scholarly journals One year change of knee cartilage morphology in the first release of participants from the Osteoarthritis Initiative progression subcohort: association with sex, body mass index, symptoms and radiographic osteoarthritis status

2008 ◽  
Vol 68 (5) ◽  
pp. 674-679 ◽  
Author(s):  
F Eckstein ◽  
S Maschek ◽  
W Wirth ◽  
M Hudelmaier ◽  
W Hitzl ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Body Mass ◽  
Statistical Significance ◽  
Weight Bearing ◽  
Rate Of Change ◽  
Cartilage Loss ◽  
Knee Oa ◽  
Symptomatic Knee ◽  
Osteoarthritis Initiative

Objective:The Osteoarthritis Initiative (OAI) is a multicentre study targeted at identifying biomarkers for evaluating the progression and risk factors of symptomatic knee OA. Here cartilage loss using 3 Tesla (3 T) MRI is analysed over 1 year in a subset of the OAI, together with its association with various risk factors.Methods:An age- and gender-stratified subsample of the OAI progression subcohort (79 women and 77 men, mean (SD) age 60.9 (9.9) years, body mass index (BMI) 30.3 (4.7)) with both frequent symptoms and radiographic OA in at least one knee was studied. Coronal FLASHwe (fast low angle shot with water excitation) MRIs of the right knee were acquired at 3 T. Seven readers segmented tibial and femoral cartilages blinded to order of acquisition. Segmentations were quality controlled by one expert.Results:The reduction in mean cartilage thickness (ThC) was greater (p = 0.004) in the medial than in the lateral compartment, greater (p = 0.001) in the medial femur (−1.9%) than in the medial tibia (−0.5%) and greater (p = 0.011) in the lateral tibia (−0.7%) than in the lateral femur (0.1%). Multifactorial analysis of variance did not reveal significant differences in the rate of change in ThC by sex, BMI, symptoms and radiographic knee OA status. Knees with Kellgren–Lawrence grade 2 or 3 and with a BMI >30 tended to display greater changes.Conclusions:In this sample of the OAI progression subcohort, the greatest, but overall very modest, rate of cartilage loss was observed in the weight-bearing medial femoral condyle. Knees with radiographic OA in obese participants showed trends towards higher rates of change than those of other participants, but these trends did not reach statistical significance.

scholarly journals Status gizi berhubungan positif dengan derajat nyeri sendi penderita osteoartritis lutut

2012 ◽  
Vol 8 (3) ◽  
pp. 144 ◽  
Author(s):  
Nyoman Kertia
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Knee Osteoarthritis ◽  
Body Mass ◽  
Joint Pain ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Knee Oa ◽  
Vas Score ◽  
Bivariate Correlation

Background: Knee osteoarthritis (OA) is a common disorder that is associated with significant morbidity, disability, and medical costs, particularly in its advanced stages. While the cause of knee OA remains unclear, it has been associated with various risk factors, such as age, sex, genetic predisposition, biomechanical, and obesity. Pain in osteoarthritis occurs due to combination of various factors. Pain significantly increases the medical and non medical cost in OA. Data showed that obesity will increase the mechanical stress and pain of knee OA. However, uncertainty remains regarding potential relationship between body mass index (BMI) and pain in osteoarthritis. Moreover, since obesity is one of modifiable and preventable risk factors for the onset and progression of the disease, it is important to know the correlation between BMI and severity of pain in knee OA.Objectives: To investigate the relationship between body mass index and severity of joint pain in knee osteoarthritis.Methods: A cross sectional study was conducted and subjects were osteoarthritis patients in rheumatology clinic of Sardjito general hospital. Body mass index and visual analogue scale (VAS) score were measured. Correlation between BMI and VAS score were analyzed by bivariate correlation test.Results: There were 80 patients with osteoarthritis who participated in the study. Mean BMI was 26.36 +4.23 kg/m2 and VAS score was 52.40+24.53 mm. The correlation test showed that there was a positive but non significant correlation between BMI and VAS scores (r = 0,11; p = 0,33).Conclusion: There was a positive but non significant correlation between body mass index and the severity of joint pain in knee osteoarthritis.

scholarly journals Body Mass Index Mediates the Association between Dietary Fiber and Symptomatic Knee Osteoarthritis in the Osteoarthritis Initiative and the Framingham Osteoarthritis Study

2018 ◽  
Vol 148 (12) ◽  
pp. 1961-1967 ◽  
Author(s):  
Zhaoli Dai ◽  
S Reza Jafarzadeh ◽  
Jingbo Niu ◽  
David T Felson ◽  
Paul F Jacques ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Knee Osteoarthritis ◽  
Dietary Fiber ◽  
Body Mass ◽  
Framingham Study ◽  
Inverse Association ◽  
Fiber Intake ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee ◽  
Osteoarthritis Initiative

ABSTRACT Background Dietary fiber reduces body weight and inflammation in clinical trials. It is unclear whether body mass index (BMI) and inflammation might explain the observed association between higher fiber intake and the lower risk of symptomatic knee osteoarthritis (SXKOA). Objectives We quantified the extent to which BMI and inflammation influenced the relation between dietary fiber and SXKOA. Methods We used longitudinal data from the Osteoarthritis Initiative (OAI) and the Framingham Offspring Osteoarthritis Study. At baseline of each study, men and women (mean age: 61 y) with or at risk of knee osteoarthritis were followed for 48 mo in the OAI. Adults (mean age: 53 y) were followed for 9.5 y in the Framingham study. Dietary fiber intake was estimated using a validated food-frequency questionnaire. Measured weight and height were used to calculate BMI. Serum high-sensitivity C-reactive protein (CRP) was measured in the Framingham study only. Incident SXKOA was defined as new onset of a combination of knee pain and radiographic osteoarthritis. We applied marginal structural models to quantify the mediation through BMI in the OAI and the sequential mediation through BMI and CRP in the Framingham study. Results Incident SXKOA occurred in 861 knees among 2876 persons in the OAI and in 143 knees among 971 persons in the Framingham study. In persons whose fiber intake was ≥21 g/d compared with those with intakes <21 g/d, the OR (95% CI) was 0.70 (0.53, 0.91) for the overall association with SXKOA and was 0.93 (0.92, 0.95) for the mediation via BMI (per kg/m2) in the OAI. In the Framingham study, the overall association was 0.57 (0.30, 1.09), the mediation through BMI (via BMI and the influence of BMI on CRP) was 0.94 (0.85, 1.02), and the mediation through CRP (per milligram per liter) was 0.99 (0.84, 1.19). Conclusion Our findings suggest that the inverse association of fiber intake and the risk of incident symptomatic knee osteoarthritis is partially mediated by BMI.

scholarly journals Association of age, sex and BMI with the rate of change in tibial cartilage volume: a 10.7-year longitudinal cohort study

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Guoqi Cai ◽  
Matthew Jiang ◽  
Flavia Cicuttini ◽  
Graeme Jones
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Average Rate ◽  
Lateral Compartment ◽  
Cartilage Volume ◽  
Rate Of Change ◽  
Cartilage Loss ◽  
Linear Regression Models ◽  
Tibial Cartilage ◽  
Radiographic Osteoarthritis

Abstract Background To describe the association of age, sex and body mass index with the rate of change of tibial knee cartilage volume over 10.7 years in a community-based sample of older adults. Methods Four hundred and eighty-one participants (49% female, mean age 60.8 years [range 51.1–79.7], 49% had knee pain and 58% radiographic osteoarthritis) were included. Tibial cartilage volume of the right knee was assessed on T1-weighted fat-suppressed 1.5 T MRI at baseline and 10.7 years. Data analyses were performed using linear regression models. Results The average rate of loss of cartilage volume was 1.2%/year (range 0.2–3.9%) with all participants losing cartilage volume over the study period. There was a significant association between age and loss of tibial cartilage volume in the medial (0.023%/year, 95% confidence interval [CI] 0.010 to 0.036%, p < 0.001), lateral (0.013%/year, 95% CI 0.003 to 0.023%, p = 0.012) and total tibia (0.018%/year, 95% CI 0.009 to 0.026%, p < 0.001). Higher body mass index at baseline and increases in body mass index over time were associated with a greater tibial cartilage loss at the medial (body mass index at baseline 0.040%/year, 95% CI 0.022 to 0.058%, p < 0.001; increases in body mass index 0.055%/year, 95% CI 0.018 to 0.093%, p = 0.004) but not lateral compartment. No evidence of non-linear relationships was observed. Compared to males, females lost more lateral tibial cartilage with increasing age (0.023%/year, 95% CI 0.003 to 0.043%, p = 0.024 for interaction). Conclusions Tibial cartilage volume declines at a faster rate with increasing age and body mass index in both males and females, particularly in the medial compartment. In contrast to the low rate of change in radiographs, our findings suggest that cartilage loss at the tibia is universal in this age group.

scholarly journals Anal and urinary incontinence in nulliparous women – Prevalence and associated risk factors

2021 ◽  
pp. 205336912110053
Author(s):  
Nicola A Okeahialam ◽  
Ranee Thakar ◽  
Andrei Ilczyszyn ◽  
Abdul H Sultan
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Urinary Incontinence ◽  
Body Mass ◽  
Anal Incontinence ◽  
Statistical Significance ◽  
Validated Questionnaire ◽  
Nulliparous Women ◽  
History Of Childbirth ◽  
Associated Risk Factors

Objective To establish the prevalence and risk factors of urinary and anal incontinence in nulliparous women. Study design Thirty-one catholic convents were sent a validated questionnaire to determine the prevalence and severity of urinary incontinence, and a similarly structured questionnaire to assess anal incontinence. Multivariable regression models were used to determine independent risk factors associated with the likelihood of urinary incontinence or anal incontinence. Main outcome measures Urine/faecal/flatal incontinence and symptom severity. Results Of 202 nuns, 167 (83%) returned the questionnaire. Twenty-two women were excluded due to history of childbirth. Of 145 nulliparous women, 56.2% reported urinary incontinence and 53.8% reported anal incontinence. Women aged 66–76 years had significantly increased odds of experiencing urinary incontinence in comparison to women aged 40–65 years: OR: 2.35 (95% CI: 1.02–5.45) ( p = 0.04). The risk of urinary incontinence was increased in women with a body mass index ≥ 30 in comparison to those with a body mass index < 19: OR: 6.25 (95% CI: 1.03–38.08) ( p = 0.04). With regards to anal incontinence, although none of the differences with age and body mass index groups reached statistical significance, there was a trend towards women in higher body mass index groups having an increased prevalence of anal incontinence. Current/previous hormonal replacement therapy was also associated with significantly increased odds of experiencing urinary incontinence: OR: 2.53 (95% CI: 1.01–6.36), ( p = 0.04). However, when adjusting for age and body mass index, there was no significant association with urinary incontinence. Conclusions This study highlights that while childbirth is an important risk factor, urinary incontinence and anal incontinence also occur in over 50% of nulliparous women. Additional studies are required to identify other risk factors that may be associated with incontinence in this population.

scholarly journals Quantitative Cartilage Imaging in Knee Osteoarthritis

Arthritis ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-19 ◽  
Author(s):  
Felix Eckstein ◽  
Wolfgang Wirth
Keyword(s):  
Risk Factors ◽  
Quantitative Imaging ◽  
Cartilage Loss ◽  
Future Directions ◽  
Knee Oa ◽  
Cartilage Imaging ◽  
Osteoarthritis Initiative ◽  
Structural Disease ◽  
Mri Changes ◽  
Radiographic Changes

Quantitative measures of cartilage morphology (i.e., thickness) represent potentially powerful surrogate endpoints in osteoarthritis (OA). These can be used to identify risk factors of structural disease progression and can facilitate the clinical efficacy testing of structure modifying drugs in OA. This paper focuses on quantitative imaging of articular cartilage morphology in the knee, and will specifically deal with different cartilage morphology outcome variables and regions of interest, the relative performance and relationship between cartilage morphology measures, reference values for MRI-based knee cartilage morphometry, imaging protocols for measurement of cartilage morphology (including those used in the Osteoarthritis Initiative), sensitivity to change observed in knee OA, spatial patterns of cartilage loss as derived by subregional analysis, comparison of MRI changes with radiographic changes, risk factors of MRI-based cartilage loss in knee OA, the correlation of MRI-based cartilage loss with clinical outcomes, treatment response in knee OA, and future directions of the field.

The Relation of Body Mass Index to Biochemical Parameters and Profile of Heart Failure

2018 ◽  
Vol 69 (7) ◽  
pp. 1673-1677
Author(s):  
Viviana Aursulesei ◽  
Andrei Manta ◽  
Razan Al Namat ◽  
Monica Hugianu ◽  
Angela Maria Moloce ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Body Mass Index ◽  
Body Mass ◽  
Patient Selection ◽  
Biochemical Parameters ◽  
Obesity Paradox ◽  
Lipid Levels ◽  
Randomized Control ◽  
Selection Parameters

The bidirectional relation between body mass index (BMI) and heart failure (HF) is complex and not fully understood. The obesity paradox phenomena is controversial and related to patient selection, parameters used for defining abnormal weight, characteristics of HF. Our study sustain the importance of controlling risk factors, in particular plasma glucose, lipid levels, as well as hypertension in patients with HF and BMI over 25 kg/m2. Also, in contrast to the randomized control studies our results can only partially support data related to obesity paradox phenomena.

scholarly journals Cardio-Metabolic Risk Factors in Scottish South Asian and Caucasian Youth

2021 ◽  
Vol 18 (9) ◽  
pp. 4667
Author(s):  
Meizi Wang ◽  
Jianhua Ying ◽  
Ukadike Chris Ugbolue ◽  
Duncan S. Buchan ◽  
Yaodong Gu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
South Asian ◽  
Metabolic Risk Factors ◽  
Individual Risk ◽  
Metabolic Risk ◽  
Asian Adolescents ◽  
Individual Risk Factors

(1) Background: Scotland has one of the highest rates of obesity in the Western World, it is well established that poor weight profiles, and particularly abdominal obesity, is strongly associated with Type II diabetes and cardiovascular diseases. Whether these associations are apparent in ethnic population groups in Scotland is unclear. The purpose of this study was to examine the associations between different measures of fatness with clustered cardio metabolic risk factors between Scottish South Asian adolescents and Scottish Caucasian adolescents; (2) Methods: A sample of 208 Caucasian adolescents and 52 South Asian adolescents participated in this study. Stature, waist circumference, body mass index, blood pressure, physical activity, and cardiovascular disease (CVD) risk were measured; (3) Results: Significant, partial correlations in the South Asian cohort between body mass index (BMI) and individual risk factors were generally moderate. However, correlations between Waist circumference (WC) and individual risk factors were significant and strong. In the Caucasian cohort, a significant yet weak correlation between WC and total cholesterol (TG) was noted although no other associations were evident for either WC or BMI. Multiple regression analysis revealed that both BMI and WC were positively associated with CCR (p < 0.01) in the South Asian group and with the additional adjustment of either WC or BMI, the independent associations with clustered cardio-metabolic risk (CCR) remained significant (p < 0.005); (4) Conclusions: No positive relationships were found between BMI, WC, and CCR in the Caucasian group. Strong and significant associations between measures of fatness and metabolic risk were evident in Scottish South Asian adolescents.

scholarly journals FRI0415 BODY MASS INDEX AND STATIC FOOT DISORDERS IN GONARTHROSIC PATIENTS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 806.3-806
Author(s):  
K. Maatallah ◽  
M. Hfaidh ◽  
H. Ferjani ◽  
W. Triki ◽  
D. Kaffel ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Demographic Data ◽  
Navicular Bone ◽  
Hindfoot Alignment ◽  
Knee Oa ◽  
Postural Changes ◽  
Flat Feet ◽  
Foot Posture ◽  
Hindfoot Deformities

Background:Several studies have shown that there is a link between body mass index (BMI) and painful foot imputed to a biomechanical change in foot structure [1].Objectives:Our objective was to study the association between BMI and static foot disorders in gonarthrosic subjects.Methods:It was a prospective descriptive study conducted in the rheumatology department of the Mohamed Kassab Institute of Orthopedics with 60 patients with Gonarthrosis. The socio-demographic data of the patients were studied. BMI was calculated for all patients. Static foot disorders have been studied.Results:Sixty patients were included, 83.3% of whom were female. The average age was 55.2 years [38-78 years]. The disease has been evolving for an average of 6 years [1-13 years]. The lesion was bilateral in 80% of cases, the average body mass index was 30.4 kg / m2 [24-36]. Knee arthritis was classified as stage I, II and III according to the Kellgren and Lawrence classification in 18.5%, 55.6% and 25.9% of patients respectively. The foot examination involved 108 gonarthrosic limbs. Examination of the integuments showed hyperkeratosis in 94.4% of the cases (79.6% calluses and 83.3% callosities). Forefoot deformities were Hallux valgus (HV) in 52.8% of cases and overlapping toes in 18.5% of cases. Pronation deformity using the Foot Posture Index (FPI) was found in 51.9% of cases. Abnormal lowering of navicular bone was noted in 51.9%. The podoscopic impression revealed flat feet in 73.2% of the cases.A statistically significant association was found between BMI and the presence of calluses (31.21 ± 2.897 vs26.83 ± 1.425, p <0.001), with HV (31.37 ± 3.086 vs29.49 ± 2.969, p = 0.002), at the overlap of the toes (33.2 ± 1.361vs29.86 ± 1.130, p <0.001), with the lowering of the navicular bone (31.17 ± 2.885vs29.68 ± 3.304, p = 0.015), FPI (p = 0.003) and flat podoscopic impression (p <0.001).Conclusion:BMI is strongly associated with static feet disorders in gonarthrosic patients by aggravating the postural changes in the foot caused by knee osteoarthritis [2]. Obesity is associated mainly with the existence of flat feet, pronation of the foot, toes deformities and hyperkeratosis.References:[1]Steele JR, Mickle KJ, Munro B. Fat flat frail feet: how does obesity affect the older foot. XXII Congress of the International Society of Biomechanics; 2009[2]Norton AA, Callaghan JJ, Amendola A, Phisitkul P, Wongsak S, Liu SS, et al. Correlation of knee and hindfoot deformities in advanced knee OA: compensatory hindfoot alignment and where it occurs. Clin Orthop Relat Res. 2015;473(1):166-74Disclosure of Interests:None declared

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