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2021 ◽  
pp. 63-71
Author(s):  
S.O. Kramarov ◽  
◽  
V.V. Yevtushenko ◽  

Acute respiratory infections are the leading cause of morbidity and mortality in childhood. Antibacterial therapy for acute respiratory infections should be prescribed carefully and under strict indications. This review analyzes the etiological structure of diseases of the upper and lower respiratory tract, identifies modern views on the rational use of antibacterial agents in diseases such as acute tonsillopharyngitis, rhinosinusitis, bronchitis and pneumonia. Among the variety of antibacterial agents, macrolide drugs, in particular azithromycin, are most often used in pediatric practice. The pharmacological properties of azithromycin, mechanisms of its antimicrobial and immunomodulatory activity, indications for use in acute respiratory infections in children are considered in the article. No conflict of interest was declared by the authors. Key words: antibiotics, acute respiratory infection, macrolides, azithromycin, children.


2021 ◽  
Vol 6 (1) ◽  
pp. 201-207
Author(s):  
D. I. Ekwoaba ◽  

There is a global concern on the challenge of indiscriminate use of antibiotics in the management of diseases. At the center of this concern is the need to prevent antibiotics resistance which could increase the morbidity and mortality of cases. This is worse off in the Sub-Saharan Africa where guidelines for management of cases are usually not complied with. The study examined socio-demographic characteristics such as age and gender and how they influence antibiotic use within a community health facility’s outpatient. Descriptive cross-sectional design was used and 630 prescriptions were examined in the month of April, 2021. All admitted, observed and referred cases were not included in the study. The data was analyzed using Statistical Package for the Social Sciences (SPSS) for descriptive and inferential statistics. The average antibiotics encounter was 37.6% and the differences of antibiotics encounter observed across different ages were statistically significant (X2=21.985, df=4, p< 0.001). There were differences in antibiotics encounter between being a child and being an adult and these differences were statistically significant (X2= 13.769, df=1, p<0.001). The odds of antibiotics encounter decreased by 28% per unit increase in age (OR = 0.715; 95%CI: 0.333 - 1.097). This predominance of antibiotic use among younger people could create resistance within this sub-population. This young population is the source of the nation’s future human resources and regular training and update courses for health workers in this field should be a priority to avoid increase in morbidity and mortality from antibiotics resistance and treatment failures. Key Words: Antibiotics; Community health; Prescription; Resistance; Socio-demographic


PHARMACON ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 294
Author(s):  
Inchristy Victoria Kondoj ◽  
Widya A Lolo ◽  
Imam Jayanto

ABSTRACTIrrational use of antibiotics occurs because of a lack of public knowledge about the use of antibiotics that a good and right. Good knowledge will change attitudes so that the actions taken become directed. This study aims to determine the effect of the level of knowledge and attitudes of the community towards the use of antibiotics at Kimia Farma Pharmacy 396 Tuminting, Manado city. This research is a descriptive study and data collection tool used is a questionnaire about antibiotic knowledge and attitudes towards antibiotic use to 290 respondents. Based on the research results obtained, it is known that the level of public knowledge about antibiotics is still classified as a poor with a percentage of 69% while public attitudes towards the use of antibiotics are quite sufficient with a percentage of 45% and there is an influence between the level of knowledge and attitudes towards antibiotic use with a significant value of 0,000.Key words : Antibiotics, Level of Knowledge, Attitude. ABSTRAK Penggunaan antibiotik yang tidak rasional terjadi karena kurangnya pengetahuan masyarakat tentang penggunaan antibiotik yang baik dan benar. Pengetahuan yang baik akan merubah sikap sehingga tindakan yang diambil menjadi terarah. Penelitian ini bertujuan untuk mengetahui pengaruh tingkat pengetahuan dan sikap masyarakat terhadap penggunaan antibiotik di Apotek Kimia Farma 396 Tuminting, kota Manado. Penelitian ini merupakan penelitian deskriptif dan alat pengumpulan data yang digunakan yaitu kuesioner tentang pengetahuan antibiotik dan sikap terhadap penggunaan antibiotik kepada 290 responden. Berdasarkan hasil penelitian yang diperoleh, diketahui bahwa tingkat pengetahuan masyarakat tentang antibiotik masih tergolong kurang dengan persentase 69% sementara sikap masyarakat terhadap penggunaan antibiotik tergolong cukup dengan persentase 45% dan terdapat pengaruh antara tingkat pengetahuan dan sikap terhadap penggunaan antibiotik dengan nilai signifikan sebesar 0,000.Kata kunci : Antibiotik, Tingkat Pengetahuan, Sikap.


Author(s):  
L. Sysa

The effect of preparations from whole blood (dry plasma) on the animal organism was studied. In the course of our research, 2 groups of animals with 15 animals in each of 10 days of age were formed on the basis of analogues. The first group of animals was given dry plasma mixed with mixed feed (based on 5% of the feed weight), the second group was the control one and received no additives. Piglets of both groups were kept in the same sanitary and hygienic conditions, every day they evaluated the clinical status of animals, took into account morbidity, mortality, mortality, weighed, and blood was taken for morphological and biochemical blood tests. It was found that in the group of animals that used dry plasma, they gained weight more intensively during 1.5-2 months than the pigs of the control group, a low percentage of the incidence of pathologies from the gastrointestinal tract and respiratory system was established (2-4% whereas in the control group - 9-14%), higher weight gain (10-15%), mortality was not observed (whereas in the control group 2 pigs fell on the background escherichiosis and salmonellosis). Piglets of the experimental group were mobile, active, appetite expressed. In the control group, in addition to the above morbidity and mortality, low daily weight gain was observed (350 grams per day), some animals were inactive, lethargic, and a decrease in appetite was observed (50% of the animals of the group). The results of laboratory studies showed that the use of dry plasma in the diet of piglets contributes to the fastest restoration of blood counts to physiological norm. So already on the 15th day after giving dry plasma, the number of red blood cells was in the range 6.0 ± 0.42 x 1012 / l, platelets 180.5 ± 1.3 x 109 / l, the amount of hemoglobin in the range of 90.5 ± 0, 95 g / l, white blood cells 15.33 ± 0.62 x 109 / l, a decrease in ESR to 1.55 ± 0.07 mm / h was observed, the amount of total protein was in the range of 64.55 ± 2.12 g / l , the level of albumin is 18.89 ± 3.52 g / l, the activity of the enzymes AsAT, AlAT 0.55 ± 0.06 μkat / l and 0.66 ± 0.03 μkat / l, respectively, the activity of alkaline phosphatase was at level 1, 01 ± 0.12 μkat / l, bilirubin 7.51 ± 0.168 mmol / l, which indicates an improvement in metabolism, in the first The next step is protein metabolism. Feeding dry plasma increases the average daily growth (500 grams per day), positively affects the improvement of the overall metabolism (especially protein metabolism), which leads to an increase in the body's resistance and, as a result, a decrease in the incidence and mortality of animals. Key words: antibiotics, antibiotic resistance, piglets, prebiotics, probiotics, synbiotics, blood products, dry blood plasma.


2018 ◽  
Author(s):  
Amber M Richards

Respiratory illnesses account for a significant proportion of pediatric morbidity and mortality. Respiratory complaints are a common cause of emergency department visits and hospital admissions. They range from mild and self-limited to severe and rapidly progressive. This review discusses the pathophysiology, assessment, stabilization, and management of asthma, community-acquired pneumonia, and bronchiolitis. Given the prevalence of these conditions and the morbidity and mortality attributed to them, it is important for clinicians to be familiar with their presentations and up to date on evidence-based management recommendations. This review contains 7 Figures, 20 Tables and 75 references Key Words: antibiotics, asthma, bronchiolitis, community-acquired pneumonia, pediatric respiratory, pneumonia, respiratory emergency, respiratory illness, respiratory syncytial virus


2018 ◽  
Author(s):  
Richard M Pino ◽  
Molly Paras ◽  
Erica S Shenoy

The aim of this review is to help clinicians optimize treatment of infections and reduce adverse events. With that goal in mind, we discuss the basis for the selection of antibiotics for the surgical patient in the intensive care unit (ICU), the mechanism of antibiotic action, and resistance of pathogens to antibiotic therapy—factors that may affect antibiotic levels, the rationales for dosing, and the role of antimicrobial stewardship programs. The evaluation and management of infections in critically ill patients are uniquely different from those of the general patient population. Age, medical comorbidities, alterations in anatomy, changes in vascular supply, insertion of vascular conduits, and orthopedic hardware are some factors that increase the risk of infection and influence antibiotic choice in the surgical ICU patient.  Key words: antibiotics, antibiotic resistance, antibiotic stewardship, intensive care unit


2018 ◽  
Author(s):  
Tatyana Vayngortin ◽  
Nisa S Atigapramoj

Urinary tract infections (UTIs) affect people of all ages. Although the incidence of invasive bacterial diseases continues to decline, the prevalence of UTIs in febrile pediatric patients continues to remain a focus for serious bacterial infection in this population. In older age groups, symptoms become more obvious and present more classically. Clinical practice guidelines have been developed because morbidity can be dependent upon the rapid identification of a UTI with prompt initiation of appropriate antimicrobials. This review provides a summary for the evaluation of UTIs with discussion of diagnosis and management.  This review contains 6 figures, 5 tables and 47 references Key words: antibiotics, cystitis, pyelonephritis, urinary tract infection, uropathogens


2018 ◽  
Author(s):  
Tatyana Vayngortin ◽  
Nisa S Atigapramoj

Urinary tract infections (UTIs) affect people of all ages. Although the incidence of invasive bacterial diseases continues to decline, the prevalence of UTIs in febrile pediatric patients continues to remain a focus for serious bacterial infection in this population. In older age groups, symptoms become more obvious and present more classically. Clinical practice guidelines have been developed because morbidity can be dependent upon the rapid identification of a UTI with prompt initiation of appropriate antimicrobials. This review provides a summary for the evaluation of UTIs with discussion of diagnosis and management.  This review contains 6 figures, 5 tables and 47 references Key words: antibiotics, cystitis, pyelonephritis, urinary tract infection, uropathogens


2018 ◽  
pp. 104-111
Author(s):  
Phuoc Bich Ngoc Nguyen ◽  
Thi Trang Truong ◽  
Thi Binh Pham

Background: Irrational use of antibiotics is always the concern of public heath. The Ministry of Health has promulgated the manual on the management of antibiotics use in hospitals that emphasizes the analysis of antibiotic drugs consumption by using ABC and DDD analysis. Objective: Analyzing the cost of antibiotics used at the 268 Military hospital according to specific treatment groups, ABC and DDD analysis. Material and methods: The list of all antibiotics used at the 268 Military Hospital in 2016. Using ABC, DDD and treatment group analysis. Results: Antibiotics constituted 21.85% the total drug expense. Nine groups of antibiotics were used and the beta-lactam group had the highest proportion (84.5%). Cefadroxil was the oral antibiotic having the most consumption. Meanwhile, for injected antibiotics, was Ceftazidime. The A class antibiotics accounted for only 20.19% of the items listing, but 90.49% of the total consumption value. Conclusion: Antibiotics, particularly Cephalosporin, accounted for the highest proportion of total drug expense. Although the 268 Military hospital gave priority to the use of first-line oral antibiotics which often had the low cost per DDD, some injected antibiotics with high cost per DDD were still used quite a lot. Key words: Antibiotics, Cost Analysis, 268 Military Hospital, ABC and DDD analysis


2018 ◽  
Author(s):  
Tatyana Vayngortin ◽  
Nisa S Atigapramoj

Urinary tract infections (UTIs) affect people of all ages. Although the incidence of invasive bacterial diseases continues to decline, the prevalence of UTIs in febrile pediatric patients continues to remain a focus for serious bacterial infection in this population. In older age groups, symptoms become more obvious and present more classically. Clinical practice guidelines have been developed because morbidity can be dependent upon the rapid identification of a UTI with prompt initiation of appropriate antimicrobials. This review provides a summary for the evaluation of UTIs with discussion of diagnosis and management.  This review contains 6 figures, 5 tables and 47 references Key words: antibiotics, cystitis, pyelonephritis, urinary tract infection, uropathogens


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