scholarly journals Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study

BMJ Open ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. e040286
Author(s):  
Simon DS Fraser ◽  
Jenny Barker ◽  
Paul J Roderick ◽  
Ho Ming Yuen ◽  
Adam Shardlow ◽  
...  

ObjectivesTo determine the associations between comorbidities, health-related quality of life (HRQoL) and functional impairment in people with mild-to-moderate chronic kidney disease (CKD) in primary care.DesignCross-sectional analysis at 5-year follow-up in a prospective cohort study.SettingThirty-two general practitioner surgeries in England.Participants1008 participants with CKD stage 3 (of 1741 people recruited at baseline in the Renal Risk in Derby study) who survived to 5 years and had complete follow-up data for HRQoL and functional status (FS).Primary and secondary outcome measuresHRQoL assessed using the 5-level EQ-5D version (EQ-5D-5L, with domains of mobility, self-care, usual activities, pain/discomfort and anxiety/depression and index value using utility scores calculated from the English general population), and FS using the Karnofsky Performance Status scale (functional impairment defined as Karnofksy score ≤70). Comorbidity was defined by self-reported or doctor-diagnosed condition, disease-specific medication or blood result.ResultsMean age was 75.8 years. The numbers reporting some problems in EQ-5D-5L domains were: 582 (57.7%) for mobility, 166 (16.5%) for self-care, 466 (46.2%) for usual activities, 712 (70.6%) for pain/discomfort and 319 (31.6%) for anxiety/depression. Only 191 (18.9%) reported no problems in any domain. HRQoL index values showed greater variation among those with lower FS (eg, for those with Karnofsky score of 60, the median (IQR) EQ-5D index value was 0.45 (0.24 to 0.68) compared with 0.94 (0.86 to 1) for those with Karnofsky score of 90). Overall, 234 (23.2%) had functional impairment.In multivariable logistic regression models, functional impairment was independently associated with experiencing problems for all EQ-5D-5L domains (mobility: OR 16.87 (95% CI 8.70 to 32.79, p<0.001, self-care: OR 13.08 (95% CI 8.46 to 20.22), p<0.001, usual activities: OR 8.27 (95% CI 5.43 to 12.58), p<0.001, pain/discomfort: OR 2.94 (95% CI 1.86 to 4.67), p<0.001, anxiety/depression: 3.08 (95% CI 2.23 to 4.27), p<0.001). Higher comorbidity count and obesity were independently associated with problems in mobility, self-care, usual activities and pain/discomfort: for three or more comorbidities versus none: (mobility: OR 2.10 (95% CI 1.08 to 4.10, p for trend 0.002), self-care: OR 2.64 (95% CI 0.72 to 9.67, p for trend 0.05), usual activities: OR 4.20 (95% CI 2.02 to 8.74, p for trend <0.001), pain/discomfort: OR 3.06 (95% CI 1.63 to 5.73, p for trend <0.001)), and for obese (body mass index (BMI) ≥30 kg/m2) versus BMI <25 kg/m2: (mobility: OR 2.44 (95% CI 1.61 to 3.69, p for trend <0.001), self-care: OR 1.98 (95% CI 1.06 to 3.71, p for trend 0.003), usual activities: OR 1.82 (95% CI 1.19 to 2.76, p for trend 0.019), pain/discomfort: OR 2.37 (95% CI 1.58 to 3.55, p for trend <0.001)). Female sex, lower FS and lower educational attainment were independently associated with anxiety/depression (ORs 1.60 (95% CI 1.18 to 2.16, p 0.002), 3.08 (95% CI 2.23 to 4.27, p<0.001) and 1.67 (95% CI 1.10 to 2.52, p 0.009), respectively). Older age, higher comorbidity count, albuminuria (≥30 mg/mmol vs <3 mg/mmol), lower educational attainment (no formal qualifications vs degree level) and obesity were independently associated with functional impairment (ORs 1.07 (95% CI 1.04 to 1.09, p<0.001), 2.18 (95% CI 0.80 to 5.96, p for trend <0.001), 1.74 (95% CI 0.82 to 3.68, p for trend 0.005), 2.08 (95% CI 1.26 to 3.41, p for trend <0.001) and 4.23 (95% CI 2.48 to 7.20), respectively).ConclusionsThe majority of persons with mild-to-moderate CKD reported reductions in at least one HRQoL domain, which were independently associated with comorbidities, obesity and functional impairment.Trial registration numberNational Institute for Health Research Clinical Research Portfolio Study Number 6632.

Author(s):  
Sau Huu Nguyen ◽  
Long Hoang Nguyen ◽  
Giang Thu Vu ◽  
Cuong Tat Nguyen ◽  
Thu Hoai Thi Le ◽  
...  

Skin diseases have caused a heavy burden on the infected population worldwide. This study aimed to examine the health-related quality of life (HRQOL) among patients with different skin diseases and identify associated factors. A cross-sectional study with 430 participants was conducted at the Vietnam National Hospital of Dermatology and Venereology (NHD) from September to November 2018. The EuroQol-5 Dimensions-5 Levels (EQ-5D-5L) instrument was employed, which measures the EQ-5D index from five domains including mobility, self-care, usual activity, pain/discomfort, and anxiety/depression. Multivariate Tobit regression was adopted to determine factors that were associated with HRQOL (EQ-5D index). The rate of atopic dermatitis was the highest with 28.8%, following by contact dermatitis (17.0%) and skin fungal infections (13.0%). Regarding HRQOL, anxiety/depression was the most common health problem in patients with skin diseases (71.8%), following by pain/discomfort (63.6%). The mean EQ-5D index score was 0.73 (SD = 0.19). The lowest EQ-5D index scores were obtained for females with skin infections (mean = 0.52) and for males with psoriasis (mean = 0.59). Females had significantly lower scores compared to males (Coef. = −0.06; 95% CI = −0.11 to −0.01). Higher income and living in rural areas were also negatively correlated with the EQ-5D index. This study demonstrated the low HRQOL among patients with skin diseases in Vietnam and emphasized the vulnerability of patients with different socioeconomic statuses to their HRQOL.


Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 3097-3097
Author(s):  
Reinhard Stauder ◽  
Ge Yu ◽  
Karin A Koinig ◽  
Dominic Culligan ◽  
Pierre Fenaux ◽  
...  

Abstract Introduction Patient perception and perspective have become relevant in individualised therapy planning in MDS. Thus, integration of patient-reported outcomes (PRO), including health-related quality of life (HRQoL), in studies and in clinical practice is essential. We demonstrated recently pronounced impairments in HRQoL in patients with MDS (Stauder et al., Leukemia 2018). However, longitudinal data on aspects of HRQoL in MDS are rare. Objectives 1. To describe longitudinal changes of HRQoL in MDS and 2. To compare the time course in different patient subgroups to define patients at high risk of deterioration of HRQoL. Methods The EUMDS Registry is a prospective, non-interventional longitudinal study, enrolling newly diagnosed patients with IPSS low or intermediate-1 MDS from 143 haematology centres in 17 European countries and Israel. HRQOL was assessed by EQ-5D questionnaire. Patients were selected, if they fully completed the EQ-5D score (five dimensions and VAS) at baseline and at 6 and 12 months, resulting in a total of 743 subjects at 86 centres in 15 countries. Differences in response for the five EQ-5D dimensions between patients subgroups were evaluated using chi-squareMcNemar tests. For EQ-VAS, the mean score with standard deviation was calculated. Wilcoxon's signed ranks tests were conducted to identify changes over time between HRQOL values at baseline and at 6, 12 months. Results Moderate/severe impairments at initial diagnosis were observed in the dimensions mobility (39.4%), self-care (10.2%), usual activities (32.6%), pain discomfort (46.6%) and anxiety/depression (36.7%). As compared with baseline a pronounced increase in moderate/severe problems was observed at 12 months in the dimensions self-care (10.2% (baseline) vs 15.5% (12 mo); p=0.003) and in usual activities (32.6% vs 40.6%; p=0.001). In contrast, self-reported mobility, pain and anxiety/depression did not change significantly. Decrease in VAS over time revealed a trend toward significance (75 vs. 70; p=0.056). More pronounced impairment of HRQOL was most significantly observed in patients of advanced age: 60-75 yrs in self-care 8.3% vs 14.3% (p=0.016) and in usual activities 28% vs 35.7% (p=0.032); in persons 75+ years in self-care 14.2% vs 19.8% (p=0.058) and in usual activities 48.7% vs 50.3% (p=0.003). Similarly, VAS significantly decreased in the latter group from 70 to 66 (p=0.038). Increases in impairments were most prominent in male patients in self-care (9.7 vs 16.7%; p=0.002) and in usual activities (29.4 vs 38.7%; p=0.003), whereas in women HRQoL at the different time points was not significantly different. Pronounced decreases in HRQoL aspects was observed in anemic patients (Hb-levels <10g/dl) at initial diagnosis: mobility 47.4 vs 55.2% (p=0.06), self-care 13.5 vs 21.1% (p=0.015), usual activities 41.3 vs 52.7% (p=0.006), pain/discomfort 43.3 vs 55.6% (p=0.058) and VAS (70 vs 68; p=0.051). A reduction in HRQoL was observed even in patients with a Hb-level ≥10 g/dl in the dimension self-care (7.9 vs 12.1%; p=0.042). Pronounced decreases in problems in HRQoL were observed in anemic patients (Hb<10 g/dL) who received transfusions in self-care (18.1% vs 25.6%; p=0.029), in usual activities (43.6% vs 61.5%; p=0.038), and in VAS (67.3 vs 61.9; p=0.003). Transfusion dependent patients were at high risk to develop impairments in VAS (70 vs 64; p=0.006) and in most dimensions of EQ-5D (mobility 50.2 vs 62%, p=0.017), self-care (8.8 vs 11.5%, p=0.017), usual activities (41.6 vs 62.9%, p=0.01) and pain/discomfort (48.3 vs 58.5%, p=0.038). Conclusions Low-risk MDS patients report relevant restrictions in distinct dimensions at initial diagnosis. A relevant drop in HRQoL is observed at 12 months particularly in self-care and in usual activities. Patients of advanced age, males and those with initial low Hb-levels most frequently reported declines in HRQoL. Transfusion-need represents a relevant predictor of deterioration of HRQoL. These analyses form the basis to identify vulnerable patients and to tailor individualized interventions and treatment approaches. Analyses are planned to unravel the role of intervention therapies on observed changes in HRQoL. Disclosures Stauder: Teva: Research Funding; Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees; Celgene: Honoraria, Membership on an entity's Board of Directors or advisory committees. Fenaux:Celgene: Honoraria, Research Funding; Jazz: Honoraria, Research Funding; Roche: Honoraria; Otsuka: Honoraria, Research Funding; Janssen: Honoraria, Research Funding. Garelius:novartis: Honoraria. Efficace:Incyte: Consultancy; Amgen: Consultancy; TEVA: Consultancy; Bristol Meyers Squibb: Consultancy; Orsenix: Consultancy; Seattle Genetics: Consultancy; Lundbeck: Research Funding; TEVA: Research Funding; AMGEN: Research Funding. de Witte:Amgen: Consultancy, Research Funding; Celgene: Honoraria, Research Funding; Novartis: Research Funding.


2020 ◽  
Author(s):  
Saber Gaffari-fam ◽  
Yosef Lotfi ◽  
Amin Daemi ◽  
Towhid Babazadeh ◽  
Ehsan Sarbazi ◽  
...  

Abstract Background Regarding the importance of health literacy as a key factor in self-care, appropriate understanding of health information by patients with type 2 diabetes mellitus (T2DM) is fundamental for better management of risk factors, which can also benefit their quality of life. This study aimed to describe the relationship between health literacy (HL), and self-care behaviors with health-related quality of life (HRQL) in patients with T2DM. Methods A cross-sectional survey was done in Iran in 2019. Patients were recruited randomly from health centers by medical records (n = 192, 55.2% male, mean age 58.12 years). The data collection included demographic form, health literacy questionnaire, diabetes self-care behavior questionnaire, and world health organization’s Quality of Life-BREF (WHOQOL-BREF). Analyses were adjusted for confounders using hierarchical regression analysis. Results HL as predictor variables explained 47.5% of variance in overall HRQL (p-value < 0.001), reading health information was the strongest HL dimension (β = 0.478). Self-care behaviors explained an additional 13.6% of the HRQL variance. In total, 65.5% of the variation in the HRQL is explained by the HL, self-care behavior, and the demographic variables. Conclusions We found that more almost two-third of the HRQL explained by the HL and self-care behaviors. Given the importance of health literacy and self-care behaviors in the quality of life in patients with T2DM, adoption of health-promoting behaviors and increasing health literacy can be beneficial for promoting quality of life among these patients.


2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Saber Gaffari-fam ◽  
Yosef Lotfi ◽  
Amin Daemi ◽  
Towhid Babazadeh ◽  
Ehsan Sarbazi ◽  
...  

Abstract Background Regarding the importance of health literacy as a key factor in self-care, appropriate understanding of health information by patients with type 2 diabetes mellitus (T2DM) is fundamental for better management of risk factors, which can also benefit their quality of life. This study aimed to describe the relationship between health literacy (HL), and self-care behaviors with health-related quality of life (HRQL) in patients with T2DM. Methods A cross-sectional survey was done in Iran in 2019. Patients were recruited randomly from health centers by medical records (n = 192, 55.2% male, mean age 58.12 years). The data collection included demographic form, health literacy questionnaire, diabetes self-care behavior questionnaire, and world health organization’s Quality of Life-BREF (WHOQOL-BREF). Analyses were adjusted for confounders using hierarchical regression analysis. Results HL as predictor variables explained 47.5% of variance in overall HRQL (p value < 0.001), reading health information was the strongest HL dimension (β = 0.478). Self-care behaviors explained an additional 13.6% of the HRQL variance. In total, 65.5% of the variation in the HRQL is explained by the HL, self-care behavior, and the demographic variables. Conclusion We found that more almost two-third of the HRQL explained by the HL and self-care behaviors. Given the importance of health literacy and self-care behaviors in the quality of life in patients with T2DM, adoption of health-promoting behaviors and increasing health literacy can be beneficial for promoting quality of life among these patients.


Author(s):  
Louis P. Garrison ◽  
Patricia Schepman ◽  
Andrew G. Bushmakin ◽  
Rebecca L. Robinson ◽  
Leslie Tive ◽  
...  

Abstract Purpose To evaluate the relationship between self-reported concerns about becoming addicted to a medication and health-related quality of life (HRQoL) in patients with osteoarthritis (OA). Methods This real-world study used patient-level cross-sectional survey data collected from the US Adelphi Disease Specific Programme (DSP). The DSP for OA selected 153 physicians who collected de-identified data on their next nine adult patients with OA. Each patient completed a disease-relevant survey, which included the Likert-scale question, “I am concerned about becoming addicted to my medicine,” (CAA) with responses ranging from “completely disagree” [1] to “completely agree” [5]. HRQoL was measured by the EQ-5D-5L index value and the EQ Visual Analogue Scale (VAS). A set of ordinary least squares regressions using HRQoL measures as outcomes and CAA as a continuous predictor were estimated. Standardized effect size (ES) was used to gauge the magnitude of effects. Results A total of 866 patients with OA completed the survey (female, 61.2%; White, 77.7%; mean age, 64.2 years). Of the 775 patients who completed the CAA question, almost one-third responded that they “agree” (18%) or “completely agree” (11%), while 27% responded “completely disagree” and 20% “disagree.” Regression analyses found that patients who have concerns about medication addiction have significantly different EQ-5D-5L index values and EQ VAS scores compared with patients who do not have this concern (p < 0.0001). Conclusion Our findings suggest that concern about medication addiction in patients with OA may have an impact on patient HRQoL, with more concerned patients reporting poorer HRQoL outcomes.


2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Hui Jie Wong ◽  
Pei Lin Lua ◽  
Sakinah Harith ◽  
Khairul Azmi Ibrahim

Abstract Background Apart from maximizing functional abilities and independence after stroke, improving overall health-related quality of life (HRQoL) should also become part of the stroke treatment and rehabilitation process goals. This study aimed to assess the HRQoL profiles and explore the dimension-specific associated factors of HRQoL among stroke survivors. Methods This was a cross-sectional study of stroke survivors attending post-stroke care clinics in three public hospitals in the states of Pahang and Terengganu, Malaysia. The HRQoL was assessed by EuroQol-5 dimension-5 levels. Data on socio-demographic, clinical profiles, malnutrition risk, and physical activity level were collected through an interviewer-administered survey. Descriptive analyses for HRQoL profiles and multiple logistic regression analyses for its associated factors were performed. Crude and adjusted odds ratios were reported. Results A total of 366 stroke survivors were recruited with a mean age of 59 ± 11 years. The most -commonly reported health problems were mobility (85%), followed by usual activities (82%), pain/discomfort (63%), anxiety/depression (51%) and self-care (41%). The mean of the EQ visual analogue scale and the median of the EQ5D summary index was reported at 60.3 ± 14.2 and 0.67 ± 0.37, respectively. Malnutrition risk (mobility, usual activities, and self-care), wheelchair users (self-care and usual activities), speech impairment (usual activities and pain/discomfort), number of stroke episodes (self-care and pain/discomfort), body mass index, physical activity level and types of strokes (usual activities), age and use of a proxy (anxiety/depression), working and smoking status (mobility), were factors associated with either single or multiple dimensions of HRQoL. Conclusion Routine malnutrition screening, tailored program for speech therapy, prevention of recurrent stroke, and physical activity promotion should be addressed and further reinforced in current rehabilitation interventions to improve the HRQoL among stroke survivors in Malaysia.


2021 ◽  
Author(s):  
Chenyang Li ◽  
Shaomei Shang ◽  
Xiaosong Dong ◽  
Jun Zhang ◽  
Xiaoling Wang ◽  
...  

Abstract Background: Narcolepsy has deleterious implications on daily life. However, few studies have fully assessed the severity of pentad symptoms of Chinese adults with narcolepsy type 1 (NT1), as well as the relation with health-related quality of life (HRQoL). It is still not clear how the global functioning of patients with NT1 are affected by these pentad symptoms and which does specific symptom affect HRQoL. This is the first study to assess the pentad symptom severity and its correlation with HRQoL in patients with NT1.Methods: Our cross-sectional study is to assess the pentad symptom severity and its correlation with HRQoL in patients with NT1. A total of 174 patients with NT1 were recruited. They completed Narcolepsy Severity Scale (NSS) and European Quality of Life-5 Dimensions Questionnaire (EQ-5D) including five dimensions (EQ-5D utility values) and a visual analog scale (EQ-5D VAS). The relation between severity of symptoms and HRQoL dimensions was assessed by Pearson correlation analyses. Logistic regression was used to identify the significant predictors of HRQoL. Nomogram was established based on results of independent predictors factors on logistic regression analyses. Results: The scores for NSS, EQ-5D utility values and EQ-5D VAS were 29.89±10.08, 0.78±0.09 and 64.30±19.84 in patients with NT1 respectively. NSS score showed a significantly correlation with self-care (r=0.157, P<0.05), usual activities (r=0.236, P<0.01), pain/discomfort (r=0.174, P<0.05), anxiety/depression (r=0.2, P<0.01) and EQ-5D utility values (r=-.261, P<0.01). EDS (excessive daytime sleep), cataplexy, hallucinations, paralysis and disrupted nocturnal sleep (DNS) were significant associated to EQ-5D VAS (r ranged from -0,154 to -0.354, P<0.05). EDS (OR=-0.297, 95% CI -1.892- -0.634) and DNS (OR=-0.16, 95% CI -0.7307- -0.446) were predictors of HRQoL. Regards the NSS scores, NSS score (OR=-0.360, 95% CI -0.979- -0.438) and treated (OR=0.215, 95% CI 3.567-16.188) were predictors of the metrics of HRQoL. The C-indices of the nomogram was 0.726 (95% CI 0.686-0.766). Conclusion: The severity of symptoms could disrupt self-care and usual activities and increase pain/discomfort and anxiety/depression. NSS score could be used for predicting HRQoL, but with a modest precision.


2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
D Fineschi ◽  
S Acciai ◽  
G Scarafuggi ◽  
M Napolitani ◽  
C Bedogni ◽  
...  

Abstract Introduction Thanks to the privileged relationship that the general practitioner establishes with patients, he well knows their personal background and assesses the disorders as a whole, without focusing only on unique pathology. The aim of the work were: I) to assess the level of concordance between the health profile (HP) of the patient measured by the doctor and that measured by the patient, and II) to and assess which variables influence the perception. Methods A cross-sectional study was conducted between Aug 2019-Jan 2020 in a primary care setting. To assess health-related quality of life we administered the EuroQol 5d-5L to patients (EQ-p). Simultaneously, we asked the doctors to fill in the questionnaire 'from the patient's point of view' (EQ-d), also based on data collected in the computerized clinical diary. Data was collected anonymously and the statistical analysis was carried out using Stata 14 (Cohen's kappa; Fisher test). Results The sample consisted of 223 patients (46% men). The mean age was 56.5±19.6 (min 18-max95). The mean BMI was 25.5±5 (28% overweight; 18% obese). Significant differences by gender were found in Pain and Anxiety/Depression dimensions (44% of men had not pain vs 33% of women (p = 0.03) and 56% of men had no Anxiety/Depression vs 36% of women (p &lt; 0.01)). These differences were not detected by doctors; As regards the concordance between EQ-p and EQ-d, it was moderate for Mobility (k = 0.45; p &lt; 0.01) and Self-Care (k = 0.46; p &lt; 0.01). The agreement was fair for usual activities (k = 0.39; p &lt; 0.01) and it was poor for Pain/Discomfort (k = 0.14; p &lt; 0.01), Anxiety/Depression (K = 0.19; p &lt; 0.01) and EQ Index (k = 0.11 p &lt; 0.01). Conclusions Our analysis shows a greater concordance especially for the dimensions that appear more objective (Mobility and self-care) than the subjective ones (Pain, Anxiety). The physicians do not seem to take into account the differences in perception between men and women when they empathize with patients. Key messages The general practitioner knows the personal history of his patients and assesses the disorders as a whole, without focusing only on the specific pathology. In the exercise of the identification, he seems to understand mainly dimensions that appear more objective without grasping the differences in perception between men and women.


2020 ◽  
Author(s):  
Saber Gaffari-fam ◽  
Yosef Lotfi ◽  
Amin Daemi ◽  
Towhid Babazadeh ◽  
Ehsan Sarbazi ◽  
...  

Abstract Background Regarding the importance of health literacy as a key factor in self-care, appropriate understanding of health information by patients with type 2 diabetes mellitus (T2DM) is fundamental for better management of risk factors, which can also benefit their quality of life. This study aimed to describe the relationship between health literacy (HL), and self-care behaviors with health-related quality of life (HRQL) in patients with T2DM.Methods A cross-sectional survey was done in Iran in 2019. Patients were recruited randomly from health centers by medical records (n= 192, 55.2% male, mean age 58.12 years). The data collection included demographic form, health literacy questionnaire, diabetes self-care behavior questionnaire, and world health organization’s Quality of Life-BREF (WHOQOL-BREF). Analyses were adjusted for confounders using hierarchical regression analysis.ResultsHL as predictor variables explained 47.5% of variance in overall HRQL (p-value< 0.001), reading health information was the strongest HL dimension (β= 0.478). Self-care behaviors explained an additional 13.6% of the HRQL variance. In total, 65.5% of the variation in the HRQL is explained by the HL, self-care behavior, and the demographic variables.Conclusions We found that more almost two-third of the HRQL explained by the HL and self-care behaviors. Given the importance of health literacy and self-care behaviors in the quality of life in patients with T2DM, adoption of health-promoting behaviors and increasing health literacy can be beneficial for promoting quality of life among these patients.


Sign in / Sign up

Export Citation Format

Share Document