Familial influence on tibiofemoral alignment

2009 ◽  
Vol 69 (3) ◽  
pp. 542-545 ◽  
Author(s):  
Abdurrahman Tufan ◽  
Ingrid Meulenbelt ◽  
Jessica Bijsterbosch ◽  
Herman M Kroon ◽  
Sita M A Bierma-Zeinstra ◽  
...  
Keyword(s):  
Familial Aggregation ◽  
Joint Involvement ◽  
Sibling Pairs ◽  
Tibiofemoral Angle ◽  
Knee Oa ◽  
History Of ◽  
Tibiofemoral Alignment ◽  
The Mean ◽  
Heritability Estimates ◽  
The Right

BackgroundTibiofemoral alignment has a role in knee osteoarthritis (OA), but which factors contribute to alignment is unknown.ObjectiveTo investigate familial aggregation of tibiofemoral alignment in participants of the GARP (Genetics ARthrosis and Progression) study.MethodsThe tibiofemoral anatomical angle on semiflexed knee radiographs was measured in sibling pairs (mean age 60 years, 81% women) with primary OA with multiple joint involvement. Radiographic OA was assessed according to the Kellgren–Lawrence (KL) method. Heritability estimates of the tibiofemoral angle were calculated by comparing twice the between-sibling variance with the total variance; adjustments were made for age, gender, body mass index, history of meniscectomy, lower limb fracture and in analyses including all knees, for KL score.Results360 subjects representing 180 families were studied. The mean (SD) tibiofemoral angle of right and left knees in the probands was 182.7 (2.9)° and 182.8 (2.6)°, respectively; similar angles were measured in the siblings. Radiographic knee OA (KL score ≥2) was present in 27% of the knees. Stratified analyses in sib pairs with non-osteoarthritic right or left knees showed adjusted heritability estimates of the tibiofemoral angle of the right and left knees of 0.42 (95% CI 0.02 to 0.82) and 0.56 (95% CI 0.19 to 0.93). In addition, adjusted heritability estimates of the tibiofemoral angle in all right and left knees were calculated, being 0.48 (95% CI 0.18 to 0.78) and 0.50 (95% CI 0.21 to 0.79), respectively.ConclusionThe alignment of the tibiofemoral joint is influenced by familial factors, implying that tibiofemoral malalignment may add to the genetic predisposition for knee OA development. These results need to be confirmed in other study populations.

scholarly journals P046 Pointing the finger: an unusual presentation of dactylitis

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_1) ◽  
Author(s):  
Natalia Cernovschi - Feasey ◽  
Julekha Wajed
Keyword(s):  
Pleural Effusion ◽  
Soft Tissue ◽  
Middle Finger ◽  
Joint Involvement ◽  
Long Bones ◽  
History Of ◽  
Systemic Symptoms ◽  
The Right ◽  
Hands And Feet ◽  
Radiographic Changes

Abstract Background/Aims  Dactylitis is commonly associated with psoriatic arthritis, and regularly presents at Rheumatology clinics. We discuss a case where progressive systemic symptoms lead to the consideration of alternate diagnoses. Methods  A 46-year-old Nepalese woman presented to the Rheumatology department with a 3 month history of diffuse swelling of the right middle finger proximal interphalangeal joint, with the appearance of dactylitis. There was pain on movement, but no other joint involvement. Simultaneously she noticed blurred and decreased vision, which on review by the ophthalmologists, was diagnosed with bilateral uveitis. There was no history of psoriasis, inflammatory bowel disease, or other past medical history of note. There was no travel history in the past 12 months. A diagnosis of a presumed inflammatory arthritis was made. Results  Blood tests showed elevated c-reactive protein 55 (normal <4 mg/l), erythrocyte sedimentation rate 138 (normal 0-22 mm/hr) and an iron deficiency anaemia. Rheumatoid factor and Anti-CCP antibody were negative. Hand radiographs were reported as normal. MRI of the third digit confirmed an enhancing soft tissue collection at the proximal phalanx of the right middle finger. She was referred for a biopsy of this lesion. Interestingly over the subsequent few months, she developed progressive breathlessness. Chest radiograph showed a left pleural effusion. Further tests showed negative serum ACE, Lyme and Toxoplasma screen. Quantiferon test was negative. Pleural aspirate showed a transudate with negative Acid-fast bacillus (AFB) test and culture. CT chest and abdomen showed a persistent pleural effusion, inflammatory changes in the small bowel and thickening of the peritoneum and omentum. In view of the systemic involvement, a peritoneal tissue biopsy was performed. This confirmed chronic granulomatous inflammation with positive AFB stain for mycobacterium tuberculosis. Our patient was started on quadruple anti- TB antibiotics for 6 months. Her systemic symptoms and dactylitis have improved, although there is on-going treatment for her ocular involvement. Conclusion  Approximately 10% of all cases of extrapulmonary TB have osteoarticular involvement. Dactylitis is a variant of tuberculous osteomyelitis affecting the long bones of the hands and feet. It occurs mainly in young children; however adults may be affected also. The first manifestation is usually painless swelling of the diaphysis of the affected bone followed by trophic changes in the skin. The radiographic changes are known as spina ventosa, because of the ballooned out appearance of the bone, although this was not seen in our case. Fibrous dysplasia, congenital syphilis, sarcoidosis and sickle cell anaemia may induce similar radiographic changes in the metaphysis of long bones of hands and feet, but do not cause soft tissue swelling or periosteal reaction. This case highlights the importance of testing for TB, especially in atypical cases of dactylitis, with other systemic features. Disclosure  N. Cernovschi - Feasey: None. J. Wajed: None.

scholarly journals Acute Testicular Torsion in Children: A Tertiary Hospital Experience in a Developing Country

2021 ◽  
Vol 2 (4) ◽  
pp. 01-03
Author(s):  
Chukwubuike Kevin Emeka
Keyword(s):  
Pediatric Surgery ◽  
Testicular Torsion ◽  
Undescended Testis ◽  
Tertiary Hospital ◽  
Prior History ◽  
Testicular Pain ◽  
History Of ◽  
The Mean ◽  
Urological Emergency ◽  
The Right

Background: Testicular torsion is a urological emergency in which there is a race against time to salvage the testis. The aim of this study was to evaluate our experience in the management of children who presented with acute testicular torsion. Materials and Methods: This was a retrospective study of children aged 15 years and below who had surgery for acute testicular torsion between January 2013 and December 2017 at the pediatric surgery unit of a teaching hospital in Enugu, Nigeria. Results: Sixty-four children were managed during the study period. The ages of the patients ranged from 2 months to 14 years with a median of 6 years. The right testis was mostly affected and the mean duration from the onset of symptom to presentation was 4 hours. All the patients presented with testicular pain and half of the patients had a prior history of intermittent testicular pain. Four (6.3%) patients had a history of trauma precipitating the testicular torsion and 3 (4.7%) patients had undescended testis. Detorsion and Orchidopexy was the most performed surgical procedure and wound infection was the most common post-operative complication. There was no mortality. Conclusion: Testicular torsion is not uncommon in children and may be associated with testicular loss. The right testis is mostly involved in children. Prior history of intermittent testicular pain, trauma and undescended testis are important considerations. Prompt detorsion and orchidopexy remains the cornerstone of treatment.

Joint-specific twin and familial aggregation of recalled physician diagnosed osteoarthritis

Twin Research ◽  
1999 ◽  
Vol 2 (3) ◽  
pp. 196-202 ◽  
Author(s):  
Urho M Kujala ◽  
Jenni Leppävuori ◽  
Jaakko Kaprio ◽  
Jaakko Kinnunen ◽  
Leena Peltonen ◽  
...  
Keyword(s):  
Environmental Effects ◽  
Twin Pair ◽  
Familial Aggregation ◽  
Knee Joints ◽  
Questionnaire Study ◽  
Gene Effects ◽  
Specific Data ◽  
Knee Oa ◽  
History Of ◽  
Additive Gene

AbstractIn our three-stage questionnaire study we investigated patterns of twin and familial aggregation of osteoarthritis (OA) for commonly affected joints. The baseline questionnaire study of the Finnish Twin Cohort was performed in 1975. In 1990, 4095 twin pairs of the same gender born 1930–1957 responded to a questionnaire and reported whether they had OA diagnosed by a physician. In 1996 both twins of 266 pairs of which at least one had reported OA in 1990 responded to a detailed questionnaire on joint-specific OA, including family history of OA. In male pairs shared (non-genetic) familial effects accounted for 37% of the total variance in liability to OA and unshared environmental effects for 63%. In female pairs additive gene effects explained 44% of the variance in liability to OA, and unshared environmental effects for 36%. Familial aggregation of finger and knee OA was clearly higher than that of hip OA. Twin-pair discordance for OA was, to some extent, associated with body-mass index, occupational loading and trauma. Our results indicate that genetic effects may be modulated by sex or by environmental factors distributed differently between men and women. Based on our joint-specific data finger and knee joints are the most optimal targets for studies of genetic factors predisposing to the development of OA.

Kienböck’s Disease in Women

1999 ◽  
Vol 24 (5) ◽  
pp. 596-597 ◽  
Author(s):  
Y. TANIGUCHI ◽  
T. TAMAKI
Keyword(s):  
Wrist Joint ◽  
Age At Onset ◽  
Joint Involvement ◽  
Female Group ◽  
Kienböck’S Disease ◽  
Kienböck's Disease ◽  
Male Patients ◽  
The Mean ◽  
The Right ◽  
Kienbock’S Disease

We examined 133 patients with Kienböck’s disease, five of whom had bilateral disease. There were 47 women and 86 men. The mean age of patients was 42.7 years (range, 14–80 years). The frequencies of involvement of the right and left sides were approximately equal for women, but male patients tended to have right wrist joint involvement. The side of the affected wrist in the female group differed significantly from that in the male group. The age at onset for women was significantly higher than that for men. The percentage of manual workers was significantly lower among women than among men. The characteristics of Kienböck’s disease in women differed from those in men and those previously reported for this disease. These findings suggest that the pathogenesis of Kienböck’s disease in women differs from that in men.

scholarly journals Angioarchitecture of the coronary arteries in Mazama gouazoubira (G. Fischer, 1814)

2021 ◽  
Vol 15 (4) ◽  
pp. 297-303
Author(s):  
Milena Sorban Zaniboni ◽  
Wilson Viotto-Souza ◽  
Drielly Gomes Assis Samora ◽  
Fernanda Coelho Simas Bernardes ◽  
André Luiz Quagliatto Santos ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Left Coronary Artery ◽  
South American ◽  
Myocardial Bridges ◽  
History Of ◽  
The Mean ◽  
Mazama Gouazoubira ◽  
The Right ◽  
South American Continent ◽  
Coronary Dominance

Mazama gouazoubira is a widely distributed deer in the South American continent. However, studies on its anatomical characteristics are still scarce. The objective of this study was to elucidate the coronary circulation of M. gouazoubira. With this aim, after collecting cadavers on highways, twenty-four hearts injected with latex and preserved in formaldehyde at 10% were dissected. The dissections revealed that all specimens presented left coronary dominance, characterized by the origin of the subsinuous interventricular branch from the circumflex branch of the left coronary artery. The number of ventricular branches originated from branches of the left coronary artery was approximately five times higher than that of the right coronary artery. The occurrence of myocardial bridges was registered in 91.7% of the individuals, with bridges predominating over the paraconal interventricular branch. The mean length of the paraconal interventricular sulcus was significantly higher in males (p = 0.02). The number of atrial branches and ventricular branches, length of myocardial bridges and length of subsinuous interventricular sulcus did not vary significantly between sex. Left coronary dominance and high frequency of myocardial bridges in M. gouazoubira are preponderant anatomical traits also present in different species of Ruminantia suborder. Coronary dominance studies in other South American deer species may confirm the correlation of this trait with the evolutionary history of these animals.

scholarly journals Frontal plane knee alignment among normal northern Nigerian adults: A radiographic study

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Abdullahi Suleiman Gwani ◽  
Eduitem Sunday Otong ◽  
Sani Abubakar Bello ◽  
Hamza Mustapha Ahmed ◽  
Dlama Zira Joseph ◽  
...  
Keyword(s):  
Frontal Plane ◽  
Equal Weight ◽  
Knee Alignment ◽  
Male Population ◽  
Female Population ◽  
Significant Difference ◽  
History Of ◽  
The Mean ◽  
Mean Differences ◽  
The Right

Studies have shown that knee alignment parameters differ among races. However, to our knowledge, radiographic frontal plane knee alignment has not been studied in normal northern Nigerian adults. The objective of this study was therefore to determine the frontal plane knee alignment in normal northern Nigerian adults. This study recruited a total of 59 consented subjects (44 males, 15 females). The entire subjects are without any history of lower extremity deformity. Anteroposterior radiographs of both knees with the patella positioned straight ahead were obtained from each participant while standing in a relaxed bipedal stance and placing equal weight on each limb. Alignment was assessed by measuring the tibiofemoral angle (TFA), distal femoral angle (DFA) and proximal tibial angle (PTA). The angles were measured with the aid of a universal plastic goniometre and a plastic ruler. Descriptive statistics of the alignment parameters, independent and paired t-test were computed. In the male population, the mean (standard deviation) obtained were 179.06 (3.87)o for the TFA, 85.94 (3.03 o for the DFA and 89.27 (3.26)o for the PTA. In the female population, the values were 179.53 (3.38)o for the TFA, 86.40 (2.97)o for the DFA and 89.27 (2.15)o for the PTA. No significant mean difference was observed between genders in all the parameters. The TFA does not show any significant difference between the right and left angle regardless of gender. However, significant mean differences were observed in the DFA and PTA of males and combined population. No significant difference was observed in the DFA and PTA of females. Accordingly, northern Nigerian adults may have varus knee alignment compared to other races. Thus, this pre-existing varus alignment should be taken into consideration during clinical examination, preoperative planning and postoperative evaluations of knee deformities in this population.

scholarly journals Evaluation of Hearing Status in Employees of Dental Prosthodontics Laboratories in Yazd

2020 ◽  
Author(s):  
Seyed Mohammad Abrisham ◽  
Mohammad Shafiee ◽  
Mohsen Abediny Sanich
Keyword(s):  
Hearing Loss ◽  
Statistical Tests ◽  
Hearing Threshold ◽  
Dental Prosthesis ◽  
Control Group ◽  
History Of ◽  
The Mean ◽  
And Gender ◽  
The Right ◽  
Experimental Group

Introduction: Noise Induced Hearing Loss (NIHL) is the first cause of acquired hearing loss. Dentists and dental prosthodontics technicians are exposed to different sounds produced by a variety of devices in their occupations. In this study, we studied the effect of dental prosthesis sounds on the auditory power of the respective staff. Methods: This case-control study was carried out among all technicians of dental prosthesis laboratories in Yazd in 2018 selected by census sampling method. A total of 23 technicians who were willing to cooperate and met the inclusion criteria were included in the experimental group. Furthermore,  23 people who referred to the audiology clinic, were matched with the experimental group in terms of age and gender, and were not working in noisy environment, and had no congenital or acquired deafness were examined as the control group.  Finally, the collected data were analyzed by SPSS version 19 using statistical tests. Result: The mean hearing threshold of the right ear at frequencies of 3000 and 4000 Hz and the mean hearing threshold of the left ear at frequencies of 3000, 4000, 6000, and 8000 Hz was significantly higher in the experimental than the control group. The mean hearing threshold of the right ear at the frequency of 4000 Hz and the hearing threshold of the left ear at frequencies of 3000, 4000, and 6000 Hz in participants with job history>4 years was significantly higher. Furthermore, the mean hearing threshold of the right ear in the frequency of 4000 Hz and the hearing threshold of the left ear at frequencies of 3000, 4000, and 6000 Hz years was significantly higher in people with job history >30 years. Conclusion: According to findings, the staffs working in dental prosthodontics laboratories suffer from NIHL at frequencies of 3000 to 8000 Hz. The hearing loss in the left ear was more severe  in  people with job history of >30 years and in people with job history of > 4 years.Therefore, the use of hearing impaired and hearing protectors is recommended in these people.

scholarly journals 3 Years Expeimental Study on Abdominal Aortic Aneurysm Patients Who were Treated with Endovascular Aneurysm Repair at Dr. Mohammad Hoesin Hospital Palembang During 1st of January 2018 – 31st of December 2020

2021 ◽  
Vol 4 (2) ◽  
pp. 286-304
Author(s):  
Muhammad Febriandi Djunaidi ◽  
Kemas Muhammad Dahlan ◽  
Fahmi Jaka Yusuf
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Femoral Artery ◽  
Iliac Artery ◽  
Endovascular Aneurysm Repair ◽  
Abdominal Aortic ◽  
Mean Diameter ◽  
History Of ◽  
The Mean ◽  
The Right

Abdominal aortic aneurysm (AAA) is a focal dilatation of the aortic segment with an increase of 1.5 times the normal value or ≥3 cm. The risk increases in old age and requires alternative surgery such as EVAR. EVAR is more useful in AAA therapy than surgery with wide incisions. This research was descriptive in RSMH Palembang for 5 years in 1st of January 2018 - 31st of December 2020 with variables of patient clinical characteristics and patient CTA results. The results showed that AAA was more common in men, aged 60-69 years with high school education, risk factors such as a history of CHF, hypertension, CAD, and smoking habits. Angiographic CT result showed proximal diameter > 2 cm, PAU, calcification, iliac aneurysm, and lowest renal artery on the left side. All AAA patients had inferior limb thrombus and angulation > 600. The average of aneurysm is 5.8 cm in diameter and 9.23 cm in length. The mean diameter of the right iliac artery differs from the mean diameter of the left iliac artery. The diameter of the right femoral artery also differs from the diameter of the left femoral artery. AAA patients mostly had no history of CKD, COPD, and DM. The patients were hospitalized for an average of 7 days, especially in the ICU for 2 days.

scholarly journals Environmental influences on familial resemblance for drug abuse in first-cousin pairs: a Swedish national study

2013 ◽  
Vol 44 (2) ◽  
pp. 371-379 ◽  
Author(s):  
K. S. Kendler ◽  
H. Ohlsson ◽  
K. Sundquist ◽  
J. Sundquist
Keyword(s):  
Drug Abuse ◽  
Environmental Factors ◽  
Age Differences ◽  
Familial Aggregation ◽  
National Study ◽  
Age Difference ◽  
Geographical Proximity ◽  
Growing Up ◽  
Sibling Pairs ◽  
History Of

BackgroundUsing three independent methods, prior studies in Swedish sibling pairs indicate that environmental factors contribute substantially to familial aggregation for drug abuse (DA). Could we replicate these results in cousin pairs?MethodUsing multiple Swedish public databases (1964–2011), we defined DA using medical, legal or pharmacy registry records and examined concordance in full cousin pairs as a function of age differences, younger–older relationships and geographical proximity while growing up.ResultsReplicating prior results in siblings, cousin pairs were significantly more similar in their history of DA if they were (i) closer versus more distant in age and (ii) grew up in high versus low geographical proximity to one another. Furthermore, controlling for background factors, having an older cousin with DA conveys a greater risk for DA than having a younger drug-abusing cousin. The greater transmission of DA from older to younger versus younger to older cousin was more prominent in pairs who grew up close to one another. In age difference and geographical proximity analyses, effects were consistently strongest in male–male cousin pairs. In analyses of older → younger versus younger → older transmission, effects were stronger in male–male and male–female than in female–female or female–male relative pairs.ConclusionsIn accord with prior results in siblings, environmental factors contribute substantially to the familial aggregation of DA in cousins and these effects are, in general, stronger in males than in females.

scholarly journals Unilateral condylar hyperplasia: evaluation of 6 cases

2015 ◽  
Vol 21 (1) ◽  
pp. 36
Author(s):  
Ana Carolina Uchoa Vasconcelos ◽  
Felipe Martins Silveira ◽  
Adriana Etges ◽  
Ana Paula Neutzling Gomes ◽  
João Luis Carlini ◽  
...  
Keyword(s):  
Orthodontic Treatment ◽  
Clinical Characteristics ◽  
Histopathological Findings ◽  
Affected Side ◽  
History Of ◽  
Study Population ◽  
Condylar Hyperplasia ◽  
The Mean ◽  
The Right

<p>This study aimed to report six cases of unilateral condylar hyperplasia (CH), regarding their demographic and clinical characteristics and imaging and histopathological findings. Sex, age, affected side, history of the case, complementary examinations and treatment were recorded. Five cases (83.3%) were females and the mean age of the study population was 19.3 years (range: 14-28 years). The right condyle was affected in 4 cases (66.6%). Five (83.3%) patients were subjected to condylotomy, and high condylectomy was done in 1 (16.6%) case. The patients were followed up postoperatively for a mean period of 27.5 months. All patients received surgical and orthodontic treatment. In the present study, CH occurred more frequently in the first decades of life and it was more prevalent in females. The right condyle was more affected than the left one and condylotomy combined with orthodontics was the main treatment performed.</p>

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