scholarly journals Biosimilar infliximab use in paediatric IBD

2017 ◽  
Vol 103 (1) ◽  
pp. 89-91 ◽  
Author(s):  
Lisa Richmond ◽  
Lee Curtis ◽  
Victoria Garrick ◽  
Pam Rogers ◽  
Michelle Wilson ◽  
...  
Keyword(s):  
Cost Savings ◽  
Electronic Patient Records ◽  
Significant Cost ◽  
Data Set ◽  
Total Cost ◽  
Significant Safety ◽  
Safety Issues ◽  
Inflammatory Bowel ◽  
The Uk ◽  
First Time

BackgroundBiosimilar infliximab became available in the UK in 2015. Paediatric experience to date on its use is limited. We prospectively evaluated the safety and efficacy of biosimilar infliximab (Remsima) in two paediatric gastroenterology networks in patients with inflammatory bowel disease.MethodsProspective clinical data were collected from laboratory reports, electronic patient records and case notes of 40 patients starting Remsima for the first time. Disease activity scores together with blood and stool biomarkers were used to assess response.ResultsOur data set highlights that Remsima was associated with a significant clinical and biochemical improvement (p<0.01 or less for all parameters assessed) in Crohn’s disease post induction. There were no significant safety issues noted. The total cost saving was £47 800, representing a 38% reduction from originator.ConclusionWe found that biosimilar infliximab is as effective as originator infliximab and its use is associated with significant cost savings.

scholarly journals Design Development of a Coffee Maker using Design for Assembly Method

2019 ◽  
Vol 9 (2) ◽  
pp. 4041-4047
Keyword(s):  
Cost Savings ◽  
Design For Assembly ◽  
Design Development ◽  
Significant Cost ◽  
Total Cost ◽  
Assembly Method ◽  
Current Design ◽  
Manual Handling ◽  
Improved Design ◽  
The Cost

The purpose of this research is to evaluate the design of a coffee maker by using Boothroyd Dewhurst Method which this method is one of the Design for Assembly (DFA) methods. DFA method will help to simplify the assembly designs of the product that will leads to significant cost savings and less tine to produce a product. Main objective of DFA is to estimate the difficulty of assembly, eliminate unnecessary parts and assembly tooling and design products that are less costly to manufacture. The study will focus on analyzing the current design of coffee maker, reducing the number of parts, comparing the design efficiency and the cost between the current and improved design. The product is evaluated by using Manual Handling Table and Manual Insertion Table. The results of current design are used to make improvement to the coffee maker. Then, new design is made by eliminating or combining the old design so that total cost and time for assemble the coffe maker is reduced. Lastly, comparison is made between new and old design.

scholarly journals The global distribution of the M1 ocean tide

Ocean Science ◽  
2019 ◽  
Vol 15 (2) ◽  
pp. 431-442
Author(s):  
Philip L. Woodworth
Keyword(s):  
Tide Gauge ◽  
Local Level ◽  
Small Degree ◽  
Ocean Tide ◽  
Tide Gauge Records ◽  
Data Set ◽  
Worldwide Distribution ◽  
Tidal Potential ◽  
The Uk ◽  
First Time

Abstract. The worldwide distribution of the small degree-3 M1 ocean tide is investigated using a quasi-global data set of over 800 tide gauge records and a global tide model. M1 is confirmed to have a geographical variation in the Atlantic consistent with the suggestion of Platzman (1984b) and Cartwright (1975) that M1 is generated in the ocean as a consequence of the spatial and temporal overlap of M1 in the tidal potential and one (or at least a small number of) diurnal ocean normal mode(s). As a consequence, it is particularly strong around the UK and on North Sea coasts (amplitudes ∼10 mm). This analysis shows that their suggestion is also consistent to a great extent with the observed small amplitudes in the Pacific and Indian oceans. However, there are differences at the regional and local level which require much further study via more sophisticated ocean tidal modelling. By contrast, what is called the M1' tide (a combination of several degree-2 lines in the tidal potential with frequencies close to that of M1) is shown to have a geographical distribution consistent with expectations from other degree-2 diurnal tides, apart from locations such as around the UK where tidal interactions introduce complications. As far as I know, this is the first time that these small tidal constituents have been mapped on a global basis and, in particular, the first time that the ocean response to the degree-3 component of the tidal potential has been investigated globally.

scholarly journals Cost Minimisation Using Clinic-Based Treatment for Common Hand Conditions – A Prospective Economic Analysis

2009 ◽  
Vol 91 (2) ◽  
pp. 135-139 ◽  
Author(s):  
JA Webb ◽  
J Stothard
Keyword(s):  
Surgical Treatment ◽  
Economic Analysis ◽  
Cost Savings ◽  
Dupuytren’S Disease ◽  
Significant Cost ◽  
Cost Of Treatment ◽  
Dupuytren's Disease ◽  
Total Cost ◽  
Cost Minimisation ◽  
The Cost

INTRODUCTION The purpose of this study was to compare the cost of treatment of Dupuytren's disease, ganglia and trigger digits in the out-patient department with the operating theatre. PATIENTS AND METHODS All patients seen in a new patient hand clinic with a diagnosis of Dupuytren's disease, trigger digit or ganglion of the wrist or hand requiring treatment were prospectively identified over a 6-month period. The numbers undergoing a procedure in the out-patient clinic or theatre were recorded. Costings of theatre time and out-patient time, as well as national tariff income, were obtained from the hospital management. RESULTS Over the 6-month period, 80, 26, and 52 patients were treated with regard to Dupuytren's disease, ganglia and trigger digits, respectively. Of these, 37, 23, and 44 were treated by an out-patient procedure, and 43, 3 and 8 underwent a formal operation. The total cost of the out-patient procedures was calculated at £1560 over 6 months. To perform these as formal operations would have cost £64,896. The cost savings were, therefore, £63,336, or £126,672 per annum. CONCLUSIONS Out-patient interventions for Dupuytren's disease, ganglia and trigger digits result in significant cost savings over formal surgical treatment.

scholarly journals International Real Estate Review

2020 ◽  
Vol 23 (3) ◽  
pp. 397-416
Author(s):  
William Miles ◽  
Keyword(s):  
House Prices ◽  
Data Set ◽  
Nonlinear Adjustment ◽  
Stable Relationship ◽  
Home Prices ◽  
Long Run ◽  
Income Ratio ◽  
The Uk ◽  
First Time ◽  
The Relationship

Asset prices and fundamentals can move apart, as is the case during bubble episodes. However, they should exhibit a stable relationship in the long run. For UK housing, previous studies have investigated whether house prices share a long run relationship with income. Results thus far have not yet found such stability in the interaction of the two variables. These previous papers have imposed linear adjustment on the relationship. Nonlinear adjustment, however, has been shown to be a feature in a number of housing market relationships. In this study, we utilize a data set that consists of home prices relative to first time buyer income for the UK and its twelve constituent regions, which gives us a direct measure of affordability. We test for the stationarity of the home price/first time buyer income ratio with linear tests, and, as in past studies, fail to find a long run relationship. However, we then employ a nonlinear test, and find a stationary relationship for the UK and seven of the twelve regions. In particular, the regions closest to London appear most clearly to have a stationary relationship between home prices and income.

scholarly journals Outsourcing in Sandy Springs and Other US Cities: Insights for Other Countries

2014 ◽  
Vol 11 (3-4) ◽  
pp. 7-24
Author(s):  
Ari-Veikko Anttiroiko ◽  
Stephen J. Bailey ◽  
Pekka Valkama
Keyword(s):  
Public Sector ◽  
Professional Practice ◽  
Large Scale ◽  
Cost Savings ◽  
Significant Cost ◽  
Key Issues ◽  
The Uk ◽  
The City ◽  
Us Cities ◽  
Special Case

This paper analyses the partnership-based outsourcing model of service transformation in USA local government, focusing on the city of Sandy Springs which became widely known for its large-scale ‘turnkey’ outsourcing of provision of its services in the mid-2000s. This city has been referred to in the literature as a special case not applicable to other countries, such as the UK, because of their very different contexts. However, there is now a public sector austerity context within which to reassess Sandy Springs’ use of turnkey outsourcing to achieve significant cost savings and improve services. The paper reports empirical research which it uses to derive insights for municipalities considering outsourcing. Those insights can help improve both policy and professional practice by outlining key issues for consideration when trying to ‘do more with less’ money.

scholarly journals The global distribution of the M1 ocean tide

2019 ◽  
Author(s):  
Philip L. Woodworth
Keyword(s):  
Tide Gauge ◽  
Local Level ◽  
Normal Modes ◽  
Small Degree ◽  
Ocean Tide ◽  
Tide Gauge Records ◽  
Data Set ◽  
Tidal Potential ◽  
The Uk ◽  
First Time

Abstract. The worldwide distribution of the small degree-3 M1 ocean tide is investigated using a quasi-global data set of over 800 tide gauge records and a global tide model. M1 is confirmed to have a geographical variation in the Atlantic consistent with the suggestion of Platzman and Cartwright that M1 is generated in the ocean as a consequence of the spatial and temporal overlap of M1 in the tidal potential and one (or at least a small number) of diurnal ocean normal modes. As a consequence, it is particularly strong around the UK and on North Sea coasts. This analysis shows that their suggestion is also consistent to a great extent with the observed small amplitudes in the Pacific and Indian Oceans. However, there are differences at the regional and local level which require much further study via more sophisticated ocean tidal modelling. By contrast, the M1' tide is shown to have a geographical distribution consistent with expectations from other degree-2 diurnal tides, apart from locations such as around the UK where tidal interactions introduce complications. As far as we know, this is the first time that these small tidal constituents have been mapped on a global basis and, in particular, the first time that the ocean response to the degree-3 component of the tidal potential has been investigated globally.

scholarly journals A pilot study of the duration of GP consultations in Ireland

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Tom Pierse ◽  
Luke Barry ◽  
Liam Glynn ◽  
Diarmuid Quinlan ◽  
Andrew Murphy ◽  
...  
Keyword(s):  
Pilot Study ◽  
Administrative Data ◽  
Average Duration ◽  
Research Network ◽  
Electronic Patient Records ◽  
Data Set ◽  
International Trends ◽  
Patients With Diabetes ◽  
The Uk ◽  
Opening And Closing

Abstract Background General practitioner (GP)-led primary care is the linchpin of health care in Ireland. Reflecting international trends, there are increasing concerns about the sustainability of the current Irish GP service due to an increasing workload. Objective data on the duration of GP consultations are currently not available in Ireland. The objective of this pilot study is to demonstrate how the duration of consultations can be collected, using readily available administrative data. Methods Software was developed to extract the duration of GP consultations using the opening and closing of electronic patient records associated with a GP consultation. GP practices (N = 3) comprising 15 GPs were recruited from a university-affiliated research network. A retrospective analysis of GP consultations with patients with diabetes for the 9 years between 2010 and 2018 was used to assess the feasibility of using this system to measure the duration of consultations. Results The average duration of a consultation was 14.1 min for the 9 years spanning 2010 to 2018. Patients had an average time between consultations of 99 days. Conclusions This pilot study confirms that an administrative data set can be utilised at negligible cost to monitor GP practice consultation workload over time. Our preliminary pilot data show that GP consultation durations among participating practices were longer than the 5–11.7 min reported in the UK and show an increase over the period. Clearly, a larger number of practices and patients are required to substantiate this finding.

Childhood Intelligence Predicts Adult Trait Openness

2016 ◽  
Vol 37 (2) ◽  
pp. 105-111 ◽  
Author(s):  
Adrian Furnham ◽  
Helen Cheng
Keyword(s):  
Structural Equation Modeling ◽  
Structural Equation ◽  
Social Background ◽  
Study Data ◽  
Equation Modeling ◽  
Direct Effects ◽  
Data Set ◽  
National Child Development Study ◽  
Nationally Representative ◽  
The Uk

Abstract. This study used a longitudinal data set of 5,672 adults followed for 50 years to determine the factors that influence adult trait Openness-to-Experience. In a large, nationally representative sample in the UK (the National Child Development Study), data were collected at birth, in childhood (age 11), adolescence (age 16), and adulthood (ages 33, 42, and 50) to examine the effects of family social background, childhood intelligence, school motivation during adolescence, education, and occupation on the personality trait Openness assessed at age 50 years. Structural equation modeling showed that parental social status, childhood intelligence, school motivation, education, and occupation all had modest, but direct, effects on trait Openness, among which childhood intelligence was the strongest predictor. Gender was not significantly associated with trait Openness. Limitations and implications of the study are discussed.

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