The epidemiology of Kawasaki disease: a global update

2015 ◽  
Vol 100 (11) ◽  
pp. 1084-1088 ◽  
Author(s):  
Surjit Singh ◽  
Pandiarajan Vignesh ◽  
David Burgner
Keyword(s):  
Public Health ◽  
Heart Disease ◽  
North America ◽  
Kawasaki Disease ◽  
Common Cause ◽  
China And India ◽  
Global Epidemiology ◽  
Acquired Heart Disease ◽  
Childhood Vasculitis ◽  
Rheumatic Heart

Kawasaki disease (KD) is a childhood vasculitis and the most frequent cause of paediatric acquired heart disease in North America, Europe and Japan. It is increasingly recognised in rapidly industrialising countries such as China and India where it may replace rheumatic heart disease as the most common cause of acquired heart disease in children. We review the current global epidemiology of KD and discuss some public health implications.

scholarly journals The emergence of Kawasaki disease in India and China

2018 ◽  
Vol 2017 (3) ◽  
Author(s):  
Ankur Kumar Jindal ◽  
Vingesh Pandiarajan ◽  
Raju Khubchandani ◽  
Nutan Kamath ◽  
Tapas Sabui ◽  
...  
Keyword(s):  
Developing Countries ◽  
Heart Disease ◽  
Kawasaki Disease ◽  
Developed Countries ◽  
Resource Constrained ◽  
Diagnosis And Management ◽  
China And India ◽  
The World ◽  
Acquired Heart Disease ◽  
India And China

Kawasaki disease (KD) is recognized as a leading cause of acquired heart disease in children in developed countries. Although global in distribution, Japan records the highest incidence of KD in the world. Epidemiological reports from the two most populous countries in the world, namely China and India, indicate that KD is now being increasingly recognized. Whether this increased reporting is due to increased ascertainment, or is due to a true increase in incidence, remains a matter of conjecture. The diagnosis and management of KD in developing countries is a challenging proposition. In this review we highlight some of the difficulties faced by physicians in managing children with KD in resource-constrained settings. 

scholarly journals Incomplete Kawasaki Disease: What Can We Do About It?

2020 ◽  
Vol 25 (4) ◽  
pp. 57-59
Author(s):  
Luminiţa Dobrotă ◽  
Corina Cazan ◽  
Dan-Vladimir Bratu ◽  
Bogdan Neamţu
Keyword(s):  
Heart Disease ◽  
Kawasaki Disease ◽  
Inflammatory Process ◽  
Rare Condition ◽  
Incomplete Kawasaki Disease ◽  
Common Cause ◽  
Surgical Interventions ◽  
Coronary Aneurysms ◽  
Acquired Heart Disease ◽  
The Right

Abstract Kawasaki disease is a rare condition that mainly affects children younger than 6 years old. However, it represents the most common cause of acquired heart disease and the second most frequent vasculitis in children. Its importance consists in cardiac (coronary) complications identified in adults younger than 40 years old. Early diagnosis is pivotal for preventing (or reducing) coronary aneurysms and avoiding, at least, later unnecessary surgical interventions. Full (classic, complete) Kawasaki disease is easily diagnosed, even if the symptoms are not always present at the same time and most of them are unspecific. Incomplete Kawasaki disease implies challenge, delay or misdiagnosis. “Picking it up early is a winner” – the specialists say, so that early treatment administered at the right moment can stop the inflammatory process leading to much better outcomes, consequently.

scholarly journals Coronary Heart Disease in Children with Kawasaki Disease : PROCEEDINGS OF THE III. CONFERENCE ON PREVENTION FOR RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE

1979 ◽  
Vol 43 (5) ◽  
pp. 469-475 ◽  
Author(s):  
HIROHISA KATO ◽  
SHIGEYUKI KOIKE ◽  
CHIHEI TANAKA ◽  
KAZUOKI YOKOCHI ◽  
FUMIO YOSHIOKA ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Kawasaki Disease ◽  
Rheumatic Fever ◽  
Rheumatic Heart Disease ◽  
Rheumatic Heart

scholarly journals Effect of COVID-19 on Kawasaki Disease: Decrease Age of Onset and Increase Skin Manifestation

2021 ◽  
Author(s):  
Hossein Esmaeilzadeh ◽  
Negar Mortazavi ◽  
Alireza Salehi ◽  
Hossein Fatemian ◽  
Seyed Mohsen Dehghani ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Clinical Laboratory ◽  
Age Of Onset ◽  
P Value ◽  
Skin Manifestation ◽  
Significant Difference ◽  
Acquired Heart Disease ◽  
Apparent Reason ◽  
Childhood Vasculitis ◽  
Echocardiographic Findings

Abstract Kawasaki Disease (KD) is most common childhood vasculitis and cause of acquired heart disease for no apparent reason. There is some evidence indicating infectious agents as possible triggers for KD. During the COVID-19 pandemic, vasculitis has been a presentation of COVID-19 in children.ObjectiveWe performed this study to assess the association between KD and COVID-19.Methods and MaterialsWe evaluated KD hospitalized children during February to September 2020 for COVID-19 (group one) and compared their demographic, clinical, laboratory, and echocardiographic findings with KD patients from the same period time in 2019 (group two). We also compared the same data in COVID-19 positive and COVID-19 negative KD patients in 2020 pandemic period.ResultsSixty eight percent of group one KD patients were positive for COVID-19 during the pandemic period. KD Age of onset in the group one was lower than group two (4.38 years VS 5.5 years, P-value= 0.044). There was no difference in the demographic, clinical, laboratory, and echocardiographic features of the patients during and before the COVID-19 pandemic (p-value > 0.05). Moreover, Comparing COVID-19 positive and negative patients, the incidence of rash was higher within COVID-19 positive cases (p<0.05), and coronary artery abnormalities were more prevalent in COVID-19 negative cases (p < 0.05).ConclusionAdmission rate of KD does not have significant difference during the COVID-19 pandemic but 68% of KD admitted patient were COVID-19 positive. Age of onset for KD during the COVID-19 pandemic was lower and skin manifestation was higher than the same period time in last year.

scholarly journals Association of Kawasaki Disease and COVID-19 in children

2021 ◽  
Author(s):  
hossein esmaeilzadeh ◽  
Negar Mortazavi ◽  
Alireza Salehi ◽  
Hossein Fatemian ◽  
Hossein Molavi Vardanjani
Keyword(s):  
Kawasaki Disease ◽  
Clinical Laboratory ◽  
Age Of Onset ◽  
Admission Rate ◽  
P Value ◽  
Significant Difference ◽  
Acquired Heart Disease ◽  
Apparent Reason ◽  
Childhood Vasculitis ◽  
Echocardiographic Findings

Abstract Kawasaki Disease (KD) is most common childhood vasculitis and cause of acquired heart disease for no apparent reason. There is some evidence indicating infectious agents as possible triggers for KD. During the COVID-19 pandemic, vasculitis has been a presentation of COVID-19 in children. Objective We performed this study to assess the association between KD and COVID-19. Methods and Materials We evaluated KD hospitalized children during February to September 2020 for COVID-19 (group one) and compared their demographic, clinical, laboratory, and echocardiographic findings with KD patients from the same period of time in 2019 (group two). We also compared the same data in COVID-19 positive and COVID-19 negative KD patients in 2020 pandemic period. Results 68% of KD patients in group one were positive for COVID-19 during the pandemic period. KD Age of onset in the group one was lower than group two (4.38 years VS 5.5 years, P-value= 0.044). There was no difference in the demographic, clinical, laboratory, and echocardiographic features of the patients during and before the COVID-19 pandemic (p-value > 0.05). Moreover, Comparing COVID-19 positive and negative patients, the incidence of rash was higher within COVID-19 positive cases (p<0.05), and coronary artery abnormalities were more prevalent in COVID-19 negative cases (p < 0.05). Conclusion Admission rate of KD does not have significant difference during the COVID-19 pandemic but 68% of KD admitted patient were COVID-19 positive. Age of onset for KD during the COVID-19 pandemic was lower than the same period of time in last year.

scholarly journals A Case of Massive Left Atrial Thrombus

2021 ◽  
Author(s):  
John Ahn ◽  
Colin Burke ◽  
Lindsay Howitt ◽  
Tim Glenie ◽  
Gary Lau
Keyword(s):  
Heart Disease ◽  
Mitral Stenosis ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Mitral Valve Stenosis ◽  
Left Atrial Thrombus ◽  
Atrial Thrombus ◽  
Left Atrial Appendage Thrombus ◽  
Common Cause ◽  
Rheumatic Heart

Rheumatic heart disease is the most common cause of mitral valve stenosis. Left atrial appendage thrombus is associated with mitral stenosis, but in rare cases the thrombus can extend to the left atrial cavity. We present a case of a severe rheumatic mitral stenosis and associated large left atrial thrombus, with embolic sequelae.

Recurrence of coronary artery lesions after complete regression in a peculiar case of Kawasaki disease

2019 ◽  
Vol 29 (5) ◽  
pp. 714-716
Author(s):  
Shiv D. Sharma ◽  
Kanupriya Chaturvedi ◽  
Avesh Saini ◽  
Swatantra Rathore ◽  
Mohit Tayal
Keyword(s):  
Heart Disease ◽  
Clinical Practice ◽  
Coronary Artery ◽  
Kawasaki Disease ◽  
Complete Regression ◽  
Coronary Artery Lesions ◽  
Acquired Heart Disease ◽  
Peculiar Case

AbstractKawasaki disease is a leading cause of acquired heart disease in children with serious repercussions of coronary artery lesions. Recurrences of the disease are relatively rare in clinical practice. We present a case of recurrent Kawasaki disease, wherein the coronary artery lesions which were documented during the initial illness demonstrated complete regression over the following months, but reappeared with recurrence of the disease.

scholarly journals Rheumatic Heart Disease Special Issue of Nepalese Heart Journal

2016 ◽  
Vol 13 (2) ◽  
Author(s):  
Dipanker Prajapati
Keyword(s):  
Heart Disease ◽  
Rheumatic Heart Disease ◽  
Social Impact ◽  
Prime Factor ◽  
Premature Death ◽  
Socioeconomic Conditions ◽  
Special Issue ◽  
Hospitalization Costs ◽  
Acquired Heart Disease ◽  
Rheumatic Heart

Rheumatic fever (RF) and Rheumatic Heart Disease (RHD) accounts for most cases of acquired heart disease in children and young adult, in the developing world. It causes considerable suffering, serious disability and premature death with significant social impact in terms of hospitalization costs and clinic visits. Prevalence is more common in areas of overcrowding and poor socioeconomic conditions. The treatment is highly influenced in our country by its geographical condition and also the lack of financial resources, but the lack of knowledge seems to be the prime factor.

scholarly journals A Decade of NT-proBNP in Acute Kawasaki Disease, from Physiological Response to Clinical Relevance

Children ◽  
2018 ◽  
Vol 5 (10) ◽  
pp. 141 ◽  
Author(s):  
Audrey Dionne ◽  
Nagib Dahdah
Keyword(s):  
Heart Disease ◽  
Coronary Artery ◽  
Kawasaki Disease ◽  
Confidence Interval ◽  
Positive Likelihood Ratio ◽  
Biological Marker ◽  
Febrile Illness ◽  
Diagnostic Algorithm ◽  
Acquired Heart Disease ◽  
Acute Kawasaki Disease

Kawasaki disease (KD) is an inflammatory febrile illness of early childhood and the primary cause of acquired heart disease during childhood. Coronary artery aneurysms (CAA) are a serious complication of KD, leading to ischemic heart disease, myocardial infarction, and sudden cardiac death. Timely diagnosis in the first ten days of fever is crucial to reduce the risk of coronary artery complications. Nitrogen-terminal B-type natriuretic peptide (NT-proBNP), originally used for the management of adults with heart disease, was shown to be useful in the diagnosis and management of patients with KD. NT-proBNP is released by cardiomyocytes in response to mechanical factors such as the dilation of cardiac chambers, and to pro-inflammatory cytokines. The utility of NT-proBNP as a biological marker in KD is based on the universal myocardial inflammatory component early in the course of the disease. Patients with KD have higher NT-proBNP at the time of diagnosis than febrile controls, with a pooled sensitivity of 89% (95% confidence interval 78–95), and a specificity of 72% (95% confidence interval 58–82). The positive likelihood ratio is 3.2:1 (95% confidence interval 2.1–4.8). Moreover, patients with resistance to intravenous immunoglobulin treatment and CAA were found to have higher levels of NT-proBNP, suggesting a prognostic role. Nevertheless, the non-specificity of NT-proBNP to KD limits its use as a stand-alone test. In this light, a tentative associative retrospective diagnostic algorithm was highly reliable for including all cases at risk of CAA, which warrants further prospective studies for a better diagnostic index of suspicion and risk stratification of patients.

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