scholarly journals AB0443 BIOMARKER SUCH AS IL-17, IL-21 AND TIMP-1, IS USEFUL FOR PREDICTING THE PATHOPHYSIOLOGY OF CONNECTIVE TISSUE DISEASE-ASSOCIATED PULMONARY HYPERTENSION

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1249.2-1249
Author(s):  
S. Nakashima ◽  
T. Kameda ◽  
H. Shimada ◽  
M. Mahmoud Fahmy Mansour ◽  
R. Wakiya ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Connective Tissue ◽  
Immunosuppressive Therapy ◽  
Connective Tissue Disease ◽  
Clinical Data ◽  
The Other ◽  
Vascular Involvement ◽  
Other Hand ◽  
Pulmonary Vasodilator ◽  
The Relationship

Background:Connective tissue disease-associated pulmonary hypertension (CTD-PH) is constructed by a variety of pathologies, including cardiac, pulmonary, and vascular involvement, as well as immune abnormalities. Because of its various constructs, it is difficult for many respiratory physicians, cardiologists, and rheumatologists to determine a treatment strategy for CTD-PH. In addition, CTD-PH has different pathologies from iPAH, and there are cases in which immunosuppressive therapy is effective. These suggests that the two PAHs may have different pathogenesis, including inflammation in the pulmonary artery. However, there are not enough biomarkers to distinguish pathologies. On the other hand, it has been reported that various cytokines such as TIMP-1, Interleukin (IL)-6, IL-17, and IL-21 are involved in the pathogenesis of CTD-PH or vasculitis. (1,2) However, the relationship between these cytokine expression and the pathogenesis or treatment of CTD-PH has not been fully clarified.Objectives:To clarify the relationship between cytokine profile and clinical features, change in cytokines and hemodynamics by treatment, association with the effectiveness of immunosuppressive therapy.Methods:Patients suspected PH was included. At the time of cardiac catheterization(RHC), sera in pulmonary pre and post-capillary were collected and TIMP-1, MCP-1, IL-17 and IL-21, IL-12p70 and IL-6 were analyzed by ELISA(ABCAM UK, Ella simple plex USA). The following clinical data were collected: age, gender, underlying disease, complication of interstitial lung disease, treatment (immunosuppressant and pulmonary vasodilator), hemodynamics. Furthermore, we investigated the relationship between cytokines and clinical data.Results:15 cases of CTD-PH, 13 cases of non-CTD-PH, and 6 cases of non-PH were analyzed. (SSc 12 cases, MCTD 7cases, SLE 2 cases, and others 13 cases) 28 cases were diagnosed with PH by RHC. There was a positive correlation between IL-6 and mean pulmonary arterial pressure in all PH case. In addition, MCP-1, IL-6, and TIMP-1 tend to be high in SSc-PH cases. On the other hand, in Non-SSc-PH, IL-12p70 and IL-17 were high. In cases who pulmonary vascular hemodynamics improved by treatment, IL-17, IL-21, and TIMP-1 decreased.Conclusion:Biomarker profiles in pulmonary capillaries may differ depending on the disease. Furthermore, it suggested that IL-17, IL-21 and TIMP-1 may be biomarkers of therapeutic effect.References:[1]Hashimoto-Kataoka T. et al. Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2677-86.[2]Jun Ishizaki et al. Arthritis Res Ther. 2017 Sep 29;19(1):218.Disclosure of Interests:None declared.

scholarly journals FRI0254 SERUM IL-17 AND IL-21 AFFECT THE HEMODYNAMICS IN CONNECTIVE TISSUE DISEASE ASSOCIATED-PULMONARY HYPERTENSION

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 711.2-711
Author(s):  
S. Nakashima ◽  
T. Kameda ◽  
H. Shimada ◽  
R. Wakiya ◽  
M. Mahmoud Fahmy Mansour ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Lupus Erythematosus ◽  
Cytokine Profile ◽  
Serum Samples ◽  
Pulmonary Hemodynamics ◽  
Clinical Appearance ◽  
Pulmonary Vasodilator ◽  
Before And After

Background:Pulmonary hypertension associated with connective tissue disease (CTD-PH) has complicated pathology including immune abnormalities, cardiac and pulmonary lesions. Therefore, it is difficult for rheumatologist to manage CTD-PH. We hesitate to use immunosuppressants in addition to pulmonary vasodilators to treat CTD-PH. Although there is a report that the cytokine such as Interleukin (IL)-6, IL-17 and IL-21 are involved in the development of PH1), changes in the hemodynamics of theses cytokines with treatment are not clear.Objectives:We investigate serum cytokine profile and clinical appearance in CTD-PH, and clarify the relationship between change in cytokines and hemodynamics before and after treatment.Methods:14 cases of CTD-PH (8 cases in Scleroderma; SSc-PH group, 4 cases in Mixed connective tissue disease; MCTD-PH group, 2 cases in Systemic lupus erythematosus; SLE-PH group), 6 cases in Other-PH group, and 2 cases of SSc without PH as controls were included. The following clinical data were collected: age, gender, underlying disease, complication of interstitial lung disease, treatment (immunosuppressant and pulmonary vasodilator). Serum samples in pre- and post-capillary before and after treatment were collected during cardiac catheterization examination. Serum cytokines (MCP-1, IL-6, IL-17 and IL-21) of these samples were measured by ELISA (ABCAM, UK).Results:Serum MCP-1, IL-6, and IL-21 levels were higher in SSc-PH group than in the other groups. Conversely, serum IL-17 levels tended to be higher in non-SSc group compared to SSc-PH group. Additionally, serum MCP-1 levels in SSc-PH group decreased in post-capillary as compared to pre-capillary. Furthermore, patients with decreased serum IL-17 and IL-21 levels before and after treatment showed improved pulmonary hemodynamics.Conclusion:SSc-PH had a different cytokine profile compared with non-SSc-PH. We suggested that the serum IL-17 and IL-21 levels effect the hemodynamics in CTD-PH.References:[1]Hashimoto-Kataoka T. et al. Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2677-86.Disclosure of Interests:None declared

‘He Brought the Cold Death on my Harandra’: The Cosmic Trilogy and the Ecotheology of Laudato si'

2018 ◽  
Vol 8 (2) ◽  
pp. 166-182
Author(s):  
Maria Poggi Johnson
Keyword(s):  
Natural Environment ◽  
The Other ◽  
Space Travel ◽  
Human Relationships ◽  
Other Hand ◽  
Divine Will ◽  
The Relationship

In his trilogy of space travel novels, published between 1938 and 1945, C.S. Lewis strikingly anticipates, and incarnates in imaginative form, the insights and concerns central to the modern discipline of ecotheology. The moral and spiritual battle that forms the plot of the novels is enacted and informed by the relationship between humans and the natural environment, Rebellion against, and alienation from, the Creator inevitably manifests in a violent and alienated attitude to creation, which is seen as something to be mastered and exploited. Lives and cultures in harmony with the divine will, on the other hand, are expressed in relationships of care and respect for the environment. The imaginative premise of the Trilogy is that of ecotheology; that the human relationships with God, neighbour, and earth and are deeply and inextricably intertwined.

KONSTRUKSI ISLAM DALAM KEKUASAAN NEGARA

1970 ◽  
Vol 6 (2) ◽  
Author(s):  
Nurul Aini Musyarofah
Keyword(s):  
Islamic Law ◽  
Social Condition ◽  
The Other ◽  
Good Society ◽  
Ideal Form ◽  
Other Hand ◽  
Islamic Politics ◽  
The Relationship ◽  
The Ideal

The relationship between Islam and state raises a controversy that includes two main groups;formalists and substantialists. Both of them intend to achieve a good social condition which is inaccordance with Islamic politics. The ideal form of good society to be achieved is principallydescribed in the main source of Islamic law, Al Qur’an and As Sunnah, as follows. A form of goodsociety should supprot equality and justice, egalitarianism, and democracy in its social community.The next problem is what the needed methods and instruments to achieve the ideal Islamic politicsare. In this case, the debate on the formalization and substance of Islamic teaching is related to therunning formal political institution.Each group claims itself to be the most representative to the ideal Islam that often leads to anescalating conflict. On the other hand thr arguments of both groups does not reach the wholeMuslims. As a result, the discourse of Islam and state seems to be elitist and political. As a result,Both groups suspect each other each other and try to utilize the controversy on the relationshipbetween Islam and state to get their own benefit which has no relation with the actualization ofIslamic teaching.

8. ADMINISTRASI HUSEMAS

2020 ◽  
Author(s):  
putri asifa ◽  
Hade Afriansyah
Keyword(s):  
School Improvement ◽  
Educational Needs ◽  
The Other ◽  
Community Interest ◽  
Other Hand ◽  
School And Community ◽  
The Relationship

This article discusses the administration of school and community relation. The existence of schools is driven by the needs of the community, because educational responsibilities are governed by the responsibilities of the community, family, and government. Based on these relationships, the relationship is always enhanced. But something is seen. Changes in nature, goals, and methods of teaching relationships. On the other hand, the community also demands the change in education. In Indonesia, the relationship between schools and the community has been established. This is good progress.Therefore, Husemas is a process of communication between schools and the community to increase community understanding of educational needs and activities and encourage community interest and cooperation in school improvement and development.

scholarly journals From reflex to reflection: Moving from the space of causes to the space of reasons and back

2020 ◽  
Vol 3 (1) ◽  
pp. 681-693
Author(s):  
Ariel Furstenberg
Keyword(s):  
The Other ◽  
Final Part ◽  
Clear Cut ◽  
Other Hand ◽  
Space Of Reasons ◽  
The One ◽  
The Relationship ◽  
Simple Picture

AbstractThis article proposes to narrow the gap between the space of reasons and the space of causes. By articulating the standard phenomenology of reasons and causes, we investigate the cases in which the clear-cut divide between reasons and causes starts to break down. Thus, substituting the simple picture of the relationship between the space of reasons and the space of causes with an inverted and complex one, in which reasons can have a causal-like phenomenology and causes can have a reason-like phenomenology. This is attained by focusing on “swift reasoned actions” on the one hand, and on “causal noisy brain mechanisms” on the other hand. In the final part of the article, I show how an analogous move, that of narrowing the gap between one’s normative framework and the space of reasons, can be seen as an extension of narrowing the gap between the space of causes and the space of reasons.

Study on the Dynamics on the Brake of Vehicle after the Effects of Deicing Salt

2010 ◽  
Vol 26-28 ◽  
pp. 862-869
Author(s):  
Tao Peng ◽  
Zhi Peng Li ◽  
Chang Shu Zhan ◽  
Xiang Luo ◽  
Qian Wang
Keyword(s):  
Simulation Model ◽  
Dynamic Model ◽  
The Other ◽  
Snow Melting ◽  
Adhesion Coefficient ◽  
Deicing Salt ◽  
Other Hand ◽  
Road Condition ◽  
Braking Distance ◽  
The Relationship

Through analyzing the process of brake, a dynamic model of automobile and a model of the relationship between braking distance and adhesion coefficient were formed; also a simulation calculating model of braking distance was established with the use of Matlab. Finally, a research was done toward the braking distance of a type of a car running on a road after using snow-melting agent. On one hand, with the application of the simulation model which has been established, calculations have been done to the braking distance of Bora vehicles running on roads after using deicing salt; on the other hand, by experiments, Bora vehicles’ braking distance and maximum braking deceleration under the same road condition were measured, meanwhile, the established simulation model was verified.

scholarly journals On Newcomb's method of investigating periodicities and its application to Brückner's weather cycle

1914 ◽  
Vol 90 (619) ◽  
pp. 349-355
Keyword(s):  
Thermal Radiation ◽  
The Other ◽  
New Method ◽  
Critical Examination ◽  
Numerical Work ◽  
Average Value ◽  
Other Hand ◽  
Relationship Of ◽  
The Relationship ◽  
Great Simplicity

During the last few years of his life Prof. Simon Newcomb was keenly interested in the problem of periodicities, and devised a new method for their investigation. This method is explained, and to some extent applied, in a paper entitled "A Search for Fluctuations in the Sun's Thermal Radiation through their Influence on Terrestrial Temperature." The importance of the question justifies a critical examination of the relationship of the older methods to that of Newcomb, and though I do not agree with his contention that his process gives us more than can be obtained from Fourier's analysis, it has the advantage of great simplicity in its numerical work, and should prove useful in a certain, though I am afraid, very limited field. Let f ( t ) represent a function of a variable which we may take to be the time, and let the average value of the function be zero. Newcomb examines the sum of the series f ( t 1 ) f ( t 1 + τ) + f ( t 2 ) f ( t 2 + τ) + f ( t 3 ) f ( t 3 + τ) + ..., where t 1 , t 2 , etc., are definite values of the variable which are taken to lie at equal distances from each other. If the function be periodic so as to repeat itself after an interval τ, the products are all squares and each term is positive. If, on the other hand, the periodic time be 2τ, each product will be negative and the sum itself therefore negative. It is easy to see that if τ be varied continuously the sum of the series passes through maxima and minima, and the maxima will indicated the periodic time, or any of its multiples.

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