Alterations in plantar vessel blood flow in patients with mild diabetic peripheral neuropathy

IntroductionEarly identification and treatment of diabetic peripheral neuropathy (DPN) are crucial. Presently, the mechanism of DPN is not very clear, and there are inconclusive conclusions about the influencing factors of vascular dynamic characteristics in DPN. This study aims to detect and compare the hemodynamic characteristics of plantar blood vessels in patients with mild DPN and healthy participants to explore a simple and reliable new idea and a potential method for early assessment of DPN and to investigate the influence of gender and age on hemodynamic characteristics.Research design and methodsSixty age-matched and gender-matched patients with mild DPN (30 men and 30 women) and 60 healthy participants were randomly recruited. Color Doppler ultrasound was used to measure and analyze the hemodynamic characteristics of plantar-related vessels.ResultsUltrasonic measurements had good test–retest reliability. There may be no statistically significant differences in the blood flow velocity and blood flow in the plantar-related blood vessels of participants, irrespective of their gender and age. For patients with mild DPN, color Doppler ultrasound may indicate early hemodynamic abnormalities when there are no obvious abnormalities in the large arteries of the lower limbs, which are specifically manifested as increased blood flow velocity and blood flow in the distal small vessels.ConclusionsOur study provides in vivo data support for the dynamic characteristics of the plantar blood vessel biomechanical model and provides a new idea of in vivo and non-invasive early diagnosis of DPN.

Download Full-text

Functional ultrasound speckle decorrelation-based velocimetry of the brain

10.1101/686774 ◽

2019 ◽

Author(s):

Jianbo Tang ◽

Dmitry D. Postnov ◽

Kivilcim Kilic ◽

Sefik Evren Erdener ◽

Blaire Lee ◽

...

Keyword(s):

Blood Flow ◽

Flow Velocity ◽

Blood Flow Velocity ◽

High Speed ◽

Imaging Techniques ◽

Color Doppler ◽

Power Doppler ◽

Frequency Noise ◽

Velocity Changes

AbstractA high-speed, contrast free, quantitative ultrasound velocimetry (vUS) for blood flow velocity imaging throughout the rodent brain is developed based on the normalized first order temporal autocorrelation function of the ultrasound field signal. vUS is able to quantify blood flow velocity in both transverse and axial directions, and is validated with numerical simulation, phantom experiments, and in vivo measurements. The functional imaging ability of vUS is demonstrated by monitoring blood flow velocity changes during whisker stimulation in awake mice. Compared to existing power Doppler and color Doppler-based functional ultrasound imaging techniques, vUS shows quantitative accuracy in estimating both axial and transverse flow speeds and resistance to acoustic attenuation and high frequency noise.

Download Full-text

Preclinical Quantification of Prostate Cancer-Associated Vascular Alterations in the Bone Microenvironment in vivo

European Surgical Research ◽

10.1159/000514224 ◽

2020 ◽

Vol 61 (6) ◽

pp. 188-200

Author(s):

Malte Schroeder ◽

Lennart Viezens ◽

Jördis Sündermann ◽

Svenja Hettenhausen ◽

Gerrit Hauenherm ◽

...

Keyword(s):

Prostate Cancer ◽

Blood Flow ◽

Flow Velocity ◽

Cell Lines ◽

Blood Flow Velocity ◽

Tumour Growth ◽

Prostate Cancer Cell ◽

Bone Microenvironment ◽

Prostate Cancer Cell Lines

Introduction: Prostate cancer has a special predilection to form bone metastases. Despite the known impact of the microvascular network on tumour growth and its dependence on the organ-specific microenvironment, the characteristics of the tumour vasculature in bone remain unknown. Methods: The cell lines LNCaP, DU145, and PC3 were implanted into the femurs of NSG mice to examine the microvascular properties of prostate cancer in bone. Tumour growth and the functional and morphological alterations of the microvasculature were analysed for 21 days in vivo using a transparent bone chamber and fluorescence microscopy. Results: Vascular density was significantly lower in tumour-bearing bone than in non-tumour-bearing bone, with a marked loss of small vessels. Accelerated blood flow velocity led to increased volumetric blood flow per vessel, but overall perfusion was not affected. All of the prostate cancer cell lines had similar vascular patterns, with more pronounced alterations in rapidly growing tumours. Despite minor differences between the prostate cancer cell lines associated with individual growth behaviours, the same overall pattern was observed and showed strong similarity to that of tumours growing in soft tissue. Discussion: The increase in blood flow velocity could be a specific characteristic of prostate cancer or the bone microenvironment.

Download Full-text

Qualitative Diagnosis of Solid Breast Mass by Blood Flow in Solid Breast Mass Based on Color Doppler Ultrasound

Journal of Medical Imaging and Health Informatics ◽

10.1166/jmihi.2021.3682 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1608-1615

Author(s):

Ding Zuopeng ◽

Liu Weiyong ◽

Hu Chunmei ◽

Wang Tao ◽

Wang Mingming

Keyword(s):

Breast Cancer ◽

Blood Flow ◽

Differential Diagnosis ◽

Color Doppler ◽

Flow Characteristics ◽

Flow Distribution ◽

Color Doppler Ultrasound ◽

Blood Flow Distribution ◽

Breast Masses ◽

Malignant Breast

The incidence of breast cancer ranks first among female malignant tumor. With the increase of the sensitivity of color Doppler ultrasound blood flow, the blood flow distribution in and around the tumor can be clearly displayed, and the analysis of hemodynamic parameters is provided, which provides convenience for the study of tumor blood flow characteristics. Studies have shown that tumor cells can secrete a substance called angiogenesis factor, which makes the tumor site form a rich vascular network to promote tumor growth and metastasis. The tumor has many new blood vessels, abnormal structure, thin wall, lack of muscle layer, and is prone to form arteriovenous rash. These characteristics provide a pathological basis for color Doppler flow imaging (CDFI) for the diagnosis of breast cancer. This article discusses the role of two-dimensional sonographic features in the differential diagnosis of benign and malignant breast masses, CDFI was used to study the blood flow distribution and hemodynamic characteristics in benign and malignant breast masses; explore the value of blood flow characteristics and blood flow parameters in the differential diagnosis of breast masses. The experimental results show that the detection rate of blood flow signals and the classification of blood flow signals in the malignant group are higher than those in the benign group, mainly level II and III blood flow, and the irregular branched blood flow is more common, especially when the tumor appears penetrating blood flow supports the diagnosis of malignancy. PSV, RI and PI have a certain differential meaning in the diagnosis of benign and malignant breast masses. PSV, RI and PI of malignant masses are higher than benign masses. For tumors without obvious necrosis, the larger the tumor diameter, the richer the blood flow and the higher the blood flow grade is. The malignant tumors have more blood flow than the benign ones.

Download Full-text

Effects of Wrist Posture and Fingertip Force on Median Nerve Blood Flow Velocity

BioMed Research International ◽

10.1155/2017/7156489 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 5

Author(s):

Katherine E. Wilson ◽

Jimmy Tat ◽

Peter J. Keir

Keyword(s):

Blood Flow ◽

Flow Velocity ◽

Median Nerve ◽

Blood Flow Velocity ◽

Nerve Blood Flow ◽

Occupational Risk Factors ◽

Early Evaluation ◽

Fingertip Force ◽

Significant Difference ◽

Healthy Participants

Purpose. The purpose of this study was to assess nerve hypervascularization using high resolution ultrasonography to determine the effects of wrist posture and fingertip force on median nerve blood flow at the wrist in healthy participants and those experiencing carpal tunnel syndrome (CTS) symptoms. Methods. The median nerves of nine healthy participants and nine participants experiencing symptoms of CTS were evaluated using optimized ultrasonography in five wrist postures with and without a middle digit fingertip press (0, 6 N). Results. Both wrist posture and fingertip force had significant main effects on mean peak blood flow velocity. Blood flow velocity with a neutral wrist (2.87 cm/s) was significantly lower than flexed 30° (3.37 cm/s), flexed 15° (3.27 cm/s), and extended 30° (3.29 cm/s). Similarly, median nerve blood flow velocity was lower without force (2.81 cm/s) than with force (3.56 cm/s). A significant difference was not found between groups. Discussion. Vascular changes associated with CTS may be acutely induced by nonneutral wrist postures and fingertip force. This study represents an early evaluation of intraneural blood flow as a measure of nerve hypervascularization in response to occupational risk factors and advances our understanding of the vascular phenomena associated with peripheral nerve compression.

Download Full-text

Absent Blood Flow in the Testis on Color Doppler Ultrasound: The Causes, Differential Diagnosis and Clinical Value

ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY ◽

10.37015/audt.2020.190035 ◽

2020 ◽

Vol 4 (3) ◽

pp. 223

Author(s):

Chen, MD Shun-Ping ◽

Chen, MD Bin

Keyword(s):

Blood Flow ◽

Differential Diagnosis ◽

Doppler Ultrasound ◽

Color Doppler ◽

Color Doppler Ultrasound ◽

Clinical Value

Download Full-text

How Variable Is the Volar Subcutaneous Tissue of the Digits on B-Mode and Color Doppler Ultrasound in Non-Psoriatic Individuals and Could It Be Included in a Dactylitis Score?

Ultraschall in der Medizin - European Journal of Ultrasound ◽

10.1055/a-1168-6636 ◽

2020 ◽

Cited By ~ 1

Author(s):

Ana Rebollo-Giménez ◽

Lina Martínez-Estupiñán ◽

Otto Olivas-Vergara ◽

Gema Fuensalida-Novo ◽

Jesús Garrido ◽

...

Keyword(s):

Blood Flow ◽

Clinical Features ◽

Subcutaneous Tissue ◽

Color Doppler ◽

Color Doppler Ultrasound ◽

Dominant Hand ◽

Scanning Method ◽

Skin Contact ◽

Gel Layer ◽

The Impact

Abstract Background Digital subcutaneous tissue (SCT) changes are involved in dactylitis, a hallmark feature of psoriatic arthritis (PsA). There are no studies on the ultrasound (US) characteristics of the digital SCT in the general population. Objectives To investigate the variability in US-measured thickness (TH) and color Doppler (CD)-detected blood flow of the SCT of the volar aspects of the fingers in a non-psoriatic population and to investigate the impact of the scanning method and demographics and clinical features on these measurements. Methods SCT TH and semiquantitative (SQD) and quantitative (QD) Doppler signals were measured in the bilateral second finger at the proximal and middle phalanges in 81 non-psoriatic volunteers [49 female, 32 men; 18–78 years]. Two scanning methods with and without (thick gel layer interposition) probe-skin contact were used. Demographics and clinical features were collected. Results There was high variability of SCT TH and Doppler measurements between individuals. All US measurements obtained without probe-skin contact were significantly greater than their corresponding measurements obtained with the probe contacting the skin (p < 0.001). SCT TH was positively related to dominant hand, age, masculine gender, weight, height, body mass index, and alcohol consumption while Doppler measurements were positively related to age and non-dominant hand. Conclusions US-measured SCT thickness and Doppler-detected SCT blood flow of the volar aspect of the fingers seem to be highly variable in the non-psoriatic population as well as highly dependent on the US scanning method. This variability is of utmost importance for assessing dactylitis in PsA.

Download Full-text