.90; 0.98]; UKB HR=0.96 [0.94; 0.98]); lower HOMA IR (RS β=-0.017 [-0.024; -0.010]); with lower C reactive protein (CRP) and higher adiponectin (Figure1). Consumers of filtered coffee had the lowest T2D risk (UKB HR=0.88 [0.83; 0.93]). CRP levels mediated 9.6% (UKB) and 3.4% (RS) of the total effect of coffee on T2D (Figure 1). Conclusions: We suggest that coffee’s beneficial effects on lower T2D risk are partially mediated by improvements in systemic inflammation.Figure 1. a CRP and a adiponectin refer to the effect of coffee intake on CRP and adiponectin levels. a CRP RS : β=-0.014 (-0.022; -0.005); UKBB a CRP UKB : β=-0.011 (-0.012; -0.009) and RS a adiponectin : β=0.025 (0.007; 0.042). b CRP and b adiponectin refer to the effect of coffee related levels in CRP and adiponectin on incident T2D, independent of coffee. RS b CRP : HR=1.17 (1.04; 1.31); UKB b CRP : HR=1.45 (1.37; 1.54); and b adiponectin : HR=0.58 (0.32; 0.83). c′ refers to coffee’ effect on T2D going directly or via others mediators. UKB c′ independent of CRP : HR=0.96 (0.94; 0.99); RS c′ independent of CRP : HR=0.94 (0.90; 0.99); and RS c′ independent of CRP+adiponectin : HR=0.90 (0.80; 1.01). Coffee related changes in CRP may partially explain the beneficial link between coffee and T2D, mediating a 3.4% (0.6; 4.8, RS) and 9.6% (5.7; 24.4, UKB). Evidence of mediation was also found for adiponectin.

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