AB0805 A SURVEY OF RHEUMATOLOGY PATIENTS’ SATISFACTION TO SWITCHING FROM ORIGINATOR TO BIOSIMILAR AGENTS

Background:The recent widespread switching of patients with inflammatory rheumatic conditions from originators to biosimilars has largely been driven by costs. The views of patients on switching are also important in the successful long term switching to biosimilars. We conducted a survey of patients views on patients satisfaction with the switch to biosimilar therapy.Objectives:To assess satisfaction and response after switching from originator (Humira or Enbrel) to biosimilar (Amgevita or Benepali respectively), and to describe efficacy, side effects and reactions to biosimilar.Methods:All patients diagnosed with an inflammatory arthritis and switched to biosimilar were identified using the Irish national HighTech electronic prescriptions system. Participants had been administered the biosimilar for > 3 months and were invited to take part via a telephone survey. This consisted of 4 questions (Question 1: satisfaction with the response to the new medication [Using 5 point Likert scale = 0: very dissatisfied; 1: dissatisfied; 2: neutral; 3 satisfied;4: very satisfied]; Question 2: overall satisfaction with biosimilar compared to originator if originator was 10 [satisfaction rating from 1 – 10 scale: 1,2: very dissatisfied; 3,4: dissatisfied; 5: neutral; 6,7,8: satisfied; 9,10: very satisfied]]; Question 3: adverse effects with biosimilars; Question 4: opinion on usage of new device [0: very difficult; 1: difficult; 2: same as previous device; 3: improvement compare to previous device).Results:Baseline characteristics of biosimilar switch patients with disease category were:Category(n)GenderMale (39), Female (56)Mean age (years)56Rheumatoid arthritis58Psoriatic arthritis18Ankylosing spondylitis16Reactive arthritis1Enteropathic arthritis1Juvenile idiopathic arthritis148 switched from Humira to Amgevita.The majority of the patients had positive view towards the effectiveness of the biosimilar: 36% very satisfied; 28% satisfied; 13% neutral; 10% dissatisfied; 13% very dissatisfied.45% of the patients gave score of 9 and 10 in the survey of overall satisfaction to biosimilar if originator was given a score of 10, followed by 32% of them gave a score from 6 to 8, 4% of the patients gave a score of 5 and 7% of them gave a score of 3 and 4. The rest of them gave a score of 1 and 2.12 participants switched back to originator (Humira, n=5; Enbrel, n=7) for the reasons of unable to use the device, anxiety, hemoptysis, nose bleeding, tongue swelling, neck pain, lethargy and generalized itchiness.The most common complaints were (12 patients) systemic side effects (tiredness, headache, nausea, skin rashes, hair loss, muscle ache, tongue swelling, mood swing, dizzy, nose bleed, erectile dysfunction, hypertension, hemoptysis and red sclera).17% of the patients find the biosimilars device easier to use compare to originator and 55% of the patients find both device are similar. 24% and 4% of them find the new device is difficult to very difficult to use respectively.Conclusion:69% of patients from Amgevita group and 60% of patients from Benepali group were satisfied with the change. Only 28% of the patients found the new device difficult to use. Overall conclusion from the study showed less than one quarter of the participants showed dissatifaction towards biosimilar and less than 12 % experienced systemic side effects and whether biosimilar could be a next cost effective biologic therapy to replace originator in future requires a longer duration of study.Disclosure of Interests:None declared

Download Full-text

Problems and Benefits Associated With Restorative Materials: Side-Effects and Long-Term Cost

Advances in Dental Research ◽

10.1177/08959374920060012001 ◽

1992 ◽

Vol 6 (1) ◽

pp. 7-16 ◽

Cited By ~ 27

Author(s):

Ivar A. Mjör

Keyword(s):

Side Effects ◽

Dental Materials ◽

Cost Effective ◽

Oral Mucous Membrane ◽

Restorative Materials ◽

Restorative Therapy ◽

Lichenoid Reactions ◽

The Cost ◽

Amalgam Restorations

The paper reviews data on biological side-effects of dental materials on patients and also on personnel who routinely handle the materials. The incidence of adverse effects is low-in one study indicated to be 1:700 for all types of treatments. For individual types of materials, it will be significantly lower, and for restorative materials, probably in the 1 : 10,000 to 1:20,000 range. Allergic reactions are the most common type of adverse effect of dental materials. Lichenoid reactions on the oral mucous membrane adjacent to amalgam restorations are the most frequently encountered side-effects for a specific group of restorative materials. Cost analyses were based on reports of longevity of different restorations and the cost of restorations at the time of placement. Amalgam restorative therapy was more cost-effective than composite restorations and gold castings.

Download Full-text

LITARARY REVIEW OF KARNINI YONIVYAPAD

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj4908102020 ◽

2020 ◽

Vol 8 (10) ◽

pp. 4871-4875

Author(s):

Manju Chouksey ◽

Suresh Kumar Solanki ◽

Hetal H. Dave

Keyword(s):

Side Effects ◽

Modern Science ◽

Cost Effective ◽

Treatment Modalities ◽

Daily Routine ◽

Gynecological Disorders ◽

Intervention Cost ◽

Almost All ◽

Cardinal Symptom

In classical Ayurveda texts almost all the gynecological disorders come under the term 'Yonivyapad’. Kar-nini Yonivyapad is one among these twenty Yonivyapadas. Although the cardinal symptom of the disease is excessive vaginal discharge, but often the long-term sequel of the disease like lower dyspareunia, ab-dominal pain, low backache, sickness feeling, fatigue etc. become too much troublesome to the patients and start affecting their daily routine. All Though it is not fatal, yet the long-term association with the dis-ease and a number of symptoms both related to the genitourinary system as well as psychological imbal-ance in the patients need attention. The treatment modalities described in modern science have their own disadvantages and side effects. Moreover, they are not cost effective and being carried at higher medical centers only. Owing to the com-plexities in the modern management, it is the basic need of time to develop a dependable and easily availa-ble therapeutic intervention cost effective, safe and devoid of complications or side effects. With this background this research project entitled.

Download Full-text

TACROLIMUS OR CYCLOSPORINE FOR IMMUNOSUPPRESSION AFTER HTx: WHICH TREATMENT REVEALS MORE SYSTEMIC SIDE EFFECTS DURING LONG TERM FOLLOW UP?

Transplantation Journal ◽

10.1097/00007890-199904150-00437 ◽

1999 ◽

Vol 67 (7) ◽

pp. S109

Author(s):

B. M. Meiser ◽

D. Schmidt ◽

M. Pfeiffer ◽

W. v. Scheidt ◽

V. Klauss ◽

...

Keyword(s):

Side Effects ◽

Long Term Follow Up ◽

Systemic Side Effects

Download Full-text

Side Effects Reported by Jordanian Healthcare Workers Who Received COVID-19 Vaccines

Vaccines ◽

10.3390/vaccines9060577 ◽

2021 ◽

Vol 9 (6) ◽

pp. 577

Author(s):

Osama Abu-Hammad ◽

Hamza Alduraidi ◽

Shaden Abu-Hammad ◽

Ahmed Alnazzawi ◽

Hamzah Babkair ◽

...

Keyword(s):

Side Effects ◽

Healthcare Workers ◽

Healthcare Professionals ◽

The Public ◽

Systemic Side Effects ◽

The Common ◽

Larger Sample ◽

Local Side

Background Distribution of COVID-19 vaccines has been surrounded by suspicions and rumors making it necessary to provide the public with accurate reports from trustworthy experts such as healthcare professionals. Methods We distributed a questionnaire in Jordan among physicians, dentists and nurses who received a COVID-19 vaccine to explore the side effects (SE) they encountered after the first or the second dose of one of three vaccines namely: AstraZeneca Vaxzevria (AZ), Pfizer-BioNTeck (PB), and SinoPharm (SP) vaccines. Results A total of 409 professionals participated. Approximately 18% and 31% of participants reported no SE after the first dose and second dose, respectively. The remainder had mostly local side effects related to injection site (74%). Systemic side effects in the form of fatigue (52%), myalgia (44%), headache (42%), and fever (35%) prevailed mainly after the first dose. These were significantly associated with AZ vaccine, and age ≤ 45 years (p = 0.000 and 0.01, respectively). No serious SE were reported. Conclusions We can conclude that SE of COVID-19 vaccines distributed in Jordan are within the common range known so far for these vaccines. Further studies are needed to include larger sample size and longer follow-up period to monitor possible serious and long-term SE of the vaccines.

Download Full-text

Potential benefits of phytochemicals for treatment of hyperpigmentation

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v9i2.2453 ◽

2019 ◽

Vol 9 (2) ◽

pp. 420-427

Author(s):

Harsimran Kaur ◽

, Afsana ◽

Geeta Aggarwal ◽

Manju Nagpal

Keyword(s):

Wound Healing ◽

Risk Factor ◽

Side Effects ◽

Uv Radiation ◽

Pharmaceutical Preparations ◽

Impaired Wound Healing ◽

Natural Extracts ◽

Potential Benefits ◽

Systemic Side Effects

UV radiation (UV) is considered as a complete carcinogen as it is both a mutagen and a non-specific damaging agent. It is the most important risk factor for skin cancer and many other skin disorders like Hyperpigmentation. There is a need of long-term topical skin care treatments (both cosmetic and cosmeceutical) to address problems associated with hyperpigmentation. Synthetic depigmenting agents, such as hydroquinone, mequinol, although highly effective, can raise several safety concerns (for example, ochronosis, cataract, impaired wound healing, desquamation, and other local or systemic side effects) with long-term exposure. The benefits of phytochemicals and natural extracts offer opportunities to develop new formulations to treat pigmentation problems. Cosmeceuticals are topical cosmetic-pharmaceutical preparations containing active ingredients which improve the appearance of skin. Among cosmeceuticals, the phytochemicals have been known to have a multitude of cellular actions for various dermatological diseases. Plant-derived compounds and their effectiveness in the treatment of hyperpigmentation disorders (Melasma) are discussed. Keywords: UV radiation, Hyperpigmentation, Phytochemicals, Cosmeceuticals

Download Full-text

Appearance of contraceptive steroids in human milk: effects on the child

Journal of Biosocial Science ◽

10.1017/s0021932000023919 ◽

1977 ◽

Vol 9 (S4) ◽

pp. 165-179 ◽

Cited By ~ 13

Author(s):

J. K. Harfouche

Keyword(s):

Side Effects ◽

Human Milk ◽

Breast Feeding ◽

Post Partum ◽

First Trimester ◽

Hormonal Contraceptives ◽

Lactating Women ◽

Systemic Side Effects ◽

Long Term Consequences

SummaryThe realization that steroidal contraceptives administered immediately after delivery to lactating women may be excreted into milk, and adversely affect the neonate, is a cause for concern. Most investigations on hormonal contraceptives have dealt with the efficacy of ovulation suppression, and systemic side effects, but little is known about the appearance of steroids or their metabolites in milk. Apart from the immediate side effects on the neonate, unforeseen long-term consequences require special consideration. Until research provides us with more information, women should use breast-feeding and IUDs instead of steroidal contraceptives during the first trimester post-partum.

Download Full-text

Lack of Systemic Side Effects of Long-Term Inhaled Fluticasone Propionate Use in a Cohort of Asthmatic Children

European Journal of Inflammation ◽

10.1177/1721727x1301100132 ◽

2013 ◽

Vol 11 (1) ◽

pp. 297-303

Author(s):

F. Angelini ◽

S. Corrente ◽

M.L. Romiti ◽

V. Moschese ◽

A. Polito ◽

...

Keyword(s):

Side Effects ◽

Fluticasone Propionate ◽

Asthmatic Children ◽

Systemic Side Effects

Download Full-text

Beliefs and reality of e-cigarette smoking

BMJ Case Reports ◽

10.1136/bcr-2018-225683 ◽

2018 ◽

pp. bcr-2018-225683 ◽

Cited By ~ 2

Author(s):

Sasmith Menakuru ◽

Mir Inzamam Ali

Keyword(s):

Side Effects ◽

Cigarette Smoking ◽

Large Scale ◽

Electronic Cigarettes ◽

Smoking History ◽

Nicotine Dependency ◽

Teenagers And Young Adults ◽

Systemic Side Effects

In this global health case study, we describe a case of nicotine addiction due to chronic use of electronic cigarettes (e-cigarette) and discuss the beliefs on safety and awareness of their side effects. Many people believe that smoking an e-cigarette (vaping) does not have any side effects, especially among teenagers and young adults. Teenagers using an e-cigarette at a young age are twice as likely to try cigarettes later in their life because of nicotine dependency or other social factors. More recent studies have shown long-term systemic side effects of vaping regardless of traditional cigarette smoking history. This report was done for further assessing their risk and to clear out misconceptions of this large-scale condition.

Download Full-text

Comparative study of the efficacy of oral caroverine versus oral Gingko biloba in the treatment of cochlear synaptic tinnitus

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20195694 ◽

2019 ◽

Vol 6 (1) ◽

pp. 82

Author(s):

Sachin Jain ◽

Kinshuk Chatterjee ◽

M. Aftab ◽

Dinesh Kumar ◽

Ramsiya Singh ◽

...

Keyword(s):

Side Effects ◽

Ampa Receptors ◽

Glutamate Release ◽

Cost Effective ◽

Oral Formulation ◽

Gingko Biloba ◽

Effective Treatment Modality ◽

Co Morbidity ◽

Term Basis

Background: Cochlear synaptic tinnitus (CST), also referred to as sensorineural type III tinnitus, is a type of transformation tinnitus, resulting due to aberrant signal transduction between Inner hair cells and afferent nerve fibres owing to excessive and pathologic glutamate release and subsequent spontaneous receptor depolarization (NMDA and AMPA receptors). Of the various pharmacologic agents used for treatment for CST, Gingko biloba and Caroverine have stood the test of time.Methods: A total 48 selected patients of CST, otherwise free from any medical or surgical co-morbidity, were included in the study and divided randomly in two groups, one group receiving oral formulation of Caroverine and the other group receiving oral Gingko biloba in appropriate doses. Both the groups were followed up for 12 weeks. Treatment outcomes were measured in terms of improvement in subjective symptoms (tinnitus grading) and psycho-acoustic measure (tinnitus matching).Results: Although oral caroverine yielded promising results in the initial month of treatment in terms of improved tinnitus matching, long term effect was found to be dissatisfying. Oral Gingko biloba, at the completion of 12 weeks of therapy was found to be more effective in terms of improvement of mean tinnitus grading and matching (p<0.05). Side effects of the test drugs were not noted in either group.Conclusions: Gingko biloba is thus found to be more effective treatment modality for CST for long term basis and is also readily available in the market, cost effective and free of side effects as well.

Download Full-text

Hybrid Theranostic Microbubbles for Ultrasound/Photoacoustic Imaging Guided Starvation/Low-Temperature Photothermal/Hypoxia-Activated Synergistic Cancer Therapy

Journal of Materials Chemistry B ◽

10.1039/d1tb01735g ◽

2021 ◽

Author(s):

Feng Tian ◽

Xingjian Zhong ◽

Junkai Zhao ◽

Yutian Gu ◽

Yadi Fan ◽

...

Keyword(s):

Side Effects ◽

Cancer Therapy ◽

Low Temperature ◽

Photoacoustic Imaging ◽

Multimodality Imaging ◽

High Contrast ◽

Theranostic Agent ◽

Systemic Side Effects ◽

Tumor Retention

Constructing a theranostic agent for high-contrast multimodality imaging-guided synergistic therapy with long-term tumor retention and minimum systemic side effects still remains a major challenge. Herein, a hybrid microbubble-based theranostic platform...

Download Full-text