scholarly journals Effects of multiparity on left ventricular diastolic dysfunction in women: cross-sectional study of the KoRean wOmen’S chest pain rEgistry (KoROSE)

BMJ Open ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. e026968 ◽  
Author(s):  
Hyun-Jin Kim ◽  
Myung-A Kim ◽  
Hack-Lyoung Kim ◽  
Wan Joo Shim ◽  
Seong Mi Park ◽  
...  
Keyword(s):  
Chest Pain ◽  
Diastolic Dysfunction ◽  
Tertiary Care ◽  
Systolic Pressure ◽  
Cross Sectional Study ◽  
Left Ventricular ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk ◽  
Lv Diastolic Dysfunction

ObjectivesTo investigate the association between left ventricular (LV) diastolic dysfunction and multiparity in patients with suspected coronary artery disease (CAD).DesignCross-sectional study.SettingLinked secondary and tertiary care records from 29 cardiac centres which participated in KoRean wOmen’S chest pain rEgistry.Participants960 women with suspected CAD who underwent invasive coronary angiography from February 2011 to May 2017. The patients were classified by parity number, as follows: low-parity, 0 to <3; multiparity, ≥3 pregnancies.Main outcome measurePrevalence of LV diastolic dysfunction.ResultsThere were 302 and 658 low-parity and multiparity patients, respectively. The prevalence of LV diastolic dysfunction was significantly higher in the multiparity than in the low-parity group. The multiparity group had significantly lower E and e´ septal velocities and E/A ratio, and had a significantly higher E/e´ ratio and right ventricular systolic pressure, which are parameters of LV diastolic dysfunction, than the low-parity group. The prevalence of CAD was significantly higher in the multiparity than in the low-parity group. Receiver operating characteristic curve analysis identified a parity of 2.5 as the cut-off for predicting LV diastolic dysfunction (area under the curve, 0.66; sensitivity, 74.1%; specificity, 52.0%; 95% CI 0.607 to 0.706; p<0.001). After adjustment for confounding factors, multivariate regression analysis showed that multiparity had a 1.80-fold increased risk for LV diastolic dysfunction (OR 1.80, 95% CI 1.053 to 3.081, p=0.032).ConclusionsThe prevalence of LV diastolic dysfunction was higher in multiparity than in low-parity women with suspected CAD. Multiparity was an independent risk factor for LV diastolic dysfunction. LV diastolic dysfunction should be evaluated in multiparous women for the risk of subsequent cardiovascular disease and facilitate the initiation of appropriate treatment.

scholarly journals Correlation of microalbuminuria with its clinical outcome in pre-hypertensives: a cross-sectional study from South India

2021 ◽  
Author(s):  
K. Manoj Kumar ◽  
K. M. Jeyabalaji
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Diastolic Dysfunction ◽  
Tamil Nadu ◽  
Ventricular Hypertrophy ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Left Ventricular ◽  
Health Concern ◽  
Sectional Study ◽  
Cross Sectional

Background: Prehypertension is a major public health concern. The condition is much prevalent in India and is often associated with other cardiovascular (CV) risk factors and independently increases the risk of hypertension and subsequent cardiovascular events. Several studies have shown microalbuminuria as a sensitive marker for predicting CV risk in pre-hypertensive. The objective of this study was to assess the prevalence of microalbuminuria in prehypertension and to determine its association with electrocardiogram (ECG) and echocardiographic (Echo) parameters indicative of CV risk.Methods: This cross-sectional study included a total of 75 subjects aged between 22 and 50 years, with prehypertension attending the medicine department of a tertiary care teaching hospital in Chennai, Tamil Nadu from April 2012 to November 2012. All the study subjects were evaluated with ECG and echo for cardiac changes. Statistical analysis was performed using SPSS software trial version-16 to determine the association of microalbuminuria with cardiac changes.Results: The prevalence of microalbuminuria among the included subjects was 60%. Mean value of urinary excretion of microalbuminuria was 90±2.1 µg/dl with a male preponderance in this study. Pre-hypertensive subjects with microalbuminuria had significant changes of left ventricular hypertrophy (LVH) as evident in ECG than those without microalbuminuria. Microalbuminuric prehypertensive subjects also had significant echocardiographic changes like LVH and diastolic dysfunction than those without microalbuminuria.Conclusions: The cardiovascular changes like left ventricular hypertrophy and diastolic dysfunction were evident in younger age among pre-hypertensives with microalbuminuria than those without microalbuminuria. 

scholarly journals Association of Body Mass Index with Left Ventricular Diastolic Dysfunction Among Ambulatory Patients with Diabetes Mellitus in Rural Uganda: A Cross Sectional Study.

2021 ◽  
Author(s):  
Boniface Amanee Elias Lumori ◽  
Edwin Nuwagira ◽  
Fardous Charles Abeya ◽  
Abdirahman Ali Araye ◽  
Godfrey Masete ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Diastolic Dysfunction ◽  
Body Mass ◽  
Cross Sectional Study ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ventricular Diastolic Dysfunction

Abstract Background: Left ventricular diastolic dysfunction (LVDD) is a recognized complication of diabetes mellitus which precedes and is a risk factor for heart failure. We aimed to determine the prevalence of LVDD and its association with body mass index (BMI) in ambulatory adults with diabetes mellitus. Methods: We conducted a cross-sectional study of 195 ambulatory Ugandan adults living with diabetes mellitus for at least five years from the time of diagnosis at Mbarara Regional Referral Hospital (MRRH). We collected demographic, clinical data and measured body mass index. Laboratory tests included glycated hemoglobin (HbA1c), low-density lipoprotein (LDL), and urine microalbumin. Echocardiography was done to determine LVDD by assessing the mitral inflow E/A ratio, E/è ratio, TR jet peak velocity, and left atrium maximum volume index. Logistic regression was used to establish associations of body mass index and other covariates with LVDD. Results: Overall, 195 participants were enrolled and 141(72.3%) were females. The mean age was 62 [standard deviation (SD), 11.5] years and median duration of diabetes diagnosis was 10 [Interquartile range (IQR), 7,15] years. LVDD was prevalent at 86% and majority, 127(65.13%) had grade-1 diastolic dysfunction. BMI ≥25kg/m2 [adjusted Odds Ratio (aOR)=2.8, (95% confidence interval (CI)=1-7.6), p=0.038], age 50 year or more [aOR= 4.9, (95%CI=1.5-16.2), p=0.010], and history of hypertension [aOR= 3.0, (95% CI= 1.1-8.1), p=0.031] were associated with LVDD.Conclusion: The prevalence of LVDD was high during the study period. We recommend early and periodic echocardiographic screening for diabetes patients with high body mass index.

scholarly journals Obstetric and neonatal outcome in women with a history of recurrent miscarriage at tertiary care hospital, Karnataka: a retrospective cross-sectional study

2018 ◽  
Vol 7 (2) ◽  
pp. 648 ◽  
Author(s):  
Chintan Upadhyay ◽  
Nisha Upadhyay
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Miscarriage ◽  
Tertiary Care ◽  
Previous History ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk ◽  
History Of

Background: When clinical pregnancy is established, the risk of spontaneous pregnancy loss is ~12-14%, and therefore the incidence of Recurrent Pregnancy Loss (RPL) by chance alone would be in the order of 0.35%. It occurs in 0.5-3% of women. The objective of this study was to evaluate the obstetric outcome in pregnancies with history of one or more abortions.Methods: It is a retrospective cross-sectional study done at Obstetrics and Gynecology Department, Dr. B. R. Ambedkar Medical College and Hospital, Bangalore. Record review of cases was done from January 2005 to December 2009. Inclusion criteria were pregnancies with history of previous abortions.Results: There were 400 cases with previous history of abortions. There were 266 (66.4%) booked cases while 134 (33.5%) were unbooked cases. 272 (68.0%) patients crossed viable period of pregnancy (more than 28 weeks). Around 56 (14.0%) cases had repeat abortions, 276 (69.0%) cases underwent vaginal delivery and 124 (31.0%) underwent cesarean section. Almost 91 (22.8%) of Babies were low birth weight while others were above 2.5 kg. There were 52 (13.0%) preterm babies and 28 (7.0%) Intrauterine demise of fetuses.Conclusions: Patients with previous history of abortions are at increased risk of adverse maternal and perinatal outcome.

scholarly journals Prevalence of Diabetes and Dyslipidemia in Hypertensive Young Adults in a Tertiary Care Centre in Nepal, a Cross Sectional Study

2020 ◽  
Vol 42 (2) ◽  
pp. 21-25
Author(s):  
Kamal Sharma Lamsal ◽  
Keshab R Neupane ◽  
Niranjan Acharya ◽  
Dinesh K Lamsal ◽  
Niraj Karmacharya ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Fasting Blood Glucose ◽  
Cardiovascular Complications ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Increased Risk

Introduction Diabetes mellitus (DM) and lipid disorders (LD) in hypertensive patients are associated with increased risk of cardiovascular complications requiring close follow-up and more aggressive treatment. Hence, the present study was done to study the prevalence of diabetes and dyslipidemia in young hypertensive patients i.e. <40 years in a tertiary care hospital, Nepal. MethodsThis is a hospital based cross-sectional study carried out in Civil Service Hospital, Kathmandu. Study included 165 patients of <40 years who had hypertension, either newly diagnosed or undergoing antihypertensive treatment from September 2018 to September 2019. Blood pressure was measured two times on right upper arm in sitting position at interval of 30 minutes and the aver­age was taken. Fasting Lipid Profile and Fasting Blood Glucose was measured after 12 hours of fasting and the prevalence of dyslipidemia and diabetes were analyzed from the data collected. All calculations and statistical analyses are processed by the SPSS 25.0. ResultsAmong 165 patients included, majority of patients, 107 (64.8%) were among 31-39 years, followed by 53 (32.1%) patients among 21-30 years. In total, 98 (59.4%) were male and 67 (40.6%) female. The prevalence of diabetes was 24 (14.5%) and pre-diabetes was 49 (29.7%). The prevalence of dyslipidemia was 125 (75.6%), high triglyceride being the most common disorder followed by low HDL in 87 (52.1%). Elevated total cholesterol was found in 53 (32.1%) patients and 48 (29%) had high LDL cholesterol level. ConclusionA high prevalence of diabetes, pre-diabetes and dyslipidemia was observed in the hypertensive patients <40 years of age.

scholarly journals Left ventricular dysfunction among chronic kidney disease patients: a cross sectional study

2018 ◽  
Vol 5 (5) ◽  
pp. 1093
Author(s):  
Tarun Rao ◽  
Mohit Karwa ◽  
Anil Wanjari
Keyword(s):  
Diastolic Dysfunction ◽  
Diastolic Function ◽  
Systolic Dysfunction ◽  
Cross Sectional Study ◽  
Left Ventricular ◽  
Sectional Study ◽  
Cross Sectional ◽  
Lv Dysfunction ◽  
Ckd Stage ◽  
Stage 1

Background: There is a significant worldwide burden of CKD; which is likely to increase further. Cardiovascular diseases constitute major cause of morbidity and mortality in CKD. LV dysfunction may be present despite the asymptomatic phase during the early stages of CKD. Thus, early detection of LV dysfunction and targeted interventions can improve prognosis in CKD.Methods: This cross-sectional study was conducted among 250 CKD admitted patients. Echocardiographic examination was done to determine the systolic and diastolic function of LV. For LV systolic function ejection fraction and % fractional shortening were calculated and for LV diastolic function E/A, E/E’, E deceleration time and IVRT were measured.Results: Among 250 study subjects, 112 (47.8%) had systolic dysfunction and 138 (55.2%) had diastolic dysfunction. The prevalence of systolic as well as diastolic dysfunction increased significantly (P<0.05) with deteriorating renal function (39.1% for CKD stage 1 and 67.8% for stage 5 for systolic dysfunction, 34.8% for CKD stage 1 and 77.8% for stage 5 for diastolic dysfunction).Conclusions: LV systolic and diastolic dysfunctions are significantly prevalent among CKD patients which increase with increasing severity of CKD. Hence, it is important to routinely screen these patients for LV dysfunction. The use of echocardiography can detect LV dysfunction at an early stage among the high-risk population of CKD to help plan appropriate strategies to slow the progression of cardiac dysfunction and improve prognosis.

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