scholarly journals Correlation of microalbuminuria with its clinical outcome in pre-hypertensives: a cross-sectional study from South India

Author(s):  
K. Manoj Kumar ◽  
K. M. Jeyabalaji

Background: Prehypertension is a major public health concern. The condition is much prevalent in India and is often associated with other cardiovascular (CV) risk factors and independently increases the risk of hypertension and subsequent cardiovascular events. Several studies have shown microalbuminuria as a sensitive marker for predicting CV risk in pre-hypertensive. The objective of this study was to assess the prevalence of microalbuminuria in prehypertension and to determine its association with electrocardiogram (ECG) and echocardiographic (Echo) parameters indicative of CV risk.Methods: This cross-sectional study included a total of 75 subjects aged between 22 and 50 years, with prehypertension attending the medicine department of a tertiary care teaching hospital in Chennai, Tamil Nadu from April 2012 to November 2012. All the study subjects were evaluated with ECG and echo for cardiac changes. Statistical analysis was performed using SPSS software trial version-16 to determine the association of microalbuminuria with cardiac changes.Results: The prevalence of microalbuminuria among the included subjects was 60%. Mean value of urinary excretion of microalbuminuria was 90±2.1 µg/dl with a male preponderance in this study. Pre-hypertensive subjects with microalbuminuria had significant changes of left ventricular hypertrophy (LVH) as evident in ECG than those without microalbuminuria. Microalbuminuric prehypertensive subjects also had significant echocardiographic changes like LVH and diastolic dysfunction than those without microalbuminuria.Conclusions: The cardiovascular changes like left ventricular hypertrophy and diastolic dysfunction were evident in younger age among pre-hypertensives with microalbuminuria than those without microalbuminuria. 

1998 ◽  
Vol 27 (6) ◽  
pp. 787-791 ◽  
Author(s):  
Yousuke Takemura ◽  
Shogo Kikuchi ◽  
Hirofumi Takagi ◽  
Yutaka Inaba ◽  
Katsuya Nakagawa

2019 ◽  
Vol 8 (2) ◽  
pp. 345-356 ◽  
Author(s):  
Theodora W. Elffers ◽  
Stella Trompet ◽  
Renée de Mutsert ◽  
Arie C. Maan ◽  
Hildo J. Lamb ◽  
...  

BMJ Open ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. e026968 ◽  
Author(s):  
Hyun-Jin Kim ◽  
Myung-A Kim ◽  
Hack-Lyoung Kim ◽  
Wan Joo Shim ◽  
Seong Mi Park ◽  
...  

ObjectivesTo investigate the association between left ventricular (LV) diastolic dysfunction and multiparity in patients with suspected coronary artery disease (CAD).DesignCross-sectional study.SettingLinked secondary and tertiary care records from 29 cardiac centres which participated in KoRean wOmen’S chest pain rEgistry.Participants960 women with suspected CAD who underwent invasive coronary angiography from February 2011 to May 2017. The patients were classified by parity number, as follows: low-parity, 0 to <3; multiparity, ≥3 pregnancies.Main outcome measurePrevalence of LV diastolic dysfunction.ResultsThere were 302 and 658 low-parity and multiparity patients, respectively. The prevalence of LV diastolic dysfunction was significantly higher in the multiparity than in the low-parity group. The multiparity group had significantly lower E and e´ septal velocities and E/A ratio, and had a significantly higher E/e´ ratio and right ventricular systolic pressure, which are parameters of LV diastolic dysfunction, than the low-parity group. The prevalence of CAD was significantly higher in the multiparity than in the low-parity group. Receiver operating characteristic curve analysis identified a parity of 2.5 as the cut-off for predicting LV diastolic dysfunction (area under the curve, 0.66; sensitivity, 74.1%; specificity, 52.0%; 95% CI 0.607 to 0.706; p<0.001). After adjustment for confounding factors, multivariate regression analysis showed that multiparity had a 1.80-fold increased risk for LV diastolic dysfunction (OR 1.80, 95% CI 1.053 to 3.081, p=0.032).ConclusionsThe prevalence of LV diastolic dysfunction was higher in multiparity than in low-parity women with suspected CAD. Multiparity was an independent risk factor for LV diastolic dysfunction. LV diastolic dysfunction should be evaluated in multiparous women for the risk of subsequent cardiovascular disease and facilitate the initiation of appropriate treatment.


2006 ◽  
Vol 24 (7) ◽  
pp. 1447 ◽  
Author(s):  
Manel Pladevall ◽  
Keoki Williams ◽  
Heidi Guyer ◽  
Josep Sadurní ◽  
Carles Falces ◽  
...  

Author(s):  
Lal Divakar Singh ◽  
Neetu Singh

Background: The electrocardiogram (ECG) is the graphical display of the various electrical changes of the heart. It plays an important role in the diagnosis of various heart diseases. It is one of the methods of assessing the effects of hypertension on one of its target organ heart. It remains one of the most sensitive methods for establishing left ventricular hypertrophy (LVH) and is often abnormal even when there is no left ventricular heave and chest x-ray shows no classical or obvious left ventricular enlargement. The study was done with objective to asses the Electrocardiographic features of male which were ≥ 30 years in Urban and Rural Prayagraj.Methods: A community based cross-sectional study was carried out in Prayagraj District. Study participants were 620 males, 310 urban and 310 rural of age equal or above 30 years and study sampling technique were two stage random sampling. The data was collected by using predesigned, pretested, semi structured questionnaire and analyzed by using SPSS 23.0 version.Results: LVH is a marker of severity of hypertension. It is an important cardiac risk factor and it has a substantial clinical significance on the course of cardiovascular events in terms of morbidity and mortality.Conclusions: Left ventricular hypertrophy, a cardinal manifestation of hypertensive cardiac damage. 


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