Metachronous prostate and colon adenocarcinomas

Multiple primaries in patients with prostate cancer are uncommon. We report a case of prostate adenocarcinoma who did not receive any form of treatment, diagnosed 7 months later with colon adenocarcinoma. The patient underwent right extended hemicolectomy and recovered well. He is planned to receive adjuvant chemotherapy and hormonal therapy. Management of such cases can present a dilemma and multiple factors must be taken into consideration, particularly when the first primary tumour is still active.

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740: Significance of Micrometastases in Pelvic Lymph Nodes Detected by Real-Time Reverse Transcriptase Polymerase Chain Reaction in Patients with Clinically Localized Prostate Cancer Undergoing Radical Prostatectomy Following Neoadjuvant Hormonal Therapy

The Journal of Urology ◽

10.1016/s0022-5347(18)30980-7 ◽

2007 ◽

Vol 177 (4S) ◽

pp. 248-248

Author(s):

Hideaki Miyake ◽

Toshifumi Kurahashi ◽

Atsushi Takenaka ◽

Isao Hara ◽

Masato Fujisawa

Keyword(s):

Prostate Cancer ◽

Polymerase Chain Reaction ◽

Radical Prostatectomy ◽

Lymph Nodes ◽

Reverse Transcriptase ◽

Real Time ◽

Hormonal Therapy ◽

Chain Reaction ◽

Pelvic Lymph Nodes ◽

Polymerase Chain

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Next generation sequencing panels to predict response to hormonal therapy in prostate cancer

Endocrine Abstracts ◽

10.1530/endoabs.42.p17 ◽

2016 ◽

Author(s):

Heini M L Kallio ◽

Matti Annala ◽

Anniina Brofeldt ◽

Reija Hieta ◽

Kati Kivinummi ◽

...

Keyword(s):

Prostate Cancer ◽

Next Generation Sequencing ◽

Hormonal Therapy ◽

Next Generation ◽

Generation Sequencing

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Faculty Opinions recommendation of Intermittent hormonal therapy in the treatment of metastatic prostate cancer: a randomized trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717956656.793462055 ◽

2012 ◽

Author(s):

Thomas Flaig

Keyword(s):

Prostate Cancer ◽

Randomized Trial ◽

Hormonal Therapy ◽

Metastatic Prostate Cancer

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A prospective clinical and transcriptomic feasibility study of oral‐only hormonal therapy with radiation for unfavorable prostate cancer in men 70 years of age and older or with comorbidity

Cancer ◽

10.1002/cncr.33556 ◽

2021 ◽

Author(s):

Benjamin E. Onderdonk ◽

Paige L. Dorn ◽

Carlos Martinez ◽

Fauzia Arif ◽

Denise Cloutier ◽

...

Keyword(s):

Prostate Cancer ◽

Feasibility Study ◽

Hormonal Therapy

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Cerebrospinal Fluid Rhinorrhea as the First Symptom of Metastatic Prostate Adenocarcinoma

Ear Nose & Throat Journal ◽

10.1177/01455613211016710 ◽

2021 ◽

pp. 014556132110167

Author(s):

Magdalena Ostrowska ◽

Maciej J. Wróbel

Keyword(s):

Prostate Cancer ◽

Cerebrospinal Fluid ◽

Paranasal Sinuses ◽

Cancer Metastasis ◽

Treatment Strategies ◽

Prostate Adenocarcinoma ◽

Cerebrospinal Fluid Rhinorrhea ◽

Csf Leakage ◽

Prostate Cancer Metastasis ◽

Csf Rhinorrhoea

The most common cause of cerebrospinal fluid (CSF) rhinorrhoea is damage to the skull base with a dura mater’s rupture due to an accident or an iatrogenic injury. This applies to over 96% of cases. Other possibilities that can lead to CSF leakage are neoplasms of the nasal cavity, paranasal sinuses, and nasopharynx. Although prostate cancer spreads to bones, cranial metastases to paranasal sinuses are extremely rare. We present a case of an 83-year-old patient with CSF leakage due to infiltrating metastatic prostate cancer. Cerebrospinal fluid rhinorrhea turned out to be the first symptom of prostate cancer metastasis. Diagnostic and treatment strategies are presented in the discussion.

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Early Salvage Hormonal Therapy for Biochemical Failure Improved Survival in Prostate Cancer Patients After Neoadjuvant Hormonal Therapy Plus Radiation Therapy—A Secondary Analysis of Irish Clinical Oncology Research Group 97-01

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2012.03.001 ◽

2013 ◽

Vol 85 (1) ◽

pp. 101-108 ◽

Cited By ~ 15

Author(s):

Aminudin R. Mydin ◽

Mary T. Dunne ◽

Marie A. Finn ◽

John G. Armstrong

Keyword(s):

Prostate Cancer ◽

Radiation Therapy ◽

Cancer Patients ◽

Clinical Oncology ◽

Hormonal Therapy ◽

Research Group ◽

Secondary Analysis ◽

Biochemical Failure ◽

Neoadjuvant Hormonal Therapy ◽

Oncology Research

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Resistance to anti-hormonal therapy in prostate cancer

memo - Magazine of European Medical Oncology ◽

10.1007/s12254-019-0503-8 ◽

2019 ◽

Vol 12 (2) ◽

pp. 136-139 ◽

Cited By ~ 1

Author(s):

Zoran Culig

Keyword(s):

Prostate Cancer ◽

Hormonal Therapy

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Circulating tumor cell heterogeneity in neuroendocrine prostate cancer by single cell copy number analysis

npj Precision Oncology ◽

10.1038/s41698-021-00211-1 ◽

2021 ◽

Vol 5 (1) ◽

Author(s):

Vincenza Conteduca ◽

Sheng-Yu Ku ◽

Luisa Fernandez ◽

Angel Dago-Rodriquez ◽

Jerry Lee ◽

...

Keyword(s):

Prostate Cancer ◽

Single Cell ◽

De Novo ◽

Genomic Analysis ◽

Treatment Resistance ◽

Circulating Tumor Cell ◽

Prostate Adenocarcinoma ◽

Neuroendocrine Prostate Cancer ◽

Patient Heterogeneity ◽

Tumor Cell Heterogeneity

AbstractNeuroendocrine prostate cancer is an aggressive variant of prostate cancer that may arise de novo or develop from pre-existing prostate adenocarcinoma as a mechanism of treatment resistance. The combined loss of tumor suppressors RB1, TP53, and PTEN are frequent in NEPC but also present in a subset of prostate adenocarcinomas. Most clinical and preclinical studies support a trans-differentiation process, whereby NEPC arises clonally from a prostate adenocarcinoma precursor during the course of treatment resistance. Here we highlight a case of NEPC with significant intra-patient heterogeneity observed across metastases. We further demonstrate how single-cell genomic analysis of circulating tumor cells combined with a phenotypic evaluation of cellular diversity can be considered as a window into tumor heterogeneity in patients with advanced prostate cancer.

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