scholarly journals Association between vitamin D and uterine fibroids: a study protocol of an open-label, randomised controlled trial

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e038709
Author(s):  
Bo Sheng ◽  
Yizuo Song ◽  
Yi Liu ◽  
Chenchen Jiang ◽  
Xueqiong Zhu
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Intervention Group ◽  
Uterine Fibroids ◽  
Vitamin D Insufficiency ◽  
Control Group ◽  
Open Label ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

IntroductionUterine fibroids are the most common pelvic benign tumour with no satisfactory long-term medical treatment. Recent studies have demonstrated that vitamin D significantly inhibited the growth of fibroids in vitro, vivo and a small-sample clinical trial. Therefore, the aim of this randomised clinical trial (RCT) is to evaluate whether supplementation with vitamin D could reduce the risk and inhibit the growth of uterine fibroids in reproductive stage women.Methods and analysisThe open-label, RCT comprises two parts, including parts I and II. In part I, 2230 vitamin D deficiency or vitamin D insufficiency patients without uterine fibroids will be randomly assigned to two groups: intervention group (according to the level of serum 25-hydroxyvitamin D3, receive 1600 or 800 IU/day of vitamin D3 for 2 years) and control group (followed up at the same time points). By using gynaecological ultrasound examinations, the incidence of uterine fibroids will be employed to measure the outcome in different groups. In part II, 360 uterine fibroids patients with vitamin D deficiency or vitamin D insufficiency will be randomly assigned to intervention group or control group. According to the level of serum 25-hydroxyvitamin D3, 180 patients will receive 1600 or 800 IU/day of vitamin D3 for 2 years. Control group will receive regular follow-up. The outcome measure will be conducted using gynaecological ultrasound examinations to detect the growth of uterine fibroids in each group.Ethics and disseminationThis study has been approved by the institutional review board of the Second Affiliated Hospital of Wenzhou Medical University (No. LCKY2018-35).Trial registration numbersNCT03586947 and NCT03584529.

Effects of Stratified Vitamin D Supplementation in Middle-Aged and Elderly Individuals with Vitamin D Insufficiency

2018 ◽  
Vol 50 (10) ◽  
pp. 747-753
Author(s):  
Yanhui Lu ◽  
Xiaomin Fu ◽  
Lili Zhang ◽  
Minyan Liu ◽  
Xiaoling Cheng ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Intervention Group ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Middle Aged ◽  
Oral Vitamin ◽  
Severe Vitamin

AbstractThe incidence of vitamin D deficiency is high globally, and vitamin D supplementation draws particular attention. The objective of this study was to investigate the effects of stratified vitamin D supplementation in middle-aged and elderly individuals with vitamin D insufficiency in Beijing. A total of 448 subjects aged over 40 years old were selected from a community in Beijing. Among them, 100 middle-aged and elderly people with vitamin D insufficiency were randomly selected on a voluntary basis. They were further divided into control group and intervention group. The control group received health education and lifestyle guidance, and the intervention group received lifestyle guidance and vitamin D supplementation for nine months. The doses were stratified as follows: for vitamin D insufficiency, oral vitamin D3 supplement was given at 5000 IU/w; for mild vitamin D deficiency, oral vitamin D3 supplement was given at 10 000 IU/w; for severe vitamin D deficiency, oral vitamin D3 supplement was given at 15 000 IU/w. Safety evaluation was conducted after three-month treatment. The intervention group consisted of 8%, 62%, and 30% of cases who had vitamin D insufficiency, mild vitamin D deficiency, and severe vitamin D deficiency, respectively, which were similar with the control group. It showed that the blood 25(OH)D level increased significantly in the intervention group, from 14.30±4.30 ng/ml to 33.62±6.99 ng/ml (p<0.001), in contrast to insignificant change in the control group. Stratified vitamin D supplementation effectively increased the blood 25(OH)D level, as well as the number of cases with corrected vitamin D insufficiency or deficiency.

scholarly journals Is the Climb Worth the View? The Savings/Alert Ratio for Reducing Vitamin D Testing

2020 ◽  
Vol 11 (01) ◽  
pp. 160-165
Author(s):  
Chase D. Hendrickson ◽  
Michael F. McLemore ◽  
Kathryn M. Dahir ◽  
Shari Just ◽  
Zahra Shajani-Yi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Medical Center ◽  
Intervention Group ◽  
Clinical Decision ◽  
Control Group ◽  
Hydroxyvitamin D ◽  
Patient Demographics ◽  
25 Hydroxyvitamin D ◽  
A Charge ◽  
The Impact

Abstract Background Despite guideline recommendations, vitamin D testing has increased substantially. Clinical decision support (CDS) presents an opportunity to reduce inappropriate laboratory testing. Objectives and Methods To reduce inappropriate testing of vitamin D at the Vanderbilt University Medical Center, a CDS assigned providers to receive or not receive an electronic alert each time a 25-hydroxyvitamin D assay was ordered for an adult patient unless the order was associated with a diagnosis in the patient's chart for which vitamin D testing is recommended. The CDS ran for 80 days, collecting data on number of tests, provider information, and basic patient demographics. Results During the 80 days, providers placed 12,368 orders for 25-hydroxyvitamin D. The intervention group ordered a vitamin D assay and received the alert for potentially inappropriate testing 2,181 times and completed the 25-hydroxyvitamin D order in 89.9% of encounters, while the control group ordered a vitamin D assay (without receiving an alert) 2,032 times and completed the order in 98.1% of encounters, for an absolute reduction of testing of 8% (p < 0.001). Conclusion This CDS reduced vitamin D ordering by utilizing a soft-stop approach. At a charge of $179.00 per test and a cost to the laboratory of $4.20 per test, each display of the alert led to an average reduction of $14.70 in charges and of $0.34 in spending by the laboratory (the savings/alert ratio). By describing the effectiveness of an electronic alert in terms of the savings/alert ratio, the impact of this intervention can be better appreciated and compared with other interventions.

scholarly journals Very high rates of vitamin D insufficiency in women of child-bearing age living in Beijing and Hong Kong

2008 ◽  
Vol 99 (6) ◽  
pp. 1330-1334 ◽  
Author(s):  
Jean Woo ◽  
Christopher W. K. Lam ◽  
Jason Leung ◽  
Winny Y. Lau ◽  
Edith Lau ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hong Kong ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Vitamin D Insufficiency ◽  
Dietary Intakes ◽  
Hydroxyvitamin D ◽  
The North ◽  
25 Hydroxyvitamin D ◽  
The Relationship

We aimed to describe the vitamin D status of young women living in two Chinese cities in the spring – Beijing in the north (latitude 39° north) and Hong Kong (latitude 22° north) in the south. We also examined the relationship between serum 25-hydroxyvitamin D and parathyroid hormone (PTH) concentrations to determine a threshold for serum 25-hydroxyvitamin D above which there is no further suppression of PTH. Finally, we examined whether dietary Ca intake influences this relationship. Non-pregnant women aged 18–40 years (n 441) were recruited between February and June. Fasting blood was collected and dietary intakes were assessed using 5 d food records. Mean serum 25-hydroxyvitamin D concentration was lower in Beijing than Hong Kong women (29 v. 34 nmol/l; P < 0·001). Vitamin D deficiency ( ≤  25 nmol/l) was indicated in 40 % of Beijing and 18 % of Hong Kong women, and over 90 % of women in both cities were insufficient ( ≤ 50 nmol/l). Mean Ca and vitamin D intakes were 478 mg/d and 2·0 μg/d, respectively. The relationship between 25-hydroxyvitamin D concentration and PTH was linear throughout the range with a slope of − 0·36 (different from 0; P < 0·001; R 0·26), with no apparent threshold. There was no influence of Ca intake on the relationship between 25-hydroxyvitamin D and PTH concentration. Vitamin D deficiency is common and insufficiency is very common in non-pregnant women in Hong Kong and Beijing during spring. Serum 25-hydroxyvitamin D was inversely associated with PTH with no apparent threshold. Strategies such as vitamin D fortification or supplementation may be required.

scholarly journals Vitamin D in Therapeutics: Past, Present and Future

2016 ◽  
Vol 3 (2) ◽  
pp. 128
Author(s):  
Jeetendra Singh ◽  
Sameer B. Dharrao ◽  
Tushar Baheti
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Human Body ◽  
Indian Population ◽  
Vitamin D Insufficiency ◽  
Direct Sunlight ◽  
Hydroxyvitamin D ◽  
Patients At Risk ◽  
25 Hydroxyvitamin D ◽  
In The Beginning

In the beginning of 20<sup>th</sup> century vitamin D was classified as a vitamin but later considered as a prohormone ("conditional" vitamin) which influences the expression of more than 200 genes in the human body. Worldwide vitamin D insufficiency affects about 50% of the population and in India about 80% of population has vitamin D level less than normal. In India sunshine is abundant but still Indians are deprived of this sunshine vitamin. Minimal exposure to direct sunlight, staying indoors, use of sunscreen lotions, pollution, clothing, dietary and cooking habits are most important factors for vitamin D deficiency in the Indian population. Serum 25 hydroxyvitamin D level is the initial diagnostic test in patients at risk for deficiency. Treatment with either vitamin D<sub>2</sub> or vitamin D<sub>3</sub> is recommended for patients having deficiency, keeping hypervitaminosis in mind.

scholarly journals Significant Independent Predictors of Vitamin D Deficiency in Inpatients and Outpatients of a Nephrology Unit

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Recep Bentli ◽  
Hulya Taskapan ◽  
Halil Toktaş ◽  
Ozkan Ulutas ◽  
Adnan Ozkahraman ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Female Gender ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Documentary Evidence ◽  
Hydroxyvitamin D ◽  
Nitrogen Levels ◽  
25 Hydroxyvitamin D ◽  
Higher Doses

Aims. Kidney disease was found to be a major risk factor for vitamin D deficiency in a population study of patients hospitalized. The aims of the study were to describe the prevalence of vitamin D deficiency inpatients and outpatients in a nephrology department during fall and to evaluate effect of assessing serum 25-hydroxyvitamin D (25(OH)D) levels and previous supplementation of cholecalciferol on vitamin D status.Methods. We studied 280 subjects in total, between October and January. The subjects were recruited from the following two groups: (a) inpatients and (b) outpatients in nephrology unit. We examined previous documentary evidence of vitamin D supplementation of the patients.Results. The prevalence of vitamin D deficiency among these 280 patients was 62,1% (174 patients). Fifty-three patients (18.9%) had severe vitamin D deficiency, 121 patients (43.2%) moderate vitamin D deficiency, and 66 patients (23.6%) vitamin D insufficiency. In logistic regression analysis female gender, not having vitamin D supplementation history, low serum albumin, and low blood urea nitrogen levels were significant independent predictors of vitamin D deficiency while no association of vitamin D deficiency with diabetes mellitus, serum creatinine, eGFR, and being hospitalized was found.Conclusion. Vitamin D deficiency, seems to be an important problem in both inpatients and outpatients of nephrology. Monitoring serum 25(OH)D concentrations regularly and replacement of vitamin D are important. Women in Turkey are at more risk of deficiency and may therefore need to consume higher doses of vitamin D.

scholarly journals Evaluation of Maternal Serum 25-Hydroxyvitamin D Levels in Patients with Hyperemesis Gravidarum at Early Gestational Weeks

2020 ◽  
Vol 9 (3) ◽  
pp. 123-130
Author(s):  
Burcu Kayılı ◽  
Muhammet Ali Oruç ◽  
Yasemin Alan ◽  
Murat Alan ◽  
Deniz Can Öztekin
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Hyperemesis Gravidarum ◽  
Control Group ◽  
Hydroxyvitamin D ◽  
Severe Deficiency ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
The Mean

Aim: The aim of this study was to compare vitamin D levels between pregnant women with hyperemesis gravidarum before 12 weeks of gestation and healthy pregnant women at similar ages. Methods: Sixty pregnancies with hyperemesis gravidarum and 60 age compatible healthy pregnancies applied to our facility were included in the study. Demographic characteristics, maternal thyroid function tests and 25-Hydroxyvitamin D levels were evaluated. Student t test was used for the variables with normal distribution and Mann-Whitney U test was used to analyze the variables without normal distribution. Results: Only one pregnant woman had normal vitamin D levels (>30ng/ml), whereas 71 patients had deficiency (10-30 ng/ml), and 48 had severe deficiency (<10 ng/ml). The mean vitamin D level of the total 120 pregnancies was 11.9±5.00 ng/ml (9.92±3.67 ng/ml in case group, 13.88±5.38 ng/ml in control group). The mean value of vitamin D was found to be significantly lower in hyperemesis gravidarum. 45% (n=27) of the pregnant women had vitamin D deficiency, whereas 55% (n=33) of them had severe deficiency. Free T3 and T4 levels were significantly higher than the control group, and thyroid-stimulating hormone level was significantly lower. Conclusion: Vitamin D levels of pregnant women with hyperemesis gravidarum were significantly lower. Vitamin D deficiency should be considered in patients with hyperemesis gravidarum. Keywords: pregnancy, hyperemesis gravidarum, Vitamin D deficiency

Prevalensi Defisiensi Vitamin D Dan Faktor-Faktor Yang Mempengaruhinya Pada Orang Hidup Dengan HIV/AIDS (ODHA) di RSPI Prof. Dr. Sulianti Saroso

2017 ◽  
Vol 1 (01) ◽  
pp. 6
Author(s):  
Maya M Montain ◽  
Janto G. Sinulingga ◽  
NFN Fatmawati ◽  
NFN Herlina ◽  
Nursanti Kurniastuti
Keyword(s):  
Vitamin D ◽  
Antiretroviral Therapy ◽  
Vitamin D Deficiency ◽  
Immune Reconstitution ◽  
Vitamin D Insufficiency ◽  
Immune Reconstitution Syndrome ◽  
Hydroxyvitamin D ◽  
The People ◽  
25 Hydroxyvitamin D ◽  
Hiv Aids

Abstract:Most people with HIV AIDS have been found with vitamin D deficiency, which is evidently influence by efavirenz as one of antiretroviral therapy (ART) regimen for HIV AIDS therapy, the characteristics of people with HIV AIDS, vitamin D intake, people with HIV AIDS life style, & drug intake that effect vitamin D level. 25-hydroxyvitamin D (D 25-OH) serumlevel measured vitamin D status at people with HIV AIDS. Vitamin D insufficiency was defined at 50-75 nmol/ml (20-30 ng/ml)D 25 OH , while vitamin D deficiency was defined under 50 nmol/ml (< 20 ng/ml) D 25-OH. Vitamin D is needed to maintain the health of bone and adequate immune function, that controled HIV infection. Vitamin D deficiency can increase the risk of bone fracture and Immune Reconstitution Syndrome(IRIS). Up to now, there has not been any data of the prevalence of vitamin D deficiency and its influencing factors on the people with HIV AIDS in Indonesia. The objective of this research is to understand the prevalence of vitamin D deficiency and its influencing factors on the people with HIV AIDS in Sulianti Saroso communicable disease hospital, that already have or not yet have ART intake . The results indicated that 88,8% people with HIV AIDS suffered vitamin D deficiency, and 11,2% suffered vitamin D insufficiency. The tested factors did not evidently influence the vitamin D deficiency.Abstrak. Defisiensi vitamin D ditemukan pada sebagian besar Orang Dengan HIV/AIDS (ODHA) dimana defisiensi ini dipengaruhi salah satunya oleh efavirenz sebagai rejimen NNRTI yang merupakan salah satu rejimen ART (Antiretroviral Therapy) dalam terapi pengobatan ODHA. Faktor-faktor lain yang juga diduga berpengaruh terhadap defisiensi vitamin D pada ODHA adalah karakteristik ODHA, asupan sumber vitamin D, perilaku ODHA, dan juga konsumsi obat-obatan yang dapat mempengaruhi kadar vitamin D. Kadar vitamin D diketahui dengan mengukur kadar serum 25-hydroxyvitamin D dan dikategorikan sebagai insufiensi atau ketidakcukupan vitamin D bila kadar D 25-OH mencapai 50-75 nmol/ml (20-30 ng/ml), dan dikategorikan sebagai defisiensi atau kekurangan vitamin D bila jika kadar D 25-OH mencapai < 50 nmol/ml (< 20 ng/ml). Vitamin D dibutuhkan untuk mempertahankan kesehatan tulang dan untuk fungsi imun yang adekuat, yang membantu mengendalikan infeksi HIV. Defisiensi vitamin D pada ODHA dapat meningkatkan resiko fraktur tulang dan terjadinya Immune Reconstitution Syndrome (IRIS). Hingga saat ini belum ada data di Indonesia tentang prevalensi defisiensi D pada ODHA, serta faktor-faktor yang mempengaruhinya. Penelitian ini bertujuan mengetahui prevalensi defisiensi vitamin D pada 107 ODHA di RSPI Prof. Dr. Sulianti Saroso tahun 2010, baik yang belum maupun yang sudah mendapat ART dengan faktor-faktor yang mempengaruhinya. Hasil penelitian menyebutkan bahwa 88,8% ODHA mengalami defisiensi vitamin D, dan yang mengalami insufisiensi vitamin D sebanyak 11,2%. Namun faktor-faktor yang diuji tidak menunjukkan pengaruh yang signifikan terhadap defisiensi vitamin D.

Comparison of 25-hydroxyvitamin D and metabolic parameters between women with and without polycystic ovarian syndrome

2017 ◽  
Vol 31 (3) ◽  
Author(s):  
Beng Kwang Ng ◽  
Chui Ling Lee ◽  
Pei Shan Lim ◽  
Hanita Othman ◽  
Nor Azlin Mohamed Ismail
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Polycystic Ovarian Syndrome ◽  
Density Lipoprotein ◽  
Control Group ◽  
Study Group ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Ovarian Syndrome

AbstractBackgroundThere is increasing evidence that supports the contribution of vitamin D deficiency in metabolic disturbances among women with polycystic ovarian syndrome (PCOS). The aim of this study was to compare 25-hydroxyvitamin D level and the prevalence of metabolic syndrome in the PCOS and normal women.Materials and methodsA case-controlled study was conducted in a teaching hospital over a 6-month duration from June 2015 to January 2016. A total of 90 women, who consisted of 45 women with PCOS (study group) and 45 women without PCOS (control group), were recruited.ResultsThe final analysis was of 80 women only and the prevalence of vitamin D deficiency (<20 ng/mL) was high between both groups, i.e. 93.7% but there was no significant difference (p = 0.874). Nevertheless, the prevalence of metabolic syndrome was significantly higher in the study group as compared to the control group (27.5% vs. 5.0%, p = 0.013). There was no statistically significant correlation between vitamin D level with clinical [age, weight, body mass index (BMI), waist and hip circumference, systolic and diastolic blood pressure (SBP and DPB, respectively)] and metabolic parameters (fasting glucose, triglycerides, cholesterol, high-density lipoprotein and low-density lipoprotein) among women with PCOS. However, height was positively correlated (r = 0.338, p = 0.033) and the contrary waist-hip ratio was negatively correlated with vitamin D level (r = −0.605, p = 0.048).ConclusionThe prevalence of vitamin D deficiency was high in our study population. Nevertheless, the prevalence of metabolic syndrome was higher among women with PCOS as compared to women without PCOS.

scholarly journals Prevalence and determinants of vitamin D deficiency and insufficiency among three immigrant groups in Finland: evidence from a population-based study using standardised 25-hydroxyvitamin D data

2020 ◽  
Vol 23 (7) ◽  
pp. 1254-1265
Author(s):  
Folasade A Adebayo ◽  
Suvi T Itkonen ◽  
Eero Lilja ◽  
Tuija Jääskeläinen ◽  
Annamari Lundqvist ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Migrant Health ◽  
Population Based ◽  
Vitamin D Insufficiency ◽  
Dietary Vitamin ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Dairy Consumption ◽  
25 Hydroxyvitamin D

AbstractObjective:We investigated the determinants of serum 25-hydroxyvitamin D [S-25(OH)D] and dietary vitamin D sources among three immigrant groups in Finland and compared their S-25(OH)D to the general Finnish population.Design:Cross-sectional population-based Migrant Health and Wellbeing Study and the nationally representative Finnish Health 2011 Survey. S-25(OH)D was standardised according to the Vitamin D Standardisation Program. Vitamin D sources were assessed by interview.Setting:Six different municipalities in Finland (60°–63°N).Participants:Immigrants aged 18–64 years (446 Russians, 346 Somalis, 500 Kurds), 798 Finns aged 30–64 years.Results:The mean of S-25(OH)D was 64 (95 % CI 62, 66), 44 (95 % CI 41, 46), 35 (95 % CI 34, 37) and 64 (95 % CI 62, 66) nmol/l for Russians, Somalis, Kurds and Finns, respectively. S-25(OH)D among Somalis and Kurds was lower compared with Finns (P < 0·001). The prevalence of vitamin D deficiency (S-25(OH)D <30 nmol/l) and insufficiency (S-25(OH)D <50 nmol/l) was higher among immigrants than Finns (P < 0·001). Vitamin D-rich foods differed between the groups; vitamin D-fortified fat spread consumption was higher among Somalis (91 %) than among Russians (73 %) and Kurds (60 %); fish was less consumed among Kurds (17 %) than among Russians (43 %) and Somalis (38 %); and 57 % Russians, 56 % Kurds and 36 % Somalis consumed vitamin D-fortified dairy daily (P < 0·001 for all). Daily smoking, alcohol consumption and winter blood sampling were determinants of vitamin D insufficiency (P ≤ 0·03). Older age, physical activity, fish and vitamin D-fortified dairy consumption were associated with lower odds of insufficiency (P ≤ 0·04).Conclusions:Vitamin D status differed among immigrant groups and the determinants are, to some degree, associated with learned or existing cultural behaviours.

scholarly journals The D-Lightful Vitamin D for Health / Vitamin D Za Dobro Zdravlje

2013 ◽  
Vol 32 (1) ◽  
pp. 1-58 ◽  
Author(s):  
Michael F. Holick
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Sun Exposure ◽  
Vitamin D Insufficiency ◽  
Skeletal Health ◽  
Neurocognitive Dysfunction ◽  
Hydroxyvitamin D ◽  
Health And Wellbeing ◽  
25 Hydroxy Vitamin D ◽  
25 Hydroxyvitamin D

Summary Vitamin D is the sunshine vitamin that is not only important for children’s and adults’ skeletal health but is also important for their overall health and wellbeing. Vitamin D deficiency has been defined as a 25-hydroxyvitamin D < 20 ng/mL and vitamin D insufficiency as a 25-hydroxyvitamin D of 21-29 ng/mL. The major source of vitamin D is sensible sun exposure since very few foods naturally contain vitamin D. Vitamin D deficiency is associated with in - creased risk for many acute and chronic diseases including infectious diseases, autoimmune diseases, cardiovascular disease, type 2 diabetes, neurocognitive dysfunction and muscle weakness. To achieve a blood level of 25-hydroxy - vitamin D >30 ng/mL children require 600-1 000 IUs and adults 1 500-2 000 IUs of vitamin D daily.

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