PPO.62 Neonatal outcomes following planned preterm delivery in diabetic mothers; a retrospective audit

2014 ◽  
Vol 99 (Suppl 1) ◽  
pp. A170.2-A170
Author(s):  
EV Cope ◽  
N Sultana ◽  
SW Lindow ◽  
EA Masson ◽  
BJ Allen ◽  
...  
Keyword(s):  
Preterm Delivery ◽  
Neonatal Outcomes ◽  
Retrospective Audit ◽  
Diabetic Mothers

Neonatal outcomes following planned preterm delivery in diabetic mothers

2017 ◽  
Vol 10 (1) ◽  
pp. 25-31
Author(s):  
E.V. Cope ◽  
N. Sultana ◽  
E.A. Masson ◽  
B.J. Allen ◽  
A. Oboh ◽  
...  
Keyword(s):  
Preterm Delivery ◽  
Neonatal Outcomes ◽  
Diabetic Mothers

scholarly journals Birth Outcomes among Diabetic Mothers Who Delivered in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Bajrond Eshetu ◽  
Yitagesu Sintayehu ◽  
Bazie Mekonnen ◽  
Woreknesh Daba
Keyword(s):  
Diabetes Mellitus ◽  
Preterm Delivery ◽  
Birth Outcomes ◽  
Fetal Outcome ◽  
Maternal Outcomes ◽  
Pregnancy Induced Hypertension ◽  
Class I Obesity ◽  
Induced Hypertension ◽  
History Of ◽  
Diabetic Mothers

Introduction. Diabetes develops in 4% of all the pregnancies worldwide, and its prevalence ranges from 1 to 14%, and 7% are complicated and results in prenatal morbidity and mortality. The disease affects women and their babies during pregnancy, labor, and delivery. However, little is known about its prevalence, birth outcomes, and associated factors in the study setting. Method. A facility-based retrospective cross-sectional study was done on all deliveries attended from January 1, 2015, to December 31, 2017, to determine the prevalence of diabetes and birth outcome. The mothers who had complete data record were identified and consecutively reviewed. The data were entered in EpiData Version 4.2 and exported to SPSS Version 23.0 for analysis. Results. Of the 14039 women who gave birth during the study period, 2.6% of them had diabetes mellitus, and from reviewed data, 54.6% had gestational diabetes and 45.4% had pregestational diabetes. Out of the diabetic mothers, 57.8% delivered by cesarean section, 39.9% by spontaneous vaginal delivery, and 26% of the pregnancies ended up with pregnancy-induced hypertension. Regarding the fetal outcome, 17.9% were preterm delivery, 17.6% macrocosmic, 9.2% respiratory distress, 10.1% low birth weight, and 65% admitted to neonatal intensive care unit. Class I obesity and history of PIH were associated with adverse maternal outcomes at aOR = 95%CI 3.8 (1.29, 8.319) and aOR = 95%CI 2.1 (1.03, 4.399), respectively. Being a house wife and preterm deliveries were associated with adverse fetal outcomes at aOR = 95%CI 2.117 (1.315, 3.405) and aOR = 95%CI 9.763 (4.560, 20.902), respectively. Conclusion. The prevalence of diabetes mellitus delivered in the hospital was 2.6%. Class I obesity and previous history of pregnancy-induced hypertension were significantly associated with adverse maternal outcomes, whereas preterm delivery and being housewife were associated with adverse fetal outcome.

scholarly journals Progesterone Intramuscularly or Vaginally Administration May Not Change Live Birth Rate or Neonatal Outcomes in Artificial Frozen-Thawed Embryo Transfer Cycles

2020 ◽  
Vol 11 ◽  
Author(s):  
Yuan Liu ◽  
Yu Wu
Keyword(s):  
Preterm Delivery ◽  
Live Birth ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Neonatal Outcomes ◽  
Progesterone Level ◽  
Delivery Rate ◽  
Serum Progesterone ◽  
Frozen Thawed Embryo Transfer ◽  
Thawed Embryo Transfer

BackgroundsPrevious studies suggested that singletons from frozen-thawed embryo transfer (FET) were associated with higher risk of large, post-date babies and adverse obstetrical outcomes compared to fresh transfer and natural pregnancy. No data available revealed whether the adverse perinatal outcomes were associated with aberrantly high progesterone level from different endometrium preparations in HRT-FET cycle. This study aimed to compare the impact of progesterone intramuscularly and vaginally regimens on neonatal outcomes in HRT-FET cycles.MethodsA total of 856 HRT-FET cycles from a fertility center from 2015 to 2018 were retrospectively analyzed. All patients had their first FET with two cleavage-staged embryos transferred. Endometrial preparation was performed with sequential administration of estrogen followed by progesterone intramuscularly 60 mg per day or vaginal gel Crinone 90 mg per day. Pregnancy outcomes including live birth rate, singleton birthweight, large for gestational age (LGA) rate, small for gestational age (SGA) rate, and preterm delivery rate were analyzed. Student’s t test, Mann-Whitney U-test, Chi square analysis, and multivariable logistic regression were used where appropriate. Differences were considered significant if p < 0.05.ResultsNo significant difference of live birth rate was found between different progesterone regimens (Adjusted OR 1.128, 95% CI 0.842, 1.511, p = 0.420). Neonatal outcomes like singleton birthweight (p = 0.744), preterm delivery rate (Adjusted OR 1.920, 95% CI 0.603, 6.11, p = 0.269), SGA (Adjusted OR 0.227, 95% CI 0.027, 1.934, p = 0.175), and LGA rate (Adjusted OR 0.862, 95% CI 0.425, 1.749, p=0.681) were not different between two progesterone regimens. Serum P level >41.82 pmol/L at 14 day post-FET was associated with higher live birth rate than serum P level ≤41.82 pmol/L in HRT-FET cycles when progesterone was intramuscularly delivered (Adjusted OR 1.690, 95% CI 1.002, 2.849, p = 0.049). But singleton birthweight, preterm delivery rate, SGA and LGA rate were not different between these two groups.ConclusionsRelatively higher serum progesterone level induced by intramuscular regimen did not change live birth rate or neonatal outcomes compared to vaginal regimen. Monitoring serum progesterone level and optimizing progesterone dose of intramuscular progesterone as needed in HRT-FET cycles has a role in improving live birth rate without impact on neonatal outcomes.

scholarly journals Pre-Conception Characteristics Predict Obstetrical and Neonatal Outcomes in Women With Polycystic Ovary Syndrome

2018 ◽  
Vol 104 (3) ◽  
pp. 809-818 ◽  
Author(s):  
Jacob P Christ ◽  
Marlise N Gunning ◽  
Cindy Meun ◽  
Marinus J C Eijkemans ◽  
Bas B van Rijn ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Preterm Delivery ◽  
Outcome Measures ◽  
Disease Risk ◽  
Adverse Outcome ◽  
Polycystic Ovary ◽  
National Registry ◽  
Neonatal Outcomes ◽  
Ovary Syndrome ◽  
Increased Risk

Abstract Context Women with polycystic ovary syndrome (PCOS) are at increased risk for obstetric and perinatal complications. At present, it is unknown how characteristics of PCOS relate to the likelihood of these complications. Objective To evaluate which preconception features are associated with obstetric and perinatal disease among infertile women with PCOS. Design Data from two prospective cohort studies completed from January 2004 until January 2014 were linked to Dutch Perinatal national registry outcomes. Setting Two Dutch university medical centers. Participants 2768 women diagnosed with PCOS were included. Participants underwent an extensive standardized preconception screening. Exclusion criteria included: age <18 years or >45 years, language barrier, or failure to meet PCOS criteria. Interventions None. Main Outcome Measures Outcome measures were obtained from the Dutch Perinatal national registry and included: preeclampsia, preterm delivery, small for gestational age (SGA), low Apgar score, and any adverse outcome. Results 1715 (62% of participants) women with PCOS were identified as undergoing a pregnancy with live birth after screening. In fully adjusted models, prepregnancy free androgen index was associated with subsequent preeclampsia [OR (95% CI), 1.1 (1.0 to 1.1)]. Fasting glucose [1.4 (1.2 to 1.7)] and testosterone [1.5 (1.2 to 1.7)] predicted preterm delivery. Fasting insulin [1.003 (1.001 to 1.005)], and testosterone [1.2 (1.1 to 1.4)] predicted any adverse outcome. SGA was only predicted by features nonspecific to PCOS. Conclusions Primary disease characteristics of PCOS, chiefly hyperandrogenism and impaired glucose tolerance, predict suboptimal obstetric and neonatal outcomes. Increased surveillance during pregnancy should focus on women with PCOS and these features to help mitigate disease risk.

Fetal and neonatal outcomes after term and preterm delivery following betamethasone administration

2015 ◽  
Vol 130 (1) ◽  
pp. 64-69 ◽  
Author(s):  
Thorsten Braun ◽  
Deborah M. Sloboda ◽  
Boris Tutschek ◽  
Thomas Harder ◽  
John R.G. Challis ◽  
...  
Keyword(s):  
Preterm Delivery ◽  
Neonatal Outcomes

scholarly journals Reproductive and neonatal outcomes in women with unicornuate uterus: a population-based study

2021 ◽  
Vol 12 (5) ◽  
pp. 344-350
Author(s):  
Ahmad Badeghiesh ◽  
Angelos G Vilos ◽  
Haitham Baghlaf ◽  
Jana Abi Rafeh ◽  
Nabigah Alzawawi ◽  
...  
Keyword(s):  
Caesarean Section ◽  
Preterm Delivery ◽  
Health Care Cost ◽  
Gestational Hypertension ◽  
Neonatal Outcomes ◽  
Baseline Risk ◽  
Multivariate Logistic Regression Model ◽  
P Value ◽  
Unicornuate Uterus ◽  
Nationwide Inpatient Sample Database

Objective: To investigate reproductive and neonatal outcomes in women with unicornuate uterus. Study design: Data from the Health Care Cost and Utilization Project-Nationwide Inpatient Sample database were extracted from 2010 through 2014 to create a delivery cohort using ICD-9 codes. Code 752.33 was used to identify cases with unicornuate uterus and reproductive outcomes were compared to pregnancies without unicornuate uterus. A multivariate logistic regression model was used to adjust for statistically significant variables (P-value<0.05). Results: Among 3,850,226 deliveries during the study period, 802 women had unicornuate uterus. Patient with unicornuate uterus were more likely to be older (P<0.001), have thyroid disease (P<0.001), previous Caesarean section (P<0.001), and to have had in-vitro fertilization (IVF) (P<0.001). The risk of gestational diabetes, pregnancy induced hypertension, gestational hypertension and preeclampsia were significantly greater in the unicornuate uterus group relative to controls, after controlling for baseline risk factors; aOR 1.32 [95% CI 1.03–1.71], aOR 1.46 [95% CI 1.16–1.85], aOR 1.16 [95% CI 1.22-2.28] and aOR 1.70 [95% CI 1.24-2.32], respectively. Also, the rates of preterm delivery, preterm premature rupture of membranes and caesarean section were higher in the unicornuate uterus group compared to controls after controlling for confounding factors, aOR 3.83 (95% CI 3.19–4.6), aOR 5.11 (95% CI 3.73–7.14) and aOR 11.38 (95% CI 9.16–14.14) respectively. At birth, 11.1% and 2.6% of neonates were small for gestational age in the unicornuate uterus and the control groups, respectively, aOR 4.90, (95% CI 3.87-6.21). Conclusion: Women with unicornuate uterus are at higher risk for pregnancy complications, preterm delivery and having small for gestation age neonates. Women with known unicornuate uterus may benefit from increased surveillance to prevent and/or decrease maternal and neonate morbidity and mortality.

Maternal and fetal factors contributing to neonatal outcome in Al-Tibri Medical College and Hospital

2021 ◽  
Vol 15 (1) ◽  
pp. 18-22
Author(s):  
Erum Saboohi ◽  
Nighat Seema ◽  
Abdulah Hadi Hassan
Keyword(s):  
Risk Factors ◽  
Antenatal Care ◽  
Preterm Delivery ◽  
Neonatal Outcome ◽  
Neonatal Outcomes ◽  
P Value ◽  
Medical College ◽  
Adverse Neonatal Outcome ◽  
Adverse Neonatal Outcomes ◽  
Nicu Admission

Background: The study was done to identify the maternal and fetal factors contributing to neonatal outcome and to evaluate the correlation between risk factors and adverse neonatal outcome. Subjects and methods: This prospective observational study was conducted on 126 mothers and their neonates fulfilling the selection criteria at Al-Tibri Medical College and Hospital. A self-designed Performa was used to enter data of subjects. Sick neonates were referred to neonatal intensive care unit for admission and management. The results were analyzed by using SPSS version 22. A p-values <0.05 was considered as significant. Results: Out of 126 enrolled subjects, 81% mothers were multigravidas, 31% were unbooked, 13.5% had gestational comorbidities, 15% were drug addict, 2% were Hepatitis B positive. 22.2% underwent emergency LSCS while 31.7% delivered babies by elective LSCS. Regarding fetal factors contributing to sick babies, IUGR (20%), twin fetuses (15.4%), prematurity (47.7%) were significant. 65 were sick babies. Adverse neonatal outcomes observed were prematurity in 25.4%, IUGR in 11.1%, NICU admission in 33.3%, and neonatal death in 2%. Risk factors associated with adverse neonatal outcomes were positive maternal drug addiction (p-value = 0.028), preterm delivery (p-value<0.001), NICU admission (p-value<0.001) and low birth weight (p-value <0.001). Conclusion: Compromised maternal antenatal care has profound deleterious effect on fetus and neonate. Obstetricians, perinatologists and neonatologists need to work in concord to improve maternal antenatal care hence improving neonatal outcome. In our study adverse neonatal outcome was associated with unbooked cases, delivery by EmLSCS, addicted mother, preterm delivery, LBW and neonates requiring NICU admission.

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