Extreme laryngeal candidiasis: airway obstruction

2021 ◽  
Vol 14 (8) ◽  
pp. e242910
Author(s):  
Susan C Murray ◽  
Christopher SG Thompson ◽  
David L Walker ◽  
Miles Bannister
Keyword(s):  
Multiple Drug ◽  
Chronic Obstructive ◽  
Drug Resistant ◽  
Obstructive Pulmonary Disease ◽  
Accident And Emergency ◽  
Multiple Drug Resistant ◽  
Female Smoker ◽  
History Of ◽  
The Subject ◽  
Accident And Emergency Department

We describe the case of a 33-year-old female smoker who presented to the Accident and Emergency department with a 1-day history of rapidly evolving airway compromise. She had no preceding illness or other objective signs/symptoms on presentation, had a history of Chronic Obstructive Pulmonary Disease (COPD) and a previous opioid addiction. Following failed endotracheal intubation, the airway was secured with an emergency surgical tracheostomy. Subsequent direct laryngoscopy revealed a severely diseased glottis and supraglottic area, from which biopsy samples revealed a multiple drug-resistant strain of Candida albicans requiring specialist microbiology input and antifungal treatment. We describe the presentation, investigation, management and outcome of this rare case, along with a literature review of the subject.

scholarly journals Etiology of Diarrhoea with Reference to Multiple Drug Resistant Enteric Bacterial Pathogens

1970 ◽  
Vol 9 ◽  
pp. 131-138 ◽  
Author(s):  
Sirjana Devi Shrestha ◽  
Sarala Malla ◽  
Shital Raj Basnyat
Keyword(s):  
Nalidixic Acid ◽  
Clinical History ◽  
Multiple Drug ◽  
Enteric Infection ◽  
Drug Resistant ◽  
Salmonella Spp ◽  
Key Words Antibiotics ◽  
Significant Incidence ◽  
Multiple Drug Resistant ◽  
History Of

A total of 340 stool samples were processed and studied from both sexes including all ages of patients. Association of enteropathogens between male and female was not statistically significant. Incidence of diarrhoea (28.23%) as well as prevalence of enteropathogens (34.31%) was found highest in the age group (20-30) years. The highest prevalence of enteropathogens (44.87%) was found in August. Of the total isolated enteropathogens, Vibrio cholerae O1 was observed in 51.96% followed by Shigella (18.6%) and Salmonella (8.82%) and parasites were also detected from 20.58% samples. All isolated V. cholerae O1 were El Tor, Inaba. Among Shigella, majority of isolates were S. flexneri. Among Salmonella, S. typhi, S. typhimurium and Salmonella spp. (polyvalent A-S positive) were identified. Entamoeba histolytica, Girdia lamblia, Ascaris lumbricoides and Trichuris trichiura were isolated among parasites. All isolated (100%) V. cholerae O1 were resistant to nalidixic acid and cotrimoxazole, whereas 68%; 63%; 53%; 37% and 11% Shigella were resistant to nalidixic acid, ampicillin, cotrimoxazol, mecillinam and ciprofloxacin respectively. Similarly, 55.5%; 44.4% and 11.1% Salmonella were resistant to nalidixic acid; ampicillin and cotrimoxazole respectively. All V. cholerae strains, 10 strains of Shigella and 2 strains of Salmonella were found multi drug resistant (MDR). The clinical history of the positive cases revealed that abdominal pain, fever, vomiting, dehydration and nausea were the symptoms of enteric infection. Key words: antibiotics; isolates; enteropathogen; Inaba DOI: 10.3126/njst.v9i0.3176 Nepal Journal of Science and Technology 9 (2008) 131-138

scholarly journals Bacteriophage therapy: a potential solution for the antibiotic resistance crisis

2014 ◽  
Vol 8 (02) ◽  
pp. 129-136 ◽  
Author(s):  
Zhabiz Golkar ◽  
Omar Bagasra ◽  
Donald Gene Pace
Keyword(s):  
Antimicrobial Agents ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Bacterial Disease ◽  
Drug Resistant ◽  
Bacteriophage Therapy ◽  
Advantages And Disadvantages ◽  
Drug Resistant Bacteria ◽  
Multiple Drug Resistant ◽  
History Of

The emergence of multiple drug-resistant bacteria has prompted interest in alternatives to conventional antimicrobials. One of the possible replacement options for antibiotics is the use of bacteriophages as antimicrobial agents. Phage therapy is an important alternative to antibiotics in the current era of drug-resistant pathogens. Bacteriophages have played an important role in the expansion of molecular biology and have been used as antibacterial agents since 1966. In this review, we describe a brief history of bacteriophages and clinical studies on their use in bacterial disease prophylaxis and therapy. We discuss the advantages and disadvantages of bacteriophages as therapeutic agents in this regard.

scholarly journals Left-Sided Bochdalek's Hernia in a Young Adult: A Case Report and Literature Review

2021 ◽  
Vol 07 (03) ◽  
pp. e124-e126
Author(s):  
Mark Portelli ◽  
Mark Bugeja ◽  
Charles Cini
Keyword(s):  
Computed Tomography ◽  
Young Adult ◽  
Rare Case ◽  
Surgical Repair ◽  
Bochdalek Hernia ◽  
Case Presentation ◽  
Atypical Case ◽  
Accident And Emergency ◽  
History Of ◽  
Accident And Emergency Department

Abstract Purpose Bochdalek's hernia is a type of congenital diaphragmatic hernia occurring secondary to a defect in the posterior attachment of diaphragm. This condition commonly presents with respiratory insufficiency in infants. To date, there are less than 100 cases of Bochdalek's hernia presenting in adults published in the literature. The mainstay treatment of Bochdalek's hernia involves reduction of hernial contents back into the peritoneal cavity with a tensionless graft repair closing the diaphragmatic defect. Case Presentation We present an atypical case of the Bochdalek hernia presenting in a previously healthy 16-year-old male who presented to the Accident and Emergency department with a 2-day history of dysphagia and loss of breath. The Bochdalek hernia was confirmed on computed tomography (CT) imaging and the patient underwent surgical repair with Gore-Tex mesh. Conclusion The report shows a rare case of the Bochdalek hernia in a young adult, successfully managed with a laparotomy.

scholarly journals trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Zachary D. Aron ◽  
Atousa Mehrani ◽  
Eric D. Hoffer ◽  
Kristie L. Connolly ◽  
Pooja Srinivas ◽  
...  
Keyword(s):  
Oral Dose ◽  
Neisseria Gonorrhoeae ◽  
Multiple Drug ◽  
Specific Inhibition ◽  
Drug Resistant ◽  
Peptidyl Transfer ◽  
Bacterial Ribosome ◽  
Multiple Drug Resistant ◽  
Unique Site

AbstractBacterial ribosome rescue pathways that remove ribosomes stalled on mRNAs during translation have been proposed as novel antibiotic targets because they are essential in bacteria and are not conserved in humans. We previously reported the discovery of a family of acylaminooxadiazoles that selectively inhibit trans-translation, the main ribosome rescue pathway in bacteria. Here, we report optimization of the pharmacokinetic and antibiotic properties of the acylaminooxadiazoles, producing MBX-4132, which clears multiple-drug resistant Neisseria gonorrhoeae infection in mice after a single oral dose. Single particle cryogenic-EM studies of non-stop ribosomes show that acylaminooxadiazoles bind to a unique site near the peptidyl-transfer center and significantly alter the conformation of ribosomal protein bL27, suggesting a novel mechanism for specific inhibition of trans-translation by these molecules. These results show that trans-translation is a viable therapeutic target and reveal a new conformation within the bacterial ribosome that may be critical for ribosome rescue pathways.

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