scholarly journals Metastatic porocarcinoma achieving complete radiological and clinical response with pembrolizumab

2019 ◽  
Vol 12 (9) ◽  
pp. e228917 ◽  
Author(s):  
Karla A Lee ◽  
Margherita Cioni ◽  
Alistair Robson ◽  
Veronique Bataille
Keyword(s):  
Squamous Cell Carcinoma ◽  
Brain Metastases ◽  
Cell Carcinoma ◽  
Clinical Response ◽  
Lower Limb ◽  
Histopathological Examination ◽  
Nodal Metastases ◽  
Left Lower Limb ◽  
Poorly Differentiated ◽  
Visceral Disease

A 67-year-old woman presented in 2012 with a crusty nodule on the left lower limb. Histopathological examination at this time reported a poorly differentiated squamous cell carcinoma (SCC). Two years later, she underwent lymphadenectomy and radiotherapy due to unilateral inguinal and pelvic sidewall nodal metastases. The following year she required excision of two subcutaneous lesions, reported pathologically to be SCC metastases. Further imaging following cyberknife radiotherapy to new brain metastases demonstrated widespread metastatic visceral disease. Twelve cycles of carboplatin and capecitabine failed to halt disease progression. In February 2017, she commenced pembrolizumab, achieving an excellent response and currently has no clinical or radiological evidence of disease. Given the unusual behaviour of her cancer, a histopathological review was requested. The diagnosis was revised to that of porocarcinoma (PC). This represents the first documented case of PC treated with immunotherapy. As of March 2019, the patient remains free of disease.

scholarly journals Penis cancer: a case report

2014 ◽  
Vol 8 (2) ◽  
pp. 45-49
Author(s):  
Gregorio Sampalmieri ◽  
Antonello Moretti ◽  
Luca De Pascale ◽  
Matteo Sampalmieri
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histopathological Examination ◽  
Final Diagnosis ◽  
Small Lesion ◽  
Corpus Spongiosum ◽  
Balanitis Xerotica Obliterans ◽  
Poorly Differentiated ◽  
Partial Penectomy

Penis cancer appears as a small lesion that extends gradually to affect the whole of the glans and the shaft of the penis. Its peak incidence is in men aged 40 to 70 years. The most frequent malignant penis tumour is squamous cell carcinoma, which occurrence is probably favoured by smegma accumulation, HPV16 and 18 infection, smoke, and balanitis xerotica obliterans. Here we discuss the case of a 74-year-old man with sovrapubic pain and swelling. Physical examination reveals swollen glans with purulent secretions and oedema. The final diagnosis of squamous cell carcinoma is established by means of RMN and biopsy. Partial penectomy surgery follows. Histopathological examination shows poorly differentiated endophytic infiltrative growth. The tumour infiltrates corpus spongiosum, corpora cavernosa, and urethra. The proximal uretheral stump is free from infiltration (pT3).

scholarly journals Leishmaniasis: still a diagnostic challenge?

2021 ◽  
Vol 5 (2) ◽  
pp. 23-25
Author(s):  
Ricardo Tadeu Villa
Keyword(s):  
Squamous Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Cutaneous Leishmaniasis ◽  
Sickle Cell Anemia ◽  
Lower Limb ◽  
Histopathological Examination ◽  
Diagnostic Challenge ◽  
Venous Ulcers ◽  
American Cutaneous Leishmaniasis

American cutaneous leishmaniasis (ACL) should be differentiated from traumatic ulcers, venous ulcers, tropical ulcer, lower limb ulcers due to sickle cell anemia, pyodermatitis, paracoccidioidomycosis, syphilis, cutaneous neoplasms, among others.1 Histopathology may be suggestive, but it is rarely specific enough to make the diagnosis without identification of the amastigote forms of the parasite.2 Among the non-specific alterations to the histopathological examination, pseudoepitheliomatous hyperplasia (PEH) presents as a challenge, especially in the differential diagnosis with squamous cell carcinoma (SCC).

scholarly journals Cutaneous squamous cell carcinoma arising in hidradenitis suppurativa: A case report

2019 ◽  
Vol 7 ◽  
pp. 2050313X1984735 ◽  
Author(s):  
Catherine F Roy ◽  
Simon F Roy ◽  
Feras M Ghazawi ◽  
Erica Patocskai ◽  
Annie Bélisle ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hidradenitis Suppurativa ◽  
Rare Complication ◽  
Excisional Biopsy ◽  
Necrosis Factor Alpha ◽  
Spindle Cells ◽  
Poorly Differentiated ◽  
Well Differentiated

We present a case of a 64-year-old man who presented with a rapidly growing tumor in the left buttock and intergluteal cleft area, which was affected by hidradenitis suppurativa. The patient was on tumor necrosis factor-alpha inhibitors for hidradenitis suppurativa for 2 years prior to the development of the mass. Initial biopsy of the mass showed a well-differentiated squamous cell carcinoma with spindle cells and positive epithelial immunomarkers. Subsequent excisional biopsy of the tumor showed an infiltrating poorly differentiated squamous cell carcinoma composed of islands of atypical sarcomatoid spindle cells. Squamous cell carcinoma arising in hidradenitis suppurativa is a rare complication which may occur secondary to chronic inflammation and epidermal hyperproliferation in hidradenitis suppurativa–affected areas.

684 MODERATELY DIFFERENTIATED ESOPHAGEAL SQUAMOUS CELL CARCINOMA HAS A POOR PROGNOSIS AFTER NEOADJUVANT CHEMORADIOTHERAPY

2021 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Xue-feng Leng ◽  
Tianqin Mao ◽  
Jiaxin Yan ◽  
Xuefeng Leng ◽  
Yongtao Han
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neoadjuvant Chemoradiotherapy ◽  
Residual Tumor ◽  
Lymph Node Status ◽  
Pathological Characteristics ◽  
Poorly Differentiated

Abstract   Neoadjuvant chemoradiotherapy (NCRT) plus surgery is the standard treatment for esophageal squamous cell carcinoma (ESCC); however, further analysis is needed to detail the histopathological characteristics of ESCC and their clinical significance after NCRT. This study aimed to present the pathological characteristics of ESCC and their association with prognosis after NCRT. Methods All patients with ESCC who underwent NCRT followed by surgical resection at Sichuan Cancer Hospital (China) from January 2018 to December 2019 were included. Resection specimens of both the primary disease and lymph nodes were re-evaluated by an experienced pathologist. After NCRT, the pathological characteristics of the residual tumor were evaluated based on the Japanese residual tumor pattern, Mandard tumor regression grade (Mandard-TRG), local inflammatory infiltration classification, and lymph node status. Results Among the 103 patients with ESCC included in this study, the pathological complete response (pCR) rate was 34% (35/103). The pCR rate of patients with poorly differentiated tumors (31/72) was higher (43.1%) than that of patients with well or moderately differentiated tumors (P < 0.05). The residual tumor rate was 66% (68/103). A positive correlation was noted between the Japanese residual tumor pattern and Mandard-TRG (Kendall’s tau-b = 0.857, P < 0.001). Tumor infiltration depth, lymph node positivity, moderate differentiation, and tumor recurrence were associated with poor oncological outcomes (P < 0.05). Conclusion Patients with poorly differentiated tumors can obtain an excellent short-term response; however, they have extremely poor long-term survival. For patients with moderately differentiated tumors, both the short- and long-term outcomes are poor. Lymph node status after NCRT is a prognostic factor for ESCC treated with NCRT.

Cervical nodal metastases from occult primary: Undifferentiated carcinoma versus squamous cell carcinoma

Head & Neck ◽  
2002 ◽  
Vol 24 (4) ◽  
pp. 361-369 ◽  
Author(s):  
Chi-Chung Tong ◽  
Mai-Yee Luk ◽  
Sin-Ming Chow ◽  
Kai-Cheong Ngan ◽  
Wai-Hon Lau
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Undifferentiated Carcinoma ◽  
Nodal Metastases

PS02.232: BASALOID CARCINOMA OF THE ESOPHAGUS: MULTIMODAL APPROACH

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 188-188
Author(s):  
Marta De Vega ◽  
Carlos Miliani ◽  
Juan Rodriguez Vitoria ◽  
Juan Antonio Martinez-Piñeiro ◽  
Fernando Pereira
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Multimodal Treatment ◽  
Locally Advanced ◽  
Distal Esophagus ◽  
Lower Esophagus ◽  
Carcinoma Of The Esophagus ◽  
Basaloid Cell ◽  
Poorly Differentiated

Abstract Background Basaloid cell carcinoma of the esophagus (BSCCE) is a rare (0.07–4%) poorly-differentiated variety of squamous cell carcinoma (SCC), more aggressive and with a worse prognosis than typical SCC. There are no published studies on the best therapeutic option for these tumors or on of the effectiveness of Neoadjuvant chemoradiotherapie; so there is no standard treatment. We describe the characteristics and the therapeutic strategy applied to a patient with an avanced basaloid squamous cell carcinoma of the distal esophagus. Methods A 70-year-old woman with dysphagia and severe malnutrition was diagnosed with locally advanced esophageal cáncer of lower esophagus The biopsy indicated moderately differentiated basaloid cell carcinoma. The clinical diagnosis was cT4NxM0, We decided multimodal treatment with curative intent: Neoadjuvant chemoradiotherapie at a dose of 41.4 Gy and concomitant carboplatin and pacliotaxel 5 cycles (CROSS scheme) plus surgery. Results PET-TAC post-neoadjuvant re-evaluation showed partial morphological response (reduction of tumor metabolism in 34.7%). 6 weeks after radiochemotherapy we performed a three fields total esophagectomy. Postoperative course without incidents. The pathological diagnosis was BASALOID cell CARCINOMA located in distal esophagus of 10 cm long with 30% tumor residual; it affects gastro-oesophageal junction. Stage TNM 7th ed: ypT3 N0 (0/17) L0V1R0 Our patient is fine and without evidence of recurrence after 15 meses. Conclusion Basal squamous cell carcinoma is more common in men around 60 years old, being rare in older women. They are located more frequently in the middle than in lower esophagus. They are tumors of poor prognosis (poorly differentiated, locally advanced and with an aggressive biological behavior that predisposes to early metastasis) although the latest publications relate the prognosis especially with the stage of the tumor. There are no published data about the use of Neoadjuvant treatment for these tumors. We have carried out a multimodal treatment (Cross scheme) followed by surgery with clinical, radiological (PET-TAC) and pathological response (30% of residual tumor in the piece) CONCLUSION The multimodal treatment with Cross scheme and surgery was useful in patients with Basaloid tumor of the esophagus can be considered for patients with this type of tumor. Disclosure All authors have declared no conflicts of interest.

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