scholarly journals Atypical cutaneous and musculoskeletal manifestation of SARS-CoV-2: ‘COVID-19 toes’ and spasticity in a 48-year-old woman

2021 ◽  
Vol 14 (3) ◽  
pp. e241410
Author(s):  
Avery Kopacz ◽  
Cameron Ludwig ◽  
Michelle Tarbox
Keyword(s):  
Nervous System ◽  
Adult Patient ◽  
Early Identification ◽  
Lower Limbs ◽  
Rare Occurrence ◽  
Cutaneous Manifestations ◽  
Crucial Component ◽  
History Of ◽  
Screening Questions ◽  
Insight Into

Establishing accurate symptomatology associated with novel diseases such as COVID-19 is a crucial component of early identification and screening. This case report identifies an adult patient with a history of clotting dysfunction presenting with rare cutaneous manifestations of COVID-19, known as ‘COVID-19 toes’', previously described predominantly in children. Additionally, this patient presented with possible COVID-associated muscle spasticity of the lower limbs, as well as a prolonged and atypical timeline of COVID-19 infection. The rare occurrence of ‘COVID-19 toes’' in this adult patient suggests that her medical history could have predisposed her to this symptom. This supports the coagulopathic hypothesis of this manifestation of COVID-19 and provides possible screening questions for patients with a similar history who might be exposed to the virus. Additionally, nervous system complaints associated with this disease are rare and understudied, so this novel symptom may also provide insight into this aspect of SARS-CoV-2.

scholarly journals The Natural History of Bulla hydatis Linn

1931 ◽  
Vol 17 (2) ◽  
pp. 567-571 ◽  
Author(s):  
N. J. Berrill
Keyword(s):  
Natural History ◽  
General Interest ◽  
Rare Occurrence ◽  
University College ◽  
History Of ◽  
University College London ◽  
Insight Into

Bulla hydatis is a mollusc of relatively rare occurrence in the Plymouth district, although fairly common across the Channel at Roscoff. Intermittent dredging and collecting in the Salcombe estuary over a period of about five years, and some rearing experiments carried out in the department of zoology, University College, London, have afforded some insight into its apparently peculiar distribution and also a few facts of certain general interest.

scholarly journals Surgical Treatment of Trigeminal Neuralgia: A History of Early Strides Toward Curing a “Cancerous Acrimony”

Neurosurgery ◽  
2010 ◽  
Vol 67 (5) ◽  
pp. 1419-1425 ◽  
Author(s):  
Robert Kellogg ◽  
Courtney Pendleton ◽  
Alfredo Quinones-Hinojosa ◽  
Aaron A Cohen-Gadol
Keyword(s):  
Nervous System ◽  
Trigeminal Neuralgia ◽  
Special Importance ◽  
Record Keeping ◽  
Harvey Cushing ◽  
Cutting Out ◽  
History Of ◽  
Insight Into ◽  
Neurosurgical Techniques ◽  
Operative Record

Abstract The pain of trigeminal neuralgia is considered one of the worst in human experience. Therefore, its treatment has been of special importance in the history of medicine and surgery. Long after physicians began prescribing various herbs and medication for trigeminal neuralgia, surgeons attempted to relieve it by cutting out parts of the nervous system they deemed responsible for the pain. Between the mid-19th and early 20th centuries, several surgeons pioneered surgical procedures aimed at the peripheral and central nervous system. Harvey Cushing contributed the most to increase the safety of these neurosurgical techniques. Due to Dr Cushing's meticulous clinical observation and operative record keeping, we are able to selectively review his newly discovered patient records at Johns Hopkins and Peter Bent Brigham Hospitals and provide insight into the early history and evolution of trigeminal neuralgia surgery. We also review the contributions of other surgeons from the same period.

scholarly journals Conjoined twins: Parapagus dithoracicus

2018 ◽  
Vol 146 (7-8) ◽  
pp. 456-459
Author(s):  
Fehim Jukovic ◽  
Ilma Pecanin ◽  
Azra Jukovic ◽  
Ruza Kalicanin-Milanovic ◽  
Suzana Matejic ◽  
...  
Keyword(s):  
Contemporary Literature ◽  
Conjoined Twins ◽  
Lower Limbs ◽  
Drug Addicts ◽  
Rare Occurrence ◽  
Rare Type ◽  
Radiologic Findings ◽  
History Of ◽  
Pathological Pregnancy ◽  
Musculoskeletal Systems

Introduction. Throughout history, various types of conjoined twins have been described, many of whom lived until adulthood. The anomaly includes several varieties, with parapagus being one of the rarer forms of conjoined twins. The aim of this paper was to present a rare case of conjoined twins ? parapagus type. Case outline. In this paper we present autopsy and radiologic findings in male 40-week-old parapagus twins from a monozygotic pregnancy, with multiple anomalies in different systems of organs and musculoskeletal systems. Parapagus twins have a side-to-side connection with shared pelvis and can be defined as one of three subtypes. In our case, it was a dithoracic parapagus subtype, with four upper and three lower limbs (tetrabrachius tripus), where the presence of the third bizarre-looking lower limb made the case even more unusual among the rare type. Both parents were drug addicts with a history of sedative abuse. The mother had regular sonographic examinations during pregnancy. Conclusion. Adequate early prenatal diagnosis of conjoined twins and possible termination of such a pregnancy are the key reasons for rare occurrence of such cases. Failure to recognize a pathological pregnancy and its maintenance until the delivery, despite regular gynecological examinations, is why our case is unique in comparison to contemporary literature.

Bilateral Acoustic Neuromas

Neurosurgery ◽  
1982 ◽  
Vol 10 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Robert L. Martuza ◽  
Robert G. Ojemann
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Positive Family History ◽  
Central Nervous System Tumors ◽  
Potential Treatment ◽  
Cutaneous Manifestations ◽  
Nervous System Tumors ◽  
Acoustic Neuromas ◽  
History Of ◽  
Treatment Alternatives

Abstract Fifteen patients with bilateral acoustic neuromas are presented. Ten patients became symptomatic before age 21. and 9 of these patients developed additional central nervous system tumors. Cutaneous manifestations of neurofibromatosis and a positive family history of this disorder were absent in many of the patients. Most patients required multiple surgical procedures, and the timing, techniques, and results of these operations are reported. The pathogenesis of these tumors, the genetic aspects of this disorder, and potential treatment alternatives are discussed.

Aspergillus Spondylodiscitis After Spinal Stenosis Surgery: A Case Report

2020 ◽  
Vol 5 (3 And 4) ◽  
pp. 155-160
Author(s):  
Mohsen Aghapoor ◽  
◽  
Babak Alijani Alijani ◽  
Mahsa Pakseresht-Mogharab ◽  
◽  
...  
Keyword(s):  
Antifungal Drugs ◽  
The Body ◽  
Lower Limbs ◽  
Lumbar Pain ◽  
Case Presentation ◽  
Delay In Diagnosis ◽  
Death Case ◽  
Therapeutic Results ◽  
History Of ◽  
Probable Diagnosis

Background and Importance: Spondylodiscitis is an inflammatory disease of the body of one or more vertebrae and intervertebral disc. The fungal etiology of this disease is rare, particularly in patients without immunodeficiency. Delay in diagnosis and treatment of this disease can lead to complications and even death. Case Presentation: A 63-year-old diabetic female patient, who had a history of spinal surgery and complaining radicular lumbar pain in both lower limbs with a probable diagnosis of spondylodiscitis, underwent partial L2 and complete L3 and L4 corpectomy and fusion. As a result of pathology from tissue biopsy specimen, Aspergillus fungi were observed. There was no evidence of immunodeficiency in the patient. The patient was treated with Itraconazole 100 mg twice a day for two months. Pain, neurological symptom, and laboratory tests improved. Conclusion: The debridement surgery coupled with antifungal drugs can lead to the best therapeutic results.

Clinical Characteristics of Patients Diagnosed with Strongyloidiasis in a United States Urban Outpatient Dermatology Department: A Case Series

2017 ◽  
Vol 1 (3) ◽  
pp. 156-160
Author(s):  
Jacqueline Watchmaker ◽  
Sean Legler ◽  
Dianne De Leon ◽  
Vanessa Pascoe ◽  
Robert Stavert
Keyword(s):  
United States ◽  
Case Series ◽  
The United States ◽  
Screening Tools ◽  
Dermatology Department ◽  
Cutaneous Manifestations ◽  
Serologic Testing ◽  
Patient Reported ◽  
History Of ◽  
Endemic Areas

Background: Although considered a tropical disease, strongyloidiasis may be encountered in non-endemic regions, primarily amongst immigrants and travelers from endemic areas.  Chronic strongyloides infection may be under-detected owing to its non-specific cutaneous presentation and the low sensitivity of commonly used screening tools. Methods: 18 consecutive patients with serologic evidence of strongyloides infestation who presented to a single urban, academic dermatology clinic between September 2013 and October 2016 were retrospectively included.  Patient age, sex, country of origin, strongyloides serology titer, absolute eosinophil count, presenting cutaneous manifestations, and patient reported subjective outcome of pruritus after treatment were obtained via chart review.  Results: Of the 18 patients, all had non-specific pruritic dermatoses, 36% had documented eosinophila and none were originally from the United States. A majority reported subjective improvement in their symptoms after treatment. Conclusion:  Strongyloides infection and serologic testing should be considered in patients living in non-endemic regions presenting with pruritic dermatoses and with a history of exposure to an endemic area.Key Points:Chronic strongyloidiasis can be encountered in non-endemic areas and clinical manifestations are variableEosinophilia was not a reliable indicator of chronic infection in this case series Dermatologists should consider serologic testing for strongyloidiasis in patients with a history of exposure and unexplained pruritus

The Subaltern Speak- A Study On The Culture Of The Arunachalis With Special Reference To Mamang Dai’s The Legends Of Pensam

2019 ◽  
Vol 5 (4) ◽  
pp. 14-20
Author(s):  
Ms. Cheryl Antonette Dumenil ◽  
Dr. Cheryl Davis
Keyword(s):  
Special Reference ◽  
Small World ◽  
Natural World ◽  
Arunachal Pradesh ◽  
North East India ◽  
North East ◽  
Shared History ◽  
History Of ◽  
And Gender ◽  
Insight Into

North- East India is an under veiled region with an awe-inspiring landscape, different groups of ethnic people, their culture and heritage. Contemporary writers from this region aspire towards a vision outside the tapered ethnic channel, and they represent a shared history. In their writings, the cultural memory is showcased, and the intensity of feeling overflows the labour of technique and craft. Mamang Dai presents a rare glimpse into the ecology, culture, life of the tribal people and history of the land of the dawn-lit mountains, Arunachal Pradesh, through her novel The Legends of Pensam. The word ‘Pensam’ in the title means ‘in-between’,  but it may also be interpreted as ‘the hidden spaces of the heart’. This is a small world where anything can happen. Being adherents of the animistic faith, the tribes here believe in co-existence with the natural world along with the presence of spirits in their forests and rivers. This paper attempts to draw an insight into the culture and gender of the Arunachalis with special reference to The Legends of Pensam by Mamang Dai.

Collected Documents on the History of the Pskov Orthodox Mission: A Recent Publication

2018 ◽  
pp. 306-312
Author(s):  
Veniamin F. Zima ◽  
Keyword(s):  
Personal Data ◽  
Prisoners Of War ◽  
Inner Life ◽  
Great Patriotic War ◽  
Occupied Territories ◽  
History Of ◽  
Underground Resistance ◽  
The Baltic ◽  
The Church ◽  
Insight Into

The reviewed work is devoted to a significant, and yet little-studied in both national and foreign scholarship, issue of the clergy interactions with German occupational authorities on the territory of the USSR in the days of the Great Patriotic War. It introduces into scientific use historically significant complex of documents (1941-1945) from the archive of the Office of the Metropolitan Sergius (Voskresensky) of Vilnius and Lithuania, patriarchal exarch in Latvia and Estonia, and also records from the investigatory records on charges against clergy and employees concerned in the activities of the Pskov Orthodox Mission (1944-1990). Documents included in the publication are stored in the archives of Moscow, St. Petersburg, Estonia, Lithuania, Leningrad, Novgorod, and Pskov regions. They allow some insight into nature, forms, and methods of the Nazi occupational regime policies in the conquered territories (including policies towards the Church). The documents capture religious policies of the Nazis and inner life of the exarchate, describe actual situation of population and clergy, management activities and counterinsurgency on the occupied territories. The documents bring to light connections between the exarchate and German counterintelligence and reveal the nature of political police work with informants. They capture the political mood of population and prisoners of war. There is information on participants of partisan movement and underground resistance, on communication net between the patriarchal exarchate in the Baltic states and the German counterintelligence. Reports and dispatches of the clergy in the pay of the Nazis addressed to the Metropolitan Sergius (Voskresensky) contain detailed activity reports. Investigatory records contain important biographical information and personal data on the collaborators. Most of the documents, being classified, have never been published before.

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