Seizure prevalence in children aged up to 3 years: a longitudinal population-based cohort study in Japan

ObjectiveTo investigate the prevalence of seizures/febrile seizures in children up to 3 years of age and examine the effects of gestational age at birth on the risk for febrile seizures.DesignRetrospective longitudinal population-based cohort study.SettingKobe City public health center, Kobe, Japan, from 2010 to 2018.ParticipantsChildren who underwent a medical check-up at 3 years of age.MethodsInformation regarding seizures was collected from the parents of 96 014 children. We identified the occurrence of seizure/febrile seizure in 74 017 children, whose gestational ages at birth were noted. We conducted a multivariate analysis with the parameter, gestational age at birth, to analyse the risk of seizure. We also stratified the samples by sex and birth weight (<2500 g or not) and compared the prevalence of seizure between those with the term and late preterm births.ResultsThe prevalence of seizure was 12.1% (11.8%–12.3%), 13.2% (12.2%–14.4%), 14.6% (12.4%–17.7%) and 15.7% (10.5%–22.8%) in children born at 37–41, 34–36, 28–33 and 22–27 gestational weeks, respectively. The prevalence of febrile seizures was 9.0% (8.8%–9.2%), 10.5% (9.5%–11.5%), 11.8% (9.7%–14.5%) and 11.2% (6.9%–17.7%) in children born at 37–41, 34–36, 28–33 and 22–27 gestational weeks, respectively. Male was an independent risk factor for seizures (OR: 1.15, 95% CI 1.09 to 1.20; absolute risk increase 0.014, 95% CI 0.010 to 0.019) and febrile seizures (OR: 1.21, 95% CI 1.15 to 1.28; absolute risk increase 0.016, 95% CI 0.012 to 0.020), respectively. Late preterm birth was not associated with an increased risk of seizure/febrile seizure.ConclusionsAlthough very preterm birth may increase the risk of seizure/febrile seizure, the risk associated with late preterm birth is considerably small and less than that associated with male.

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Late preterm birth in the far south of Brazil: a population based study

Revista Brasileira de Saúde Materno Infantil ◽

10.1590/1806-93042016000200003 ◽

2016 ◽

Vol 16 (2) ◽

pp. 113-120 ◽

Cited By ~ 1

Author(s):

Adriana Kramer Fiala Machado ◽

Luana Patrícia Marmitt ◽

Juraci Almeida Cesar

Keyword(s):

Preterm Birth ◽

Skin Color ◽

Causal Relation ◽

Population Based ◽

Late Preterm ◽

Population Based Study ◽

Factors Associated ◽

Late Preterm Birth ◽

Effect Measure ◽

South Of Brazil

Abstract Objectives: to describe the prevalence of late preterm birth (LPB) and identify factors associated with its occurrence in the municipality of Rio Grande, RS. Methods: a standardized questionnaire was applied to allpuerperal women resident in the municipality who had children in theyear 2013. Preterm birth was defined as birth occur-ring between the 34th and 36th week of gestation, preferably evaluated by means of ultra-sonography in the 6th to 20th weeks. The analysis used Poisson regression with robust adjustment of variance, following the hierarchical model.The effect measure used was the preva-lence ratio (PR). Results: of the 2286 births included in the study, 11.8% (CI95%: 10.5-13.1) were LPBs. After adjusted analysis, the PRfor occurrence of LPB among black-skinned motherswas 1.40 (1.01-1.96) in relation to white-skinned women; 1.74 (1.23-2.45) among those who attended less than sixprenatal consults compared to those who attended nine or more; the PR was 1.36 (1.11-1.68) for those classified as depressives compared to others and 1.29 (1.01-1.65) for those undergoing caesarian. Conclusions: the results suggest the existence of inequality in relation to skin color and the important impact of the number ofprenatal consults on the outcome. More appropriately designed studies are needed to confirm the causal relation among maternal depression, caesarian and LPB.

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Second and third trimester fetal ultrasound population screening for risks of preterm birth and small-size and large-size for gestational age at birth: a population-based prospective cohort study

BMC Medicine ◽

10.1186/s12916-020-01540-x ◽

2020 ◽

Vol 18 (1) ◽

Cited By ~ 1

Author(s):

Jan S. Erkamp ◽

Ellis Voerman ◽

Eric A. P. Steegers ◽

Annemarie G. M. G. J. Mulders ◽

Irwin K. M. Reiss ◽

...

Keyword(s):

Cohort Study ◽

Preterm Birth ◽

Gestational Age ◽

Prospective Cohort ◽

Population Based ◽

Third Trimester ◽

Fetal Ultrasound ◽

Large Size ◽

Gestational Age At Birth ◽

Age At Birth

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Late preterm birth and previous cesarean section: a population-based cohort study

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.1080/14767058.2018.1438397 ◽

2018 ◽

Vol 32 (14) ◽

pp. 2400-2407 ◽

Cited By ~ 3

Author(s):

Abdool S. Yasseen III ◽

Kate Bassil ◽

Ann Sprague ◽

Marcelo Urquia ◽

Jonathon L. Maguire

Keyword(s):

Cohort Study ◽

Preterm Birth ◽

Cesarean Section ◽

Population Based ◽

Late Preterm ◽

Previous Cesarean Section ◽

Late Preterm Birth ◽

Previous Cesarean

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The Late Preterm Birth Rate and Its Association with Comorbidities in a Population-Based Study

American Journal of Perinatology ◽

10.1055/s-0031-1280592 ◽

2011 ◽

Vol 28 (09) ◽

pp. 703-708 ◽

Cited By ~ 20

Author(s):

Margaret Carter ◽

Sharon Fowler ◽

Alan Holden ◽

Elly Xenakis ◽

Donald Dudley

Keyword(s):

Preterm Birth ◽

Birth Rate ◽

Population Based ◽

Late Preterm ◽

Population Based Study ◽

Late Preterm Birth ◽

Preterm Birth Rate

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Long-term trends in spontaneous and iatrogenic late preterm birth in South Australia - A population-based study 1986-2014

Journal of Paediatrics and Child Health ◽

10.1111/jpc.13494_317 ◽

2017 ◽

Vol 53 ◽

pp. 107-108

Keyword(s):

Preterm Birth ◽

South Australia ◽

Population Based ◽

Late Preterm ◽

Population Based Study ◽

Late Preterm Birth ◽

Long Term Trends

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Economic costs associated with moderate and late preterm birth: a prospective population-based study

BJOG An International Journal of Obstetrics & Gynaecology ◽

10.1111/1471-0528.13515 ◽

2015 ◽

Vol 122 (11) ◽

pp. 1495-1505 ◽

Cited By ~ 37

Author(s):

KA Khan ◽

S Petrou ◽

M Dritsaki ◽

SJ Johnson ◽

B Manktelow ◽

...

Keyword(s):

Preterm Birth ◽

Population Based ◽

Late Preterm ◽

Economic Costs ◽

Population Based Study ◽

Late Preterm Birth

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Faculty Opinions recommendation of Effects of gestational age at birth on health outcomes at 3 and 5 years of age: population based cohort study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14264188.15777343 ◽

2012 ◽

Author(s):

Mark Sullivan

Keyword(s):

Cohort Study ◽

Health Outcomes ◽

Gestational Age ◽

Population Based ◽

Gestational Age At Birth ◽

Age At Birth

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Morbidity in Late Preterm Birth: A Retrospective Cohort Study Assessing the Role of Immaturity versus Antecedent Factors

Neonatology ◽

10.1159/000515089 ◽

2021 ◽

pp. 1-8

Author(s):

Melissa Lorenzo ◽

Megan Laupacis ◽

Wilma M. Hopman ◽

Imtiaz Ahmad ◽

Faiza Khurshid

Keyword(s):

Cohort Study ◽

Preterm Birth ◽

Preterm Delivery ◽

Gestational Age ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Late Preterm ◽

Multiple Gestation ◽

Late Preterm Birth ◽

Apnea Of Prematurity

Introduction: Late preterm infants (LPIs) are infants born between 340/7 and 366/7 weeks gestation. Morbidities in these infants are commonly considered a result of prematurity; however, some research has suggested immaturity may not be the sole cause of morbidities. We hypothesize that antecedents leading to late preterm birth are associated with different patterns of morbidities and that morbidities are the result of gestational age superimposed by the underlying etiologies of preterm delivery. Methods: This is a retrospective cohort study of late preterm neonates born at a single tertiary care center. We examined neonatal morbidities including apnea of prematurity, hyperbilirubinemia, hypoglycemia, and the requirement for continuous positive airway pressure (CPAP). Multivariable logistic regression analysis was performed to estimate the risk of each morbidity associated with 3 categorized antecedents of delivery, that is, spontaneous preterm labor, preterm premature rupture of membranes (PPROM), and medically indicated birth. We calculated the predictive probability of each antecedent resulting in individual morbidity across gestational ages. Results: 279 LPIs were included in the study. Decreasing gestational age was associated with significantly increased risk of apnea of prematurity, hyperbilirubinemia, and requirement of CPAP. In our cohort, the risk of hypoglycemia increased with gestational age, with the greatest incidence at 360−6 weeks. There was no significant association of risk of selected morbidities and the antecedents of late preterm delivery, with or without adjustment for gestational age, multiple gestation, small for gestational age (SGA), antenatal steroids, and delivery method. Discussion and Conclusion: This study found no difference in morbidity risk related to 3 common antecedents of preterm birth in LPIs. Our research suggests that immaturity is the primary factor in determining adverse outcomes, intensified by factors resulting in prematurity.

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Maternal biological age assessed in early pregnancy is associated with gestational age at birth

Scientific Reports ◽

10.1038/s41598-021-94281-7 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Eva E. Lancaster ◽

Dana M. Lapato ◽

Colleen Jackson-Cook ◽

Jerome F. Strauss ◽

Roxann Roberson-Nay ◽

...

Keyword(s):

Risk Factors ◽

Preterm Birth ◽

Early Pregnancy ◽

Gestational Age ◽

Cellular Aging ◽

Biological Age ◽

Potential Candidate ◽

A Genome ◽

Gestational Age At Birth ◽

Age At Birth

AbstractMaternal age is an established predictor of preterm birth independent of other recognized risk factors. The use of chronological age makes the assumption that individuals age at a similar rate. Therefore, it does not capture interindividual differences that may exist due to genetic background and environmental exposures. As a result, there is a need to identify biomarkers that more closely index the rate of cellular aging. One potential candidate is biological age (BA) estimated by the DNA methylome. This study investigated whether maternal BA, estimated in either early and/or late pregnancy, predicts gestational age at birth. BA was estimated from a genome-wide DNA methylation platform using the Horvath algorithm. Linear regression methods assessed the relationship between BA and pregnancy outcomes, including gestational age at birth and prenatal perceived stress, in a primary and replication cohort. Prenatal BA estimates from early pregnancy explained variance in gestational age at birth above and beyond the influence of other recognized preterm birth risk factors. Sensitivity analyses indicated that this signal was driven primarily by self-identified African American participants. This predictive relationship was sensitive to small variations in the BA estimation algorithm. Benefits and limitations of using BA in translational research and clinical applications for preterm birth are considered.

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